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Alzheimer's disease & dementia news
Alzheimer's disease & dementia
An fMRI marker of Alzheimer's-related cognitive decline
Researchers at Université Savoie Mont Blanc, Radboud University and the University of Oxford's Wellcome Center for Integrative Neuroimaging, report that attenuation of the brain's intrinsic anticorrelation between the default ...
Nov 25, 2025
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Alzheimer's disease & dementia
How antibody therapy clears Alzheimer's plaques: Key immune mechanism identified
Lecanemab, sold under the name Leqembi, is a monoclonal antibody therapy for Alzheimer's disease that clears toxic amyloid plaques and delays cognitive decline. Researchers from VIB and KU Leuven have now demonstrated the ...
Nov 25, 2025
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Key marker linking coronary artery disease to cognitive decline identified
Individuals with coronary artery disease (CAD)—a constricting or blocking of blood vessels feeding the heart—face increased risks of strokes, cognitive impairment and dementia. However, the link between CAD and cognitive ...
Nov 25, 2025
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Immediate treatment for traumatic brain injuries linked to lower risk for Alzheimer's disease
Getting treatment within one week of a serious head injury can reduce the risk of developing Alzheimer's disease by up to 41%, according to new research from Case Western Reserve University.
Nov 25, 2025
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Pill form of semaglutide fails to slow Alzheimer's in large trial
A pill version of semaglutide, the ingredient in Ozempic and Wegovy, did not slow the progress of Alzheimer's disease, drugmaker Novo Nordisk announced on Nov. 24.
Nov 25, 2025
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Novel discovery reveals how brain protein OTULIN controls tau expression and could transform Alzheimer's treatment
Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease. The findings, published in Genomic Psychiatry, ...
Nov 25, 2025
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Hospital infections associated with higher risk of dementia
A large-scale meta-analysis, led by first author Wei Yu Chua from the National University of Singapore and corresponding author Eng-King Tan at the National Neuroscience Institute and Duke-NUS Medical School in Singapore, ...
Nov 25, 2025
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Rare mutation protects brain's immune cells from Alzheimer's disease
Rutgers neuroscientist Peng Jiang and his neuroscience colleague Mengmeng Jin have made a discovery they say could reshape how scientists think about Alzheimer's treatment.
Nov 24, 2025
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Reduction of amyloid-β using red OLED restores memory in Alzheimer's model
A Korean research team has identified the most effective OLED color capable of enhancing cognitive function in Alzheimer's patients. The OLED platform developed for this study can precisely control color, brightness, flicker ...
Nov 24, 2025
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Astrocytes clear amyloid plaques and preserve cognitive function in Alzheimer's mouse models
Researchers at Baylor College of Medicine have discovered a natural mechanism that clears existing amyloid plaques in the brains of mouse models of Alzheimer's disease and preserves cognitive function. The mechanism involves ...
Nov 21, 2025
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How the cheese-noodle principle could help counter Alzheimer's
Researchers at the Paul Scherrer Institute PSI have clarified how spermine—a small molecule that regulates many processes in the body's cells—can guard against diseases such as Alzheimer's and Parkinson's: It renders ...
Nov 21, 2025
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Targeting brain immune cells could restore Alzheimer's-related lipid imbalance, research shows
More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as "lipoid granules," along with the buildup of amyloid‐beta (amyloid) plaques and tau protein tangles. These observations ...
Nov 21, 2025
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Arginine supplementation curbs Alzheimer's disease pathology in animal models
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is one of the leading causes of dementia worldwide, and currently has no definitive cure. Although antibody-based therapies that target amyloid β (Aβ) ...
Nov 21, 2025
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Genetic risk combined with cardiovascular factors may help predict and delay dementia
Combining genetic risk with cardiovascular disease risk factors—such as high LDL cholesterol, obesity, and hypertension—may predict who is more likely to develop dementia, according to a new study led by UC San Francisco.
Nov 21, 2025
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Long-term pharmacological treatment shows promise against memory impairments in Down syndrome
In 2019, a research group led by Andrés Ozaita, of the Department of Medicine and Life Sciences at Pompeu Fabra University, described that mice models for Down syndrome have more cannabinoid receptor 1 (CBR1) in some regions ...
Nov 20, 2025
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Exercising in mid and later life can reduce dementia risk, new study suggests
For years, scientists have known that moving our bodies can sharpen our minds. Physical activity boosts blood flow to the brain, enhances neuroplasticity and reduces chronic inflammation. These processes are believed to protect ...
Nov 20, 2025
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Staying connected: How social ties can protect aging brains
"Social frailty" is a major dementia risk. A UNSW researcher is changing how to spot and treat it early.
Nov 20, 2025
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Simple blood test may someday allow for diagnosis of LATE dementia during life
Jijing Wang, Ph.D., and Hyun-Sik Yang, MD, of the Department of Neurology at Mass General Brigham, are the lead and senior authors of a paper published in Molecular Neurodegeneration titled "Plasma TDP-43 is a potential biomarker ...
Nov 20, 2025
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Microglia modulate the reactivity of astrocytes in Alzheimer's disease, study finds
Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease characterized by the progressive loss of memory and decline of mental functions. Earlier research has uncovered some of the neural and biological ...
Clogged 'drains' in the brain likely an early-warning sign of Alzheimer's disease
"Drains" in the brain, responsible for clearing toxic waste in the organ, tend to get clogged up in people who show signs of developing Alzheimer's disease, a study by researchers from Nanyang Technological University, Singapore ...
Nov 19, 2025
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Investigating lithium's potential role in slowing cognitive decline in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline such as memory loss and behavioral disturbances that severely impair quality of life. Despite decades of research, effective ...
Nov 19, 2025
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Study links depression, insomnia to higher risk of dementia
A study conducted by researchers at Saint Louis University found that people over 50 who suffer from both depression and insomnia are significantly more likely to develop Alzheimer's disease and related dementias.
Nov 19, 2025
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Muscle protein linked to exercise opens new way to treat Alzheimer's
Alzheimer's disease (AD) is a devastating cause of memory loss and cognitive decline, for which no curative treatment is available. Among lifestyle factors, physical activity stands out as possibly one of the strongest defenders ...
Nov 18, 2025
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Shingles vaccine most promising common drug to potentially prevent Alzheimer's
A new study has identified three existing medications that could be repurposed to treat or prevent Alzheimer's disease.
Nov 18, 2025
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Gene 'switch' reverses Alzheimer's risk in experimental model
University of Kentucky researchers have developed a new experimental model that could point the way toward more effective Alzheimer's disease treatments by targeting one of the brain's most important genes for risk and resilience.
Nov 17, 2025
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