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Clinical pharmacology news
This common antidepressant helps people cut back on methamphetamine: New study
Methamphetamine—more commonly known as meth, crystal or ice—is a highly addictive, stimulant drug.
11 hours ago
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A potential universal flu shot? Intranasal EV vaccine protected mice from H5N1, H7N9
A novel vaccine platform has been developed to induce broad, protective immunity against numerous influenza virus infections, showing promise as an effective mucosal vaccine strategy, according to a study published by researchers ...
Apr 3, 2026
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Kratom poisonings surged 1,200% over the past decade, and regulators are struggling to keep up with the dangers
Proposals to ban or regulate kratom, a plant-based substance sold in gas stations, convenience stores and vape shops, are making headlines in local newspapers across the United States. But as lawmakers debate whether to regulate ...
Apr 3, 2026
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Mechanisms behind tumor suppressor BAP1 highlight new treatment strategies for aggressive cancers
A team of scientists led by the National Cancer Center Singapore (NCCS) and Duke-NUS Medical School (Duke-NUS) has found a new approach for treating some of the world's most aggressive cancers associated with BAP1 mutations. ...
Apr 2, 2026
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Small molecule drug candidate offers hope for rare kidney stone disease with no current treatment
Scientists at the Buck Institute for Research on Aging have shown that an orally administered small molecule, N-propargylglycine (N-PPG), can completely prevent the formation of calcium oxalate kidney stones, protect against ...
Apr 2, 2026
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Zebrafish reveal new insights into the biology of autism
In recent decades, the zebrafish has become one of the most valuable model organisms in scientific research. For a variety of reasons, including their genetic similarities to humans, these tiny tropical fish have helped researchers ...
Apr 2, 2026
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Innovative targeted therapy halts prostate cancer spread to the bone
New findings from VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM), published in Pharmacological Research, show that an innovative drug effectively prevents prostate tumors from spreading ...
Apr 2, 2026
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FDA approves new weight loss pill in record time
A new daily pill to help with weight loss has been approved by the U.S. Food and Drug Administration (FDA), and it moved through review faster than most drugs in recent years.
Apr 2, 2026
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New pill could change plaque psoriasis treatment
Folks with severe plaque psoriasis often have to choose between convenient pills that don't work very well or highly effective injections that come with the hassle of needles. That trade-off may soon change. New clinical ...
Apr 2, 2026
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First-in-class dual HIF inhibitors eliminate tumors in mice when combined with immunotherapy
Researchers at Johns Hopkins University and the University of Maryland School of Pharmacy have developed a set of novel, first-in-class drugs that inhibit hypoxia-inducible factors 1 and 2, a pair of transcription factors ...
Apr 2, 2026
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Poison centers see jump in kava calls
Calls to poison centers about kava—a drug found in drinks marketed as a healthy alternative to alcoholic beverages—rose 383% between 2011 and 2025, according to a new UVA Health study. The findings have been published in ...
Apr 2, 2026
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Small molecule could slow or stop progress of Parkinson's disease and related brain disorders, not just treat symptoms
A team of researchers from NYU Abu Dhabi and the University of Denver has identified a promising small molecule that could help slow or halt the progression of serious brain diseases such as Parkinson's disease, offering ...
Apr 1, 2026
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Common antidepressant offers fresh hope for people looking to reduce methamphetamine use
For the first time, people who want to stop using crystal methamphetamine may be able to treat their addiction with a cheap and readily available medication, say researchers at the National Drug and Alcohol Research Center ...
Apr 1, 2026
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A safer opioid? DFNZ discovery suggests pain relief with minimal addictive properties
Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential as a therapy for both pain and opioid use disorder. In a study published in Nature, the team observed ...
Apr 1, 2026
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Gene editing therapy shows success against severe sickle cell disease
New results from a clinical trial show promising outcomes for a gene-edited treatment for severe sickle cell disease, a genetic blood disorder with few curative options. After research conducted as part of the multicenter ...
Apr 1, 2026
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Natural compound nigericin reduces endotrophin tied to obesity, study shows
Obesity is known to be a major risk factor that exacerbates metabolic disorders, such as type 2 diabetes. A key molecule involved in this process is endotrophin, a signaling protein that links excess fat accumulation to metabolic ...
Apr 1, 2026
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Dangers of 'anti-aging' supplements in cancer protection revealed
Millions of Americans take daily supplements—nicotinamide mononucleotide (NMN), nicotinamide riboside (NR) and nicotinamide (NAM)—to boost energy, slow aging and protect the heart and brain. Many cancer patients also take ...
Apr 1, 2026
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Will medicinal cannabis help my mental health? Here are the evidence and the risks
Anxiety, depression and post-traumatic stress disorder (PTSD) are among the most common mental health conditions for which Australians are prescribed medicinal cannabis.
Apr 1, 2026
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Probing a paradoxical drug response for irregular heartbeat
Irregular heartbeat, or arrhythmia, can be treated with various procedures or medication, but not all medications work for all patients. In fact, one arrhythmia medication can actually cause arrhythmia in people with a common ...
Apr 1, 2026
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AAD: Significant benefits seen for brepocitinib 30 mg in dermatomyositis
For adults with dermatomyositis, brepocitinib, an oral tyrosine kinase 2/Janus kinase 1 inhibitor, demonstrates significant benefits at a 30-mg dose compared with placebo, according to a study published online March 28 in ...
Apr 1, 2026
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More patients receive recommended heart failure treatment, Swedish registry study finds
An increasing proportion of patients with heart failure receive a combination of four medications shown to improve prognosis and recommended in guidelines. However, there is still room for improving adherence and persistence ...
Apr 1, 2026
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Mirror fragments intercept Alzheimer's-causing protein
Understanding how proteins interact with their own mirror images enabled a Kobe University research team to design a small mirror protein that disables a causal factor of Alzheimer's disease, amyloid-beta.
Mar 31, 2026
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Nursing home flu outbreaks—statistical approach reveals keys to preventing hospitalizations
In nursing homes, influenza spreads quickly. Even in facilities with separate wings, staff move throughout the home, caring for medically complex older adults who often share rooms. In this way, a single case of influenza ...
Mar 31, 2026
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Common antidepressant eases fatigue associated with long COVID, study finds
A global research team co‑led by McMaster University has identified one of the first medications shown to meaningfully reduce fatigue in people living with long COVID—a breakthrough for millions still struggling with persistent ...
Mar 31, 2026
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New discovery could slow Parkinson's disease and reduce life-threatening lung injury
Scientists at Florida International University have developed a promising new compound that could slow the progression of Parkinson's disease and protect against life-threatening lung injury by targeting a key process inside ...
Mar 31, 2026
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