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Cardiology news

Biological pacemaker dogma challenged as TBX18 fails and Hcn2 delivers

Researchers from Amsterdam UMC have overturned a key assumption in the biological pacemaker field. In a new preclinical study, they show that the transcription factor TBX18 does not generate true biological pacemaker activity, ...

Researchers develop first synthetic mitral valve model to replicate the heart's natural mechanics

Researchers at RCSI University of Medicine and Health Sciences have developed an artificial model of the mitral heart valve that faithfully mimics the valve's complex mechanical behavior in the human heart. The study could ...

Brain aneurysm map reveals cell types tied to rupture risk

A new study from UC San Francisco shows how certain cells in the brain may cause aneurysms to weaken and rupture. It helps explain why some aneurysms burst while others do not and could lead to new ways of predicting and ...

Molecular mechanics behind heart cell restructuring revealed

Microtubules, part of heart muscle cells' internal "skeleton," help determine how the heart changes shape under stress, and a common signaling pathway called the ERK pathway acts as a key controller of where the building ...

Statin use linked to lower risk of frailty in older veterans

Researchers at Mass General Brigham have demonstrated that older U.S. veterans who initiated statin therapy were significantly less likely to develop frailty over time, suggesting that the cholesterol-lowering medications ...

Disrupted metabolism linked to heart failure

When heart cells burn fat without normal metabolic controls, they can deplete a lipid needed to keep mitochondria functioning properly, according to a study by UT Southwestern Medical Center researchers. The findings, published ...

Unraveling the mystery of misfolded proteins in the heart

Researchers in the del Monte Lab at the Medical University of South Carolina (MUSC) are the first to observe defects in the protein repair system associated with the peculiar, misfolded protein plaques previously observed ...

Protecting heart health in an era of temperature extremes

Extreme heat and cold are growing cardiovascular risks that can trigger heart attacks, strokes, heart failure, and sudden cardiac death, according to a recent scientific statement by experts at Weill Cornell Medicine and ...