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Genetics news
Genetics
Decade-long genome study reveals best practices for managing large DNA databases
At a time when large-scale human genome analysis was not yet common, the Tohoku Medical Megabank Organization (ToMMo) launched its genome cohort study. After 10 years of operating this ambitious project, they are sharing ...
17 minutes ago
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Genetics
Brain tumor patients miss out on new treatments due to unequal access to tumor freezing and genetic testing, study warns
Molecular and genetic testing has become a game-changer in brain tumor care—shaping diagnosis, guiding treatments and opening doors to new therapies. Once available to a handful of patients, these tests are now rapidly ...
3 hours ago
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Human gene PARP14 could be novel target for viral diseases or immune-mediated disorders
Researchers at the University of Kansas have discovered a human gene, the protein PARP14, plays a role in regulating interferon, part of the body's innate immune system. Their study, appearing in the journal mBio, could guide ...
20 hours ago
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Surprising blood stem cell diversification revealed in humans
Every second, millions of blood cells are produced in the human body, and about 90% of the cells replaced daily are blood cells. These include red blood cells essential for oxygen transport, platelets for blood clotting, ...
22 hours ago
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Unlocking key insights into gene expression using a novel mouse model
A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as reported by researchers from Science Tokyo. The team engineered mice to produce a fluorescent antibody ...
19 hours ago
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Genetic testing trifecta predicts risk of sudden cardiac death and arrhythmia
In a new Northwestern Medicine study, scientists have developed a more precise genetic risk score to determine whether a person is likely to develop arrhythmia, an irregular heartbeat that can lead to serious conditions such ...
Nov 11, 2025
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Gene therapy for sickle cell and β-thalassemia works by disrupting three-dimensional genome structure
Scientists at St. Jude Children's Research Hospital and Northwestern University identified a previously unknown treatment opportunity for sickle cell disease and β-thalassemia. The discovery, published in Blood, is based ...
Nov 11, 2025
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Q&A: Research offers hope for new autoimmune treatments
Alec Whited ('25 MS, Biology) is helping uncover how cells remove waste, a process that could lead to better treatments for autoimmune diseases and improved wound healing.
Nov 11, 2025
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Tracking RNA levels reveals new clues in triple-negative breast cancer progression
When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer's development or ...
Nov 10, 2025
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Family history of heart disease linked to specific protein pattern in blood
A specific pattern of proteins in the blood may reflect an increased risk of hereditary atherosclerosis. This is shown in a new study from Karolinska Institutet, examining close relatives of people who had suffered a heart ...
Nov 10, 2025
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New clinical practice resource on managing RAD51C, RAD51D, and BRIP1 variants released
The American College of Medical Genetics and Genomics (ACMG) has published a new clinical practice resource, "Management of Individuals with Heterozygous Germline Pathogenic Variants in RAD51C, RAD51D, and BRIP1: A clinical ...
Nov 10, 2025
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Should kids be screened for high cholesterol genes? Study weighs costs and benefits
In the United States, 1 in every 250 people has inherited a genetic variant that leads to dangerously high cholesterol levels from birth.
Nov 9, 2025
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James Watson helped crack DNA's code, sparking medical advances and ethical debates
On a foggy Saturday morning in 1953, a tall, skinny 24-year-old man fiddled with shapes he had cut out of cardboard. They represented fragments of a DNA molecule, and young James Watson was trying to figure how they fit together ...
Nov 8, 2025
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Alternate proteins from the same gene can contribute differently to health and rare disease
Around 25 million Americans have a rare genetic disease, and many of them struggle with not only a lack of effective treatments, but also a lack of good information about their disease. Clinicians may not know what causes ...
Nov 7, 2025
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Genetically altered hair cells show how inner ear structures are organized
Northwestern Medicine scientists have uncovered how a specific type of cell in the inner ear plays a commanding role in shaping the cellular landscape of the organ responsible for hearing, according to a study published in ...
Nov 6, 2025
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Maternal type 1 diabetes may protect children through epigenetic changes
Type 1 diabetes is an autoimmune disease in which the immune system destroys the body's own insulin-producing beta-cells in the pancreas, leaving patients with a lifelong dependency on external insulin.
Nov 6, 2025
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Key histone variant may explain some forms of infertility
An epigenetic factor that is essential for producing mature egg cells in mice has been identified by RIKEN researchers for the first time. This discovery could aid research into cases of infertility caused by immature eggs.
Nov 6, 2025
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Marker that predicts cell death in kidneys identified
When the kidneys are damaged—after surgery, cardiac arrest, or as a side effect of certain medications—doctors often face one crucial question: Will the kidneys recover, or is the damage permanent?
Nov 6, 2025
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Breast cancer relapse: Key cellular resistance mechanism discovered
Triple-negative breast cancer is one of the most aggressive and difficult cancers to treat. It can initially respond well to therapeutic combinations of chemotherapy, but a tiny minority of tumor cells may manage to tolerate ...
Nov 6, 2025
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Hundreds of genes act differently in the brains of men and women
Differences between men and women in intelligence and behavior have been proposed and disputed for decades.
Nov 6, 2025
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Missing enzyme may explain impaired bone growth
Chondrocytes play a crucial role in skeletal development. Many bones, such as those in the arms and legs, are formed through endochondral ossification, in which chondrocytes assemble to create a cartilage scaffold that is ...
Nov 6, 2025
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Bowel cancer's 'Big bang': How a crucial moment determines future growth
Like the astronomical explosion that kickstarted the universe, bowel cancer has a "Big Bang" moment which determines how it will grow, according to new research.
Nov 5, 2025
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Missing a common protein could affect how muscles respond to testosterone
Lacking a common protein may affect how muscles respond to testosterone, potentially affecting athletic performance and age-related muscle loss, according to a new study.
Nov 5, 2025
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Experimental drug blocks key protein to trigger cancer cell self-destruction in lung tumors
NYU Langone Health researchers found that a type of cell death caused by a buildup of highly reactive molecules suppresses lung tumor growth.
Nov 5, 2025
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Two main gene discovery methods reveal complementary aspects of biology
The two main approaches for discovering disease genes reveal distinct aspects of biology, a new study shows. While both methods are widely used, the research found that they identify different genes with major implications ...
Nov 5, 2025
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