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Clinical pharmacology news
Large-scale study challenges link between acetaminophen use during pregnancy and autism risk in children
A team of Taiwanese researchers have used a nationwide, population-based cohort to examine whether taking acetaminophen during pregnancy might be linked to a higher likelihood of attention-deficit/hyperactivity disorder ...
9 hours ago
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Study uncovers a new mechanism explaining how chemicals affect sex hormones
Researchers at the University of Oulu have identified a previously unknown mechanism in humans that may explain why certain medicines and environmental chemicals disrupt the balance of sex hormones. The finding deepens scientific ...
1 hour ago
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Active ingredient of Viagra can help treat rare genetic disease
Sildenafil—an active ingredient also marketed under the name of Viagra—improves symptoms in patients with Leigh syndrome. This has now been reported in the journal Cell by researchers at Charité—Universitätsmedizin ...
6 hours ago
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Safer blood clot treatment: Apixaban beats rivaroxaban in head-to-head comparison
The first clinical trial to compare two commonly used drugs head-to-head for venous thrombosis treatment has found a clear winner: while both drugs work well to prevent recurrent blood clots, apixaban is safer than rivaroxaban, ...
4 hours ago
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Claims data study ties epilepsy drugs in pregnancy to developmental risks
Findings published by The BMJ reinforce previous research linking use of the antiseizure drug valproate during pregnancy to neurodevelopmental disorders such as ADHD and autism in children, and indicate no substantial risk ...
3 hours ago
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Study finds ALS drug hope via AI and veteran records
A Lawrence Livermore National Laboratory (LLNL)-led team of scientists and computational engineers using one of the largest electronic health record datasets ever assembled for ALS has identified several existing medications ...
3 hours ago
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Dengue vaccine remains 80.5% effective against severe cases after five years
In a phase 3 clinical trial, the tetravalent dengue vaccine, developed by the Butantan Institute in São Paulo, Brazil, was 80.5% effective against severe dengue cases with warning signs over a five-year period. The results ...
4 hours ago
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FDA approves Sotyktu for adults with active psoriatic arthritis
The U.S. Food and Drug Administration has approved Sotyktu (deucravacitinib) for the treatment of adults with active psoriatic arthritis.
7 hours ago
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Medicinal cannabis eases endometriosis, pelvic pain
Medicinal cannabis could provide a new treatment option for those with endometriosis, with a study led by the University of Otago, Wellington showing it reduced pain, improved sleep and lowered anxiety. The study, led by ...
8 hours ago
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Deep learning model enables accurate and scalable drug-drug interaction prediction
Managing complex medical conditions often requires the simultaneous use of multiple different drugs, referred to as polypharmacy. While necessary, this significantly increases the risk of drug-drug interactions (DDIs), which ...
8 hours ago
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Nanohydrogels steer cancer drugs to tumors, aiming to spare healthy tissue
Exhaustion creeps in. Appetite vanishes. Hair thins. The person in the mirror looks gaunt. It's the paradox of cancer treatment: The same drugs meant to save a life can also wear the body down. Nick Housley, assistant professor ...
Mar 10, 2026
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Wegovy may have highest 'eye stroke' and sight loss risk among semaglutide GLP-1 agonists
Wegovy, a GLP-1 agonist for weight loss, may carry the highest risk of "eye stroke" (ischemic optic neuropathy) and sudden sight loss of the semaglutide drugs, finds an analysis of unintended side effect reports published ...
Mar 10, 2026
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GLP-1 medication changes may support long-term weight management
Patients without diabetes who switched GLP-1 receptor agonist (GLP-1RA) drugs for overweight or obesity were more likely to stick with their treatment longer than those who didn't switch, according to a new study by UT Southwestern ...
Mar 10, 2026
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Approved IV drug reduces lupus symptoms, clinical trial finds
An already-approved IV drug significantly reduces the symptoms of lupus, a new clinical trial showed. More than three-quarters of lupus patients taking obinutuzumab (Gazvya) had a significant improvement in their symptoms ...
Mar 10, 2026
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Experimental vaccine could help turn the tide on America's opioid epidemic
Virginia Tech researchers are advancing a new generation of vaccines designed to block opioids from reaching the brain and triggering their addictive effects, work that could help prevent overdose deaths that now exceed 100,000 ...
Mar 10, 2026
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Does ginkgo help memory? New review finds limited gains, mainly in dementia
An updated systematic review of dozens of studies finds that Ginkgo biloba may offer modest short-term improvements for people with dementia, but shows little to no benefit for individuals with subjective memory complaints, ...
Mar 10, 2026
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New mRNA platform remains effective even in aging and obesity
Since the COVID-19 pandemic, mRNA vaccines have gained attention as a next-generation pharmaceutical technology. mRNA therapeutics work by delivering genetic instructions that enable cells to produce specific proteins for ...
Mar 10, 2026
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Boron agents reach previously untreatable tumors
Boron agents termed GluBs, developed by Science Tokyo researchers, have overcome a key limitation in cancer therapy by entering tumor cells through a pathway that standard drugs cannot use. The GluBs target ASCT2, a transporter ...
Mar 10, 2026
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Mouse brain study reveals why blockbuster weight-loss drugs may work differently in females and males
The drugs have names that sound like small planets: semaglutide, liraglutide, lixisenatide. Collectively, they belong to a class of glucagon-like peptide 1 (GLP-1) analogs that has reshaped the treatment of obesity and diabetes ...
Mar 10, 2026
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Most blood thinners not tied to higher risks after free flap surgery
Blood thinners are a common medication for much of the older adult population, prescribed to prevent blood clots that can cause adverse events like heart attack or stroke. They are often stopped prior to most surgeries because ...
Mar 10, 2026
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Spike in deaths from novel benzos a major public health concern
Poisoning deaths from "novel" benzodiazepines (NBZDs)—designed to mimic brand-name drugs like Valium and Xanax but with greater potency—have spiked in the last six years. Out of nearly 260 fatal NBZD-related toxicity ...
Mar 10, 2026
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Study demonstrates potential broad-spectrum anti-alphavirus therapeutics
A recent collaborative study has identified two promising single-domain antibodies (sdAbs) that may offer a therapeutic option against multiple subtypes of Venezuelan equine encephalitis virus (VEEV). The researchers, from ...
Mar 10, 2026
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Rapid opioid dose reduction increases risk of mental health emergency department presentations
New Monash University research has found that rapidly reducing or abruptly stopping prescription opioids significantly increases the risk of mental health or substance use-related emergency presentations. For the study, researchers ...
Mar 10, 2026
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2018 to 2025 saw rise in GLP-1 receptor agonist Rx for bariatric surgery-eligible patients
Among patients eligible for metabolic and bariatric surgery (MBS), glucagon-like peptide-1 receptor agonist (GLP-1 RA) prescriptions increased from 2018 to 2025, while MBS use decreased beginning in 2023, according to a research ...
Mar 10, 2026
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