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Clinical pharmacology news
AI-powered 'lab-on-a-chip' platform may enable same-day treatment decisions for pediatric patients
Scientists at the University of Utah (the U) have developed a new "lab-on-a-chip" device that uses artificial intelligence to rapidly predict cancer cell sensitivity to targeted therapies for children with T-cell acute lymphoblastic ...
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Strong patient diversity in biobanks reveals new genetic links to disease risk and treatment response
A new study by UCLA Health published in Cell presents a major advancement in the future of personalized medicine by pinpointing new connections between people's genes, disease risk and medicine response by using a clinically ...
1 hour ago
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Treating disease at birth: How a brief spike in testosterone sets the trajectory for disease that appears decades later
Spinal and bulbar muscular atrophy (SBMA) is a rare inherited disease that causes progressive muscle weakness and wasting in men. Patients typically develop early symptoms such as hand tremors in their 30s, but diagnosis ...
6 hours ago
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TIE2 protein emerges as potential drug target to prevent development of dangerous blood vessel defects in brain
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a cell surface receptor protein called TIE2 as the missing link between two key signaling pathways that drive the growth of ...
2 hours ago
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Why some cancer therapies don't work for all patients: A tumor backup survival pathway
Drugs that block enzymes called tyrosine kinases are among the most effective targeted therapies for cancer. However, they typically work for only 40% to 80% of the patients who would be expected to respond to them. In a ...
21 hours ago
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Weight-loss medications may affect some complications after panniculectomy
For patients undergoing body contouring surgery to remove excess abdominal skin after massive weight loss, use of GLP-1 weight-loss medications may have mixed effects on complication risks, suggests a study in the April issue ...
16 hours ago
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Kratom calls skyrocket to nation's poison centers
Calls to poison centers about kratom, a drug widely available in vape shops and gas stations, increased more than 1,200% between 2015 and 2025, with a corresponding rise in hospitalizations, an alarming new UVA Health analysis ...
23 hours ago
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Influencers promoting prescription drugs on social media pose public health risks
In today's world, attention is increasingly focused on social media and its influencers, a shift reflected in the industry's rapid growth and a global market projected to surpass $32 billion. The marketing teams of pharmaceutical ...
Over the past decade, early-stage drug innovation has shifted toward China, researchers find
Early-stage drug development worldwide has nearly doubled over the past decade and shifted from a U.S.-dominated model to a dual hub centered in the United States and China, according to new research described by Georgetown ...
Mar 26, 2026
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Common blood pressure drug can boost cancer treatment
In a new Dartmouth Cancer Center (DCC) study led by clinical researcher Tyler J. Curiel, MD, MPH, FACP, investigators found that the FDA-approved blood pressure drug telmisartan can significantly enhance the cancer-killing ...
Mar 25, 2026
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Passion fruit–derived molecule shows promise as a future Alzheimer's drug candidate
Four years ago, a research group at the University of Oslo made what would turn out to be a major discovery. They found that an extract from passion fruit had the potential to slow the development of Alzheimer's disease. ...
Mar 25, 2026
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New medicine piggybacks onto fat absorption pathways to allow oral delivery in major depressive disorder
Monash University and Seaport Therapeutics have developed a new approach to delivering drug molecules that piggybacks onto natural fat absorption pathways to allow oral delivery of some drugs previously requiring injection. ...
Mar 25, 2026
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Could a new type of weight‑loss pill shake up the market? Here's what to know about orforglipron
A new type of daily pill has proven more effective for weight loss and blood sugar control than its currently available counterparts, according to a recent trial. The drug, known as orforglipron, could be a game-changer in ...
Mar 25, 2026
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FDA approves Icotyde for moderate-to-severe plaque psoriasis
The U.S. Food and Drug Administration has approved Johnson & Johnson's Icotyde (icotrokinra), an interleukin-23 (IL-23) receptor antagonist, for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric ...
Mar 25, 2026
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Dramatic reduction in prescribing of hepatitis C antivirals may leave many curable patients untreated
Direct-acting antivirals (DAAs) can cure hepatitis C (HCV) in more than 95% of individuals treated. But only 1 in 3 people with HCV in the U.S. receive treatment within a year of diagnosis. A new study by investigators from ...
Mar 25, 2026
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Dengue fever is a growing problem: Why it's so hard to beat with vaccines
Dengue, a mosquito-borne disease, affects millions of people every year across Asia, Africa and Latin America. And it's expanding geographically as warmer temperatures and urban growth allow mosquito populations to thrive ...
Mar 25, 2026
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Cancer drug can treat drug-resistant herpes, too
UIC researchers have successfully repurposed an FDA-approved cancer drug, doxorubicin, to treat drug-resistant strains of herpes. Their work appears in the journal Drug Resistance Updates.
Mar 24, 2026
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FDA-approved fatty liver drug also suppresses liver tumors in mice
A research team from the Department of Pathology, School of Clinical Medicine, LKS Faculty of Medicine of the University of Hong Kong (HKUMed), in collaboration with the HKU State Key Laboratory of Liver Research, has found ...
Mar 24, 2026
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Hair loss therapeutic agent safe for both men and women, study finds
Using computational modeling, a research team has developed a novel peptide (MLPH) that promotes hair growth without the side effects of existing drugs. This achievement, accomplished through a joint research project led ...
Mar 24, 2026
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Soy isoflavone prodrugs target CB1 receptor to protect blood vessels from atherosclerosis
A research team at National Taiwan University found that abnormal blood flow activates CB1 receptors in endothelial cells, promoting vascular inflammation and dysfunction. Soy-derived isoflavone prodrugs that inhibit CB1 ...
Mar 24, 2026
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Bone pain reduced with pegfilgrastim administration 72 hours after chemo
For patients with breast cancer, administration of pegfilgrastim 72 hours postchemotherapy reduces pegfilgrastim-induced bone pain (PIBP) compared with administration at 24 and 48 hours, according to a study published online ...
Mar 24, 2026
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Self-management of warfarin dose is safe, effective and empowering, clinical trial shows
Warfarin is an oral anticoagulant, commonly known as blood thinner, that is prescribed to help treat the formation of dangerous blood clots that can lead to stroke or heart attacks. Even with newer medications on the market, ...
World's only deuterium-labeled guinea pig helps scientists study metabolism
A Skoltech scientist has raised the world's only isotope-labeled guinea pig. For 156 days, the animal, named Khryun, was given only heavy water to drink. Such water is non-radioactive and has long been used in biomedical ...
Mar 23, 2026
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Lyme disease vaccine shows over 70% efficacy, but phase three misses main goal
An experimental vaccine for Lyme disease is broadly effective, pharmaceutical companies Pfizer and Valneva announced Monday; however, the latter firm's shares fell because the clinical trial did not reach its main goal.
Mar 23, 2026
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FDA approves higher-dose Wegovy to help people lose more weight
A stronger version of the popular weight loss drug Wegovy is on the way after federal regulators signed off on a higher dose. The U.S. Food and Drug Administration (FDA) approved a 7.2-milligram dose of Novo Nordisk's semaglutide, ...
Mar 23, 2026
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