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Clinical pharmacology news
No clear evidence that cannabis-based medicines relieve chronic nerve pain, updated review finds
There is no clear evidence that cannabis-based medicines provide pain relief for chronic neuropathic pain, an updated review in the Cochrane Database of Systematic Reviews finds.
1 hour ago
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Shelf-stable mRNA delivery system targets bladder cancer cells without immune response
Published, peer-reviewed research shows a patent-pending, virus-mimicking platform technology developed at Purdue University improves upon traditional methods of targeting bladder cancer cells with messenger RNA (mRNA) therapies.
8 hours ago
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Alpha-2 receptor drugs reduce heavy alcohol drinking, study finds
Alcohol use is widespread and alcohol use disorder (AUD) causes substantial harm. AUD affects 29 million individuals and causes more than 140,000 deaths annually in the U.S. alone. Individuals with AUD also often struggle ...
Jan 17, 2026
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Seniors with dementia being prescribed dangerous mind-altering drugs, study says
Many seniors with dementia are being put at risk by brain-altering medications linked to falls, confusion and hospitalization, a new study says.
Jan 17, 2026
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Oral drug can safely lower triglycerides and other blood lipids, clinical trial finds
When eating, the body converts extra calories, especially from carbs, sugar, fats, and alcohol, into triglycerides. Triglycerides are a form of fat or lipid, which the body stores away into its fat cells as an energy fuel ...
Jan 16, 2026
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Simulations predict antibody drug viscosity, paving way for easier self-injection
Monoclonal antibodies (mAbs) aid the body against autoimmune diseases and cancer, among other things. Patients have to pick up the medicine every few weeks. It would be easier for them to be able to inject the medicine themselves ...
Jan 16, 2026
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The stop-smoking medication varenicline may also work for cannabis use disorder
A new randomized controlled trial has found promising evidence that the smoking cessation medication varenicline (Chantix/Champix) can help people with cannabis use disorder (CUD) to reduce cannabis use. CUD is a rising problem ...
Jan 15, 2026
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Studies show that less frequent, all-injectable treatment for HIV is safe and preferred by adolescents
Adolescents with Human Immunodeficiency Virus (HIV) in Botswana, South Africa, Thailand, Uganda and the United States who received the injectable intramuscular antiviral medications cabotegravir and rilpivirine for nearly ...
Jan 15, 2026
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Findings suggest that certain medications for type 2 diabetes reduce risk of dementia
A large McGill University study has found that two classes of medications commonly prescribed for type 2 diabetes, both incretin-based, are associated with a reduced risk of dementia.
Jan 15, 2026
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FDA moves to remove suicide warnings from GLP-1 weight loss drugs
Federal health regulators say popular weight loss drugs like Wegovy and Zepbound do not increase the risk of suicidal thoughts, and they have asked drugmakers to remove those warnings from medication labels.
Jan 15, 2026
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Safe, low-cost Alzheimer's drug demonstrates efficacy against sickle cell anemia
Memantine, a long-approved and cost-effective drug used to treat Alzheimer's disease, could also benefit patients with sickle cell anemia in the future. Initial clinical data from an international research group led by the ...
Jan 15, 2026
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Potential new treatment for sepsis
Griffith University researchers may have unlocked the secret to treating sepsis, with a Phase II clinical trial in China successfully concluding with promising results.
Jan 15, 2026
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Trial reveals gene variant may affect prostate cancer drug efficacy
Data from a major U.S. clinical trial from the Alliance for Clinical Trials in Oncology has uncovered a genetic factor that may inform how to optimize the dosing of abiraterone, a widely used hormone treatment for advanced ...
Jan 15, 2026
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Researchers revive an abandoned depression drug target using structurally novel NK1 receptor inhibitors
For decades, scientists have investigated the neurokinin-1 receptor (NK1R) as a potential target for treating major depressive disorder. Early studies suggested promise, but enthusiasm faded after clinical trials of drugs ...
Jan 14, 2026
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CBD treatment reverses key effects of fetal alcohol spectrum disorder in mouse model
Cannabidiol (CBD) could become a therapeutic tool to address some of the most frequent and disabling consequences of fetal alcohol spectrum disorder (FASD), a condition caused by alcohol exposure during pregnancy. This is ...
Jan 14, 2026
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Q&A: Want to buy weight loss drugs? Here's what you should know first
When endocrinologist Dan Bessesen, MD, looked online and saw how easy it would be for him to purchase a weight loss drug from a compounding pharmacy without being seen by a medical provider, he was disturbed.
Jan 14, 2026
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Study focuses on safer opioid prescribing
With an estimated 5 million Americans battling opioid use disorder—resulting in tens of thousands of deaths each year—a new study by the University of Texas at Arlington examines how updated Centers for Disease Control ...
Jan 14, 2026
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Study finds non-hallucinogenic psilocybin neural receptor: A novel target for treating depression and anxiety
Psilocybin—the psychedelic compound that occurs naturally in certain "magic" mushroom species—has been shown in trials to provide long-term treatment for depression and anxiety. But the chemical's hallucinogenic effects ...
Jan 13, 2026
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New drug candidate reverses metabolic liver disease and fibrosis, pre-clinical data show
Researchers at McMaster University are leading preclinical studies into a novel drug candidate developed by Espervita Therapeutics that has the potential to prevent and reverse liver fibrosis—a dangerous, disease-induced ...
Jan 13, 2026
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Novel immunotherapy demonstrates early potential to overcome resistance to immune checkpoint therapy
According to a Phase I study led by researchers at The University of Texas MD Anderson Cancer Center, published in Nature Medicine, the novel monoclonal antibody linavonkibart has demonstrated the potential to overcome treatment ...
Jan 13, 2026
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The journey of the molecule behind a male birth control pill
A newly published manuscript authored by Dr. Gunda Georg, YourChoice Therapeutics and Columbia University Medical Center describes the chemical journey of YCT-529, a non-hormonal male birth control pill, and the promising ...
Jan 13, 2026
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New combination therapy developed for frequent form of lung cancer
A research team at the Medical University of Vienna has discovered a new approach to treating a particularly frequent and difficult-to-treat form of lung cancer. The study shows that a combination of two well-studied classes ...
Jan 13, 2026
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Abnormally slow heart rate associated with xylazine-fentanyl overdose
Researchers have identified bradycardia—an abnormally low heart rate—as a symptom of xylazine-opioid overdose. This breakthrough finding from the Icahn School of Medicine at Mount Sinai may help emergency medicine physicians ...
Jan 13, 2026
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Disrupting HDAC1 condensates in glioblastoma could help to overcome drug resistance
Glioblastoma (GBM) is one of the most common and aggressive primary brain tumors in adults, carrying an extremely poor prognosis and a median overall survival typically less than two years. Temozolomide (TMZ) is currently ...
Jan 13, 2026
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Three-dimensional magnetic torque enables heart mechanics in organoids
Heart disease remains the leading cause of death worldwide, yet progress in understanding and treating cardiac disorders is limited by the shortcomings of existing experimental models. Traditional animal models often fail ...
Jan 13, 2026
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