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Immunology news
Oncology & Cancer
Reviving exhausted immune cells boosts tumor elimination
A new study has discovered a molecular signal that tumors exploit to exhaust the T cells meant to destroy them—and how silencing that signal could revive the body's immunity.
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Immunology
Aging spleen creates toxic environment that forces T cells into self-protective but weakened state, study shows
Researchers at the Technion—Israel Institute of Technology Faculty of Biology have identified a unique mechanism involved in the aging of the immune system—along with a framework for enhancing its function in older individuals. ...
23 minutes ago
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Precision therapy could stop breast cancer at the source
Researchers at the University of California San Diego School of Medicine have identified a promising new therapy for triple-negative breast cancer (TNBC), which is among the most aggressive and difficult-to-treat forms of ...
3 hours ago
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What are the big unanswered questions about cancer? Experts discuss
Over the 40-year history of the University of Colorado Cancer Center, its investigators have answered many questions about cancer—what causes it, how to prevent it, and how to treat it. Those discoveries have helped many ...
7 hours ago
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How weakness in cell structure affects the host–microbiome relationship
Cells have an internal skeleton that maintains their structure and also drives their movement. Known as the cytoskeleton, this scaffold is composed of a network of dynamic filaments made of a protein called actin.
Nov 14, 2025
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Reversing fibrosis: New research provides insight for novel therapies
Yale School of Medicine (YSM) researchers have made key breakthroughs in understanding how to treat fibrotic diseases such as scleroderma and graft-versus-host disease.
Nov 14, 2025
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Combination immunotherapy for rare cancers shows improved efficacy and survival rates
New results from a multicenter clinical trial show that combining immunotherapy drugs nivolumab and ipilimumab significantly improves treatment response in patients with advanced and difficult-to-treat cancers. The trial ...
Nov 14, 2025
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Shaping immunity: The secrets behind the shape of neutrophils
Researchers at the Kennedy Institute have provided the most comprehensive overview to date of how the distinctive segmented nucleus of neutrophils influences their function in health and disease.
Nov 14, 2025
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Surgery after immunotherapy boosts survival for liver cancer patients
A new Cedars-Sinai Cancer study shows that patients with advanced liver cancer who receive immunotherapy to shrink their tumors have improved outcomes after liver transplant or tumor removal.
Nov 14, 2025
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Immune reactions found behind human rejection of transplanted pig kidneys
Researchers have uncovered and then overcome an obstacle that has led to the failure of pioneering efforts in xenotransplantation, in which an animal kidney is transplanted into a human.
Nov 13, 2025
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Researchers reveal intricate control system for key immune gene
The immune system faces a delicate balancing act: It must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues.
Nov 13, 2025
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Gut bacterium may sabotage liver cancer immunotherapy, study suggests
A research team led by the Department of Clinical Oncology, Center of Cancer Medicine, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has identified a critical factor contributing ...
Nov 13, 2025
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Common cold virus may unlock better COVID vaccine
Prior exposure to coronaviruses that cause ordinary colds can boost the immune system's ability to attack a vulnerable site on the COVID-19-causing coronavirus SARS-CoV-2, according to a study led by investigators at Weill ...
Nov 13, 2025
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Lifelong drugs for autoimmune diseases don't work well. Now scientists are trying something new
Scientists are trying a revolutionary new approach to treat rheumatoid arthritis, multiple sclerosis, lupus and other devastating autoimmune diseases—by reprogramming patients' out-of-whack immune systems.
Nov 13, 2025
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Scientists tie lupus to a virus nearly all of us carry
One of humanity's most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic lupus erythematosus (lupus), Stanford Medicine investigators and their colleagues have found.
Nov 12, 2025
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Flu vaccine performance varies by age, study reveals
New research comparing four different flu vaccines found that the ability of the vaccines to activate cells of the immune system that help to protect against infection varied greatly depending on the vaccine type and age ...
Nov 12, 2025
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Cellular protein FGD3 boosts breast cancer chemotherapy and immunotherapy, study finds
A naturally-occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the effectiveness of some anticancer agents, including doxorubicin, one of the most widely used chemotherapies, and a ...
Nov 12, 2025
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Mental and physical coaching before surgery prepares immune system and reduces complications, trial finds
The weeks leading up to a major surgery can be a time of uncertainty and worry for patients, many of whom anticipate the need for rehabilitation to get back on their feet. But if patients improve their physical and mental ...
Nov 12, 2025
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Halting pancreatic cancer spread: Protein-degrading drugs show promise in preclinical models
Last year, researchers at the University of California, Riverside, developed a novel "molecular crowbar" strategy to degrade the oncogenic enzyme Pin1, a protein that is overexpressed in many tumors, including pancreatic ...
Nov 12, 2025
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Study reveals why some myeloma patients stay cancer-free for years after CAR T therapy
A new study from the Icahn School of Medicine at Mount Sinai helps explain why some people with multiple myeloma, a type of blood cancer, stay in remission for many years after receiving CAR T cell therapy, while others see ...
Nov 12, 2025
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The internal clock of immune cells: Is the immune system younger in the morning?
As the immune system ages, it reacts more slowly to pathogens, vaccines become less effective, and the risk of cancer increases. At the same time, the immune system follows a 24-hour rhythm, as the number and activity of ...
Nov 12, 2025
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Rapid growth of radiopharmaceutical therapy highlights need for expertise
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has released a position paper outlining the education, training, and experience needed to ensure the safe and effective delivery of radiopharmaceutical therapy ...
Nov 12, 2025
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Researchers aim to disrupt breast cancer line of communication and prevent spread
Cancer Center at Illinois (CCIL) Program Leader Erik Nelson's lab made an important discovery about the relationship between cholesterol and breast cancer progression with crucial implications for breast cancer therapeutics.
Nov 12, 2025
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Study tracking how tumor microenvironment develops signals opportunity for early detection, risk prediction
Colorectal cancer precursor lesions are benign growths that can develop into colorectal cancer (CRC) over time, through either a conventional or serrated pathway. Understanding how the immune system reacts to these precursor ...
Nov 12, 2025
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Self-reactive T cells may explain why some patients can't reach undetectable HIV levels
Despite the capability of antiretroviral drugs to suppress HIV to undetectable levels, some people living with the human immunodeficiency virus can't reach the goal of viral imperceptibility even with daily doses of the potent ...
