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Clinical genetics news
Experimental drug cuts Parkinson's-linked protein up to 60% in early trial
An experimental drug designed to silence a gene strongly linked to Parkinson's disease has shown encouraging effects in a first-in-human clinical trial, according to a study published in Nature Medicine. The drug, known as ...
23 hours ago
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Genetic variants in 1 in 10 people may reduce blood‑sugar response to GLP‑1 diabetes drugs
More than a quarter of people with Type 2 diabetes take GLP-1 receptor agonists, but the popular diabetes drugs might not work as well for people who have certain genetic variants, according to a new study by Stanford Medicine ...
Apr 11, 2026
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Skin protein K16 found to control inflammation in stressed skin
Keratin is the fibrous, waterproof protein that builds everything from our hair and nails to a rhino's horn. However, a tiny glitch in it can have problematic outcomes. A new study has found that changes in a keratin gene ...
Long non-coding RNA may be a promising therapeutic target for cancer
Northwestern Medicine scientists have discovered that a specific long non-coding RNA activates oncogenic signaling pathways in prostate cancer cells and drives tumor progression, underscoring its potential as a therapeutic ...
Apr 9, 2026
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Overlooked non-coding genes cause diabetes in babies, study reveals
Scientists have found new genetic causes for diabetes in babies—in a part of the genome that has historically been overlooked in genetic studies. Until recently, most research has investigated causes of disease in "coding" ...
Apr 9, 2026
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Why autism affects more men than women—MDGA1 gene mutation may help explain
Researchers have discovered that a mutation of the MDGA1 gene, a key factor modulating the connections and characteristics between nerve cells, serves as a new cause of autism spectrum disorder (ASD), and suggested the possibility ...
Apr 9, 2026
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New method provides clearer view of how genome functions in cancer
Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer picture of how the genome is regulated and disrupted in diseases like cancer. The findings were ...
Apr 9, 2026
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Mental and physical illnesses go hand in hand. A new genetic study explains why
For centuries, mental illness and physical disease have been viewed as two distinct categories, each with its own field of study, its own doctors, and its own menu of treatments. New University of Colorado Boulder research ...
Apr 8, 2026
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Mapping mutations at scale in a single gene reveals new neurodevelopmental condition
The ability of different genetic variants—changes to one or more building blocks of DNA—to cause disease, and to what extent, has historically been opaque. Geneticist and Crick group leader Greg Findlay has pioneered a new ...
Apr 8, 2026
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Extra chromosomes may seed childhood leukemia years before disease, study suggests
B-cell acute lymphoblastic leukemia is the most common form of childhood cancer. In this type of cancer, which affects blood cells, one of the most common abnormalities is the presence of cells with an excess of chromosomes ...
Apr 8, 2026
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Lab-grown pineal gland organoids produce melatonin, offering a new sleep model
Organoids are miniature, simplified versions of an organ. Over the past two decades, scientists have developed them for the gut, lung, liver, mammary gland, brain, and more. Now, researchers at Yale School of Medicine (YSM) ...
Apr 8, 2026
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Genetic predictors for GLP-1 weight loss efficacy and side effects identified
23andMe Research Institute, a nonprofit medical research organization, announced the publication of a study that identifies genetic predictors for GLP-1 weight loss efficacy and side effects. GLP-1 receptor agonists, including ...
Apr 8, 2026
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Light in the dark: The search for new treatments for hereditary blindness
One night, Tomás realized something was seriously wrong. He went for a stroll, along the same paths near his village that he had walked along countless times with his friends, their cheerful voices echoing in the still of ...
Apr 8, 2026
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How childhood dementia begins in brain cells
An Australian-led international research collaboration has delivered a promising breakthrough in the quest to better understand and treat childhood dementia. Recently published in the journal Nature Communications, the study ...
Apr 7, 2026
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Blood-based biomarker could help stratify cancer risk in Lynch Syndrome
Researchers at The University of Texas MD Anderson Cancer Center have discovered a new blood-based biomarker that can help identify and characterize asymptomatic people with Lynch Syndrome (LS) who are more susceptible to ...
Apr 7, 2026
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Scientists uncover previously unknown chromatin regulation mechanism with therapeutic potential for pediatric cancer
As many as 1 in 4 cancers are driven by mutations in the SWI/SNF chromatin-remodeling complex, which controls access to DNA. A study led by St. Jude Children's Research Hospital recently identified the gene-regulatory protein ...
Apr 7, 2026
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Nearly 29,000 genetic 'switches' found unique to East Asian populations
Researchers have mapped how genetic switches are regulated in East Asian populations, identifying tens of thousands of unique markers linked to complex diseases. This massive dataset bridges a crucial diversity gap in genetics, ...
Apr 7, 2026
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New approach could transform epilepsy treatment
University of Virginia School of Medicine researchers have used an advanced gene-editing technique to correct the underlying cause of a severe form of epilepsy in lab mice. This breakthrough could one day lead to new treatments ...
Apr 7, 2026
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Researchers predict coronary heart disease in diabetes subgroup
A growing body of research shows that diabetes can be stratified into five different subgroups. Researchers at Lund University have now investigated whether a person's genetic predisposition to different diabetes subgroups ...
Apr 7, 2026
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Researchers pinpoint genetic identifier in deadly cardiovascular disease
A University of Alberta research team has found a genetic variant that can be used to identify which patients with pulmonary arterial hypertension need the most urgent care. "This could potentially save lives and health-care ...
Apr 7, 2026
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How does mitochondrial DNA influence human health?
Some of your most important life partners are the mitochondria that power all your cells. You and these little cellular powerhouses are in a 1.5-billion-year-old evolutionary relationship—but mitochondria brought some baggage. ...
Apr 6, 2026
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Study identifies genetic drivers of resistant hypertension
Cedars-Sinai investigators have identified distinct genetic variants associated with resistant hypertension, a type of high blood pressure that remains uncontrolled despite medication. Their findings, published in the journal ...
Apr 6, 2026
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Rare MGRN1 gene variant tied to fetal heart malformations
The Human Genetics Research Group of the University of Tartu Faculty of Medicine has identified a gene whose defect may cause congenital heart malformations in the fetus. The MGRN1 gene has not previously been associated ...
Apr 4, 2026
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How an Alzheimer's risk gene disrupts brain circuits long before memory loss
For the millions of people who carry the gene APOE4, the strongest known genetic risk factor for Alzheimer's disease, their brain activity may begin changing long before any memory problems appear. Now, researchers at Gladstone ...
Apr 3, 2026
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How calcium channel mutations disrupt early brain development in childhood epilepsy
Researchers at Baylor College of Medicine have uncovered a previously unrecognized mechanism by which inherited calcium channel mutations disrupt early brain development and predispose children to epilepsy and related cognitive ...
Apr 3, 2026
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