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Clinical genetics news

Uncovering gene-based clues to how disrupted healing in stomach cells increases cancer risk

Few areas of the body face more daily stress and potential damage than the stomach, which must manage everything we swallow. Along with this constant strain, the stomach also produces acid that can damage its own lining and ...

Rare aging disorder links 'biological clock' to disease

Scientists have discovered a rare genetic condition that causes people to age at a much faster rate, offering fresh insights into the aging process. The study shows for the first time how a "biological clock" present in every ...

Gene discovery could help prevent stroke in young people

UVA Health stroke researchers have identified a distinct and temporary pattern of gene behavior during cervical artery dissections, a leading cause of stroke in young people. These unusual gene changes may help explain the ...

Reproduction affects health—and so does biological sex

Starting one's sex life and having children at a young age can run in the family. But can pregnancy have beneficial health effects, and do the partner's genes contribute to them? "We are just beginning to understand how pregnancy ...

What a 'silenced' chromosome can tell us about autoimmunity

Systemic lupus erythematosus (SLE), the most common form of lupus, is an autoimmune disorder that occurs more frequently in women. Having multiple X chromosomes has been associated with an increased risk of developing lupus; ...

Why pollution affects some asthma patients more than others

For many people with asthma, air-quality advisories are harbingers of worsening symptoms. But for reasons science has struggled to explain, the extent to which pollution exacerbates asthma varies widely from person to person.

Ménière's disease may begin early in inner ear development

By analyzing genetic data from nearly 2 million people, researchers have unlocked a new scientific understanding of Ménière's disease, a chronic and often debilitating inner ear disorder. A team from the Perelman School of ...

AI and polygenic scores improve breast cancer risk assessment

A risk model that combines a mammographic artificial intelligence (AI) risk score with polygenic and clinical risk scores more accurately identifies women at high risk of developing breast cancer than clinical risk scores ...