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Allergy and immunology news

Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases

In autoimmune disorders, immune cells targeting "self" proteins are mistakenly activated, resulting in abnormal expansion and responsiveness. These disorders are known to reduce patients' quality of life over a prolonged ...

Gut-homing antibodies help protect against norovirus, paving path for new vaccines, therapies

As the leading cause of viral gastroenteritis worldwide, norovirus is an all too familiar ailment. Its telltale digestive upset—not to mention its reputation for being notoriously contagious—has earned it the nicknames "winter ...

What a 'silenced' chromosome can tell us about autoimmunity

Systemic lupus erythematosus (SLE), the most common form of lupus, is an autoimmune disorder that occurs more frequently in women. Having multiple X chromosomes has been associated with an increased risk of developing lupus; ...

Why pollution affects some asthma patients more than others

For many people with asthma, air-quality advisories are harbingers of worsening symptoms. But for reasons science has struggled to explain, the extent to which pollution exacerbates asthma varies widely from person to person.

Gut fungi may hold the key to treating asthma worldwide

Two new studies jointly published in Nature Communications reveal that certain species of fungi in the gut play a key role in the development of immune dysregulation and some pediatric allergic diseases—and may be promising ...

How RSV manipulates the immune response in respiratory cells

Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infections, particularly in newborns and older adults. How the virus manages to evade the immune system and what changes it triggers in infected cells ...

Can we cure asthma? Yes, and we have a plan

Asthma is conventionally viewed as "treatable but incurable." In other words, we can manage its symptoms but not reverse the underlying condition. But advances in science are challenging this view, and we think a cure may ...

Neuroimmune abnormalities may play a key role in fibromyalgia

Fibromyalgia is a complex disorder characterized primarily by chronic widespread pain, fatigue and other physical and cognitive symptoms. Although it affects millions of people worldwide, the underlying biological mechanisms ...

New tool maps how T cells move within tumors

Researchers at UT Southwestern Medical Center led a study to develop a computational method that reveals how immune cells navigate the complex environment inside tumors, offering insights that could inform future cancer therapies. ...