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Clinical pharmacology news
Target trial does not suggest major adverse outcomes with early GLP-1 use in pregnancy
A target trial emulation estimated the risks associated with glucagon-like peptide-1 receptor agonist (GLP-1RA) exposure in early pregnancy. The findings did not indicate a substantially increased risk for nonlive birth, ...
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Left-handed DNA tubes double cancer drug killing by boosting cell uptake
Researchers in the lab of Cancer Center at Illinois (CCIL) member Xing Wang have discovered the influential role of structural chirality, or "handedness," of a DNA nanostructure to dictate cancer cell response to targeted ...
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New GLP-1 oral pill lowers blood sugar and reduces bodyweight, clinical trial finds
Oral GLP-1 medications have the potential to increase access to therapies that can help lower blood sugar and reduce bodyweight. At the American Diabetes Association's Scientific Session, Mass General Brigham physician investigator ...
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New drug could slow the development of Alzheimer's
"Compound 10" is how Ursula Quitterer refers to the chemical compound that her team has developed and that could slow the progression of Alzheimer's disease. Quitterer is a professor of molecular pharmacology at ETH Zurich ...
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Ultrasound turns anticancer molecule into deep-lung bacteria killer
An anticancer medication called TLD1433, a ruthenium(II) complex that has entered Phase II trials for conditions such as non-muscle-invasive bladder cancer, is now being repurposed to address one of the biggest public health ...
New map reveals how antidepressants reshape the brain's serotonin system
A new study has uncovered how antidepressants affect different groups of serotonin-producing brain cells in opposite ways, offering new insights into why selective serotonin reuptake inhibitors (SSRIs) can cause unpleasant ...
5 hours ago
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Africa races for Ebola vaccine as outbreak outpaces response
Researchers racing to develop a vaccine to fight the growing Ebola outbreak centered in the Democratic Republic of the Congo (DRC) say doses could be ready for human testing within "two to three months," while the more promising ...
5 hours ago
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Hay fever, antihistamines and the evidence on dementia risk
For millions of people around the world, pollen season means weeks of sneezing, itchy eyes, and a blocked or runny nose. The timing varies depending on where you live and which plants are in flower, but grass pollen is one ...
3 hours ago
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Ozempic, GPL-1s may help curb substance use disorders, study finds
A new study led by researchers at the University of Texas at El Paso found that use of weight-loss drugs like Ozempic and other GLP-1s is associated with a lower risk of developing alcohol, opioid, nicotine and cocaine use ...
7 hours ago
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Study proposes reconsidering how histone deacetylase inhibitors work in cancer treatment
Researchers at Baylor College of Medicine and collaborating institutions are challenging the traditional understanding of how cancer drugs called histone deacetylase (HDAC) inhibitors function. For decades, scientists believed ...
Jun 7, 2026
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Antibody fragment prevents hemorrhages associated with new Alzheimer's treatments
In 2025, the European Medicines Agency approved two antibodies for Alzheimer's disease: lecanemab (LeqembiTM, from Biogen) and donanemab (Kisunla, from Eli Lilly and Co.), both based on immunotherapy (the use of molecules ...
Jun 6, 2026
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Drug nearly doubles survival in advanced pancreatic cancer—how daraxonrasib overcame an 'undruggable' disease
For a long time, the likelihood of surviving pancreatic cancer has been extremely low. For patients who were diagnosed with metastatic pancreatic cancer between 2015 and 2021, about 97% died within five years of their diagnosis.
Jun 6, 2026
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GLP-1-based meds are linked to fewer heart events in adults with obesity, autoimmune disease
Among adults with both obesity and an autoimmune disease, those taking a glucagon-like peptide-receptor 1 agonist (GLP-1RA) medication had lower rates of emergency department visits and were less likely to experience serious ...
Jun 6, 2026
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Vitamin A poisonings rose almost 40% as measles misinformation spread in 2025
There can be too much of a good thing, and that has been the case with Vitamin A in the U.S.. A recent study in JAMA Network Open has found that between January and March 2025, America's Poison Centers reported a 38.7% increase ...
Flu drugs show promise against cognitive decline
A class of flu drugs may reduce cognitive decline and premature aging in people living with chronic viral infection, reports a new study led by Northwestern University that began with blood samples from people with HIV and ...
Jun 5, 2026
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Three new Ebola vaccines are being developed: An infectious disease expert explains
When it comes to Ebola outbreaks, it's not often we have two pieces of good news in one week. First, we heard there's new funding of up to US$62 million to fast-track the development of vaccine candidates against the type ...
Jun 5, 2026
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Topical gel helps burn wounds heal faster using an existing FDA-approved drug
Researchers at the Terasaki Institute for Biomedical Innovation and the University of Arizona College of Medicine have developed a topical gel formulation with 4-aminopyridine (4-AP), to treat burn wounds, achieving near-complete ...
Jun 4, 2026
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New drug cuts relapse risk by half in rare immune disorder trial
Stanford Medicine researchers and their colleagues found that a new drug, obexelimab, significantly reduces the risk of relapse in patients with IgG4-related disease, a rare chronic immune condition often misdiagnosed as ...
Jun 4, 2026
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At least two weather patterns increase headaches, study suggests
Two specific weather patterns have been identified as capable of increasing the risk of headaches, thanks to physicians at the University of Cincinnati College of Medicine, along with researchers at the Icahn School of Medicine ...
Jun 4, 2026
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Injectable hydrogel relieves osteoarthritis pain and repairs cartilage in preclinical tests
For millions of people living with osteoarthritis, daily life can involve a frustrating cycle of pain and stiffness. While current treatments like over-the-counter medications or steroid injections can temporarily dull the ...
Jun 3, 2026
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New antibiotic kills drug-resistant bacteria by targeting previously unknown vulnerability
Researchers at McMaster University have discovered a new antibiotic that kills some of the world's most dangerous and drug-resistant bacteria—and does so by targeting a previously unknown vulnerability, opening the door to ...
Jun 3, 2026
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Aspirin may unmask silent bladder cancer by triggering bleeding
The presence of blood cells in urine is a sign of bladder cancer. Because aspirin blocks platelets from forming harmful blood clots, the medication can cause mild bleeding or worsen existing bleeding in the urinary tract. ...
Jun 3, 2026
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Potential gene therapy for late-stage Parkinson's side-effects uncovered
Northwestern Medicine scientists have discovered that suppressing excitatory synaptic transmission in a small group of neurons in the brain may reverse levodopa-induced dyskinesia in patients with late-stage Parkinson's disease ...
Jun 3, 2026
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AI misses cancer drug target, revealing why lab validation still matters
Researchers at the Icahn School of Medicine at Mount Sinai have identified a previously hidden druggable site in a cancer-related protein that could open the door toward the development of a new generation of more precise ...
Jun 3, 2026
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Novel vaccine adjuvant could make it easier to eradicate polio
In the United States, children routinely receive an injectable form of the polio vaccine. This vaccine is very effective at preventing illness, but it doesn't block transmission of the polio virus as well as the oral polio ...
Jun 3, 2026
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