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Allergy and immunology news
Why CAR T therapy works for some patients but fails for others may be getting clearer
Chimeric antigen receptor (CAR) T-cell therapy is one of oncology's most powerful ideas: Harvest a cancer patient's own immune cells, genetically engineer them to recognize tumor cells, multiply them in a laboratory and reinject ...
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A natural molecule boosts CAR-T therapy and turns cold tumors hot
CAR-T cell therapy works well in blood cancers, but many patients still become resistant. A key reason is the presence of CAR-T regulatory T cells (CAR-Tregs), which weaken immune responses. Therefore, selectively targeting ...
2 hours ago
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Scientists recruit red blood cells to deliver genetic cargo with instructions to kill cancer
Scientists have developed a way to turn the body's own immune cells into cancer-fighting agents—without removing them from the body—by using red blood cells to deliver genetic instructions. Current CAR (chimeric antigen receptor) ...
Maternal antibodies in pregnancy may shape lifelong defenses against gum disease
A study from the Hebrew University of Jerusalem has identified a significant link between maternal care and lifelong oral health. Led by Prof. Avi-Hai Hovav and the DMD/Ph.D. student Reem Naamneh from the Faculty of Dental ...
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New dual-target drug may help overcome immunotherapy resistance in pancreatic cancer
Pancreatic ductal adenocarcinoma is one of the deadliest cancer types, with a five-year survival rate of 13%. There are only two treatment regimens available with limited efficacy. Pancreatic cancers do not respond to immunotherapy ...
2 hours ago
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Your nose may be the gateway to a stronger immune system
At the moment, an influenza vaccine called FluMist is the only licensed intranasal vaccine approved for use in humans. The vaccine is administered through a spray of fluid in the nose, rather than with an injection.
5 hours ago
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How eating primes immune cells for future responses
Diets and healthy eating habits hold promise for preventing and treating diseases, but far less is known about acute effects on the immune system shortly after a meal.
8 hours ago
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B-cell clusters inside kidneys mark faster diabetic disease progression, new maps reveal
A detailed new map of the human kidney revealed a previously unrecognized form of diabetic kidney disease (DKD) marked by clusters of immune cells—specifically B cells—that are linked to faster disease progression. The findings ...
6 hours ago
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Allergic rhinitis could lead to hearing impairment in children, teens
Allergic rhinitis (AR) could lead to hearing impairment in children/adolescents, according to a study published online April 9 in Frontiers in Pediatrics.
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How killer T cells attack tumors in 3D could sharpen future cancer immunotherapy
Cytotoxic T lymphocytes are the body's specialized "killer" cells, precisely eliminating infected or cancerous cells. Their action relies on a specialized exchange zone called the "immune synapse," where they release active ...
12 hours ago
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Researchers deepen understanding of molecular pathways responsible for airway inflammation in asthma
Johns Hopkins Medicine researchers say they have identified molecular pathways controlled by the protein RhoA in club cells—a specialized population of epithelial cells that exclusively lines the inner and outer surfaces ...
7 hours ago
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How the immune system battles lifelong viral infections acquired at birth
Millions of people worldwide carry viral infections they acquired at birth, often for life. For a long time it was assumed that the immune system hardly fights these pathogens. Researchers from the University of Basel show ...
Apr 28, 2026
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Why bone metastases resist treatment: New method identifies immune cells shielding tumors
Researchers at Baylor College of Medicine and collaborating institutions have developed a method that reveals the cellular makeup of tissues that support metastatic cancer growth, which is the primary cause of death for most ...
Apr 28, 2026
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T cells, not B cells, are the culprit in kidney damage in lupus, study shows
Kidney damage is a serious complication affecting individuals with lupus, an autoimmune disease where immune B cells malfunction and produce antibodies that attack the body's own cells, tissues, and organs.
Apr 28, 2026
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Key molecular dynamic could boost cancer treatments while limiting stem cell transplant rejection
A key molecular dynamic could be the key to fighting tumors while allowing patients to still receive life-saving cell transplantation, according to the latest finding published by a team of scientists from the Hackensack ...
Apr 28, 2026
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Experimental drug offers new hope for celiac disease treatment
An experimental drug may in future provide a new form of protection for people with celiac disease. According to an international study led by the Universities of Oulu and Tampere, the drug dampens the harmful effects of ...
Apr 28, 2026
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Research uncovers fatal delays in EpiPen treatment for food anaphylaxis in children
Fatal delays in administering life-saving adrenaline autoinjector (EpiPen) for food anaphylaxis, a severe and rapid allergic reaction, are highlighted in research presented at the Royal College of Emergency Medicine Conference. ...
Apr 28, 2026
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Turning immune cells into tumor allies: A cancer cell protein can reprogram frontline defenders
Cancer cells can disarm the immune system not just by hiding from it, but by actively reprogramming nearby immune cells into a suppressed state. This previously unrecognized molecular interaction, discovered by scientists ...
An unexpected limit to SARS-CoV-2's immune defenses reveal a hidden virus trade-off
A new study has revealed that while SARS-CoV-2 can weaken part of the body's early immune response, it may also unintentionally trigger another defense that helps cells fight back. A new collaborative study has revealed a ...
Apr 27, 2026
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Obesity leaves a lasting memory in immune cells, 10-year study shows
People who live with obesity are "tagging" a memory of being overweight on a key part of the immune system—leaving people with ongoing risk of obesity-related conditions years after losing weight, according to a 10-year-long ...
Apr 27, 2026
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Key protein in the inflammatory response to infections identified
Whenever there is a wound or infection, the body produces an inflammatory response. This is the body's first line of defense, and macrophages—cells of the innate immune system—play a key role: first, they help eliminate pathogens ...
Apr 27, 2026
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Inside lungs, tumor position reveals immune shifts missed by other models
Researchers at VIB and VUB have developed a powerful new way to study how the immune system behaves inside lung tumors. By combining a patient-relevant mouse model with single-cell technologies, the team provides one of the ...
Apr 27, 2026
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Unleashing natural killer cells against cancer
Scientists have developed a strategy to boost the cancer-fighting power of natural killer (NK) cells, part of the immune system's first line of defense. NK cells can detect and destroy cancer cells, but tumors often create ...
Apr 27, 2026
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Blocking immune 'signal two' expands gut tolerance cells, may open new IBD treatments
Weill Cornell Medicine investigators made an unexpected finding about how the immune system normally suppresses inappropriate chronic inflammation in the intestine, potentially opening new avenues for therapies against inflammatory ...
Apr 26, 2026
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Antibodies can selectively shut down harmful T cells without weakening whole immune system
The immune system is the frontline protection against infection, continually searching for and destroying unknown pathogens. While typical operation of the immune system scans for threats, some systems attack the body's own ...
Apr 26, 2026
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