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Immunology news
Medical research
T-bet protein found essential for maintaining flu-fighting memory B cells
At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the immune system, and immune cells produce a potentially lifesaving antibody against the virus. Antigen ...
13 hours ago
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Major progress in fertility preservation after treatment for cancer of the lymphatic system
Young patients with advanced Hodgkin's lymphoma, a cancer of the lymphatic system, now have a better chance of having their own children after treatment.
Jul 11, 2025
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Microglia replacement halts progression of rare genetic brain disease in mice and humans
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive neurological disease with an average age of onset at 43 years and an average life expectancy of only three to five years after ...
Jul 10, 2025
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Gene-editing platform could boost anti-cancer immune responses
Researchers have developed a new gene-editing platform that will enable safer and more effective T cell–based immunotherapies to treat cancer.
Jul 10, 2025
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Most patients with advanced melanoma remain disease-free 4 years after pre-surgical immunotherapy, study finds
Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage III melanoma remained alive, according to new results from a study led ...
Jul 10, 2025
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New survival benchmark for patients with advanced biliary tract cancer reached using combination therapy
In a follow-up analysis to the pivotal TOPAZ-1 study, which established the combination therapy of durvalumab (an immunotherapy drug) plus gemcitabine and cisplatin (GemCis, chemotherapy drugs) as the first-line treatment ...
Jul 10, 2025
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Universal stem cells reset immunity in a systemic sclerosis patient
Research led by Naval Medical University's Changzheng Hospital in China reports that an off-the-shelf cell therapy built from induced pluripotent stem cells (iPSCs) loosened life-limiting skin and organ scarring in a woman ...
Chromosomal abnormality scores unlock path to personalized immunotherapy
In a newly published article in Nature Genetics, researchers from the University of Chicago have identified tumor aneuploidy—an imbalance in the number of chromosomes—as a powerful biomarker associated with resistance ...
Jul 9, 2025
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Aggressive breast cancer triggered by obesity-related blood signals, study shows
Breast cancer is the most commonly diagnosed cancer among women worldwide and represents a major public health concern due to its high incidence and significant mortality rates. In the U.S. alone, approximately 297,790 new ...
Jul 9, 2025
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Novel T-cell subtypes in follicular lymphoma linked to patient prognosis
Researchers at University of Tsukuba have identified multiple T-cell subtypes with unique characteristics in follicular lymphoma, a prevalent type of blood cancer. These T cells regulate the proliferation and apoptosis of ...
Jul 9, 2025
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Insured? You're more likely to survive cancer through immunotherapy treatment
Powerful new immunotherapies are offering fresh hope for patients with many different types of cancer.
Jul 9, 2025
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Data show teclistamab can benefit many multiple myeloma patients who would have been ineligible for pivotal trial
Teclistamab-cqyv is a T-cell-engaging bispecific antibody that targets multiple myeloma cells via the B-cell maturation antigen (BCMA) receptor. It received accelerated approval in 2022 for patients treated with four or more ...
Jul 9, 2025
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Researchers identify project manager of the immune defense in the brain
Infections in the brain can have serious consequences and are often fatal. The immune defense system works differently here than in the rest of the body. A team of researchers at TWINCORE—Center for Experimental and Clinical ...
Jul 9, 2025
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Camel milk intake suppresses allergic asthma in mice
Research led by the Joldasbekov Institute of Mechanics and Engineering in Kazakhstan, reports that camel milk intake significantly reduced airway hyperresponsiveness and lung inflammation in a laboratory model of allergic ...
Common autoimmune drug may help reverse immunotherapy-induced diabetes
A team of researchers at the UCLA Health Jonsson Comprehensive Cancer Center has identified a potential new strategy to prevent, and even reverse, immune checkpoint inhibitor–induced type 1 diabetes, a rare but life-threatening ...
Jul 8, 2025
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Study lays groundwork for precision treatment of HR+/HER2- breast cancer
Preliminary results of an observational clinical trial underway at Roswell Park Comprehensive Cancer Center are shedding light on why some patients with an aggressive form of metastatic breast cancer fare better than others ...
Jul 8, 2025
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Common fungal molecule can prime lung immune cells for damaging overreaction to infection signals
Exposure to a common fungal molecule can reprogram immune cells in the lungs, causing them to overreact to infection-like signals and worsen lung damage, according to new research.
Jul 8, 2025
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Cancer-fighting herpes virus shown to be an effective treatment for some advanced melanoma
The herpes simplex virus type 1 (HSV-1), which affects almost two‑thirds of the world's population and is generally associated with oral herpes, may cause painful cold sores or fever blisters around the mouth.
Jul 8, 2025
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Common medication for lung cancer symptoms found to limit immunotherapy effectiveness
Corticosteroids, a commonly prescribed medication to alleviate cancer-related symptoms for non-small cell lung cancer patients treated with immunotherapy, are the main reason certain immunotherapies may fail in treating the ...
Jul 7, 2025
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CAR-T cells engineered to attack two leukemia proteins show promise in preclinical tests
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive form of blood cancer that can occur in both children and adults. It is characterized by failures in the maturation of T-lymphocytes, key immune cells involved ...
Jul 7, 2025
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Simultaneous kidney and stem cell transplants may enable patients to ditch lifelong immunosuppressants
While immunosuppressive medications are critical to preventing rejection of transplant organs, they also come with plenty of downsides. They can cause harsh side effects, like headaches and tremors, and increase the risk ...
Jul 7, 2025
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Cancer cells form protective microenvironment against CDK4/6 inhibitors, study shows
Targeted cancer drugs known as CDK4/6 inhibitors have improved outcomes for patients with advanced or metastatic HR+/HER2- breast cancer, but many patients still eventually relapse and become resistant to therapy. New research ...
Jul 7, 2025
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ISS researcher links bone loss in astronauts to stem cell changes in microgravity
Mayo Clinic physician and researcher Dr. Abba Zubair's work combines two passions—medicine and space—for the benefit of astronauts and people on Earth. His research in space is yielding discoveries in cancer, stroke, ...
Jul 7, 2025
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A Māori worldview describes the immune system as a guardian—this could improve public health in Aotearoa NZ
In biomedical science, the immune system is described as a cellular defense network that identifies and neutralizes threats. In te ao Māori (the Māori worldview), it can be seen as a dynamic system of guardianship, known ...
Jul 7, 2025
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