Oncology & Cancer

Scientists identify novel therapeutic target for ovarian cancer

New research by Wistar Institute scientists shows how targeting a cleft in the retinoblastoma protein can kill tumor-protecting macrophages in ovarian cancer. The discovery provides a novel therapeutic target that could potentially ...

Oncology & Cancer

Why preventive mastectomy isn't offered to everyone at risk

When Jesse J, Christina Applegate and Katie Thurston spoke openly about their mastectomies, their candor did more than share private struggles. It highlighted a procedure that, while often life saving, is unevenly available ...

Oncology & Cancer

Scientists develop off-the-shelf immunotherapy for ovarian cancer

Ovarian cancer is the leading cause of death among women with gynecological cancers. The current medical playbook—surgery followed by chemotherapy—initially shows promise. Tumors shrink, sometimes disappearing entirely. ...

Oncology & Cancer

Ovarian tumor immune landscapes offer clues to better therapy

The immune system is a major determinant of how patients respond to standard treatments for ovarian cancer, the leading cause of death from gynecological malignancies. But little was known about how the immune landscape of ...

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Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early on and may include: bloating, pelvic pain, difficulty eating and frequent urination, and are easily confused with other illnesses.

Most (more than 90%) ovarian cancers are classified as "epithelial" and are believed to arise from the surface (epithelium) of the ovary. However, some evidence suggests that the fallopian tube could also be the source of some ovarian cancers. Since the ovaries and tubes are closely related to each other, it is thought that these fallopian cancer cells can mimic ovarian cancer. Other types may arise from the egg cells (germ cell tumor) or supporting cells. These cancers are grouped into the category of gynecologic cancer.

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