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Clinical pharmacology news
Potential gene therapy for late-stage Parkinson's side-effects uncovered
Northwestern Medicine scientists have discovered that suppressing excitatory synaptic transmission in a small group of neurons in the brain may reverse levodopa-induced dyskinesia in patients with late-stage Parkinson's disease ...
4 hours ago
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Injectable hydrogel relieves osteoarthritis pain and repairs cartilage in preclinical tests
For millions of people living with osteoarthritis, daily life can involve a frustrating cycle of pain and stiffness. While current treatments like over-the-counter medications or steroid injections can temporarily dull the ...
8 hours ago
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AI misses cancer drug target, revealing why lab validation still matters
Researchers at the Icahn School of Medicine at Mount Sinai have identified a previously hidden druggable site in a cancer-related protein that could open the door toward the development of a new generation of more precise ...
6 hours ago
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Novel vaccine adjuvant could make it easier to eradicate polio
In the United States, children routinely receive an injectable form of the polio vaccine. This vaccine is very effective at preventing illness, but it doesn't block transmission of the polio virus as well as the oral polio ...
7 hours ago
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New antibiotic kills drug-resistant bacteria by targeting previously unknown vulnerability
Researchers at McMaster University have discovered a new antibiotic that kills some of the world's most dangerous and drug-resistant bacteria—and does so by targeting a previously unknown vulnerability, opening the door to ...
9 hours ago
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Life-changing benefits of hydroxyurea for sickle cell anemia affirmed by 10-year study
Fewer serious complications. Fewer hospitalizations and blood transfusions. Better growth and development. And a markedly lower risk of death from the complications of sickle cell anemia.
5 hours ago
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Dengue vaccine shows favorable safety profile in travelers from non-endemic regions
Data from 1,028 people vaccinated with TAK-003 in Catalonia suggests the dengue vaccine has a good tolerability profile in routine clinical practice among travelers from regions where dengue is not endemic. The findings come ...
1 hour ago
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Aspirin may unmask silent bladder cancer by triggering bleeding
The presence of blood cells in urine is a sign of bladder cancer. Because aspirin blocks platelets from forming harmful blood clots, the medication can cause mild bleeding or worsen existing bleeding in the urinary tract. ...
18 hours ago
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Semaglutide linked to better quality of life in diabetes and kidney disease, trial shows
New findings from the landmark FLOW trial, presented at the 63rd ERA Congress, show that once-weekly semaglutide significantly improved health-related quality of life in adults with type 2 diabetes and chronic kidney disease, ...
3 hours ago
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Telehealth booms as demand for GLP-1s surges and questions mount about safety, oversight
Within 24 hours of injecting the first dose of a weight loss medication she received following a visit with a telehealth doctor, Karleigh McClain was admitted to the hospital, she said. The 31-year-old compliance consultant ...
3 hours ago
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To curb overprescribing for seniors, researchers urge annual prescription checkups
To address the growing problem of overprescribing for seniors, a new Canadian guideline is calling for routine medication reviews. In Canada, roughly two in three adults age 65 or older take five or more medications. While ...
7 hours ago
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Single-cell platform tracks antibody drug delivery inside stubborn solid tumors
A recent paper in Nature Biotechnology examines problems and solutions for antibody-based therapies for solid pancreatic cancers and tumors of the head and neck.
16 hours ago
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Mathematical modeling tackles the human psychedelic experience
Psychedelic drug experiences are among the most fascinating but mysterious journeys of the human mind. Long the domain of indigenous shamans and modern "psychonauts" who seek self-discovery, the sensory-rich experiences often ...
9 hours ago
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Early paracetamol treatment may speed closure of preterm infants' ductus arteriosus
Patent ductus arteriosus (PDA) is a common condition in preterm infants in which the fetal blood vessel connection between the aorta and the pulmonary artery does not close normally after birth. The condition can increase ...
10 hours ago
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Ranking high blood pressure drug combinations from most to least tolerated
The Global Hypertension Report by the World Health Organization (WHO) revealed that 1.4 billion people were living with hypertension in 2024. Yet, only a little over one in five of those diagnosed have it under control, whether ...
Existing drug enhances muscle repair during GLP-1 weight-loss treatment in mice
Millions of Americans are currently taking GLP-1 medications such as Ozempic or Wegovy for weight loss. But along with the fat, many are quietly losing something else: muscle. Unlike fat, muscle doesn't return quickly, and ...
Jun 2, 2026
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Serious infection risks linked to targeted cancer therapies
A major real-world study by University of California, Irvine pharmacy researchers has found serious blood-related side effects associated with antibody-drug conjugates, an increasingly important class of targeted cancer therapies. ...
Jun 2, 2026
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Combination of five mRNAs mitigates heart failure after myocardial infarction, research reveals
A heart attack is far from an isolated, acute event. The consequences of an attack can cause serious and lasting damage, including heart failure. However, researchers and clinicians have been unable to determine a standardized ...
Jun 2, 2026
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Acetaminophen reaffirmed as first-line medication for treating pain and fever during pregnancy
Acetaminophen remains the recommended first-line medication to treat pain and fever during pregnancy, according to an updated statement from the Society for Maternal-Fetal Medicine (SMFM). A comprehensive review of the available ...
Jun 2, 2026
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GLP-1 agonists linked to significantly lower long-term risk of knee replacement
GLP-1 receptor agonist drugs, used for the treatment of diabetes—and more recently, weight loss—are associated with a significantly lower long-term risk of knee replacement surgery as a result of osteoarthritis, finds an ...
Jun 2, 2026
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Understanding the complex relationship between opioids and suicidal ideation in spinal cord injury survivors
For the roughly 300,000 Americans living with a spinal cord injury (SCI), chronic pain is often a part of daily life, and—for many—opioids are prescribed to combat it. In addition to the serious physical considerations, mental ...
Jun 2, 2026
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GLP‑1 drugs like Ozempic show promise for more than weight loss, but what's science vs. hype?
You've probably heard of Ozempic or Wegovy. These are the injectable drugs that have become household names for weight loss and diabetes.
Jun 2, 2026
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First‑in‑human study tests gamitrinib designed to disrupt cancer cells' energy systems
Cancer cells need large amounts of energy to survive and multiply. To produce that energy, they rely on structures inside the cell called mitochondria, often described as the cell's "powerhouse." Unlike healthy cells, cancer ...
Jun 2, 2026
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NASA medication storage protocols evaluated
Southwest Research Institute evaluated NASA's medication handling practices, which currently call for removing medications from their original packaging and storing them in resealable plastic bags. Although this allows astronauts ...
Jun 2, 2026
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GLP-1 use linked to lower breast cancer incidence in large cohort study
A retrospective analysis of more than 110,000 women between the ages of 45 and 80 found that those who took GLP-1 medications were about 30% less likely to develop breast cancer than those who did not take GLP-1 medications, ...
Jun 2, 2026
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