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Gastroenterology news
Inflammation may trigger protective cell shift in ulcerative colitis, study finds
Paneth cell metaplasia (PCM), long viewed as a consequence of chronic inflammation in ulcerative colitis, may also help protect and repair the intestine, according to researchers at Science Tokyo. The study found that inflammation ...
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Colon cancer cells may change identity to metastasize
Loss of GATA6—a transcription factor that controls which genes are turned on or off—can reprogram colorectal cancer cells into more primitive, adaptable states that can then spread to the liver and establish new tumors, according ...
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Certain demographic, birth, and parental characteristics may increase risk of early-onset colorectal cancer
A recent study has found that factors such as a person's birth weight, sex, ethnicity and father's age may affect their risk of being diagnosed with colorectal cancer at a young age. The findings are published in Cancer.
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Gene therapy shows promise in ARC syndrome, a deadly childhood liver disease
A new gene therapy has been used to successfully treat a deadly childhood liver disease in mice that model the disease, according to researchers at UCL and Great Ormond Street Hospital. Arthrogryposis, renal dysfunction and ...
Jun 19, 2026
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Engineered probiotic heads to human trials
A probiotic bioengineered by UBC Okanagan researchers to thrive in the inflamed gut is set to enter human clinical trials in Australia this summer, capping a decade-long effort to turn a beneficial bacterium into a treatment ...
Jun 19, 2026
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Microplastics may worsen fatty liver disease, new study suggests
Microplastics—minuscule pieces of plastic broken down from larger plastic waste—are a growing concern for human health, especially for the liver. A study from the University of Oklahoma, published in Science Advances, demonstrates ...
Jun 18, 2026
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Rhythmic drug dosing may boost safety and efficacy in chronic liver disease
Metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are progressive chronic liver diseases linked to abnormal bile acid metabolism. Although ...
Jun 18, 2026
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Colonoscopy remains the top choice for colorectal cancer screening amid new guidance
As new colorectal cancer screening guidance draws attention to the growing number of testing options, the American Gastroenterological Association urges patients and primary care providers to understand how those options ...
Jun 18, 2026
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Colorectal tumors use mitochondrial complex II to stockpile iron, but eliminating it causes cell death
Scientists know that colorectal cancer cells require large amounts of iron and that as cancer becomes more aggressive, the cells have even higher amounts of iron. Normal cells with high levels of iron would undergo a type ...
Jun 17, 2026
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Exploiting a common weakness in enzymes could lead to a single vaccine against diarrhea-causing gut pathogens
The bacteria enterotoxigenic E. coli and Shigella together cause hundreds of millions of infections each year and are among the leading causes of diarrheal death, especially in children. Decades of vaccine development efforts ...
Jun 17, 2026
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Digital tool flags cancer patients at risk of serious immunotherapy bowel side effects
Immune checkpoint inhibitors are a form of cancer immunotherapy successfully used to treat a wide range of cancers. However, these treatments can cause side effects including immune-related colitis, or inflammation of the ...
Jun 17, 2026
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Liver cancer deaths are rapidly increasing. Tackling preventable causes would save lives
Liver cancer is one of the fastest-rising causes of cancer-related deaths in the UK and the third-leading cause of cancer deaths worldwide.
Jun 17, 2026
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Beyond GLP-1s: The next chapter of obesity care
The rapid rise of GLP-1 medications such as semaglutide and tirzepatide has transformed obesity treatment. Still, experts say medications alone are not enough to address one of the nation's most pressing chronic diseases.
Jun 17, 2026
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Immune cell circuit restores barrier function in inflammatory bowel disease
Scientists have discovered a new protective communication circuit between specialized immune cells in the intestines, a circuit that may be therapeutically targeted to improve inflammatory bowel disease outcomes, according ...
Jun 16, 2026
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Mapping immune cell interactions in gut tissue reveals changes in ulcerative colitis
In a new study published in Science Immunology, researchers at King's College London looked at a type of tissue important for the immune response called gut-associated lymphoid tissue (GALT), which is located within the lining ...
Jun 16, 2026
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Large-scale genetic study uncovers new factors associated with a pregnancy-related liver disease
Intrahepatic cholestasis of pregnancy (ICP) affects approximately 0.2–2% of pregnant women and typically develops after 30 weeks of gestation. As the most common symptom is severe itching of the palms and the soles of the ...
Jun 16, 2026
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Expanding the evidence for behavioral interventions in gastroenterology
The Division of Gastroenterology and Hepatology at Feinberg has a distinct strength in understanding how behavior and lifestyle influence gastrointestinal (GI) health. Through its work and in collaboration with the Northwestern ...
Jun 16, 2026
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Developing clinical-grade intestinal organoids for regenerative medicine applications
Inflammatory bowel disease (IBD) and other intestinal disorders affect millions of people worldwide, often causing lasting damage to the lining of the gut. In severe cases, this damage can become irreversible, leaving surgery ...
Jun 16, 2026
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Crohn's atlas maps gene shifts across more than 50 gut cell types
A detailed cellular study of Crohn's disease has mapped how gene activity changes across more than 50 cell types in the gut. The study provides an open resource of the genes that characterize each cell type and those whose ...
Jun 15, 2026
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Cohabiting people share about a quarter of their gut and oral microbiota, study finds
People who live together share more oral and gut microbes with each other than with other people in their communities, according to a study published in Cell Press Blue. This was true regardless of the cohabitants' relationships—siblings, ...
Jun 15, 2026
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Blueberry-size capsule tracks core temperature from inside the body
In a hospital or at home, temperatures are usually taken using an oral or forehead thermometer, but these do not always accurately reflect core body temperature. Measuring core temperature from within the body could make ...
Jun 15, 2026
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Your gut talks to your liver: Study reveals how microbes influence liver function through DNA 'switches'
A study led by scientists from the A*STAR Genome Institute of Singapore (A*STAR GIS) has uncovered how the gut microbiome can influence gene activity in the liver by acting on short stretches of regulatory DNA that function ...
Jun 15, 2026
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Dietary fiber supplement shows promise for fatty liver, with effects linked to gut microbiota
A new study is the first to investigate the effects of prebiotic xylo-oligosaccharides (XOS) on fatty liver in humans. The findings suggest the fiber supplement may reduce harmful metabolic byproducts in the gut and thereby ...
Jun 15, 2026
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Genetic marker may flag severe IBD earlier in some patients
In the largest genetic study of inflammatory bowel disease (IBD) traits to date, researchers have identified a genetic marker associated with more severe ulcerative colitis and Crohn's disease—the major forms of IBD.
Jun 15, 2026
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Long naps may increase the risk of chronic liver disease in people with diabetes
People with type 2 diabetes who nap longer than 30 minutes every day, regardless of their sleep patterns at night, increase their risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD), according ...
Jun 15, 2026
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