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Clinical pharmacology news
New review points to faster, safer vaccine development
Viral mimic systems and other tech platforms could enable local testing of vaccine candidates and antiviral therapies. This is important in the context of low-resourced health settings, Africa's focus on increasing its vaccine ...
7 minutes ago
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Weight-loss wonder pills prompt scrutiny of their key ingredient
Blockbuster weight-loss drugs are transforming the way we treat obesity. But while costly injectable versions remain out of reach for many, newly approved tablet forms are expected to significantly boost access and demand. ...
14 hours ago
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HIV entry blocker pairs CD4 mimic and antibody, showing sevenfold higher efficacy
Drug conjugates (ADCs) developed at Institute of Science Tokyo combine a CD4 mimic with neutralizing antibodies for enhanced suppression of human immunodeficiency virus (HIV) infection. By targeting the gp120 on the viral ...
15 hours ago
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Single dose of a psychedelic drug can rapidly reduce depressive symptoms, clinical trial suggests
A single dose of the psychedelic drug dimethyltryptamine (DMT), given with psychological support, rapidly reduced depressive symptoms in 34 adults with major depressive disorder, according to a clinical trial published in ...
21 hours ago
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Key brain DMT theory takes a hit: Rat study finds no detectable DMT in serotonin neurons
For decades, the idea that the human brain might naturally produce the psychedelic compound DMT has attracted considerable attention. It has been speculated that DMT could function as a natural signaling substance in the ...
16 hours ago
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Ostarine: The performance-enhancing drug giving anti-doping agencies a headache
A drug designed to help cancer patients rebuild wasting muscles has become one of the most contentious substances in elite sport—and the scientist who discovered it now spends more time trying to stop people using it than ...
10 hours ago
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The outrage over the Enhanced Games ignores the risks many already accept in sport
The Enhanced Games, slated to commence in May 2026, has sparked outrage across the sporting world. This new competition is the first in history to openly permit performance-enhancing drugs, and sporting bodies aren't happy ...
12 hours ago
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Predicting and preventing the risk of hip fracture related to osteoporosis
Researchers at Pompeu Fabra University (UPF) have made a great leap toward predicting the risk of hip fracture among people with osteoporosis and evaluating the effectiveness of specific drugs to prevent it. The BCN Med Tech ...
15 hours ago
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Taking the next shot: GLP-1 research and the new era of weight loss
Soaring in popularity, GLP-1 medications—from weekly injections to newly available pills—are rapidly reshaping how Americans think about weight loss. In fact, a recent poll finds 1 in 8 adults are now taking medications ...
18 hours ago
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Younger men experience more harms using steroids than older men, study finds
Younger men who use anabolic-androgenic steroids (AAS) experience a greater overall burden and complexity of harms than older men, new Griffith University research has found. Researchers investigated whether age influenced ...
Feb 17, 2026
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Alzheimer's gene boosts seizures, but pathway can be targeted, study finds
The gene most strongly correlated with Alzheimer's disease also boosts seizure activity by decreasing levels of ion pumps and energy-producing enzymes in neurons, a new study by researchers at the University of Illinois Urbana-Champaign ...
Feb 16, 2026
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Ketamine's 'mystical' effects fail to explain alcohol abstinence gains, study suggests
The psychedelic effects recreational users often seek from taking ketamine do not predict the therapeutic benefits for people being treated for alcohol use disorder. The popular theory, which says that ketamine may have its ...
Feb 16, 2026
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Helping mothers with epilepsy take life-saving medication without fear of birth defects
Scientists are moving toward a genetic test that could help thousands of mothers with epilepsy safely take life-saving medication without fear of it causing birth defects in their children.
Feb 16, 2026
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Research: FDA drug labels not proof of patent violation
Federal law requires every prescription drug to include a document describing dosing guidelines, contraindications, results from clinical trials and safety considerations. But a spate of recent court decisions has problematically ...
Feb 16, 2026
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Will Ozempic-style patches help you lose weight? Two experts explain
Could a simple patch, inspired by the weight-loss drug Ozempic, really help you shed excess kilos without the pain and effort of an injection?
Feb 15, 2026
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Combining GLP-1 drugs with hormones may lower uterine cancer risk
Adding GLP-1 medications like Ozempic to progestin therapy could cut the risk of developing endometrial cancer. A retrospective study published in the journal JAMA Network Open found that women using this combination had ...
Use of meds for mental health up in children, young adults from 2001 to 2020
Use of medications for mental health and behavioral conditions among children and young adults increased steadily for two decades, according to a study published online recently in the Journal of the American Academy of Child ...
Feb 14, 2026
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HIV antibody opens up new approaches for vaccine development and combination therapies
An international research team has identified a novel HIV antibody that targets the virus at a particularly vulnerable site and overcomes previous limitations of known antibodies. This study, led by Professor Dr. Florian ...
Feb 12, 2026
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Multi-country malaria trial shows a more efficient way to treat the disease
Landmark findings from a major malaria clinical trial led by Menzies School of Health Research (Menzies) and international collaborators have confirmed the safety and effectiveness of two Plasmodium vivax (P. vivax) malaria ...
Feb 12, 2026
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A glaucoma drug may help prevent opioid relapse
An existing drug currently used to treat glaucoma, altitude sickness, and seizures may also have the potential to prevent relapse in opioid use disorder, according to a study by researchers at University of Iowa Health Care. ...
Feb 12, 2026
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Commonly used drugs could help prevent delirium after surgery
A new study has found that several commonly used drugs could significantly reduce the risk of delirium in older people following surgery. Delirium—a sudden state of confusion and memory problems—affects around one in ...
Feb 12, 2026
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Brexpiprazole add-on may speed information processing in schizophrenia patients
Cognitive impairment, including decreased attention and memory, remains one of the most disabling aspects of schizophrenia, affecting the social life of patients. However, no effective treatment has yet been established for ...
Feb 12, 2026
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Seven-day buprenorphine injection matches daily tablets for ED opioid treatment
More than 15 years ago, Yale's Gail D'Onofrio started studying the effectiveness of sublingual (under-the-tongue) buprenorphine for treatment of opioid use disorder (OUD) in the emergency department. At the time, buprenorphine ...
Feb 12, 2026
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World-first clinical practice guideline for the appropriate use of psychedelics
The new "Clinical Practice Guideline for the Appropriate Use of Methylenedioxymethamphetamine-assisted psychotherapy (MDMA-AP) for Post-Traumatic Stress Disorder (PTSD)" has been approved by the National Health and Medical ...
Feb 12, 2026
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FDA rejects Moderna's mRNA flu vaccine application, for reasons with no basis in the law
The Food and Drug Administration has refused to review an application from the biotech company Moderna to approve its mRNA-based flu vaccine.
Feb 12, 2026
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