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Clinical genetics news
More accurate risk assessment developed for Alzheimer's disease among nonwhite patients
Late-onset Alzheimer's disease (AD) is a progressive disorder characterized by cognitive decline and memory impairment, affecting an estimated 6.9 million people in the U.S. The clinical course of AD unfolds over many years, ...
2 hours ago
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Children of centenarians often live longer and face lower cardiovascular risks, analysis finds
Adults with at least one parent who reached age 100 lived longer and had substantially lower risks of cardiovascular disease and hypertension than people whose parents had shorter lifespans, according to a study published ...
16 hours ago
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Inherited genetic variants help identify patients at higher risk of aggressive therapy-related blood cancers
Some patients develop aggressive blood cancers years after receiving chemotherapy or radiotherapy for a previous cancer. These conditions, known as therapy-related myeloid neoplasms (t-MN), are currently classified mainly ...
15 hours ago
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Stress gene 'stuck on' in the brains of people with schizophrenia, study finds
Experts at the University of Sydney have found that a gene involved in regulating the body's response to stress switches on more easily in the brains of people who live with schizophrenia.
Aug 26, 2026
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People say they would not want to test embryos for traits like low IQ. But if given the information, they act on it
A study of more than 2,000 people in the United States and China finds that the line between medical and nonmedical traits, which underpins rules on embryo testing in most countries, does not match public preferences.
Aug 26, 2026
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How DNA folding controls immune gene activity in T cells
A new study by researchers at the Perelman School of Medicine at the University of Pennsylvania reveals that the three-dimensional folding of DNA at a key genetic locus helps determine when two related immune genes, Ets1 ...
Aug 26, 2026
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First-in-human pilot trial improves stem cell collection and delivery for sickle cell gene therapy
Patients with sickle cell disease are often hesitant to undergo transformative gene therapy—the current lengthy process requires multiple hospital visits to collect enough stem cells. Researchers from Boston Children's Hospital ...
Aug 25, 2026
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Abnormal differentiation of fetal neural progenitor cells causes autistic-like behavior in mice
Autism spectrum disorder is a developmental disorder characterized by difficulties with social interaction, restricted interests and repetitive behaviors. It has attracted significant attention because of its high prevalence, ...
Aug 25, 2026
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Turning up protein production: A new genetic approach to polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney failure. Despite decades of research, treatment options for the disease remain limited, and many patients ultimately require ...
Aug 25, 2026
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New clues to the genetic roots of hair-pulling and skin-picking
Two disorders with big names—trichotillomania (repeated hair-pulling) and excoriation disorder (repeated skin-picking)—were the focus of a recent Yale study looking at potential genetic causes. The two disorders are part ...
Aug 25, 2026
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A single genetic test can uncover causes of previously unexplained premature ovarian insufficiency
Premature ovarian insufficiency affects up to 3.5% of women and is an important cause of female infertility. However, in most cases, the underlying cause remains unknown. A recent study by researchers at the University of ...
Aug 25, 2026
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Spatial atlas reveals how ovarian clear cell tumors vary from core to edge
Ovarian clear cell carcinoma (OCCC) has a higher prevalence among East Asian women and is characterized by poor clinical outcomes. An interdisciplinary team led by Professor Ruby Yun-Ju Huang at National Taiwan University ...
Aug 24, 2026
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Previously missed DNA mutation pattern in colorectal cancer identified
Researchers from the University of California San Diego and collaborators have identified a previously overlooked pattern of DNA mutations in colorectal cancer. Scientists use these patterns, known as mutational signatures, ...
Aug 22, 2026
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Younger adults with lung cancer more likely to have targetable genetic changes, study finds
Younger adults with non-small cell lung cancer are significantly more likely than older patients to have genetic alterations that can be matched with targeted therapies, according to a large international study led in part ...
Aug 21, 2026
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A unified framework to explain one of cancer's major drivers
In a rare pair of papers published back-to-back in the journal Genes & Development, research teams led by senior author Anindya Bagchi, Ph.D., associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham ...
Aug 20, 2026
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AI-guided screening identifies nine drugs that may slow childhood dementia
An Australian research collaboration has identified several existing TGA-approved medicines that could help slow brain damage in children with a rare form of dementia—offering hope for faster treatment options.
Aug 20, 2026
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International study marks step forward in genetic understanding of eating disorders
New research led by the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London, in collaboration with an international partnership of researchers, has, for the first time, compared the genetics ...
Aug 19, 2026
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Single gene injection reverses inherited heart disease in mice and patient-grown tissue
Melbourne researchers have made a gene therapy breakthrough that could restore heart function in children with genetic heart disease, sparing them the need for transplants.
Aug 19, 2026
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Genetic risk score identifies nearly one in five MODY referrals with hidden type 1 diabetes
A new study shows that incorporating a genetic risk score into standard testing for a genetic form of diabetes that affects young people could identify hidden type 1 diabetes in about 1 in 5 patients with a negative genetic ...
Aug 19, 2026
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Mapping the diversity of chronic lymphocytic leukemia at single-cell resolution
Two patients with chronic lymphocytic leukemia (CLL) can face very different futures. One may live for decades without needing treatment, while another may develop rapidly progressing disease. In a new study from Karolinska ...
Aug 19, 2026
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Hidden aggressive cells reveal why some lower-risk childhood cancers turn deadly
New insights into why some children with rhabdomyosarcoma (RMS) develop aggressive disease despite being classified as non-high-risk have been uncovered. The discovery could help clinicians identify children with potentially ...
Aug 19, 2026
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Patchy brain development may help explain autism's varied traits
Autism spectrum disorder (ASD) affects every individual differently. Scientists have identified more than a thousand genes associated with ASD, yet no single gene accounts for most cases. This has left researchers with a ...
Aug 18, 2026
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Study demonstrates a new standard for pediatric research
A new analysis from the Gabriella Miller Kids First Data Resource Center (Kids First DRC) shows how a collaborative, data-driven research model is creating broader opportunities to understand pediatric disease.
Aug 18, 2026
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Rare gene variants may multiply Alzheimer's disease risk
Alzheimer's disease is the most common form of dementia worldwide, and its development is influenced by a combination of genetic and environmental factors. In recent years, the PLCG2 gene and its encoded enzyme, PLCγ2, have ...
Aug 17, 2026
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Advanced genetic testing opens new treatment options for nearly one in three cancer patients, study finds
A new study from London Health Sciences Centre Research Institute (LHSCRI) shows that expanded genetic testing can help match cancer patients with more personalized treatment options, with nearly one in three found eligible ...
Aug 17, 2026
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