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Clinical genetics news
New gene-editing approach shows promise in treating Huntington's disease in mice
Huntington's disease is caused by repetitive "stutters" in DNA—specifically repeated CAG sequences—that expand abnormally over time, leading to toxic protein accumulation that contributes to the progression of the disease. ...
10 hours ago
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Liver tumors form without detectable driver mutations in mice, revealing epigenetic route
Cancers can develop through epigenetic pathways even without driver gene mutations (DGMs), according to a study from Science Tokyo. Researchers uncovered the YAP1–TEAD–TET1 axis, which triggers DNA demethylation and activates ...
11 hours ago
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'Average' human genome described for first time, with implications for disease risk
A new study has characterized the "average" human genome, providing key information on normal human genetic variation and genetic disease risk. The researchers conclude that everyone—regardless of their current health status—could ...
15 hours ago
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MRI scans and DNA data uncover new genetic links to fatty liver disease
Fatty liver disease is characterized by the accumulation of triglycerides—a type of fat—in the liver. The disease has a strong genetic component, but until now, knowledge about which genes influence its development has been ...
13 hours ago
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Comprehensive DNA sequencing reveals hidden drivers of cancer
Michigan's Oncology Sequencing Program, or MiOncoSeq, was the first of its kind in the nation to sequence patient tumors. Launched in 2010, the program analyzes DNA and RNA from normal tissue and tumors to identify alterations ...
12 hours ago
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Pancreatic cancer study highlights body's natural molecules as potential treatment tools
Pancreatic cancer cells are remarkably good at doing one thing: growing. But new Texas A&M research suggests that two tiny molecules already present in the body may help slow them down.
Oct 21, 2026
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Experimental treatment selectively reduces harmful protein in lab models of rare inherited brain disorder
Researchers from DZNE and the Hertie Institute for Clinical Brain Research (HIH) at the University of Tübingen, together with experts from Bonn, London and Portugal, have developed and successfully tested in human neurons ...
Oct 21, 2026
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Personalized medicine breakthrough for childhood leukemia
Researchers from Newcastle University and Great Ormond Street Hospital have identified new predictors of relapse in children and young people with acute lymphoblastic leukemia (ALL) treated with the immunotherapy drug blinatumomab, ...
Oct 21, 2026
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Buildup of normally harmless enzyme stunts brain growth in mice with Angelman syndrome
Angelman syndrome is a rare disease with a single known cause: one missing gene. The lack of that gene, normally inherited from the mother, occurs in approximately one in 20,000 births and is associated with cognitive and ...
Oct 21, 2026
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Reducing nuclear damage improves heart function and survival in mice
Reducing damage to the nuclei of heart muscle cells improved heart function and extended survival in mice with a form of inherited heart disease, according to a new study led by Cornell researchers. The findings point to ...
Oct 21, 2026
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Substance use disorder recovery, remission linked with genetic, psychosocial factors
A new study by researchers at the University of Illinois Urbana-Champaign highlights the importance of considering both psychosocial and genetic factors in patients' prognoses and intervention planning in their recovery from ...
Oct 21, 2026
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Brazilian biobank may help personalize cancer prevention in the public health system
A bank of biological samples from thousands of Brazilians could help the Unified Health System (SUS), which is public and free, identify people at higher risk of developing certain types of cancer. In the future, the SUS ...
Oct 21, 2026
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Spouses mattered more than genes for the risk of severe COVID-19
Why did some people become severely ill with COVID-19 while others experienced only mild symptoms? Associate professor Maria Timofeeva and assistant professor Jacob Krabbe Pedersen from the Department of Public Health at ...
Oct 20, 2026
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Q&A: Gene editing is coming for common diseases. Cardiologists discuss if we are ready
Gene therapy is no longer the future of medicine—it's reality. Treatments that replace, silence or edit genes are already changing clinical care.
Oct 20, 2026
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Gene variants that can cause sudden death mapped
Using a high-throughput technique, an international collaboration led by Vanderbilt Health researchers has created a "map" of 1,757 genetic variations that can trigger a life-threatening heart rhythm disorder called long ...
Oct 20, 2026
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Repeating stretch of DNA offers a new clue to Alzheimer's susceptibility
A three-letter sequence repeating along a stretch of DNA could offer new clues about why some people are more susceptible to Alzheimer's disease than others. The sequence, CCG, sits in a region of DNA that controls the gene ...
New CRISPR approach targets gene fusions found in 1 in 5 cancers
Peter Mac scientists have developed a way to precisely target the "unique molecular fingerprint" created when two genes become abnormally fused together, a discovery that could lead to a new way to treat a wide array of cancers.
Oct 19, 2026
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Advanced paternal age has sex-specific effects on fetal brain gene expression, mouse study suggests
When genes are "expressed," it is like reading an instruction manual to create things the body needs—such as proteins or RNA. It is an important process in regulating normal cellular functions. Understanding more about gene ...
Oct 19, 2026
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Fast-tracked genetic testing helping sick kids
A new genetic testing approach for sick children with immune conditions could slash diagnosis waiting times from 12 months to as little as two weeks, University of Queensland research has found.
Oct 19, 2026
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DNA sequencing reveals how rare cancer spread between twins before birth
Two identical sisters came into the world carrying the same rare cancer. They lost their lives to an undifferentiated sarcoma, a soft-tissue cancer driven by a unique gene fusion (MN1::ZNF341). The story began before they ...
Genomic cancer driver study reveals new clues to why some prostate cancers become aggressive
Why do some prostate cancers grow slowly for years, while others progress quickly to life-threatening metastatic disease? An international team of researchers co-led by the Ontario Institute for Cancer Research (OICR) and ...
Oct 16, 2026
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Researchers develop new AI tool to better predict stroke risk
Researchers from the University of Technology Sydney (UTS) have developed an AI model that analyzes a person's DNA to better identify genetic risk factors for stroke, paving the way for more personalized risk assessments.
Oct 16, 2026
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AI tool helps identify harmful epilepsy genetic variants
A new artificial intelligence tool developed by Northwestern Medicine scientists and collaborating institutions can help determine whether genetic variants associated with a severe form of childhood epilepsy will cause disease, ...
Oct 15, 2026
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Reversing age by reprogramming gene expression networks
Every organ and tissue progressively loses function and integrity as it ages. In fact, researchers have identified "hallmarks of aging" that not only present specific processes impacted by age, but are also thought of as ...
Oct 14, 2026
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What happens when brain tumors return? International study tracks genetic changes behind recurring cancers
When patients are diagnosed with certain brain tumors, one of the biggest unanswered questions is what happens when the cancer returns. Among those are IDH-mutant gliomas, a group of brain tumors that invariably recur despite ...
Oct 14, 2026
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