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Clinical pharmacology news
One inhibitor, opposite outcome: How a double-target effect could reshape ferroptosis therapies
Switching off an enzyme that plays an important role in sugar metabolism, glycolysis, would normally be expected to cause serious problems for cells. Surprisingly, the opposite is also true: Cells can become highly resistant ...
22 hours ago
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Tezepelumab helps severe asthma patients reduce oral steroids over 28 weeks
New results from the Phase III SUNRISE clinical trial show that tezepelumab significantly reduced the need for long-term oral corticosteroid use in adults with severe oral corticosteroid-dependent asthma while maintaining ...
14 hours ago
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Cannabidiol significantly reduces chronic pain for those with nerve damage
A new study by researchers at the University of Sydney has shown that taking cannabidiol (CBD) can significantly reduce chronic neuropathic pain in those suffering from it. The findings of the randomized placebo-controlled ...
May 29, 2026
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Why metformin matters beyond diabetes: New target could reshape aging and cancer research
Scientists at Université de Montréal have figured out how metformin—a common drug that's used to treat type-2 diabetes and that may cut the risk of developing cancer and even help humans and other mammals live longer—actually ...
May 29, 2026
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Targeted drug outperforms chemotherapy for patients with hard-to-treat lung cancer
The targeted therapy sunvozertinib was more effective than standard platinum-based chemotherapy as a first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) driven by EGFR exon 20 insertion mutations ...
May 29, 2026
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Simulation-guided search uncovers two promising tuberculosis drug candidates targeting CYP
A research team led by Associate Professor Noriyuki Kurita from the Department of Computer Science and Engineering at Toyohashi University of Technology and by Associate Professor Pornpan Pungpo from Ubon Ratchathani University ...
May 29, 2026
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New antibiotic design could help treat drug-resistant infections
A new way of designing antibiotics could support the discovery of new treatments for drug-resistant infections. It could also help revive antibiotics that have lost effectiveness because bacteria have evolved over time to ...
May 29, 2026
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Rise of dangerous drug adulterant and public health response tracked in New York State
A dangerous sedative called medetomidine has been quietly spreading through New York's illicit drug supply. A new analysis shows how, over several years of careful tracking and coordination, public health agencies in New ...
May 28, 2026
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New study points to possible new treatment for rheumatoid arthritis
There is good news for patients with rheumatoid arthritis. Research from Aarhus University and Aarhus University Hospital may have opened the door to an entirely new way of reducing inflammation in the joints. The study is ...
May 28, 2026
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African Union's health agency vows Ebola Bundibugyo vaccine by end of 2026
A vaccine against the Bundibugyo strain of the Ebola virus will be ready by the end of the year, the head of Africa Centers for Disease Control and Prevention (Africa CDC) said Thursday.
May 28, 2026
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The Enhanced Games set out to 'transform sport' but the results looked surprisingly ordinary
The Enhanced Games promised a revolution. Athletes on supervised drug regimens, unshackled from the anti-doping rules of the Olympics, were going to show us what the human body was truly capable of. The event was transhumanism ...
May 28, 2026
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Why caffeine can sabotage deep sleep even when you still get eight hours
Evening coffee has sparked controversy for years. Some people fall asleep without difficulty, while others toss and turn for half the night. However, a growing body of research suggests the question of whether coffee makes ...
May 27, 2026
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Medical marijuana: Can getting high be good for your health?
Cannabis is a psychoactive drug derived from the Cannabis sativa plant. Users can smoke the dried flowers and leaves as marijuana or make them into an oil or resin.
May 27, 2026
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Machine learning closes research gaps in drug safety during pregnancy, research shows
A report in the Journal of Medical Internet Research shows developments in the evidence gap in drug safety during pregnancy in its News and Perspectives section. In "How Machine Learning Can Help Close Evidence Gaps for Drug ...
May 27, 2026
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KRAS degradation induces rapid lung cancer regression in preclinical mouse models
KRAS is one of the oncogenes most frequently altered in cancer, mutating in approximately one-third of lung adenocarcinomas. For decades, it was considered undruggable, until the recent approval of the first inhibitors against ...
May 27, 2026
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Tirzepatide superior to intensified conventional care for early type 2 diabetes
Tirzepatide is superior to intensified conventional care (ICC) for adults with early type 2 diabetes (T2D) uncontrolled with metformin, according to a study published online May 26 in the Annals of Internal Medicine.
May 27, 2026
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Direct-to-consumer pharmacies could save commercially insured patients 85% on high-cost generic drugs, report suggests
A report comparing the Mark Cuban Cost Plus Drug Company (MCCPDC) to copayments or coinsurance under employer-sponsored insurance found that patients with high-cost generic prescriptions could lower their out-of-pocket costs ...
May 26, 2026
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Experimental mRNA vaccine shows promise against multiple Ebola strains
Scientists from China have developed a new broad-spectrum mRNA vaccine that could provide long-term protection against the most lethal family of Ebola viruses, including the Bundibugyo strain behind the current outbreak in ...
AI-guided drug search flags folic acid for diabetic wound healing
Researchers from the National University of Singapore (NUS) have developed an AI-guided workflow that combines artificial intelligence (AI) with molecular simulations to identify potential drug candidates for diabetic wound ...
May 25, 2026
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Macrophage cell therapy boosts four-year transplant-free survival in advanced cirrhosis
A new type of cell therapy shows promise as the first treatment for advanced liver disease, following results from a clinical trial. Patients with the condition who were treated with the cell therapy had a significantly lower ...
May 25, 2026
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FDA approves Enhertu as neoadjuvant, adjuvant treatment for breast cancer
The U.S. Food and Drug Administration has approved AstraZeneca's Enhertu (fam-trastuzumab deruxtecan-nxki) for both the neoadjuvant and adjuvant treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive ...
May 25, 2026
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The enhanced games, or 'steroid Olympics', are on—they pose risks for athletes and viewers
The inaugural Enhanced Games are underway in Las Vegas and are set to be a unique spectacle that promotes drug-induced "enhancement." The International Olympic Committee has condemned the event as a way to "destroy any concept ...
May 25, 2026
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Cholesterol-craving cancers need lipid enzymes to use metabolites for growth, study shows
While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite. Some tumor cells use as much cholesterol as they can access to accelerate their growth ...
May 22, 2026
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A once-daily pill takes aim at measles, croup and other dangerous viruses
A new oral antiviral drug candidate has been developed for the treatment of diseases caused by orthoparamyxoviruses, such as measles and croup syndrome, according to a study published by researchers in the Center for Translational ...
May 22, 2026
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Psilocybin cuts nerve pain for weeks and boosts gabapentin in mice
A single dose of psilocybin, the active compound in magic mushrooms, reduces nerve pain for up to a month and makes a widely used painkiller work more effectively, University of Reading research has found.
May 22, 2026
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