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Genetics news
Oncology & Cancer
Stop through SPOP: Researchers develop strategy against aggressive blood cancer
When blood cancer in children progresses particularly aggressively, it is often due to a genetic defect: a gene fusion, such as the NUP98 fusion oncoprotein, which drives uncontrolled cell growth. Standard therapies are often ...
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Oncology & Cancer
Cancer-promoting DNA circles hitchhike on chromosomes to spread to daughter cells
Small, cancer-associated DNA circles "hitchhike" on chromosomes during cell division to spread efficiently to daughter cells by co-opting a process used to maintain cellular identity through generations, Stanford Medicine-led ...
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Another cancer patient achieves HIV remission after stem cell transplant
Details of a 60-year-old male individual from Germany who achieved sustained HIV remission after a stem cell transplant, the seventh-known case reported to date, are published in Nature this week.
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New technique maps genetic variants driving neurodegenerative disease risk
Disease development is often shaped by genetics, with how much or how little a gene is expressed influencing disease risk. While advances in technology and sequencing methods have led to a greater understanding of gene structure, ...
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Mutant GFAP disrupts mitochondrial fission in astrocytes, offering insight into Alexander disease
Some brain disorders are straightforward, such as the direct frontal lobe assault of a concussion or traumatic brain injury. Others, like Alexander disease, are akin to guerrilla warfare. Patients suffering from this genetic ...
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Landscape of KRAS mutations and targeted therapies in colorectal cancer mapped in new study
A team of researchers from the Germans Trias i Pujol Research Institute (IGTP) and Institut Català d'Oncologia (ICO) has studied alterations in the KRAS gene in colorectal cancer by combining genomic analyses with a systematic ...
21 hours ago
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Muscle regeneration hindered by missing protein in rare muscular dystrophy, study shows
For more than two decades, researchers at the University of Basel, Switzerland, have been investigating a severe form of muscular dystrophy in which muscles progressively degenerate. The research team has now discovered that ...
20 hours ago
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Parents of children with a genetic diagnosis need better support
Research into parental support needs is informing Cambridge Children's Hospital's commitment to provide a "whole family" approach to care.
23 hours ago
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Switching risk and protective alleles improves Alzheimer's-disease-like signatures and disruptions in mice
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive degradation of brain cells, as well as an associated decline in memory and other mental functions. Earlier research found that different ...
New insight into how protein TDP-43 affects gene expression in ALS and FTD
Neurodegenerative diseases, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are medical conditions characterized by the progressive degradation of cells in the brain, ...
Why important genes 'go quiet' as we get older
The human gut renews itself faster than any other tissue: every few days, new cells are created from specialized stem cells. However, as we get older, epigenetic changes build up in these stem cells. These are chemical markers ...
Nov 28, 2025
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How a gene shapes the architecture of the human brain
Researchers around the world are studying how the human brain achieves its extraordinary complexity. A team at the Central Institute of Mental Health in Mannheim and the German Primate Center—Leibniz Institute for Primate ...
Nov 28, 2025
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A rare respiratory disease may be more prevalent in Quebec
A study led by the Research Institute of the McGill University Health Center (The Institute) has identified a rare genetic variant in the ODAD4 gene that causes primary ciliary dyskinesia (PCD), a chronic hereditary disorder ...
Nov 28, 2025
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When ribosomes collide, cells launch emergency stress defenses
Ribosomes, the protein factories of the cell, are essential for all living organisms. They bind to mRNA and move along the messenger molecule, reading the genetic code as they go. Using this information, they link amino acids ...
Nov 27, 2025
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New mutation hotspot discovered in human genome
Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we study genetics and disease.
Nov 26, 2025
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Missing cancer gene explains why some lung tumors respond well to immunotherapy
For some patients with the most common type of lung cancer, known as lung adenocarcinoma, there's new hope. In a new study published in Cell Reports, Mayo Clinic researchers have found several previously unknown genetic and ...
Nov 26, 2025
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Shapeshifting tumors unmasked: New insights into master regulators reveal therapeutic vulnerabilities
Some tumors are almost impossible to treat. That's especially true for carcinomas, which don't behave like other malignancies. Some of these tumors act as shapeshifters and start to resemble cells from other organs of the ...
Nov 25, 2025
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Research challenges idea that gene PTPN22 boosts production of interferons
A new paper from the University of Kansas overturns the idea that a "risk gene" carried by millions of people worldwide influences production of type 1 interferon, a workhorse of the immune system. The work is published in ...
Nov 25, 2025
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Deep learning model has identified imaging biomarker for chronic stress
A deep learning model has identified an imaging biomarker of chronic stress, according to a study to be presented at the annual meeting of the Radiological Society of North America, being held from Nov. 30 to Dec. 4 in Chicago.
Nov 25, 2025
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Novel discovery reveals how brain protein OTULIN controls tau expression and could transform Alzheimer's treatment
Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease. The findings, published in Genomic Psychiatry, ...
Nov 25, 2025
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MRIs reveal genetic clues in cerebral palsy
A national study by University of Adelaide researchers is paving the way for more precise diagnosis and treatment for children with cerebral palsy.
Nov 25, 2025
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Genetic study links impulsive decision making to a wide range of health and psychiatric risks
Researchers from University of California San Diego have identified 11 genetic regions linked to delay discounting—the tendency to prefer smaller, immediate rewards over larger, delayed ones—shedding new light on how ...
Nov 24, 2025
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Rare mutation protects brain's immune cells from Alzheimer's disease
Rutgers neuroscientist Peng Jiang and his neuroscience colleague Mengmeng Jin have made a discovery they say could reshape how scientists think about Alzheimer's treatment.
Nov 24, 2025
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AI learns from the tree of life to support rare disease diagnosis
Researchers have created an artificial intelligence model that can identify which mutations in human proteins are most likely to cause disease, even when those mutations have never been seen before in any person.
Nov 24, 2025
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APOE gene raises delirium risk even without dementia, global analysis reveals
A major genetic risk factor for delirium has been identified in a study that analyzed the DNA of more than 1 million people worldwide.
Nov 24, 2025
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