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Clinical pharmacology news
Stem cell therapy shows promise for reversing aging-related frailty in new clinical trial
Stem cells are gaining attention for their potential to treat leukemia, certain solid tumor cancers, and inherited metabolic disorders. Now, a clinical trial reports that a single dose can significantly improve physical strength ...
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Results support use of weekly extended-release buprenorphine for opioid use disorder during pregnancy
In a clinical trial, a research team found that administering weekly injectable extended-release buprenorphine for treatment of opioid use disorder (OUD) during pregnancy led to higher rates of abstinence from illicit opioids ...
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Experimental oral therapy PrimeC shows safety and signals of clinical benefit in ALS
In a phase 2b clinical trial, an investigational oral therapy called PrimeC was found to be safe and well tolerated in people living with amyotrophic lateral sclerosis (ALS), with exploratory findings suggesting target engagement ...
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Twice‑yearly injectable HIV regimen treatment demonstrates strong efficacy and safety in Phase 2 trial
A new study published in The Lancet Microbe reports the first twice-yearly injectable HIV treatment regimen—combining lenacapavir, teropavimab, and zinlirvimab—has achieved high rates of viral suppression and demonstrated ...
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Higher buprenorphine doses help patients stay in opioid use disorder treatment, new study finds
Patients who are prescribed higher daily doses of the medication buprenorphine for opioid use disorder are significantly more likely to stay in treatment. Those on 17 to 24 milligrams averaged 190 days in care compared to ...
18 hours ago
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Links between brain regions could predict the efficacy of antidepressants
Major depressive disorder (MDD) is a severe form of depression characterized by a persistent low mood, hopelessness, disruptions in sleep and/or eating habits, as well as a loss of motivation and interest in daily activities. ...
How psychedelics push your brain to dream while awake: New study
A new study in mice suggests psychedelics make the brain more likely to "see" images from memory rather than what's actually in front of it.
Mar 14, 2026
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FDA warns Novo Nordisk broke safety reporting rules
Federal regulators have warned the maker of Ozempic and Wegovy that it failed to report possible drug side effects to the government.
Mar 14, 2026
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Kids can take tablets, so why are we still giving liquid medicines?
When six-year-old Seren was prescribed antibiotics, taking them four times a day quickly became a battle. The orange liquid tasted revolting, and much of it ended up on kitchen surfaces rather than in her mouth. Her mother ...
Mar 14, 2026
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Experimental Alzheimer's drug reverses memory loss in mice by reprogramming gene activity
A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease. Unlike current drugs, which mainly ...
Mar 13, 2026
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How vitamin B2 could pave the way to new cancer therapies
The human body cannot produce vitamin B2—also known as riboflavin—itself; it must absorb the important substance through diet. The vitamin can be found in dairy products, eggs, meat and green vegetables. The metabolism ...
Mar 13, 2026
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Novel compounds open new research avenues for Alzheimer's disease therapeutics
Alzheimer's disease is the most common cause of dementia, and it affects over 7 million people in the United States alone. Although there are treatments that can slow its progression, most of them treat its symptoms only ...
Mar 13, 2026
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Berberine as a natural Ozempic? An analysis of a popular myth
In recent years, berberine has increasingly appeared in the public sphere as a "natural way" to improve metabolism. In social media, it is sometimes compared to incretin drugs and even referred to as "plant-based Ozempic." ...
Mar 13, 2026
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Roflumilast cream has long-term safety, efficacy in young children
For children aged 2 to 5 years with atopic dermatitis (AD), roflumilast cream 0.05% has a favorable long-term safety profile and efficacy for up to 56 weeks, according to a study published online March 8 in Pediatric Dermatology.
Mar 13, 2026
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What happens when patients stop taking GLP-1 drugs? New study reveals real world insights
As the use of injectable GLP-1 drugs continues to rise, questions persist about what happens after patients stop taking them in real-world settings. A new Cleveland Clinic analysis of nearly 8,000 patients suggests that discontinuing ...
Mar 13, 2026
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Study finds CDK4/6 plus EGFR blockade kills pancreatic cancer cells without KRAS drugs
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 inhibition offers an indirect ...
Mar 13, 2026
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Aligning genomic data and clinical health records identifies potential medications for treating alcohol use disorder
A novel approach has identified drugs in current use that could be repurposed for treating alcohol use disorder (AUD). In 2023, 28 million US adults had experienced AUD in the past year. But only three medications are approved ...
Mar 13, 2026
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Scientists find a new therapeutic target present on up to half of all tumors
For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden ...
Mar 12, 2026
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Federal drug price reforms are improving medication adherence, new study finds
More than 1 in 4 U.S. adults struggle to afford their prescription medications. Those who can't are left with grim choices—such as skipping doses, cutting pills in half, or abandoning prescriptions entirely—that can come ...
Mar 12, 2026
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Romiplostim prevents serious side effect of chemotherapy in phase 3 trial
Results from a global phase 3 clinical trial led by investigators at Mass General Brigham show that the medication romiplostim can effectively prevent chemotherapy from destroying platelet-producing bone marrow cells, a common ...
Mar 12, 2026
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FDA provides fast track designation to nipocalimab for systemic lupus erythematosus
Johnson & Johnson's nipocalimab has been granted U.S. Food and Drug Administration Fast Track designation as a potential treatment for adults with systemic lupus erythematosus (SLE).
Mar 12, 2026
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Trial finds vitamin D supplements don't reduce COVID severity but could reduce long COVID risk
In a large, randomized trial, researchers at Mass General Brigham found that high-dose vitamin D3 did not reduce COVID-19 infection severity, but may impact long COVID outcomes. Results of the study are published in The Journal ...
Mar 12, 2026
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Evaluating the effects of hypnotics for insomnia in obstructive sleep apnea
Obstructive sleep apnea (OSA) is a common sleep disorder characterized by oxygen desaturation due to repeated airway collapse during sleep. This leads to oxygen desaturation or awakening from sleep. It is often linked to ...
Mar 12, 2026
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Large-scale study challenges link between acetaminophen use during pregnancy and autism risk in children
A team of Taiwanese researchers have used a nationwide, population-based cohort to examine whether taking acetaminophen during pregnancy might be linked to a higher likelihood of attention-deficit/hyperactivity disorder ...
Active ingredient of Viagra can help treat rare genetic disease
Sildenafil—an active ingredient also marketed under the name of Viagra—improves symptoms in patients with Leigh syndrome. This has now been reported in the journal Cell by researchers at Charité—Universitätsmedizin ...
Mar 11, 2026
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