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Common deworming drug helps restore lung cancer's sensitivity to targeted therapy in mice
A form of lung cancer, which is found in about 10%–15% of Western patients and 40%–50% of Asian patients, is driven by a mutation in the epidermal growth factor receptor (EGFR) gene. Gefitinib is a go-to drug that shuts down ...
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Epilepsy associated with increased risk of dementia before age 65
People with epilepsy may be more likely to develop young-onset dementia than people without epilepsy, according to a study published in Neurology. Young-onset dementia, sometimes called early-onset dementia, develops before ...
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Medical research news
Cancer-linked protein needs a partner to activate silent DNA, fruit fly experiments reveal
In Ewing sarcoma, an abnormal protein formed by the fusion of two genes can activate repetitive DNA regions that normally remain silenced and turn them into gene regulatory elements. This mechanism contributes significantly ...
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Experimental gene therapy shows promise against hydrocephalus
Researchers at the University of Cincinnati College of Medicine have published the first proof-of-concept study showing the potential of an experimental gene therapy for hydrocephalus. The preclinical research from the lab ...
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Study finds diet and culture influence Hispanic children's exposure to 'forever chemicals'
Participation in school meal programs was linked to lower blood concentrations of certain PFAS, pollutants commonly known as "forever chemicals," in a new study of Hispanic children in Northern Virginia.
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Weight loss drugs may protect against heart failure
Weight-loss drugs known as GLP-1s may help protect against heart failure even at doses too low to produce significant weight loss, according to a laboratory study led by Cedars-Sinai Health Sciences University investigators.
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Maternal vaccination helps protect newborns from deadly bacterial bloodstream infections, mouse study suggests
Researchers at Washington University School of Medicine in St. Louis found that a vaccine given to pregnant mice protected their newborn pups from a severe bloodstream infection caused by Klebsiella pneumoniae, a dangerous ...
2 hours ago
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Skin measurements show link between insomnia and disrupted fear responses
A new computational model using skin conductance measurements to estimate stress-related emotional arousal found a significant difference in learned fear and safety responses over time between adults with and without insomnia.
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A gut microbe makes a fatty acid that cuts artery plaque in half in mice
A common gut bacterium produces a molecule that slows cholesterol production in the liver. When researchers gave the molecule to mice prone to artery disease, the animals developed roughly half as much fatty plaque as untreated ...
What if mosquito saliva holds the key to better fighting Zika, dengue and West Nile viruses?
Mosquitoes do more than simply transmit the viruses they carry: Their saliva may actively help these viruses establish infection in the body from the very moment of the bite. This is the finding of a study conducted by a ...
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Study offers insights on how heart valves last so long
Collagen plays a critical role in keeping heart valves strong, but the heart is surrounded by enzymes designed to break down collagen. So how can heart valves function efficiently decade after decade? A new study shows that ...
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Trapping cancer-driving DNA rings outside cell nucleus silences their genes, researchers find
Cells from rapidly growing, highly metastatic tumors often contain numerous rings of extrachromosomal DNA (ecDNA). This circular DNA frequently carries oncogenes—genes that promote cancer. Researchers have long sought vulnerabilities ...
3 hours ago
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Studies examine the connection between primary care provider resources and health outcomes for type 2 diabetes patients
Within the medical ecosystem, health guidelines aim for timely diagnosis and regular follow-up of chronic illnesses, such as type 2 diabetes, to ensure that no patient gets left behind. However, two studies by researchers ...
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AI misuse and nuclear famine could threaten humanity's survival before 2100
The fate of global health does not rest on any single disease. True preparedness means pairing the fight against illness with strength in finance, climate, defense and security. The COVID-19 pandemic, which brought the world ...
Deep brain stimulation study links multiple pathways to sustained improvement in treatment-resistant depression
Stimulation of specific brain connections was associated with sustained improvement in people receiving deep brain stimulation (DBS) for treatment-resistant depression, Mount Sinai researchers reported. The findings could ...
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Higher childhood BMI associated with greater body dissatisfaction at age 14 in both boys and girls
Children who follow higher trajectories of body mass index (BMI) and fat mass index across childhood report greater body dissatisfaction at age 14, in both boys and girls, according to a new study published in PLOS One by ...
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Molecular glue degraders show early promise in reducing Alzheimer's-linked brain plaques
A research team led by Indiana University School of Medicine scientists has discovered a new method for reducing the formation of amyloid plaques, which disrupt brain function in all aging adults but are particularly prevalent ...
4 hours ago
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Survival mechanism in the brain may help explain PTSD
A surprising feature of how the brain stores memories could help explain why harmless situations can sometimes quickly feel threatening, a hallmark of anxiety and trauma disorders.
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Ovaries remain active decades after menopause, study reveals
Contrary to popular belief, the postmenopausal ovary is not defunct. In a new study of ovaries from 28 women, scientists at Northwestern University and the Buck Institute for Research on Aging found that in the decades well ...
15 hours ago
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Overlooked DNA regions surrounding 'microexons' may hold missing pieces of autism's genetic puzzle
New research from scientists at the University of Toronto, the Sloan Kettering Institute, King's College London (KCL) and the Francis Crick Institute is helping piece together the missing genetics of autism spectrum disorder ...
5 hours ago
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