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Clinical genetics news
Genes give neurons a 'GPS' to form the brain's neural circuits, scientists show
How complex neural circuits are genetically designed and wired is a fundamental question in neuroscience. Scientists have shown for the first time that genes encode a "wiring map" that guides neurons to connect with the correct ...
11 hours ago
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Your address, ancestry and gut may be steering aging in ways medicine has barely begun to map
Researchers at the Stanford School of Medicine have found that ethnicity and geography may influence human molecular makeup—from metabolism and immunity to gut microbiota and biological aging. The findings, published in Cell, ...
16 hours ago
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Hidden genetic defect linked to Kaposi sarcoma for the first time
A new study has uncovered a genetic cause that may explain why some people develop Kaposi sarcoma despite having no apparent immune deficiency. The rare cancer, which forms in the cells lining blood vessels, is caused by ...
15 hours ago
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Novel tool enables high-precision, low-cost pediatric leukemia diagnostics
Researchers have introduced a novel diagnostics method that can more sensitively detect gene fusions in B-cell acute lymphoblastic leukemia (B-ALL), the most common type of pediatric cancer, compared to other publicly available ...
10 hours ago
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Drug trial finds that a treatment shift is needed for brittle bone disease
Increasing bone density in patients with a rare genetic condition that causes bones to break easily does not prevent fractures, a large clinical trial has found. Patients with brittle bone disease who were given treatments ...
16 hours ago
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Study finds one in eight adults carries hidden genetic risk—and reveals what it takes to act on it
When Mayo Clinic researchers sequenced the genomes of 484 seemingly healthy adults, they found that about 13% carried a serious, previously unrecognized genetic risk—conditions those patients did not know about and that standard ...
14 hours ago
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Genetic research could help patients avoid amputations
Physicians may one day be able to identify which patients with peripheral artery disease are most likely to develop complications and intervene earlier, thanks to a Northeastern University discovery. Peripheral artery disease ...
18 hours ago
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Non-coding gene is linked to core social and behavioral traits in autism
A long-overlooked stretch of the human genome appears to play a distinct role in shaping the social and stereotypic repetitive behaviors that define autism spectrum disorder (ASD), without affecting learning or other cognitive ...
May 13, 2026
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Genetic risk of schizophrenia manifests in early adolescence, study shows
Research has found that children with higher genetic susceptibility to schizophrenia show decreases in frontal cortical surface area during early adolescence, in contrast to the regional expansion observed in children with ...
May 13, 2026
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A 13-gene panel may help predict response to chemotherapy in triple-negative breast cancer
Researchers at The University of Texas MD Anderson Cancer Center have characterized cancer cell-specific features in the tumor microenvironment (TME) of early-stage triple-negative breast cancer (TNBC) tissues, identifying ...
May 13, 2026
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Researchers successfully treat hereditary epilepsy in a mouse model
In a world first, a research team at the University of Zurich has successfully treated mice carrying an inherited form of epilepsy. The scientists used gene editing to fix faulty DNA directly in the brain cells of mice, which ...
May 13, 2026
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Genetic link between cannabis use and psychosis could help to identify those most at risk
New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London has highlighted the distinct and shared molecular pathways linking cannabis use disorder (CUD) and psychosis, offering ...
May 13, 2026
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Calculating cancer risk through the genetic fingerprints of tumors
Why do two people with the same cancer diagnosis—the same stage, the same cell type, and the same clinical profile—often have completely different outcomes? For decades, scientists have studied acquired mutations in cancer ...
May 13, 2026
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New guideline aims to reduce severe allergic reactions to epilepsy drugs
Researchers from the Center of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx) have published a new prescribing guideline aimed at reducing the incidence of serious allergic reactions to common ...
May 13, 2026
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Gut problems in people with a genetic disorder are not caused by structural problems with the esophagus, study confirms
A study, led by experts at the University of Nottingham, has found that persistent and distressing upper gut symptoms experienced by people with hypermobile Ehlers-Danlos syndrome (hEDS), are not due to structural problems ...
May 13, 2026
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New genomic approaches uncover surprising cellular dynamics of the aging brain
While much is mysterious about the aging process, change over time remains its cornerstone. The biological shifts that accompany aging seemingly occur in many cells in the body. The problem is, we have tens of billions of ...
May 12, 2026
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Research into Friedreich's ataxia reveals how DNA folding can silence a key gene
Researchers have uncovered a fundamental rule that governs how genes are physically arranged inside the cell nucleus, and how disruptions to that organization can contribute to human disease.
May 12, 2026
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Human islet map links cell mix to insulin output and diabetes risk
Diabetes is the most common and serious chronic disease worldwide, characterized by insufficient insulin to maintain proper blood glucose levels. It affects more than 12% of Americans and is the eighth leading cause of death ...
May 12, 2026
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Tiny worms, with help from researchers, may hold key to treating rare childhood disease
A new worm model developed by Brown University researchers could play a key role in treating a rare genetic disease that causes paralysis in children and worsens with age. Developed in the lab of neuroscientist Anne Hart, ...
May 12, 2026
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Loss of the X chromosome is associated with reduced chance of natural pregnancy
Chromosomes carry genetic information for biological sex, which generally assigns women two X chromosomes and men XY chromosomes. This is a basic principle of human genetics most are taught in grade school biology, but it ...
May 12, 2026
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Are your meds and DNA a bad match? This test alerts clinicians
Differences in people's genes can affect how they respond to medications, including how well a drug works and the chances of side effects. About 1 in 10 of prescriptions given to patients outside the hospital don't work as ...
May 12, 2026
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A hidden inheritance could explain disease risks beyond DNA: Q&A
When we think about genetic inheritance, we usually leap to DNA, the four-letter code containing the instructions for building a living organism. Scientists know that DNA encodes everything from hair and eye color to a person's ...
May 11, 2026
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Children with rare debilitating brain diseases suffer from mutations in a little-known protein complex
Thousands of times per year, a family's moment of joy turns to unexpected grief. A seemingly healthy infant stops smiling or making eye contact. Their limbs grow weak. The tiny child suffers seizures and breathing problems.
May 8, 2026
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How a tiny cell structure may shape brain development and drive disease
A largely overlooked structure inside our cells may play a crucial role in how the brain forms, offering new insight into developmental disorders and potential therapies.
May 8, 2026
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What lies behind hereditary heart rhythm disorders
Short QT syndrome is a genetic disease that leads to sudden cardiac death at a young age. Mutations in the SLC4A3 gene, which regulates bicarbonate-chloride exchange, were recently described as a potential cause. An international ...
May 8, 2026
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