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Allergy and immunology news
Crohn's atlas maps gene shifts across more than 50 gut cell types
A detailed cellular study of Crohn's disease has mapped how gene activity changes across more than 50 cell types in the gut. The study provides an open resource of the genes that characterize each cell type and those whose ...
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Genetic cause for rare skin condition points to new therapeutic option
An international team of researchers report in the journal Nature Immunology that a mutation in the gene OTULIN causes pediatric-onset pyoderma gangrenosum, characterized by recurrent ulcerating skin sores. They classify ...
2 hours ago
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Asthma attacks reshape airway tissue through mechanical stress, lung-on-a-chip reveals
About 25 million people in the U.S.—roughly eight out of 100—are diagnosed with asthma. Allergens, air pollution, extreme weather conditions and other irritants can cause chronic lung inflammation, leading to coughing, wheezing ...
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In vivo CRISPR therapy successfully reduces hereditary angioedema attacks in first Phase III trial
Researchers from Amsterdam UMC, in collaboration with other hospitals, have successfully completed the first Phase III study of an in vivo CRISPR therapy. In this large-scale, double-blind trial, 80 patients with hereditary ...
6 hours ago
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Target with potential to improve CAR T-cell therapy response in patients with blood cancers identified
Researchers at the University of Maryland School of Medicine (UMSOM) have identified a target that may improve the response to CAR T-cell therapy, a treatment for patients with recurrent or difficult-to-treat blood cancers.
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Why some immunotherapy fails: Tumor-triggered neutrophils can shut down cancer-killing T cells
Certain white blood cells in the immune system, known as neutrophils, can make cancer immunotherapy less effective, according to a new study from Karolinska Institutet published in the journal Immunity. The results show that ...
5 hours ago
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Immune activation may determine success of dual-target CAR T therapy in glioblastoma
Dual-target CAR T-cell therapy for recurrent glioblastoma (GBM), delivered directly into the cerebrospinal fluid (CSF), triggers a broad immune response, with natural killer (NK) cell activation linked to better patient outcomes ...
3 hours ago
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Killing cancer requires immune cells to infiltrate tumors' hostile microenvironment—sugar shields can help them break in
You might think of cancer as a mass of rogue cells that grow uncontrollably. But cancer is more organized and strategic than that. Rather, cancer is a tightly controlled cellular neighborhood that can keep the body's defenses ...
6 hours ago
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What to know about alpha-gal syndrome, the life-threatening meat allergy caused by tick bites
It's common knowledge that ticks can spread infections that cause serious illnesses, including Lyme disease. Now health officials are trying to raise awareness of a lesser-known problem: a life-threatening allergy to meat ...
15 hours ago
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Sugar-coated CAR-T cells survive longer and shrink lymphoma tumors in mice
Scientists at Florida International University may have found a way to make a powerful cancer treatment work even better. The treatment, called CAR-T therapy, uses a patient's own immune cells to fight cancer. Doctors remove ...
Jun 13, 2026
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Flu infection may weaken tuberculosis defenses by disrupting key immune pathways
New research from Imperial College London suggests that infection with the influenza virus may leave people more susceptible to tuberculosis. The findings suggest that seasonal flu vaccines could offer a potential new strategy ...
Jun 12, 2026
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Severe COVID-19 reveals distinct immune patterns tied to metabolism, not just antiviral response
Patients with COVID-19 can show several different antiviral immune response patterns, which may influence how the disease develops. This is shown in a new study from Karolinska Institutet, published in Genome Medicine, highlighting ...
Jun 12, 2026
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Teaching the immune system to fight aging
Maybe we shouldn't be surprised that so-called "zombie cells" come with a catch. In response to severe damage, when cells can't recover full function but aren't ready to die, they can become senescent, in a zombie-like state ...
Jun 12, 2026
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Supercharged natural killer cells suppress solid tumors in mice
Scientists have made great progress in harnessing the body's own immune cells to treat so-called liquid tumors, cancers of the blood and lymphatic system. Yet these powerful cell therapies have been no match for solid tumors, ...
Jun 11, 2026
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How body clock may shape inflammation, cancer risk and timing of future treatments
Daily life is shaped by the solar day, influencing when we wake up, eat, work and sleep. Inside the body, a similar internal timing system—present in nearly every cell—known as the circadian clock synchronizes many biological ...
Jun 11, 2026
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Scientists reveal an autoimmune vicious cycle in Sjögren's disease
Sjögren's disease is a widespread chronic autoimmune disorder that attacks the body's own glands, yet its underlying disease mechanisms remain poorly understood. In a recent study, researchers from Japan discovered a self-reinforcing ...
Jun 11, 2026
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New treatment shows promise for patients with rare blood disorder
A new treatment that involves growing a patient's immune cells and then infusing them back into their body has shown promise for people with the rare blood disorder aplastic anemia. Results from the Phase 1 trial, led by ...
Jun 11, 2026
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Decades-old puzzle solved as scientists uncover cause of inflammatory bowel disease
Researchers at the Nuffield Department of Medicine, University of Oxford, together with Newcastle University's Translational and Clinical Research Institute and the Department of Immunology at Cambridge University Hospitals ...
Jun 10, 2026
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Living with cats does not worsen asthma in children, suggests study
Asthma is the most common chronic disease and one of the main causes of hospitalization among children. The Global Asthma Network has estimated that its global prevalence is 9.1% for children and 11.0% for adolescents, but ...
Jun 10, 2026
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Sleep and exercise may curb heart risk from mutant white blood cells
Healthy sleep and regular exercise can work to counteract genetic mutations in white blood cells that are associated with cardiovascular disease and are most common among older people, Mount Sinai researchers have found. ...
Jun 10, 2026
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Immune biomarkers may predict response to bladder cancer treatment
A Northwestern Medicine study has offered new clues as to why immunotherapy works well for some bladder cancer patients but fails for others, according to a study published in the Journal of Clinical Investigation.
Jun 10, 2026
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Celiac risk may begin with weaker helper T cells, not just overactive immunity
New research from the Snow Center for Immune Health is challenging long-held assumptions about autoimmune disease, revealing that celiac disease may be driven not just by an overactive immune system, but by subtle defects ...
Jun 9, 2026
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Tiny protein tail helps one immune gene fight two very different viruses
Our genomes contain hundreds of genes with antiviral jobs that are called into action when a virus succeeds in infecting one of our cells. By acting cooperatively, these genes provide defense against a wide range of viruses, ...
Jun 8, 2026
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Hidden kidney effects emerge in LRBA deficiency, with polyuria in some patients
LRBA deficiency has long been viewed primarily as an immune disorder, but researchers at Science Tokyo have found that the condition may also impair urinary concentrating ability. Using patient registry data from 43 individuals, ...
Jun 8, 2026
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Hay fever, antihistamines and the evidence on dementia risk
For millions of people around the world, pollen season means weeks of sneezing, itchy eyes, and a blocked or runny nose. The timing varies depending on where you live and which plants are in flower, but grass pollen is one ...
Jun 8, 2026
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