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Genetics news
Genetics
APOE gene raises delirium risk even without dementia, global analysis reveals
A major genetic risk factor for delirium has been identified in a study that analyzed the DNA of more than 1 million people worldwide.
3 hours ago
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Genetics
AI learns from the tree of life to support rare disease diagnosis
Researchers have created an artificial intelligence model that can identify which mutations in human proteins are most likely to cause disease, even when those mutations have never been seen before in any person.
3 hours ago
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Epigenetic changes regulate gene expression, but what regulates epigenetics?
All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in each cell. Mistakes or ...
18 hours ago
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Many who die by suicide aren't depressed, genetic research suggests
Among friends and family of those who die by suicide, a common refrain is: I didn't know. While some people who die by suicide have prior attempts, about half of people who die by suicide have no documented suicidal thoughts ...
Nov 21, 2025
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Genetic events that can trigger leukemia in patients with a rare disorder deciphered
Two parallel and complementary studies conducted by the IDIBELL team led by Dr. Alessandra Giorgetti have succeeded in recreating models of GATA2 deficiency disease, a rare genetic disorder that affects fewer than 1 million ...
Nov 21, 2025
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Genetic risk combined with cardiovascular factors may help predict and delay dementia
Combining genetic risk with cardiovascular disease risk factors—such as high LDL cholesterol, obesity, and hypertension—may predict who is more likely to develop dementia, according to a new study led by UC San Francisco.
Nov 21, 2025
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Study uncovers and predicts widespread molecular changes in ALS brain cells
Researchers at the University of Toronto's Temerty Faculty of Medicine have found widespread genetic and protein changes in the brain cells of people with amyotrophic lateral sclerosis (ALS), which may help shed light on ...
Nov 21, 2025
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How a consortium is advancing the diagnostics of rare diseases
The National Institutes of Health established the Genomics Research to Elucidate the Genetics of Rare Diseases (GREGoR) Consortium in 2021 with the goal of finding molecular diagnoses for individuals with rare diseases who ...
Nov 21, 2025
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Population-specific genetic risk scores advance precision medicine for Han Chinese populations
Researchers at Academia Sinica have developed the first population-specific polygenic risk score (PRS) models for people of Han Chinese ancestry, achieving unprecedented accuracy in predicting risks for common diseases such ...
Nov 21, 2025
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Redheads face impaired wound healing: MC1R dysregulation to blame, but a new treatment might help
Chronic wounds (CWs), like diabetic ulcers or pressure sores, are a major health care challenge, especially in the elderly. These wounds, marked by persistent inflammation, often lead to infection and poor patient outcomes. ...
RNA editing study finds many ways for neurons to diversify
All starting from the same DNA, neurons ultimately take on individual characteristics in the brain and body. Differences in which genes they transcribe into RNA help determine which type of neuron they become, and from there, ...
Nov 20, 2025
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Heat shock protein masks BRCA1 mutations, suggesting a new treatment path
Researchers from The University of Texas MD Anderson Cancer Center identified a new role for heat shock protein 90 (HSP90) in cancer predisposition and treatment resistance.
Nov 20, 2025
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Genome-scale models can predict how the gut microbiome influences health
The gut microbiome is made up of trillions of microbes that play a vital role in keeping us healthy. A disturbance in the balance of these microbes can contribute to a variety of health conditions, such as inflammatory bowel ...
Nov 20, 2025
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Ancient Arctic adaptations may influence modern disease risk
Over the past 25 years, Greenlanders have experienced a dramatic increase in cardiometabolic diseases, including type 2 diabetes and cardiovascular disease. Scientists have already linked their increased risk of these diseases ...
Nov 20, 2025
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Gene scissors in camouflage mode help in the search for cancer therapies
The immune system plays a crucial role in fighting tumors and metastases. Consequently, it is decisive to conduct cancer research in mouse models with an immune system that is as natural as possible—which is easier said ...
Nov 20, 2025
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Gene variant increases brain inflammation in those with repetitive head impacts
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head impacts (RHI). However, individuals with similar RHI exposure have shown differing pathology, suggesting a role for genetic variation. ...
Nov 20, 2025
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Order of genetic mutations shapes cancer's development and patient outcomes
In many aspects of our lives, we find meaning in the order in which events occur. We buy into myths about "middle child syndrome," talk of calm before storms, and consider it strange to start a meal with dessert.
Nov 20, 2025
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Researchers identify genetic factors influencing bone density in pediatric patients
Researchers at Children's Hospital of Philadelphia (CHOP) revealed important genetic components that affect bone density in children and adolescents. This information could help identify pediatric patients who may benefit ...
Nov 20, 2025
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Single prime editing system could potentially treat multiple genetic diseases
A team of researchers at the Broad Institute, led by gene-editing pioneer David Liu, has developed a new genome-editing strategy that could potentially lead to a one-time treatment for multiple unrelated genetic diseases.
Nov 19, 2025
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Uncovering the hidden cellular connections that bridge aging and disease
A Yale research team has created a new imaging technique that reveals the hidden connections between aging, disease, and genetic activity in human cells.
Nov 19, 2025
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Most people with a genetic condition that causes significantly high cholesterol go undiagnosed, study finds
Current genetic screening guidelines fail to identify most people with an inherited condition known as familial hypercholesterolemia that can cause dangerously high cholesterol and early heart disease, a Mayo Clinic study ...
Nov 19, 2025
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Genomic analysis tool aids Scotland's fight against antibiotic-resistant infections
Bacterial infections can spread quickly, especially in hospital settings or crowded communities, where vulnerable people are treated in close proximity and bacteria move between them. Antimicrobial-resistant infections are ...
Nov 19, 2025
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Rare genetic variants can increase ADHD risk by up to 15 times
ADHD is a neurodevelopmental disorder with a high heritability, in which the genetic component consists of thousands of genetic variants. Most variants only slightly increase the likelihood of receiving the diagnosis. Now ...
Nov 18, 2025
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Chronic lymphocytic leukemia: New origins and biomarkers revealed
Researchers at the University of Eastern Finland and their international collaborators have identified key developmental and molecular differences between the two main subtypes of chronic lymphocytic leukemia, CLL. The findings, ...
Nov 18, 2025
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RNA therapy silences KRAS gene and boosts immune attack on cancer cells
Two complementary studies led by researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have demonstrated a new RNA-based therapeutic strategy that effectively targets one of ...
Nov 18, 2025
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