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Oncology news

Antidepressant unable to prevent chemotherapy-associated nerve damage

A randomized trial conducted by the Alliance for Clinical Trials in Oncology has found that duloxetine, a medication commonly used to treat chronic pain and psychiatric conditions, does not prevent nerve damage caused by ...

Researchers map prostate immune niches, showing T cells persist months in mice

More than 35,000 men in the United States die from prostate cancer each year. Now, a new study reveals the immune cell weaponry we might use to save lives.

How an overactive immune system can drive cancer

The immune system is designed to protect us against viruses and bacteria. In autoimmune diseases, however, the immune system instead attacks the body's own cells. Conditions such as systemic lupus erythematosus (lupus) and ...

Why anti-cancer drugs do not always live up to expectations

For more than a decade, a class of drugs called BET inhibitors has been tested in cancer trials with high expectations. The biology looked promising. Many cancers depend on oncogenes that "Bromo- and Extra-Terminal domain" ...

New tool offers personalized approach to blood cancer care

Researchers have developed a new tool to help clinicians tailor personalized treatment plans for patients with a rare blood cancer called chronic myelomonocytic leukemia (CMML). The tool, called the international CMML Prognostic ...

Scientists reveal a new way cancer cells survive DNA damage

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered that the enzyme Pol theta ...