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Allergy and immunology news
How mRNA cancer vaccines still destroy tumors when a key immune cell is missing
The advent of mRNA vaccines against SARS-CoV-2 in 2020 changed the course of the COVID-19 pandemic. Now, the Nobel Prize–winning technology is being adapted to fight cancer, with mRNA vaccines in clinical trials for melanoma, ...
23 hours ago
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Cutting calories to slow aging—without compromising health
Restricting calorie intake in species such as mice, rhesus monkeys, and fruit flies has been shown to extend their lifespans. In some cases, these animals not only live longer, but are also free of disease. But when pushed ...
Apr 17, 2026
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First-in-human trial primes immune system to accept donor livers
UPMC and University of Pittsburgh clinician-scientists have weaned and kept multiple liver transplantation patients off of all immunosuppressant drugs for more than three years through a first-in-human clinical trial of a ...
Apr 17, 2026
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Older mice may offer new insight into cancer and aging
Cancer risk increases with age and is often more aggressive and difficult to treat in older adults. However, fewer than 10% of mouse studies use aged animals, with most relying on mice roughly equivalent to humans in their ...
Apr 17, 2026
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High-precision human immune aging clock identifies RUNX1 as key target for T cell senescence
The immune system acts as a critical sentinel of organismal aging, integrating the sensing of physiological states with the execution of defense and clearance functions. Immunosenescence not only reflects systemic functional ...
Apr 16, 2026
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Programming the immune system to manufacture its own therapeutic proteins
An innovative gene-editing strategy could establish a new way for the body to manufacture therapeutic proteins—including certain kinds of highly potent antibodies that are naturally difficult to produce—by reprogramming the ...
Apr 16, 2026
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A hidden army of zombie immune cells may drive fatty liver disease, inflammation and aging
UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation ...
Apr 16, 2026
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Immune system uses a conveyor belt-like process to edit defective antibodies, new research finds
The immune system's B cells create antibodies that can mount a response against just about anything—either destroying a pathogen or instructing the rest of the immune system to go after the offender. But what happens when ...
Apr 15, 2026
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Mitochondria keep key immune cells battle-ready by sustaining electron flow, study reveals
Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) show that active mitochondria maintain dendritic cells, the immune system's sentinels, in a "ready-to-respond" state, linking cellular ...
Apr 15, 2026
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How a misdirected DNA alarm could reshape treatment for rare rapid-aging diseases
The human immune system is finely tuned to detect and destroy viral threats. But this same defense system can misfire. When fragments of the body's own damaged DNA are mistaken for viral invaders, the result is a powerful, ...
Apr 15, 2026
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Silent B-cell mutations may build for years before thyroid autoimmunity appears
New research suggests that autoimmune diseases may be driven by DNA mutations in immune cells that remove the natural brakes on the immune system. It reveals a previously hidden role for somatic mutations—DNA changes acquired ...
Apr 14, 2026
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Taking a closer look at immune 'memory' could spur progress in the fight against lethal illnesses
The average human has about 1.8 trillion immune cells. These cells patrol the body for bacteria, viruses, cancers, and other threats. Vaccines enhance this security system by teaching our immune cells to target specific pathogens. ...
Apr 14, 2026
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High antibodies create disparities in donor search for blood and bone marrow transplants
People who have elevated levels of donor-specific anti-HLA antibodies (DSAs)—immune system proteins that can target and attack donor stem cells—wait an average of three additional months to receive blood or bone marrow transplants ...
Apr 14, 2026
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Nuts.com recalls 10,000+ pounds of candy over allergy risk
The U.S. Food and Drug Administration (FDA) has issued a Class I recall for Nuts.com's Espresso Malted Milk Balls after finding the product contains undeclared wheat and soy, two major allergens.
Apr 14, 2026
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Neuroinflammation triggers autism-like regression in mouse model
Autism spectrum disorder (ASD) is a neurodevelopmental condition estimated to affect approximately 1 in 100 children worldwide. This condition is characterized by differences in how people communicate and interact with others, ...
Why some vaccine side effects may be avoidable without weakening protection
Vaccines play a critical role in preventing infectious diseases, but their success often depends on adjuvants—substances that enhance immune responses. While these compounds improve vaccine effectiveness, they can also trigger ...
Apr 13, 2026
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Genetic risk for type 1 diabetes extends to brain cells, study finds
Type 1 diabetes is an autoimmune condition in which the body attacks its own insulin-producing cells in the pancreas. Some individuals with type 1 diabetes experience cognitive differences, sometimes described as "brain fog," ...
Apr 13, 2026
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PEPITEM 'replacement therapy' shows potential for early-stage inflammatory arthritis
Scientists investigating the naturally occurring immunopeptide PEPITEM have shown reductions in arthritic joint swelling to a degree comparable to the current standard of care, and reduce the inflammatory changes that cause ...
Apr 13, 2026
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Obesity can derail vaccine response, forcing lung T cells to defend instead
New findings reveal that obesity significantly impaired the quality and longevity of antibody responses to a Pseudomonas aeruginosa vaccine in a mouse model. The impaired antibody production was due to defects in germinal ...
Apr 13, 2026
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New flu and COVID variants spread, but immune defenses still blunt severe disease
We're keeping an eye on new influenza and SARS-CoV-2 viral variants. Here's what we know about those viruses—and your immune system's ability to fight back.
Apr 13, 2026
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Immune cells in the nose slow influenza virus, study finds
A new study from the University of Gothenburg may help guide the development of better influenza vaccines. Memory cells in the nose slow the influenza virus as soon as it enters the body. They reduce viral levels and may ...
Apr 12, 2026
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A new sepsis drug target: Boosting a chloride channel helps immune cells kill bacteria
A research team has discovered a previously unknown mechanism by which the immune system fights bacterial infections. The scientists found that a specific protein, the chloride channel PACC1, is crucial for immune cells to ...
Apr 12, 2026
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Water contaminated with 'forever chemicals' during pregnancy linked to an increased risk of childhood asthma
PFAS, or per- and polyfluoroalkyl substances, are a group of human-made chemicals found in everything from food packaging to firefighting foam. Often called "forever chemicals" due to their persistence in the environment, ...
Apr 12, 2026
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Molecular maps reveal how allergic reactions work and a new way to block them
Allergy affects more than one billion people worldwide—and the number is rising. For many, it means mild symptoms such as itching and a runny nose. For others, it can develop into life-threatening reactions. Now, two new ...
Apr 11, 2026
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Researchers map prostate immune niches, showing T cells persist months in mice
More than 35,000 men in the United States die from prostate cancer each year. Now, a new study reveals the immune cell weaponry we might use to save lives.
Apr 11, 2026
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