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A unified framework to explain one of cancer's major drivers

Clinical genetics news

A unified framework to explain one of cancer's major drivers

In a rare pair of papers published back-to-back in the journal Genes & Development, research teams led by senior author Anindya Bagchi, Ph.D., associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham ...

2 hours ago

AI-guided screening identifies nine drugs that may slow childhood dementia

An Australian research collaboration has identified several existing TGA-approved medicines that could help slow brain damage in children with a rare form of dementia—offering hope for faster treatment options.

8 hours ago

Mapping the diversity of chronic lymphocytic leukemia at single-cell resolution

Two patients with chronic lymphocytic leukemia (CLL) can face very different futures. One may live for decades without needing treatment, while another may develop rapidly progressing disease. In a new study from Karolinska ...

23 hours ago

International study marks step forward in genetic understanding of eating disorders

New research led by the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London, in collaboration with an international partnership of researchers, has, for the first time, compared the genetics ...

Aug 19, 2026

Single gene injection reverses inherited heart disease in mice and patient-grown tissue

Melbourne researchers have made a gene therapy breakthrough that could restore heart function in children with genetic heart disease, sparing them the need for transplants.

Aug 19, 2026

Genetic risk score identifies nearly one in five MODY referrals with hidden type 1 diabetes

A new study shows that incorporating a genetic risk score into standard testing for a genetic form of diabetes that affects young people could identify hidden type 1 diabetes in about 1 in 5 patients with a negative genetic ...

Aug 19, 2026

Hidden aggressive cells reveal why some lower-risk childhood cancers turn deadly

New insights into why some children with rhabdomyosarcoma (RMS) develop aggressive disease despite being classified as non-high-risk have been uncovered. The discovery could help clinicians identify children with potentially ...

Aug 19, 2026

Patchy brain development may help explain autism's varied traits

Autism spectrum disorder (ASD) affects every individual differently. Scientists have identified more than a thousand genes associated with ASD, yet no single gene accounts for most cases. This has left researchers with a ...

Aug 18, 2026

Study demonstrates a new standard for pediatric research

A new analysis from the Gabriella Miller Kids First Data Resource Center (Kids First DRC) shows how a collaborative, data-driven research model is creating broader opportunities to understand pediatric disease.

Aug 18, 2026

Rare gene variants may multiply Alzheimer's disease risk

Alzheimer's disease is the most common form of dementia worldwide, and its development is influenced by a combination of genetic and environmental factors. In recent years, the PLCG2 gene and its encoded enzyme, PLCγ2, have ...

Aug 17, 2026

Advanced genetic testing opens new treatment options for nearly one in three cancer patients, study finds

A new study from London Health Sciences Centre Research Institute (LHSCRI) shows that expanded genetic testing can help match cancer patients with more personalized treatment options, with nearly one in three found eligible ...

Aug 17, 2026

What is sudden adult death syndrome?

When Mark Hughes, the former Manchester United and Wales manager, lost his 38-year-old son, an inquest found the cause was sudden adult death syndrome, or SADS.

Aug 16, 2026

New approach opens rare immune cells to genetic risk research

Much of how genetic risk leads to disease has remained hidden. In many cases, genetic variants linked to disease do not act on nearby genes along the chromosome. Instead, they influence genes located far away along the DNA ...

Aug 15, 2026

Genome analysis uncovers candidate genes for hereditary breast and ovarian cancer

Breast cancer is the most common form of cancer among women in Germany: Around 1 in 8 women will develop it during their lifetime. In around 5% to 10% of cases, the condition is caused by a hereditary predisposition. Thirteen ...

Aug 14, 2026

In vivo CRISPR screen identifies gene edits that strengthen CAR-T therapy against solid tumors

For patients with blood cancers like leukemia and lymphoma, the immunotherapy known as CAR-T cell therapy can be lifesaving. Doctors remove a patient's immune cells, called T cells, engineer them in the lab to better recognize ...

Aug 12, 2026

Machine learning approach could bring greater certainty to prenatal genetic testing

Advances in genome sequencing are giving more families access to prenatal genetic testing and new information about an unborn baby's health, including whether genetic changes may be linked to a neurodevelopmental condition.

Aug 12, 2026

Genomic newborn screening could identify some children at risk for early cancers

A large population-based study led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Mass General Brigham suggests that genetic testing added to routine newborn screening could identify ...

Aug 12, 2026

Key genetic differences between pediatric and adult forms of immune-mediated inflammatory diseases identified

Researchers from Children's Hospital of Philadelphia (CHOP) have found that pediatric-onset rheumatic and inflammatory diseases have distinct genetic architecture compared with those in adults. The findings, published today ...

Aug 12, 2026

Computational framework identifies novel pathway for asthma inflammation

Researchers at Columbia University Mailman School of Public Health, in collaboration with investigators at the University of Chicago, have developed a new computational framework that helps scientists identify genes that ...

Aug 11, 2026

Long before adulthood, a chemical mark may quietly shape how the brain handles stress

Stress or trauma during childhood may leave people more vulnerable to mental health struggles and stress later in life. Scientists think one reason could be that early-life stress leaves lasting molecular bookmarks on DNA, ...

Aug 11, 2026 report

Genetic variants shed light on kidney transplant rejection

Immunosuppressive medications help prevent organ rejection following transplantation, yet some patients still experience rejection despite receiving adequate treatment. New research from Yale, published in the Journal of ...

Aug 11, 2026

Heart assembloids give researchers a new way to study heart valve disorders

A multidisciplinary, multi-institution group of researchers focused their expertise in genetics, mechanics, chemistry and biology on a chip the size of a postage stamp to model a particular class of heart conditions.

Aug 11, 2026

Solving a mysterious inflammatory fever opens the book on a much bigger story

Three research teams working independently around the world have landed on the same discovery: A single molecular "handshake" inside our cells controls a family of inflammatory diseases, including one of the most common inherited ...

Aug 10, 2026

Molecular structures provide roadmap for targeted Parkinson's disease therapeutics

Researchers at Weill Cornell Medicine have uncovered how a key Parkinson's protein called LRRK2 shifts between inactive and active forms, revealing the structural changes that enable certain mutations to push the protein ...

Aug 10, 2026