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Immunology news
Genetics
Chromosomal abnormality scores unlock path to personalized immunotherapy
In a newly published article in Nature Genetics, researchers from the University of Chicago have identified tumor aneuploidy—an imbalance in the number of chromosomes—as a powerful biomarker associated with resistance ...
5 hours ago
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Immunology
Universal stem cells reset immunity in a systemic sclerosis patient
Research led by Naval Medical University's Changzheng Hospital in China reports that an off-the-shelf cell therapy built from induced pluripotent stem cells (iPSCs) loosened life-limiting skin and organ scarring in a woman ...
13 hours ago
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Aggressive breast cancer triggered by obesity-related blood signals, study shows
Breast cancer is the most commonly diagnosed cancer among women worldwide and represents a major public health concern due to its high incidence and significant mortality rates. In the U.S. alone, approximately 297,790 new ...
8 hours ago
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Novel T-cell subtypes in follicular lymphoma linked to patient prognosis
Researchers at University of Tsukuba have identified multiple T-cell subtypes with unique characteristics in follicular lymphoma, a prevalent type of blood cancer. These T cells regulate the proliferation and apoptosis of ...
10 hours ago
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Insured? You're more likely to survive cancer through immunotherapy treatment
Powerful new immunotherapies are offering fresh hope for patients with many different types of cancer.
13 hours ago
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Researchers identify project manager of the immune defense in the brain
Infections in the brain can have serious consequences and are often fatal. The immune defense system works differently here than in the rest of the body. A team of researchers at TWINCORE—Center for Experimental and Clinical ...
8 hours ago
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Data show teclistamab can benefit many multiple myeloma patients who would have been ineligible for pivotal trial
Teclistamab-cqyv is a T-cell-engaging bispecific antibody that targets multiple myeloma cells via the B-cell maturation antigen (BCMA) receptor. It received accelerated approval in 2022 for patients treated with four or more ...
21 hours ago
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Camel milk intake suppresses allergic asthma in mice
Research led by the Joldasbekov Institute of Mechanics and Engineering in Kazakhstan, reports that camel milk intake significantly reduced airway hyperresponsiveness and lung inflammation in a laboratory model of allergic ...
Common autoimmune drug may help reverse immunotherapy-induced diabetes
A team of researchers at the UCLA Health Jonsson Comprehensive Cancer Center has identified a potential new strategy to prevent, and even reverse, immune checkpoint inhibitor–induced type 1 diabetes, a rare but life-threatening ...
Jul 8, 2025
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Common fungal molecule can prime lung immune cells for damaging overreaction to infection signals
Exposure to a common fungal molecule can reprogram immune cells in the lungs, causing them to overreact to infection-like signals and worsen lung damage, according to new research.
Jul 8, 2025
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Study lays groundwork for precision treatment of HR+/HER2- breast cancer
Preliminary results of an observational clinical trial underway at Roswell Park Comprehensive Cancer Center are shedding light on why some patients with an aggressive form of metastatic breast cancer fare better than others ...
Jul 8, 2025
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Cancer-fighting herpes virus shown to be an effective treatment for some advanced melanoma
The herpes simplex virus type 1 (HSV-1), which affects almost two‑thirds of the world's population and is generally associated with oral herpes, may cause painful cold sores or fever blisters around the mouth.
Jul 8, 2025
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CAR-T cells engineered to attack two leukemia proteins show promise in preclinical tests
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive form of blood cancer that can occur in both children and adults. It is characterized by failures in the maturation of T-lymphocytes, key immune cells involved ...
Jul 7, 2025
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Common medication for lung cancer symptoms found to limit immunotherapy effectiveness
Corticosteroids, a commonly prescribed medication to alleviate cancer-related symptoms for non-small cell lung cancer patients treated with immunotherapy, are the main reason certain immunotherapies may fail in treating the ...
Jul 7, 2025
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Simultaneous kidney and stem cell transplants may enable patients to ditch lifelong immunosuppressants
While immunosuppressive medications are critical to preventing rejection of transplant organs, they also come with plenty of downsides. They can cause harsh side effects, like headaches and tremors, and increase the risk ...
Jul 7, 2025
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Cancer cells form protective microenvironment against CDK4/6 inhibitors, study shows
Targeted cancer drugs known as CDK4/6 inhibitors have improved outcomes for patients with advanced or metastatic HR+/HER2- breast cancer, but many patients still eventually relapse and become resistant to therapy. New research ...
Jul 7, 2025
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ISS researcher links bone loss in astronauts to stem cell changes in microgravity
Mayo Clinic physician and researcher Dr. Abba Zubair's work combines two passions—medicine and space—for the benefit of astronauts and people on Earth. His research in space is yielding discoveries in cancer, stroke, ...
Jul 7, 2025
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A Māori worldview describes the immune system as a guardian—this could improve public health in Aotearoa NZ
In biomedical science, the immune system is described as a cellular defense network that identifies and neutralizes threats. In te ao Māori (the Māori worldview), it can be seen as a dynamic system of guardianship, known ...
Jul 7, 2025
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Tracing dormant cancer cells: Chemotherapy spurs awakening, but senolytic drugs may prevent relapse
Breast cancer often relapses in distant organs even when complete regression of primary tumors is achieved after initial treatment. Dormant and persistent disseminated tumor cells (DTCs) have been observed in animals with ...
Jul 4, 2025
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Alveolar macrophage cell surface receptor TREM2 promotes lung fibrosis, study shows
Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages—the white blood cells that defend the body by killing microbes, removing dead cells and stimulating immune responses—are ...
Jul 3, 2025
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T cells take aim at Chikungunya virus
A new study, published recently in Nature Communications, offers the first-ever map of which parts of the Chikungunya virus trigger the strongest response from the body's T cells.
Jul 3, 2025
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Antibody sIgM emerges as a key guardian of gut health and metabolism
A pioneering new study published in Nature Microbiology, led by J. Oriol Sunyer, professor of immunology and pathobiology at the School of Veterinary Medicine, and a team of researchers at Penn Vet and the University of New ...
Jul 3, 2025
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Researchers reveal key differences in STING inhibition between humans and mice
Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's natural defenses against cancer. This pathway, which plays a key role in helping the body defend ...
Jul 3, 2025
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Rare kidney cancer resists immune therapies due to lack of active T-cells
Cancer-fighting T-cells, the immune system's primary enforcers, are scarce in the rare kidney cancer called chromophobe renal cell carcinoma (ChRCC) and those that are present are indifferent to the tumor threat and traditional ...
Jul 3, 2025
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Combined therapy integrates Chinese herb Astragalus and methotrexate to address drug resistance in autoimmune diseases
Researchers at the School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), have found that combining the active ingredient extracted from the traditional Chinese medicine Astragalus membranaceus ...
Jul 3, 2025
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