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Clinical genetics news
Clinical trial explores whether a genetic test can improve early detection of prostate cancer
A genetic test developed by researchers at Broad Clinical Labs and the U.S. Department of Veterans Affairs (VA) is now enabling a large, nationwide clinical trial aimed at improving health care for men at increased risk of ...
4 hours ago
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Eye cancer genes predetermine liver metastasis, study finds
Cells from cancerous tumors can spread, or metastasize, throughout the body. Researchers have long sought to understand what determines where those cells will go and thrive in order to more effectively treat the cancer and ...
10 hours ago
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Why Huntington's proteins pile up: Two key tags guide their disposal
There is no known cure for Huntington's disease. A genetic mutation creates harmful proteins that accumulate and cause the disease's typical symptoms. A team from the Department of Human Genetics at Ruhr University Bochum, ...
Feb 8, 2026
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Review of 40 years of genetics suggests dyslexia involves broader brain networks
A University of Houston psychology professor is challenging the notion that dyslexia, or specific reading disorder, stems from a single faulty gene in the brain, suggesting instead that it is caused by an overall brain network ...
Feb 8, 2026
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i-DNA 'peek-a-boo structures' form in living cells and regulate genes linked to cancer
DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown that one such structure, ...
Feb 7, 2026
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Haemochromatosis: The iron overload condition that too often goes undiagnosed
When we think about iron imbalance, most people are familiar with iron deficiency and the health problems it can cause. What many may not realize is that the opposite problem, iron overload, can be just as serious—yet many ...
Feb 7, 2026
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Genetic testing in sports: Fairness, human rights and the law
Testing the biological sex of an athlete is becoming more common in sport, with governing bodies defending the practice as safeguarding fairness for women. But as the introduction of mandatory genetic testing raises questions ...
Feb 7, 2026
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What a new twins study reveals about genes, environment and longevity
Why do some people live to 100 while their sibling dies decades earlier? Is it luck, lifestyle, or something written into their DNA? Relative to many other species, humans are particularly long-lived, but there is an ongoing ...
Feb 7, 2026
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Understanding the path from genetic changes to Parkinson's disease opens possibilities for early diagnosis
A team led by researchers at Baylor College of Medicine and the Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital has uncovered a chain of events that connects genetic alterations, disruptions ...
Feb 6, 2026
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Tiny 'mini-me' organs grown from children's cells are transforming cystic fibrosis care
When UNSW Associate Professor Shafagh Waters explains cystic fibrosis (CF) to the children she works with, she asks them to imagine what is happening inside their own bodies. "I tell them to picture an airport," she says. ...
Feb 6, 2026
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Genetic study shows that anxiety disorders have many causes
About 1 in 4 people suffer from an anxiety disorder at some point in their lives. These include panic disorder with sudden, severe anxiety attacks; generalized anxiety disorder, in which sufferers worry about everyday things ...
Feb 5, 2026
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Five mutational 'fingerprints' could help predict how visible tumors are to the immune system
Researchers from the HUN-REN Szeged Biological Research Centre and HCEMM have just published a new study suggesting that it's not simply the number of tumor mutations that matters for immunotherapy, but the kind of mutation ...
Feb 5, 2026
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DNA marker in malaria mosquitoes may be pivotal in tackling insecticide resistance
A new study has detected a DNA marker in a gene encoding a key enzyme known as cytochrome P450 that helps mosquitoes to break down and survive exposure to pyrethroids, the main insecticides used for treating bed nets. This ...
Feb 4, 2026
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Nine-gene biomarker paves way for tailored psoriasis treatments
Psoriasis is a common inflammatory skin disease linked to several long-term health conditions, such as heart disease, arthritis and type 2 diabetes, and has a substantial impact on sufferers' quality of life. Although the ...
Feb 4, 2026
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Gene-editing therapy proves effective for Leber's hereditary optic neuropathy
A research team has successfully demonstrated the world's first gene-editing treatment for Leber's hereditary optic neuropathy (LHON). The study was conducted in collaboration with the Seoul National University College of ...
Feb 4, 2026
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Hereditary disease CADASIL linked to changes in brain energy and blood vessels
A new study from Karolinska Institutet shows that damage to small blood vessels in the hereditary disease CADASIL may disrupt important brain functions in the hippocampus, a region involved in memory. The findings help explain ...
Feb 4, 2026
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Premature aging may result from immune responses triggered by faulty DNA repair
DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that aid DNA in carrying out essential processes such as replication, repair, and transcription. Under ...
'Celtic curse' genetic disease hotspots revealed in UK and Ireland
People from the Outer Hebrides and north-west Ireland have the highest risk of developing a genetic disease that causes a dangerous build-up of iron in the body, a study published in the journal Nature Communications suggests.
Feb 3, 2026
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How a tiny cellular signal helps shape the human heart
Australian researchers have uncovered a crucial new mechanism that helps explain how the heart's major blood vessels form during early development, and how disruptions to this process can lead to serious congenital heart ...
Feb 3, 2026
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Potent DNA-recombination method developed for large cargo delivery in gene therapy
Delivery of therapeutic genes is essential for gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying gene cargoes because of their superior gene segmentation flexibility and robust gene reconstitution ...
Feb 3, 2026
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Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents
A University of Calgary-led international research team has identified a genetic factor that may explain why people respond so differently to opioid pain medications, and why some individuals face greater risk of side effects ...
Feb 3, 2026
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MDGA2 gene malfunction removes brain's excitatory 'brake' to trigger severe epilepsy, study finds
The DGIST Center for Synapse Diversity and Specificity has identified MDGA2 as a novel causative gene for developmental and epileptic encephalopathy (DEE), a rare and intractable neurological disorder occurring in infancy ...
Feb 3, 2026
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Examining DNA molecules one by one: How combining techniques can help us understand diseases such as dementia
"By cleverly combining new techniques for analyzing DNA at the level of individual molecules, we can achieve real breakthroughs in research into conditions such as dementia," predicts Professor John van Noort. Together with ...
Feb 3, 2026
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Protective mechanism discovered in female brain: Switched-off X chromosome can reactivate to reduce disease severity
Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have identified a mechanism that protects the female brain from genetic diseases. Although one of the two X chromosomes is switched off in female cells ...
Feb 2, 2026
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New genetic tools offer more accurate breast cancer prediction for women of African ancestry
Despite major advances in genetic testing for breast cancer risk prediction, death rates remain disproportionately high among women of African ancestry. This is often due to a combination of factors, including failure of ...
Feb 2, 2026
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