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Clinical genetics news

Decades-old puzzle solved as scientists uncover cause of inflammatory bowel disease

Researchers at the Nuffield Department of Medicine, University of Oxford, together with Newcastle University's Translational and Clinical Research Institute and the Department of Immunology at Cambridge University Hospitals ...

CRISPR enzyme precisely detects and shreds DNA in cancer mutations once considered 'undruggable'

In 2020, Jennifer Doudna won the Nobel Prize in chemistry for her work on the CRISPR-Cas9 gene-editing technology that allows scientists to precisely modify DNA by cutting it at specific locations. Six years later, a new ...

3D genome architecture pre-wires early developmental decisions

New research tracks how cells prepare gene regulatory decisions that will define their fate during the earliest stages of human development. The study reconstructs a timeline of chromosome folding that brings remote DNA regulatory ...

A heritable 'brake' for stopping cocaine use in rats

Cocaine produces strong euphoric effects, but many users experience unpleasant effects after the rewarding aspects of the drug wear off, which serve as a "brake" for continued use. Research suggests that those who go on to ...

Heart elasticity may hinge on a hidden genetic switch

The human heart must constantly adapt to changing demands—a task that requires tightly coordinated molecular shuffling in heart cells. One of the key regulators of this process is RBM20, a protein that controls an editing ...

Genetic trade-off between youth and longevity uncovered

A new study identifies vgll3 as a key gene that promotes rapid growth and early reproduction while increasing the risk of aging and cancer later in life. The findings provide rare experimental evidence for the theory that ...