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Clinical genetics news
Uncovering gene-based clues to how disrupted healing in stomach cells increases cancer risk
Few areas of the body face more daily stress and potential damage than the stomach, which must manage everything we swallow. Along with this constant strain, the stomach also produces acid that can damage its own lining and ...
24 minutes ago
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Rare aging disorder links 'biological clock' to disease
Scientists have discovered a rare genetic condition that causes people to age at a much faster rate, offering fresh insights into the aging process. The study shows for the first time how a "biological clock" present in every ...
4 minutes ago
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Inherited BRCA2 changes could drive some multiple lung cancers, genomic analysis suggests
Lung cancer remains the leading cause of cancer-related deaths worldwide and is generally thought to arise from mutations acquired over a lifetime through environmental exposures. However, clinicians are increasingly encountering ...
44 minutes ago
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Gene discovery could help prevent stroke in young people
UVA Health stroke researchers have identified a distinct and temporary pattern of gene behavior during cervical artery dissections, a leading cause of stroke in young people. These unusual gene changes may help explain the ...
1 hour ago
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Genetic test ranks risk for Black people hoping to donate a kidney
New evidence supports genetic testing of prospective Black kidney donors to see if they face elevated risks for low kidney function—a factor that could compound health issues if they donate.
2 hours ago
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Eating disorders and obsessive-compulsive disorder show shared brain gene expression changes
Researchers at the Icahn School of Medicine at Mount Sinai and the Lieber Institute for Brain Development have identified substantial similarities in brain gene activity among people with eating disorders and obsessive-compulsive ...
21 hours ago
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Large multiple sclerosis brain cohort reveals biological differences linked to disease severity
Why does multiple sclerosis progress quickly in some people, while others remain stable for years? Researchers from the Netherlands Institute for Neuroscience have identified biological patterns in the brain that may help ...
16 hours ago
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Genetically lower systolic BP linked to increased risk of allergic rhinitis
Genetically predicted lower systolic blood pressure (SBP) seems to increase susceptibility to allergic rhinitis (AR), according to a study published online May 29 in Tobacco Induced Diseases.
15 hours ago
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Thirty years later: A reappraisal of Alzheimer's disease risk in Japanese APOE-e4 homozygotes
Researchers at Niigata University have conducted the first comprehensive reappraisal in nearly 30 years of the risk of Alzheimer's disease (AD) associated with APOE-e4 homozygosity (e4*4) in the Japanese population. Their ...
Jun 29, 2026
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Reproduction affects health—and so does biological sex
Starting one's sex life and having children at a young age can run in the family. But can pregnancy have beneficial health effects, and do the partner's genes contribute to them? "We are just beginning to understand how pregnancy ...
Jun 28, 2026
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New tool helps uncover rare genetic mutations in common diseases, including Parkinson's
Studies of genetics conducted in yeast cells, human neurons, mice or other model systems often reveal networks of genes that could contribute to complex diseases, such as breast cancer, type 2 diabetes and Parkinson's disease. ...
Jun 26, 2026
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First use of precision editing to study human embryo development reveals role of master gene
Research led by the University of Cambridge Loke Center for Trophoblast Research has shown that a genome-editing technique can be used to alter a single gene in human embryonic cells, enabling the study of very early human ...
Jun 25, 2026
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What a 'silenced' chromosome can tell us about autoimmunity
Systemic lupus erythematosus (SLE), the most common form of lupus, is an autoimmune disorder that occurs more frequently in women. Having multiple X chromosomes has been associated with an increased risk of developing lupus; ...
Jun 24, 2026
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Genomic tool highly effective at detecting rare disease diagnoses
A newly developed open-source tool designed for rigorous reanalysis of genomic data is highly effective at detecting new rare disease diagnoses. The tool's ability to frequently and automatically reexamine stored DNA data ...
Jun 24, 2026
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Hidden protein linked to severe COVID-19 and lung disease risk
A genetic difference carried by nearly one in three people may increase the risk of severe COVID-19 and lung fibrosis by disrupting the function of a previously unknown protein, according to a new study published in Nature ...
Jun 24, 2026
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Genetic testing projected to increase ALS clinic visits over next decade
The availability of genetic testing for amyotrophic lateral sclerosis (ALS) for people with a family member diagnosed with the disease is expected to greatly increase the number of clinic visits to specialized ALS centers ...
Jun 24, 2026
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Why pollution affects some asthma patients more than others
For many people with asthma, air-quality advisories are harbingers of worsening symptoms. But for reasons science has struggled to explain, the extent to which pollution exacerbates asthma varies widely from person to person.
Jun 23, 2026
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Discovery of BIRC3 gene variants in Crohn's disease yields a druggable pathway
Researchers from The Hospital for Sick Children (SickKids) in Toronto have found a previously unknown genetic cause of Crohn's disease and uncovered how those changes trigger inflammation through a key immune pathway. The ...
Jun 23, 2026
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Link between parents' and children's weight is mostly genetic, study finds
The association between parents' body mass index (BMI) and their children's childhood BMI may be primarily due to genetic inheritance rather than any direct biological effect of parental weight during pregnancy, according ...
Jun 23, 2026
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Ménière's disease may begin early in inner ear development
By analyzing genetic data from nearly 2 million people, researchers have unlocked a new scientific understanding of Ménière's disease, a chronic and often debilitating inner ear disorder. A team from the Perelman School of ...
Jun 23, 2026
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Scientists uncover a genetic 'shield' that lowers the risk of colorectal cancer
A team of scientists from the Barbara Ann Karmanos Cancer Institute, Wayne State University and institutions across the U.S. have published a new paper on the role of TGFBR1*6A, a naturally occurring genetic mutation in the ...
Jun 23, 2026
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AI and polygenic scores improve breast cancer risk assessment
A risk model that combines a mammographic artificial intelligence (AI) risk score with polygenic and clinical risk scores more accurately identifies women at high risk of developing breast cancer than clinical risk scores ...
Jun 23, 2026
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More than 600 schizophrenia-associated genes uncovered by network model
Schizophrenia is more complicated than ever imagined. Advanced gene network analysis reveals how distant genetic variants work together to influence brain function and mental health. Scientists have long known that schizophrenia ...
Jun 22, 2026
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Quantum-inspired AI could tailor patients' cancer treatment to their entire molecular background
For a child diagnosed with neuroblastoma—the most common infant cancer, occurring when early nerve cells grow out of control—the path to treatment isn't simple. Some types of neuroblastoma resolve on their own, while others ...
Jun 22, 2026
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Social determinants of health can match or beat genetic risk in predicting some common diseases
A new study from the Icahn School of Medicine at Mount Sinai shows that social determinants of health—including environmental conditions, health behaviors, access to resources and social well-being—can play an equally important ...
Jun 22, 2026
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