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Clinical pharmacology news
An experimental molecule 'reprograms' the brain's defenses against Alzheimer's disease
A team has identified an experimental molecule capable of "reprogramming" the brain's immune cells to restore part of their protective function against Alzheimer's disease. The study, published in the journal Cell Death and ...
2 hours ago
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Can use of popular weight loss medications reduce behaviors linked to violent crime?
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for diabetes and obesity, but studies have found evidence that the medications may also influence behavior, such as supporting impulse control and ...
5 hours ago
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Beyond GLP-1s: The next chapter of obesity care
The rapid rise of GLP-1 medications such as semaglutide and tirzepatide has transformed obesity treatment. Still, experts say medications alone are not enough to address one of the nation's most pressing chronic diseases.
3 hours ago
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Kidney healing improves after protein blockade, with less scarring and faster recovery
A drug previously developed at UCLA to help heart tissue repair itself after a heart attack might also help kidney tissue repair and regenerate, researchers have found.
16 hours ago
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Hidden PIM1 pathway helps prostate cancer survive treatment, pointing to new drug strategy
Cancer cells are remarkably good at adapting to stress. When treatments damage them, they often find new ways to survive, fueling drug resistance and disease progression.
16 hours ago
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Repurposed drugs move through late-stage trials at up to 90% lower cost
Universities and hospitals are repurposing existing drugs through late-stage trials with funded costs up to 90% lower than those in the pharmaceutical industry. This "hidden" research system, which operates outside the patent ...
13 hours ago
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Tirzepatide outperformed semaglutide weight-loss drug results in real world patients, study shows
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become popular for weight loss, but results vary from person to person and from drug to drug. Venky Soundararajan and colleagues explored the full range of responses ...
16 hours ago
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ADA: Orforglipron beneficial for reducing HbA1c in type 2 diabetes
Orforglipron is beneficial for blood glucose control in individuals with type 2 diabetes using metformin or taking insulin glargine, according to two studies published online June 8 in The Lancet and the JAMA to coincide ...
15 hours ago
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Three men's health drugs that were originally designed for a different purpose
Many medicines begin life with one purpose and end up proving useful for a completely different reason.
20 hours ago
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Copper drug restores memory and clears toxic Alzheimer's proteins, preclinical study finds
Monash University researchers have found in laboratory experiments that a drug that delivers copper to the brain significantly reduces toxic Alzheimer's proteins and improves long-term spatial memory.
Jun 15, 2026
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Why some cancers return: Robotic mini tumor tests point to new ways to target persister cells
Cancer drugs can shrink fast-growing tumors. But sometimes a few tumor cells survive. These "persister" cells seed new tumors, forcing cancer patients into arduous cycles of testing and treatment.
Jun 15, 2026
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Combo treatment delays multiple myeloma progression and may improve survival, study finds
Patients with multiple myeloma who received a new immunotherapy combination lived significantly longer without their cancer worsening and showed early signs of improved survival in a large international clinical trial.
Jun 15, 2026
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Anti-inflammatory molecule shows potential against Parkinson's in murine study
Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have discovered a new strategy that may protect neurons and other brain cells involved in Parkinson's disease in the future. The results of the study, ...
Jun 15, 2026
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Targeting delivery to the lungs: Inhaled vitamin D could be new strategy
People with chronic lung diseases like chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis tend to have low vitamin D levels, and these low levels are linked to worse respiratory health outcomes. This ...
Jun 15, 2026
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ENDO: GLP-1 receptor agonists tied to higher hypotension risk in patients on BP meds
Among patients with preexisting hypertension taking antihypertensive medications, glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with an increase in hypotensive-related events, according to a study ...
Jun 15, 2026
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Tirzepatide GLP-1 medication may be most effective for weight loss
GLP-1 medications are marketed to help you lose weight, but one may be better at it than the rest, according to a new meta-analysis from the University of Georgia.
Jun 15, 2026
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Tirzepatide may change how the body uses energy, trial suggests
Tirzepatide doesn't just help people lose weight; it also activates brown adipose tissue, representing a major milestone in obesity research, according to a study presented at ENDO 2026, the Endocrine Society's annual meeting ...
Jun 15, 2026
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As injectable peptides surge online, researchers warn regulation is falling behind
A new Viewpoint published in JAMA from researchers at the University of Queensland, the University of Toronto and the University of California, San Francisco, is raising concern about a fast-growing but poorly understood ...
Jun 15, 2026
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Behavioral modifications like goal setting could lead to greater weight loss on tirzepatide
One of the largest real-world studies of people taking GLP-1 medications found women, those without pre-existing conditions such as type 2 diabetes and high blood pressure, and behavioral factors such as previously setting ...
Jun 15, 2026
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Clinical trials suggest GLP-1s may improve fertility in men with obesity
GLP-1s do not harm male hormones or fertility after long-term use, according to a study being presented Monday at ENDO 2026, the Endocrine Society's annual meeting in Chicago. In fact, the research team found GLP-1s may improve ...
Jun 15, 2026
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Study of 5.8 billion medicines dispensed in England exposes stark health inequalities
Scientists have revealed striking inequalities and changing trends in medicines dispensing for more than 52 million people living in England during and after the COVID-19 pandemic.
Jun 15, 2026
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Laxative drug could ease depression-related brain fog, early trial suggests
People with depression who find that it affects their memory or attention span could benefit from an existing licensed drug currently used to treat chronic constipation.
Jun 14, 2026
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Creating mini-brains from stem cells reveals a new, promising treatment for a devastating childhood disease
Variants in the DHDDS gene cause a severe neurodegenerative condition, characterized by tremors, seizures, coordination and learning difficulties, usually manifesting in early childhood. This Parkinson's-like condition is ...
Jun 14, 2026
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Semaglutide linked to lower bone fracture risk
In people with type 2 diabetes, semaglutide was associated with a 15% reduction in bone fractures and greater weight loss compared with other anti-obesity medications, according to a study presented at ENDO 2026, the Endocrine ...
Jun 14, 2026
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Inflation Reduction Act's out-of-pocket cap lowered insulin costs, improved usage for some patients
The Inflation Reduction Act's attempt to improve insulin costs for Medicare beneficiaries—by capping out-of-pocket costs at $35—was associated with lower out-of-pocket costs and increased insulin use, but only for a small ...
Jun 14, 2026
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