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Clinical genetics news

Genetic map for cocaine addiction points beyond brain to liver

Researchers at the University of California San Diego have completed a massive genetic study that identifies key biological drivers of cocaine addiction, uncovering a potential new target for treatment that resides in the ...

CRISPR enzyme precisely detects and shreds DNA in cancer mutations once considered 'undruggable'

In 2020, Jennifer Doudna won the Nobel Prize in chemistry for her work on the CRISPR-Cas9 gene-editing technology that allows scientists to precisely modify DNA by cutting it at specific locations. Six years later, a new ...

3D genome architecture pre-wires early developmental decisions

New research tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development. The study reconstructs a timeline of chromosome folding that brings remote DNA regulatory ...

A heritable 'brake' for stopping cocaine use in rats

Cocaine produces strong euphoric effects, but many users experience unpleasant effects after the rewarding aspects of the drug wear off, which serve as a "brake" for continued use. Research suggests that those who go on to ...

Heart elasticity may hinge on a hidden genetic switch

The human heart must constantly adapt to changing demands—a task that requires tightly coordinated molecular shuffling in heart cells. One of the key regulators of this process is RBM20, a protein that controls an editing ...