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Gastroenterology news
Why fatty liver results can mislead: RNA changes often fail to predict proteins
Fatty liver is an increasingly common disease that can progress toward more severe forms, involving inflammation, fibrosis, and, in some cases, cirrhosis and liver cancer. While it is known that a high-fat diet alters gene ...
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Gut inflammation may rewire the 'second brain,' triggering lasting motility problems
Research by Milena Bogunovic, MD, Ph.D., associate professor of pathology, sheds light on how inflammation in the gastrointestinal (GI) tract, such as that associated with inflammatory bowel disease (IBD), can lead to long-lasting ...
21 hours ago
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Some common IBS treatments are linked to a higher risk of death, say study
A large, long-term study led by Cedars-Sinai Health Sciences University investigators suggests that some medications commonly prescribed to treat irritable bowel syndrome (IBS)—including antidepressants—may be associated ...
Apr 8, 2026
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Loss of microbiota alters the profile of cells that protect the intestinal wall, experiments reveal
A research team led by scientists from the State University of Campinas (UNICAMP) in São Paulo, Brazil, has made significant progress in understanding the relationship between gut microbiota and intestinal cells. The study, ...
Apr 8, 2026
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Can gluten pass through a kiss? New data are reassuring
For people living with celiac disease, the fear of gluten exposure can extend beyond food—sometimes even into moments of intimacy. A new study published in Gastroenterology offers reassuring news: while gluten can be transferred ...
Apr 8, 2026
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Are your bathroom habits normal? New book addresses concerns
When you're an expert on the gut, you're used to conversations others might shy away from. So a book on pooping and what can go wrong in the process is on brand for Trisha Pasricha, a second-generation gastroenterologist ...
Apr 7, 2026
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Researchers identify potential therapeutic target for alcohol-associated liver disease and alcohol use disorder
Scientists have identified a particular protein in the body that may influence the progression of alcohol-associated liver disease and drinking behavior. The protein aquaporin 9 (AQP9) helps liver cells absorb and excrete ...
Apr 7, 2026
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AI tool can predict Barrett's esophagus recurrence after therapy with 90% accuracy
A new artificial intelligence (AI)-based tool shows promise for improving surveillance in patients treated with endoscopic eradication therapies for Barrett's esophagus (BE)-related dysplasia and early esophageal adenocarcinoma. ...
Apr 7, 2026
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Researchers start to clarify the likelihood of recovery after alcohol-associated hepatitis
Returning to drinking after alcohol-associated hepatitis (AH) is closely related to recurrent liver disease and death. Of those hospitalized for AH, 30% die within 90 days. Among the survivors, alcohol use is key to outcomes. ...
Apr 7, 2026
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GLP-1 agonist drugs show digestive side effects but may help fight infections
Originally developed to treat diabetes, a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are now stepping into the spotlight as weight loss drugs. A recent umbrella review draws attention to ...
New mouse model of virus-driven liver cancer may boost diagnosis and treatments
Liver cancer is one of the world's deadliest cancers, and most cases are linked to chronic viral hepatitis. Yet scientists have lacked an animal model that faithfully recapitulates how the disease unfolds in people, from ...
Apr 6, 2026
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High‑fat diets linked to rapid decline in protective gut immune cells
In a preclinical study from Mass General Brigham, researchers have found that even short-term exposure to high levels of dietary fat results in a quick and selective loss of critical gut immune cells called ILC3s, promoting ...
Apr 6, 2026
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Novel treatment protocol targets the deadliest cases of C. difficile infection
A new study from the University of Minnesota Medical School has demonstrated that fecal microbiota transplantation (FMT) can rapidly reverse systemic inflammation and improve survival in patients with fulminant Clostridioides ...
Apr 6, 2026
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New therapeutic target identified for neuroendocrine tumors in the gastrointestinal tract
Neuroendocrine cells are unique in their ability to act both as nerve cells and hormone-making cells. They're scattered throughout the body, including the stomach, intestines, pancreas and lungs. Tumors that arise from these ...
Apr 6, 2026
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Scientists target key protein duo driving colon, liver cancer
Cedars-Sinai Health Sciences University investigators have identified a drug-like compound that prevents two proteins from working together to promote the growth of colorectal and liver cancer. Findings from the preclinical ...
Apr 6, 2026
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Researchers create first working model of specialized gut cells
Cedars-Sinai Health Sciences University investigators have for the first time created human intestinal organoids that include functional Paneth cells, a specialized cell type that is found in the inner lining of the intestine. ...
Apr 6, 2026
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Cellular pathways that drive precancerous lesions to form pancreatic tumors identified
Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and has a low five-year survival rate. It begins with a reversible state called acinar-to-ductal metaplasia, where cells can heal after injury ...
Apr 3, 2026
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Overnight machine perfusion lets liver transplants safely shift to daytime, study shows
It is safe for patients to receive a donor liver that has been intentionally preserved overnight using machine perfusion to enable a daytime transplant. This is shown by a study performed at the University Medical Center ...
Apr 3, 2026
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Could one protein play both sides? How Stard7 shifts colon cancer in different models
Alain Chariot's team has just published a study in EMBO Molecular Medicine shedding light on the unexpected role of the Stard7 protein in the development of intestinal cancers. Long regarded as a simple lipid transporter, ...
Apr 2, 2026
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How pancreatic tumors thwart an iron-driven demise
Tumors driven by cancer-driving KRAS mutations are often susceptible to ferroptosis, a type of cell death that can be harnessed for cancer therapy. Given that more than 95% of pancreatic ductal adenocarcinomas (PDACs) harbor ...
Apr 2, 2026
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Occasional heavy drinking may triple the risk of liver damage, research suggests
People may assume that if they drink lightly during the week or month, heavy drinking on the occasional Friday or Saturday may not cause their liver harm. New research suggests otherwise, according to a Keck Medicine of USC ...
Apr 2, 2026
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Radiation therapy improves outcomes for 'supermassive' bile duct tumors
A new study from researchers at The University of Texas MD Anderson Cancer Center demonstrates that a specialized high-dose type of radiation delivery may significantly improve outcomes for patients with large bile duct tumors ...
Apr 2, 2026
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Cause or effect? Study answers question about gene linked with colorectal cancer
A new study has answered a question that has puzzled cancer researchers for decades: Does a genetic defect found in nearly all human colorectal cancers simply accompany the disease, or does it trigger its development? A team ...
Apr 1, 2026
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How stomach cells rebuild after injury: Study uncovers key players in tissue regeneration
Researchers at Baylor College of Medicine and collaborating institutions took a closer look at how the gastrointestinal tissue repairs itself. They reveal in the Proceedings of the National Academy of Sciences key players ...
Apr 1, 2026
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