Medications

Doctors, hospitals, pharmacies warned not to stockpile meds

(HealthDay)—In a joint statement released by the American Medical Association, American Pharmacists Association, and American Society of Health-System Pharmacists, the professional groups "strongly oppose" physicians, pharmacies, ...

Vaccination

Race for vaccine tests limits of drug innovation

From medical workers struggling to care for the rising tide of COVID-19 patients to the billions of people told to stay home to slow the pandemic, everyone is waiting for one thing: a vaccine.

Diseases, Conditions, Syndromes

US regulator approves limited use of malaria drugs for virus

A limited emergency-use authorization for two antimalarial drugs touted as game-changers by President Donald Trump has been issued by the US Food and Drug Administration to treat coronavirus patients.

Arthritis & Rheumatism

Lung diseases linked to higher rheumatoid arthritis risk

Asthma and chronic obstructive pulmonary disease (COPD) were each associated with increased risk for developing rheumatoid arthritis in a study published in Arthritis & Rheumatology.

Arthritis & Rheumatism

A protein that controls inflammation

A study by the research team of Prof. Geert van Loo (VIB-UGent Center for Inflammation Research) has unraveled a critical molecular mechanism behind autoimmune and inflammatory diseases such as rheumatoid arthritis, Crohn's ...

Medications

Antimalarial drug no better than standard coronavirus care: study

Hydroxychloroquine, an antimalarial drug dubbed a "gift from God" by US President Donald Trump for its potential ability to fight the new coronavirus, was found to be no more effective than standard treatment in a small Chinese ...

Diseases, Conditions, Syndromes

Virus and elderly: Avoid crowds, cruises, long plane trips

The U.S. government's coronavirus recommendations tell older adults to avoid crowds, cruises and long plane rides—advice that one public health official acknowledged won't be welcomed by many.

page 1 from 100

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints. The process produces an inflammatory response of the capsule around the joints (synovium) secondary to swelling (hyperplasia) of synovial cells, excess synovial fluid, and the development of fibrous tissue (pannus) in the synovium. The pathology of the disease process often leads to the destruction of articular cartilage and ankylosis of the joints. Rheumatoid arthritis can also produce diffuse inflammation in the lungs, membrane around the heart (pericardium), the membranes of the lung (pleura), and white of the eye (sclera), and also nodular lesions, most common in subcutaneous tissue. Although the cause of rheumatoid arthritis is unknown, autoimmunity plays a pivotal role in both its chronicity and progression, and RA is considered a systemic autoimmune disease.

About 1% of the world's population is afflicted by rheumatoid arthritis, women three times more often than men. Onset is most frequent between the ages of 40 and 50, but people of any age can be affected. It can be a disabling and painful condition, which can lead to substantial loss of functioning and mobility if not adequately treated. It is a clinical diagnosis made on the basis of symptoms, physical exam, radiographs (X-rays) and labs, although the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) publish diagnostic guidelines. Diagnosis and long-term management are typically performed by a rheumatologist, an expert in joint, muscle and bone diseases.

Various treatments are available. Non-pharmacological treatment includes physical therapy, orthoses, occupational therapy and nutritional therapy but these do not stop the progression of joint destruction. Analgesia (painkillers) and anti-inflammatory drugs, including steroids, are used to suppress the symptoms, while disease-modifying antirheumatic drugs (DMARDs) are required to inhibit or halt the underlying immune process and prevent long-term damage. In recent times, the newer group of biologics has increased treatment options.

The name is based on the term "rheumatic fever", an illness which includes joint pain and is derived from the Greek word ῥεύμα-rheuma (nom.), ῥεύματος-rheumatos (gen.) ("flow, current"). The suffix -oid ("resembling") gives the translation as joint inflammation that resembles rheumatic fever. The first recognized description of rheumatoid arthritis was made in 1800 by Dr. Augustin Jacob Landré-Beauvais (1772–1840) of Paris.

This text uses material from Wikipedia licensed under CC BY-SA