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Clinical genetics news

Next-generation RNA approach provides hope for genetic diseases missed by current drugs

Researchers at the University of Toronto have developed a next-generation RNA therapeutic approach with the potential to treat a wide range of genetic diseases that share certain disease-causing mutations. The work advances ...

Largest ever molecular map of autism opens new paths to precision therapies

For more than two decades, researchers have identified hundreds of genes that increase the risk of autism spectrum disorder (ASD). Yet multiple fundamental questions have remained unanswered: Among them, how do mutations ...

How DNA folding controls immune gene activity in T cells

A new study by researchers at the Perelman School of Medicine at the University of Pennsylvania reveals that the three-dimensional folding of DNA at a key genetic locus helps determine when two related immune genes, Ets1 ...

A unified framework to explain one of cancer's major drivers

In a rare pair of papers published back-to-back in the journal Genes & Development, research teams led by senior author Anindya Bagchi, Ph.D., associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham ...