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Oncology news
Immune system protein is a cancer killer on its own, new study shows
For decades, scientists have known that a protein made by T cells and natural killer (NK) cells in the immune system, called perforin, can kill tumor cells by punching a hole in the cell wall and injecting proteases called ...
11 hours ago
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Colorectal cancer in younger patients shows distinct cellular and gene-activity patterns
Mass General Brigham researchers from the Gene Lay Institute of Immunology and Inflammation, along with researchers at Dana-Farber Cancer Institute and the Broad Institute, have uncovered biological clues to why colorectal ...
22 hours ago
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Known for preventing cancer, p53 could also help immune cells fight it
Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a new strategy to make cancer-fighting immune cells stronger and potentially longer-lasting, a discovery that could help improve the effectiveness ...
10 hours ago
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Tumor mutations and immune activity may reveal who benefits from investigational lymphoma drug
Researchers at the University of Tsukuba conducted a physician-initiated phase 2 clinical trial of dasatinib in patients with relapsed or refractory T-follicular helper cell lymphoma (TFHL), an aggressive and difficult-to-treat ...
11 hours ago
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Blood test offers new way to track lung cancer
Northwestern Medicine scientists and collaborators have demonstrated a novel liquid biopsy technique that can measure cancer burden and reveal molecular characteristics of small cell lung cancer (SCLC), according to a new ...
13 hours ago
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Antibody candidate could help preserve appetite and muscle strength in patients with cancer
In cancer cachexia, patients continue to lose weight, muscle and fat even when they eat. A KAIST research team has developed a therapeutic candidate that blocks a signal responsible for appetite suppression, weight loss and ...
14 hours ago
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Researchers identify critical window for boosting immunotherapy response in prostate cancer
Researchers at Roswell Park Comprehensive Cancer Center have shown that hormone-blocking therapies commonly used to treat prostate cancers temporarily activate the body's immune response before those immune effects begin ...
19 hours ago
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Residential fine particulate matter linked to minimal residual disease in pediatric leukemia
For pediatric patients with high-risk B-cell acute lymphoblastic leukemia (B-ALL), residential fine particulate matter (PM₂.₅) concentrations during induction therapy are associated with positive end-of-induction (EOI) minimal ...
12 hours ago
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Healthy diet may lower heart disease risk after cancer
Eating a healthy diet is associated with a reduced risk of heart disease and death among cancer survivors, according to a study published today in JACC: Advances.
14 hours ago
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Immune changes linked to diabetes could guide development of new cancer treatments
New research in The Journal of Immunology uncovers how high blood sugar (hyperglycemia) and type 1 diabetes (T1D) may protect against certain cancers like melanoma, breast and colon cancer. T1D has been associated with a ...
Oct 29, 2026
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Personalized ovarian cancer vaccines spark immunity in phase 1 trial
Rapidly dividing cancer cells can develop DNA mutations that produce abnormal proteins called antigens, which are unique to each patient's cancer. Scientists are now testing personalized cancer vaccines that target these ...
Arsenic drug combo resurrects 'guardian of the genome' to fight aggressive blood cancers
A combination cancer therapy that relies on the reactivation of a tumor suppressor protein to kill leukemic and other blood cancer cells has shown promise in a small pilot trial.
Smarter CAR-T cells could beat a deadly pediatric brain cancer
Scientists at UC San Francisco have engineered CAR-T cells that stay dormant until they reach the brain, where they switch on and destroy tumor cells. In mice, these CAR-T cells were able to clear diffuse midline glioma (DMG), ...
Oct 28, 2026
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Unifying mechanism explains how common cancer mutations fuel growth
A family of mutations seen in about 20% of human cancers drives malignancy by changing the accessibility of genes to a particular regulatory protein, according to a study by Weill Cornell Medicine investigators. The findings ...
Oct 28, 2026
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Wider surgical margins may not mean better cancer control
It's a question that surgeons often face: How much surrounding healthy tissue should they take out when removing a patient's cancer to be sure it is fully eliminated? Removing more can sacrifice nearby nerves, blood vessels, ...
Oct 28, 2026
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Lab-on-a-chip predicts which cancer treatments may work for pediatric acute lymphoblastic leukemia
More than 120,000 people in the U.S. are living with acute lymphoblastic leukemia (ALL), and 6,000 new cases are diagnosed each year. Of those, more than 3,500 will be in children. Responsible for 75% of all pediatric leukemia ...
Oct 28, 2026
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Combining targeted therapies significantly boosted survival in kidney cancer study
Results of a phase 1/2 trial led by Roswell Park Comprehensive Cancer Center show that combining the targeted therapies bevacizumab (Avastin) and pazopanib (Votrient) significantly extends both progression-free and overall ...
Oct 28, 2026
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Preclinical research shows macrophages can be programmed to fight solid cancer tumors
One person dies every 50 seconds in the U.S. from cancer, and an estimated 39% of people in the country will develop cancer during their lifetime. Survival rates have improved in recent decades from innovations and combinations ...
Oct 28, 2026
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Obesity in young adulthood linked to increased risk of early-onset cancer
Having obesity in your 20s and 30s could raise your risk for early-onset cancer.
Oct 28, 2026
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Improve IBD bowel checks for early cancer detection
The first U.K.-wide analysis of bowel screening for patients with inflammatory bowel disease (IBD) has identified opportunities to improve the early detection of cancer. The study—the largest of its kind globally—found that ...
Oct 28, 2026
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Researchers develop privacy-friendly, secure and sustainable AI techniques for medical imaging
Artificial intelligence can be helpful in analyzing medical images and support radiotherapy planning workflows. However, huge amounts of sensitive patient data are needed to train robust AI models. Researchers at the Karlsruhe ...
Oct 28, 2026
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How the tumor environment influences bowel cancer cells' behavior and chemotherapy response
New research led by experts at the University of Nottingham has revealed how collagen in the tumor environment can alter bowel cancer cell behavior and influence inflammatory responses to chemotherapy, highlighting potential ...
Oct 28, 2026
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Cell-level analysis reveals how ovarian tumors may develop resistance to chemotherapy
High-grade serous ovarian cancer is an aggressive form of ovarian cancer, characterized in particular by high diversity among the cells that compose a given tumor. This intratumor heterogeneity is a major challenge in understanding ...
Oct 28, 2026
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Fighting cancer also means fighting against social stigma
Cancer-related discrimination arises from long-lasting cultural and institutional misconceptions, with significant impacts on every part of a person's quality of life and health—and Flinders University researchers say it ...
Oct 28, 2026
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Targeted drug significantly delays advanced breast cancer progression but increases toxicity, phase III trial reports
In a global phase 1 trial, trastuzumab rezetecan showed promising signs of fighting ERBB2-low metastatic breast cancer in patients who had already undergone extensive treatment. Also known as HER2-low breast cancer, this ...
