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Immunology news
Medications
FDA approves Breyanzi for relapsed, refractory marginal zone lymphoma
The U.S. Food and Drug Administration has approved a new indication for Breyanzi (lisocabtagene maraleucel) for treating adults with marginal zone lymphoma (MZL) who have failed treatment or relapsed after two or more prior ...
41 minutes ago
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Diseases, Conditions, Syndromes
How the immune system keeps mucosal fungi in check
The microbiome not only consists of bacteria, but also of fungi. Most of them support human and animal health. However, some fungi also have pathogenic potential. For instance, the yeast Candida albicans can grow in an uncontrolled ...
3 hours ago
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Dramatic drop in HIV-infected immune cells occurs in patient who received cancer treatment
Advancements in HIV/AIDS research, drug development and clinical practice since the 1980s have made it possible for people living with HIV to lead long, productive lives and keep the virus in check at undetectable levels ...
3 hours ago
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Building a better vaccine: Flu antibodies show expanded role in preventing transmission
Today's influenza vaccines primarily prevent infection in individuals, but new research led by the University of Michigan and the Institut Pasteur suggests that incorporating antibodies generated after infection could lead ...
5 hours ago
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Decoding long COVID: Investigators reveal why the body keeps fighting the war
A new study from investigators at Beth Israel Deaconess Medical Center (BIDMC) sheds light on why some people never fully recover from COVID-19.
6 hours ago
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Targeting B-cells may boost immunotherapy in liver cancer treatment
Scientists have identified a promising strategy to improve liver cancer immunotherapy: targeting B-cells. While immunotherapy has transformed cancer treatment by activating T-cells—a type of immune cell that fights cancerous ...
4 hours ago
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Large-scale study provides real-world data on rare side effect of cancer immunotherapy
Researchers led by investigators at Mass General Brigham have published valuable information about a rare but serious complication of anti-cancer immunotherapy, providing the first large-scale description of its risk factors ...
Dec 14, 2025
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First patient in Arizona treated with new immune cell therapy
A patient with synovial sarcoma, a soft-tissue cancer that usually occurs in the large joints of the arms and legs, is the first in Arizona treated with a new immune cell therapy known as TECELRA at the HonorHealth Research ...
Dec 14, 2025
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Study shows IL-36 gamma 'armored' CAR T cells can eradicate solid tumors
A laboratory study out of Roswell Park Comprehensive Cancer Center outlines a new way to boost the effectiveness of chimeric antigen receptor (CAR) T-cell therapy in solid-tumor cancers, resulting in their eradication. Led ...
Dec 12, 2025
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Switching immune cells to 'night mode' could limit damage after a heart attack
Researchers at Yale University School of Medicine have identified a way to suppress the daily fluctuations in the activity of key immune cells known as neutrophils.
Dec 12, 2025
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New immunotherapy targets for glioblastoma identified by mapping cell interactions
Glioblastoma is the most common form of brain cancer in adults, and its consequences are usually quick and fatal. After receiving standard-of-care treatment (surgery followed by radiation and chemotherapy), fewer than half ...
Dec 12, 2025
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Mini-tumors combine synthetic and real cells to simulate immune responses
Normally, the immune system recognizes and eliminates abnormal cells. However, cancer cells can develop strategies to evade this control: they block defense mechanisms or send inhibitory signals. In this way, tumors can grow ...
Dec 12, 2025
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Exploring how misguided antibodies cause attacks on the nervous system
A review on autoimmune neurological diseases reveals what occurs in our body when the immune system, by mistake, produces antibodies that target a protein essential for the normal functioning of nerves. The result is hyperexcitability, ...
Dec 12, 2025
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Tricking tumors into marking themselves for destruction with focused ultrasound
USC biomedical engineers have found a way to make a solid tumor paint a target on its own back in order to train the body's immune system to find and destroy it.
Dec 11, 2025
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CAR T-cell therapy accelerates intestinal healing in aging mice
Ever notice that as you get older, some foods no longer sit with you the same? This could be due to a breakdown of the intestinal epithelium, a single layer of cells that forms the organ's lining. The intestine plays a crucial ...
Dec 11, 2025
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Antibody formulation could enable simple injections instead of lengthy hospital infusions
Antibody treatments for cancer and other diseases are typically delivered intravenously, because of the large volumes that are needed per dose. This means the patient has to go to a hospital for every treatment, where they ...
Dec 11, 2025
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Farm-living families develop earlier immune maturation against food allergies, study finds
Children who grow up in farming communities have long been known to develop far fewer allergies than their urban peers. A new study from the University of Rochester Medical Center (URMC), offers one possible reason why: their ...
Dec 11, 2025
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New vulnerability of asthma immune cells discovered
Why do certain immune cells remain permanently active in allergic asthma—even in an environment that should actually damage them? A team from the University Hospital Bonn (UKB) and the University of Bonn has discovered ...
Dec 11, 2025
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How CAR T-cell therapies target myeloma at the molecular level
In multiple myeloma, plasma cells proliferate uncontrollably in the bone marrow, disrupting the growth of healthy blood-forming cells. If the disease recurs after treatment or fails to respond, CAR T-cell therapy may be considered. ...
Dec 11, 2025
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Short-term stress primes immune cells for action in animal models
Stress affects many systems in our body and biologists Marcel Schaaf and Erin Faught at Radboud University are figuring out how that works. Their recent study showed how stress changes behavior by using two different receptors. ...
Dec 11, 2025
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CAR-T therapy yields long-term survival for patients with lymphoma
A study published in the Journal of Clinical Oncology confirms that one of the first Food and Drug Administration-approved CAR-T cell therapies offers long-term survival and potential cures for adult patients with relapsed ...
Dec 11, 2025
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Allergy risk varies by region: IgE profiles highlight environmental influence and hypoallergenic region
Allergic sensitization follows distinct regional patterns, and molecular IgE profiling can reveal these profiles in detail. An international research team has now demonstrated both phenomena in a population-based study of ...
Dec 11, 2025
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Gut cells aid intestinal healing, hope for IBD patients
A team led by scientists at King's College London, in collaboration with national and international partners, has discovered how a specific group of immune cells in the gut—Group 3 Innate Lymphoid Cells (ILC3s)—promote ...
Dec 11, 2025
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Preoperative radiation may improve antitumor immune response in most common form of breast cancer
Preoperative radiation improved T-cell infiltration (TCI) in patients with hormone receptor (HR)-positive, HER2-negative breast cancer when administered in combination with pembrolizumab (Keytruda) and chemotherapy and led ...
Dec 11, 2025
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Immune system's 'on-off' switch may hold answers for cancer and autoimmunity
A single signaling pathway controls whether immune cells attack or befriend cells they encounter while patrolling our bodies, researchers at Stanford Medicine have found. Manipulating this pathway could allow researchers ...
Dec 10, 2025
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