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Genetics news
Oncology & Cancer
Mutation yields hot new clues for treating immune 'cold' tumors
Immune checkpoint inhibitors (ICIs) emerged in the US about 15 years ago as an exciting class of cancer treatments that have achieved complete and durable remissions for thousands of people with end-stage metastatic cancers. ...
8 hours ago
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Genetics
Common genetic causes across motor neuron diseases identified
Motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP), share physical similarities but have been largely viewed as genetically distinct. However, an analysis led by investigators ...
9 hours ago
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MAGIC: AI-assisted 'laser tag' illuminates cancer origins
The human body relies on precise genetic instructions to function, and cancer begins when these instructions get scrambled. When cells accumulate genetic errors over time, they can break free of the normal controls on their ...
13 hours ago
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Challenging conventional wisdom on a common cause of melanoma
University of Queensland researchers have found that a genetic mutation that causes melanoma can lie dormant in healthy skin, a finding that could improve screening of areas more prone to the disease.
4 hours ago
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Fruit flies offer new insights into how Alzheimer's disease risk genes affect the brain
Scientists have identified hundreds of genes that may increase the risk of developing Alzheimer's disease but the roles these genes play in the brain are poorly understood. This lack of understanding poses a barrier to developing ...
14 hours ago
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Changing the 'packaging' of DNA in neurons can turn memories on or off in mice
Our experiences leave traces in the brain, stored in small groups of cells called engrams. Engrams are thought to hold the information of a memory and are reactivated when we remember, which makes them very interesting for ...
19 hours ago
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3D genome mapping tool reveals hidden complexity in DNA
Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new discoveries.
10 hours ago
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Heart 'blueprint' reveals origins of defects and insights into fetal development
New research in Sweden has produced a "blueprint" revealing how the human heart is built during prenatal development. It offers insights that could lead to improved prenatal care and new treatments for heart defects, such ...
19 hours ago
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New genetic marker could improve prediction of severe gout drug reactions in US patients
A newly identified genetic marker may significantly improve the ability to predict life-threatening reactions to the gout medication allopurinol in U.S. patients.
14 hours ago
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Additional testing of FISH-negative tests for renal cell carcinoma can improve kidney cancer diagnosis
A study from the University of Michigan Health Rogel Cancer Center and Department of Pathology shows that further testing in renal cell carcinoma with an overexpression of gene TRIM63 could uncover a mutation otherwise undetected, ...
11 hours ago
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Oxygen deprivation heightens risk of illness by changing genes, researchers discover
Low oxygen levels in the blood can alter the genetic makeup of key immune cells, weakening the body's ability to fight infection, new research shows.
Oct 28, 2025
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Previously unknown genetic cause of microcephaly identified
Microcephaly is a congenital malformation that leads to a significantly reduced brain size and is often accompanied by developmental delay. An international research team led by Dr. Tran Tuoc from the Department of Human ...
Oct 28, 2025
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Genetic variants can simultaneously increase BMI and lower cholesterol risk
Individuals with a genetic profile that puts them at risk of obesity may not necessarily be at risk of having high cholesterol, UTHealth Houston researchers discovered.
Oct 28, 2025
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Rebalancing the gut: How AI solved a 25-year Crohn's disease mystery
UC San Diego researchers have settled a decades-long debate surrounding the role of the first Crohn's disease gene to be associated with a heightened risk for developing the auto-immune condition.
Oct 27, 2025
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Up to 5% of Americans carry genetic mutations associated with cancer risk
New Cleveland Clinic research reveals that up to 5% of Americans—approximately 17 million people—carry genetic mutations or "variants" linked to increased cancer susceptibility, regardless of risk factors like personal ...
Oct 27, 2025
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Uncovering new therapeutic targets for a common KRAS mutation behind cancer
A team of Northwestern investigators has discovered novel molecular underpinnings of a common oncogenic mutation in cancer, findings that may inform the development of new therapeutic strategies, according to findings published ...
Oct 27, 2025
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Increased risk of developing alcohol addiction linked to gene mutation
Researchers from the Yong Loo Lin School of Medicine at the National University of Singapore (NUS Medicine) report that the gene, CHRNA3, acts as a key regulator of alcohol sensitivity. Published in the Journal of Neuroscience, ...
Oct 27, 2025
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Blood immune cell analysis tested in patients shows promise for early Parkinson's detection
The genetic analysis of a blood sample could become a tool for the early diagnosis of Parkinson's disease, according to an exploratory study led by researchers from the Miguel Hernández University of Elche (UMH). Although ...
Oct 27, 2025
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Genetic underpinnings of substance use disorders in Europe, Africa and America identified, some previously unknown
Substance use disorders (SUDs) are mental health conditions characterized by the compulsive, uncontrolled and deleterious use of alcohol, tobacco, stimulants (e.g., cocaine or methamphetamines), opioids, cannabis and/or various ...
Study reveals how a stubborn lung infection evolves inside patients over years
Researchers at Trinity Translational Medicine Institute (TTMI) and the Irish Mycobacterial Reference Laboratory at St James's Hospital have uncovered how the bacterium Mycobacterium avium—a leading cause of difficult-to-treat ...
Oct 24, 2025
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HIV's shape-shifting protein reveals clues for smarter drug design
The rate of HIV infection continues to climb globally. Around 40 million people live with HIV-1, the most common HIV strain. While symptoms can now be better managed with lifelong treatment, there is no cure to fully eliminate ...
Oct 24, 2025
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'Guided missile' drug molecule seeks out and destroys cancer's genetic lifeline
Researchers have created a new type of drug molecule that can precisely destroy TERRA, an RNA molecule that helps certain cancer cells survive. Using advanced "RIBOTAC" technology, their compound finds TERRA inside cells ...
Oct 23, 2025
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Study reveals epigenetic mechanisms regulating ILC2 memory and asthma recurrence
Researchers have revealed a novel mechanism by which the chromatin remodeler brahma-related gene 1 (Brg1) regulates Group 2 innate lymphoid cells (ILC2s) in allergic lung inflammation. Brg1 exacerbates allergic lung inflammation ...
Oct 23, 2025
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International experts produce guidelines for treating hereditary hearing loss with gene therapy
Up to 60% of congenital and early-onset hearing loss is caused by genetic mutations in an inherited gene, and gene therapy has recently emerged as a potential treatment option. To provide a standardized framework for conducting ...
Oct 23, 2025
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Scientists develop a way to track donor bacteria after fecal microbiota transplants
Researchers at the Icahn School of Medicine at Mount Sinai and their collaborators have developed a new technology to track beneficial bacteria after fecal microbiota transplants (FMT). The approach provides a detailed view ...
Oct 22, 2025
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