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Allergy and immunology news

New Tfr cell model uncovers molecular switches that restrain antibody responses

For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular regulatory T cells (Tfr cells) play a key role in this process by limiting excessive immune responses ...

AI framework helps identify new targets for CAR T cell therapy

Leading CAR T cell therapy researchers have developed a human-in-the-loop artificial intelligence (AI) framework that centers scientists' expertise to find viable target antigens for CAR T cell therapy. The work was led by ...

Mapping the hidden rules of a key immune sensor

The immune system depends on molecular alarms that detect danger inside cells. One of these alarms is STING, short for "stimulator of interferon genes." STING helps cells respond to infections, damaged DNA and cancer. When ...

What a 'silenced' chromosome can tell us about autoimmunity

Systemic lupus erythematosus (SLE), the most common form of lupus, is an autoimmune disorder that occurs more frequently in women. Having multiple X chromosomes has been associated with an increased risk of developing lupus; ...

Why pollution affects some asthma patients more than others

For many people with asthma, air-quality advisories are harbingers of worsening symptoms. But for reasons science has struggled to explain, the extent to which pollution exacerbates asthma varies widely from person to person.

Gut fungi may hold the key to treating asthma worldwide

Two new studies jointly published in Nature Communications reveal that certain species of fungi in the gut play a key role in the development of immune dysregulation and some pediatric allergic diseases—and may be promising ...

How RSV manipulates the immune response in respiratory cells

Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infections, particularly in newborns and older adults. How the virus manages to evade the immune system and what changes it triggers in infected cells ...