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Clinical pharmacology news
HIV antibody opens up new approaches for vaccine development and combination therapies
An international research team has identified a novel HIV antibody that targets the virus at a particularly vulnerable site and overcomes previous limitations of known antibodies. This study, led by Professor Dr. Florian ...
17 hours ago
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Multi-country malaria trial shows a more efficient way to treat the disease
Landmark findings from a major malaria clinical trial led by Menzies School of Health Research (Menzies) and international collaborators have confirmed the safety and effectiveness of two Plasmodium vivax (P. vivax) malaria ...
19 hours ago
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Seven-day buprenorphine injection matches daily tablets for ED opioid treatment
More than 15 years ago, Yale's Gail D'Onofrio started studying the effectiveness of sublingual (under-the-tongue) buprenorphine for treatment of opioid use disorder (OUD) in the emergency department. At the time, buprenorphine ...
17 hours ago
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Commonly used drugs could help prevent delirium after surgery
A new study has found that several commonly used drugs could significantly reduce the risk of delirium in older people following surgery. Delirium—a sudden state of confusion and memory problems—affects around one in ...
18 hours ago
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World-first clinical practice guideline for the appropriate use of psychedelics
The new "Clinical Practice Guideline for the Appropriate Use of Methylenedioxymethamphetamine-assisted psychotherapy (MDMA-AP) for Post-Traumatic Stress Disorder (PTSD)" has been approved by the National Health and Medical ...
13 hours ago
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Brexpiprazole add-on may speed information processing in schizophrenia patients
Cognitive impairment, including decreased attention and memory, remains one of the most disabling aspects of schizophrenia, affecting the social life of patients. However, no effective treatment has yet been established for ...
22 hours ago
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FDA rejects Moderna's mRNA flu vaccine application, for reasons with no basis in the law
The Food and Drug Administration has refused to review an application from the biotech company Moderna to approve its mRNA-based flu vaccine.
14 hours ago
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Medicine shortages in the UK have become a 'new normal,' report finds
The U.K.'s supply of essential medicines is in a fragile state, with a "vicious cycle" where rising costs and supply chain issues are making it harder for patients to get the treatments they need, according to a new House ...
22 hours ago
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Speech latency may predict schizophrenia trial response, boosting drug-placebo separation
Researchers have identified a promising new speech biomarker that could significantly enrich clinical trials by reducing sample size requirements and enhancing statistical outcomes. By using speech latency, participants who ...
Feb 12, 2026
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Single DMT dose treats stress-induced depression more effectively than Prozac in mice
Psychedelics are psychoactive substances that trigger unusual mental states, also referred to as "trips," altering the perceptions, thoughts, and emotions of those taking them and typically inducing hallucinations. Over the ...
Common anti-seizure drug prevents Alzheimer's plaques from forming, study shows
While physicians and scientists have long known that Alzheimer's disease involves the buildup of toxic protein fragments in the brain, they have struggled to understand how these harmful fragments are produced. Now, in a ...
Feb 11, 2026
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HPV cancer vaccine slows tumor growth and extends survival in preclinical model
Throughout the past decade, Northwestern University scientists have uncovered a striking principle of vaccine design: Performance depends not only on vaccine components but also on vaccine structure. After proving this concept ...
Feb 11, 2026
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Tiny worm offers clues to combat chemotherapy neurotoxicity
Chemotherapy remains one of the most powerful tools in the fight against cancer, yet it often comes with significant long-term side effects that can dramatically affect patients' quality of life. Among the most debilitating ...
Feb 11, 2026
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Established cancer drug can reactivate immunotherapy
Genetically modified immune cells can offer precious additional time to patients with advanced multiple myeloma. However, these therapies lose their impact as the molecules on cancer cells that immune cells recognize gradually ...
Feb 11, 2026
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Experimental drug may protect the brain against depression and cognitive impairment caused by whole brain radiotherapy
Whole brain radiotherapy (WBRT) saves lives by treating cancer that has spread to the brain, but it also causes long-standing brain damage. Many patients who go through radiation treatment later develop memory problems, thinking ...
Feb 11, 2026
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Triple therapy shown to help with cystic fibrosis in the long term
Cystic fibrosis (CF) is the most common inherited metabolic disease in Europe. More than 8,000 people in Germany are affected. Every year, about 150 to 200 children are born with this incurable disease. It is caused by a ...
Feb 11, 2026
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Discontinuing antidepressants in pregnancy nearly doubles risk of mental health emergencies, finds study
Pregnant patients who stopped taking their antidepressant medication during pregnancy were almost twice as likely to experience a mental health emergency compared with pregnant patients who continued taking their prescription, ...
Feb 11, 2026
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Natural gut-based compound developed to support weight loss safely
A new orally taken, gut-based compound developed by scientists from Nanyang Technological University, Singapore (NTU Singapore), reduces the amount of dietary fat absorbed in the intestines. This differs from most existing ...
Feb 11, 2026
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Investigators study ivermectin's 'ability to kill cancer cells'
The National Cancer Institute, the federal research agency charged with leading the war against the nation's second-largest killer, is studying ivermectin as a potential cancer treatment, according to its top official.
Feb 11, 2026
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Moderna says FDA refuses its application for new mRNA flu vaccine
The U.S. Food and Drug Administration is refusing to consider Moderna's application for a new flu vaccine made with Nobel Prize-winning mRNA technology, the company announced Tuesday.
Feb 11, 2026
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In comparing real-world costs and benefits of fibromyalgia medications, a clear winner emerges
Fibromyalgia is a long-term chronic condition that causes widespread pain in the muscles and soft tissues throughout the body. The illness can affect people of all ages and has a major impact on quality of life, often making ...
Wastewater reveals increase in new synthetic opioids during major New Orleans events
In early 2025, the party-loving city of New Orleans, Louisiana, hosted two major events within the span of a month: Super Bowl LIX and Mardi Gras. And, as with many major events, it appears there was an increase in recreational ...
Feb 10, 2026
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Can a 'love hormone' drug prevent stress anxiety? What rat tests suggest
Researchers at São Paulo State University (UNESP) in Brazil have demonstrated in rats that a synthetic version of oxytocin can prevent anxiety-related behaviors caused by social stress. The study was published in the journal ...
Feb 10, 2026
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Global study marks major treatment advance for tough-to-treat high-risk blood cancer
Results from a new clinical trial led by Wake Forest University School of Medicine and Atrium Health Levine Cancer show that a new therapy could provide significantly better outcomes for patients with high-risk essential ...
Feb 10, 2026
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