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Genetics news
Oncology & Cancer
Cancer's hidden 'safety switch': Silencing TAK1 gene could boost immunotherapy performance
Australian researchers have discovered that the TAK1 gene helps cancer cells survive attack from the immune system, revealing a mechanism that may limit the effectiveness of immunotherapy treatments.
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Hidden 'switches' in DNA reveal new insights into Alzheimer's disease
A tiny percentage of our DNA—around 2%—contains 20,000-odd genes. The remaining 98%—long known as the non-coding genome, or so-called 'junk' DNA—includes many of the "switches" that control when and how strongly genes ...
Dec 18, 2025
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Genetic influences on health can ripple through social groups via shared microbes
Your "roommate's" genes could be influencing the bacteria living in your gut, and vice versa, according to a study of rats published in Nature Communications.
Dec 18, 2025
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Subtyping colorectal cancer may improve patient outcome predictions
Colorectal cancer, or CRC, is the world's second most lethal cancer based on the number of deaths, and is the third most prevalent malignant tumor. Doctors and patients have long been hoping for better diagnostics for prognosis, ...
Dec 18, 2025
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How disabling one gene protects mice against Type 1 diabetes
Scientists at the University of Wisconsin–Madison have uncovered a possible way to protect key cells in the pancreas that are targeted during the development of Type 1 diabetes.
Dec 17, 2025
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Individual genetic differences can render some antibody-based therapies ineffective
Antibody-based therapies are used to treat numerous diseases, from cancer to rheumatic disorders and multiple sclerosis. Antibodies recognize and bind to very specific structures. This allows them to direct active substances ...
Dec 17, 2025
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New details on role of fat transport molecules in Alzheimer's onset
A new study presents robust evidence on the role of lysophosphatidylcholines (LPCs) in the onset of Alzheimer's disease. Researchers discovered that LPCs—compounds that transport a variety of healthy fatty acids to the ...
Dec 17, 2025
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'Molecular glue' stabilizes protein that inhibits development of non-small cell lung cancer
Lung cancer is the second-most common cancer and the leading cause of cancer death in the United States. Over 80% of lung cancers are non-small cell lung cancers, in which tumor cells are larger and grow more slowly than ...
Dec 17, 2025
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Gene therapy advances as scientists guide jumping DNA to target faulty genes
JABSOM Cell and Molecular Biology researcher Dr. Jesse Owens has spent the better part of two decades chasing a vision that began with the revolutionary idea that DNA can move itself. Now, his team's latest breakthrough is ...
Dec 17, 2025
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Alcohol-linked DNA damage tied to cancer risk: Study reveals repair enzyme's role
Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA. A research team from IOCB Prague has now described in detail how cells repair this damaged genetic information.
Dec 16, 2025
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Using both genetic information and AI to diagnose pneumonia could curb the overuse of antibiotics
Lung infections like pneumonia are among the world's top killers—but diagnosing them is notoriously hard. Now, researchers at UC San Francisco have found a way to identify these infections in critically ill patients by ...
Dec 16, 2025
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Multiple myeloma develops differently in men and women, study reveals
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have uncovered biological differences in how multiple myeloma develops and progresses in men and in women. The rare blood cancer occurs ...
Dec 16, 2025
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Study finds combined gene mutations better mimic rare gut disorder in mice
During development of the digestive system, a complex network of nerves forms around it, creating a "second brain"—the enteric nervous system (ENS)—which controls the movement of food and waste through the gut. But a ...
Dec 16, 2025
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Childhood maltreatment leaves genetic scars tied to lifelong mental health risks
A research team led by the Department of Pediatrics and Adolescent Medicine, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has conducted a pioneering study that established a ...
Dec 16, 2025
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Who is more likely to get long COVID? New study uncovers genetic drivers behind the disease
Australian scientists have identified the key genetic drivers behind long COVID, revealing why some people continue to experience debilitating symptoms long after their initial infection.
Dec 16, 2025
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New AI tool identifies not just genetic mutations, but the diseases they may cause
Scientists at the Icahn School of Medicine at Mount Sinai have developed a novel artificial intelligence tool that not only identifies disease-causing genetic mutations but also predicts the type of disease those mutations ...
Dec 15, 2025
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Fertility gene helps glioblastoma tumors survive chemotherapy and return after treatment, researchers discover
Research by University of Sydney scientists has uncovered a mechanism that may explain why glioblastoma returns after treatment, offering new clues for future therapies which they will now investigate as part of an Australian ...
Dec 15, 2025
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Neurons use simple rules to localize genetic messages, scientists discover
Scientists found that messenger RNA (mRNA) molecules that carry genetic instructions to the far reaches of neurons in the brain tend to cluster together mostly because they are abundant, not because they move in coordinated ...
Dec 15, 2025
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Gene therapy for hereditary spastic paraplegia hits proof-of-principle milestone
There is no cure for the rare disease Hereditary Spastic Paraplegia (HSP), but researchers from Drexel University's College of Medicine and the UMass Chan Medical School have achieved proof-of-principle success with "silence ...
Dec 15, 2025
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Key proteins identified in Oroya fever reveal new target for potential treatment
The so-called "Oroya fever" is an extremely severe infectious disease, yet it is classified among the so-called neglected tropical diseases. This is because the infection occurs—so far—exclusively in high-altitude valleys ...
Dec 15, 2025
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Tapt1 gene found crucial for protein balance and healthy brain development
A research team led by Prof. Xu Zhiheng from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has identified Tapt1, together with its partner Suco, as important genes for brain development. ...
Dec 15, 2025
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Refining the uncharted landscape of human transcription factors—strategic framework created for future prioritization
The human genome contains approximately 1,600 types of transcription factors responsible for regulating gene activity across more than 400 tissue and cell types. Chromatin immunoprecipitation sequencing (ChIP-seq) is a key ...
Dec 15, 2025
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Chromatin accessibility maps reveal how stem cells drive myelodysplastic syndrome progression
Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation. In myelodysplastic syndrome (MDS), however, this ...
Dec 13, 2025
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Circular single-stranded DNA molecules for safer genetic medicine
To our immune system, a potentially lifesaving gene therapy can look a lot like a dangerous infection. That's because most genetic medicine uses viruses or double-stranded DNA to deliver genetic information to target cells. ...
Dec 13, 2025
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