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Oncology news
T cells secrete DNA to boost the immune system's cancer-fighting ability
Activated immune cells secrete tiny capsules bearing DNA that can enter other immune and tumor cells to stimulate the body's defense systems, according to a study led by investigators at Weill Cornell Medicine. The discovery ...
8 hours ago
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Restoring protein recycling helps exhausted T cells fight tumors again
T cells are crucial components of our immune system, serving as critical protectors against infection and disease. But there are limits to their defensive capabilities. T cells are not inexhaustible protectors. Often, when ...
9 hours ago
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Blocking energy metabolism may help treat an aggressive pediatric brain tumor
Blocking energy production pathways in an aggressive type of brain cancer in children could be a promising new therapeutic strategy, according to research in mice by Johns Hopkins Kimmel Cancer Center investigators. The paper ...
6 hours ago
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Genetic discovery may explain why pancreatic cancer is so difficult to treat
Pancreatic cancer can remain quiet for years, developing undetected before causing symptoms that lead to a diagnosis. Even after a surgeon removes a pancreas tumor, other cells often hide and erupt later. But University of ...
13 hours ago
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Why this CAR T advance matters: Complete remissions without chemotherapy at doses as low as 250,000 cells/kg
Stem-cell memory T (TSCM) cells are a rare subset of immune cells with the ability to self-renew, persist long term, and mount potent anti-tumor responses. These properties make them an attractive candidate for next-generation ...
15 hours ago
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Cervical cancer: Study reveals a growing gap between high- and low-income countries
While high-income countries like Canada could eliminate cervical cancer by 2048 through human papillomavirus (HPV) vaccination and screening, the gap with lower-income countries is widening. A study published in The Lancet ...
7 hours ago
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Novel theranostic approach for radioimmunotherapy achieves curative responses in colorectal cancer tumors
A new pretargeted radioimmunotherapy (PRIT) technique has been shown to be safe and effective in eradicating tumors from a preclinical colorectal cancer model. The multi-step theranostic approach delivers alpha-emitting radiation ...
8 hours ago
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Targeted maternal screening could prevent rare, deadly leukemia in the US
A deadly form of leukemia may be stopped before it ever develops by introducing targeted maternal screening in the United States, according to new research. The national study, led by physician-scientists at Sylvester Comprehensive ...
15 hours ago
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AI-assisted approach identifies IRS4 as a promising drug target in multiple solid tumors
Leveraging AI capabilities combined with genetic data led St. Jude Children's Research Hospital investigators to predict new cancer drug targets that carry a limited risk of side effects. For their study, published in Science ...
10 hours ago
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Scientists discover new way to make drug-resistant cancer treatable again
Cancer cells survive by repairing damage to their DNA—even damage that would normally be fatal. One of their most important defense systems is homologous recombination, a high-precision repair pathway that fixes broken DNA ...
11 hours ago
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Caregivers of ovarian cancer patients face high stress and major gaps in support
A new scoping review from the University of Toronto reveals that caregivers of loved ones with ovarian cancer face significant emotional strain, heavy caregiving responsibilities, and limited support throughout the disease ...
12 hours ago
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How melatonin could improve fertility-preserving ovarian transplants after cancer treatment
Administering melatonin via an absorbable sponge improved the effectiveness of autologous ovarian tissue transplantation. This procedure is used to preserve the fertility of children and adolescents who have undergone cancer ...
8 hours ago
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Gentler blood cancer treatment could boost survival and quality of life
A gentler treatment for children whose leukemia has come back could boost survival and quality of life, a study led by a UCL academic has found. The new regime significantly reduces the need for intensive chemotherapy and ...
14 hours ago
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Multiple myeloma linked to higher risk for hematologic second cancers
Patients with multiple myeloma (MM) have a distinct pattern of second primary malignancy (SPM), with a markedly increased risk of hematologic SPMs, according to a review published online April 6 in Frontiers in Oncology.
9 hours ago
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Targeted 'biological missile' blocks leukemia growth while sparing healthy tissue
New research out of VCU Massey Comprehensive Cancer Center has uncovered a targeted cancer therapy that significantly prevents leukemia progression, improves survival rates and minimizes damage to surrounding healthy tissue.
16 hours ago
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A routine virus can slow breast cancer spread to the lungs, offering hidden protective power
Respiratory syncytial virus (RSV), mostly infects the lungs, nose, throat, and respiratory tract, and can cause illness ranging from mild cold and fever-like symptoms to severe pneumonia and bronchitis. A recent study has ...
Glioblastoma mapping uncovers four recurring tumor cell communities, revealing treatment targets
Glioblastoma (GBM) is an aggressive type of brain cancer that is known to be very difficult to treat. One reason why this type of cancer is often resistant to available treatments is that it is characterized by a highly diverse ...
Scientists recruit red blood cells to deliver genetic cargo with instructions to kill cancer
Scientists have developed a way to turn the body's own immune cells into cancer-fighting agents—without removing them from the body—by using red blood cells to deliver genetic instructions. Current CAR (chimeric antigen receptor) ...
A natural molecule boosts CAR-T therapy and turns cold tumors hot
CAR-T cell therapy works well in blood cancers, but many patients still become resistant. A key reason is the presence of CAR-T regulatory T cells (CAR-Tregs), which weaken immune responses. Therefore, selectively targeting ...
Apr 29, 2026
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New dual-target drug may help overcome immunotherapy resistance in pancreatic cancer
Pancreatic ductal adenocarcinoma is one of the deadliest cancer types, with a five-year survival rate of 13%. There are only two treatment regimens available with limited efficacy. Pancreatic cancers do not respond to immunotherapy ...
Apr 29, 2026
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How eating primes immune cells for future responses
Diets and healthy eating habits hold promise for preventing and treating diseases, but far less is known about acute effects on the immune system shortly after a meal.
Apr 29, 2026
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Rethinking mRNA vaccines: Liver targeting can suppress immunity, while muscle boosts it
A new study by researchers at the Icahn School of Medicine at Mount Sinai overturns a longstanding assumption about how mRNA vaccines generate immunity, revealing that certain non-immune cells help determine vaccine effectiveness.
Apr 29, 2026
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Nerves in skin can slow melanoma growth
Nerve fibers within melanomas can slow their growth, according to a study led by Weill Cornell Medicine investigators. The findings help clarify the emerging field of cancer neuroscience and may inform future therapeutic ...
Apr 29, 2026
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Revealing the unusual ability of a protein involved in lung and thyroid cancer
Research conducted at the National Cancer Research Centre (CNIO) has revealed an unexpected behavior observed in a protein involved in several types of cancer: it manages to self-activate, meaning it gives itself the order ...
Apr 29, 2026
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Why CAR T therapy works for some patients but fails for others may be getting clearer
Chimeric antigen receptor (CAR) T-cell therapy is one of oncology's most powerful ideas: Harvest a cancer patient's own immune cells, genetically engineer them to recognize tumor cells, multiply them in a laboratory and reinject ...
Apr 29, 2026
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