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Clinical pharmacology news
A nasal spray reaches a woman's brain differently depending on the week, study finds
Consider what is asked of a clinical trial. Researchers gather people who differ in nearly every way that matters. They are given the same drug at the same dose, and then they average the result and call the average truth. ...
3 hours ago
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Copper drug restores memory and clears toxic Alzheimer's proteins, preclinical study finds
Monash University researchers have found in laboratory experiments that a drug that delivers copper to the brain significantly reduces toxic Alzheimer's proteins and improves long-term spatial memory.
15 hours ago
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Why some cancers return: Robotic mini tumor tests point to new ways to target persister cells
Cancer drugs can shrink fast-growing tumors. But sometimes a few tumor cells survive. These "persister" cells seed new tumors, forcing cancer patients into arduous cycles of testing and treatment.
16 hours ago
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Combo treatment delays multiple myeloma progression and may improve survival, study finds
Patients with multiple myeloma who received a new immunotherapy combination lived significantly longer without their cancer worsening and showed early signs of improved survival in a large international clinical trial.
10 hours ago
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Anti-inflammatory molecule shows potential against Parkinson's in murine study
Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have discovered a new strategy that may protect neurons and other brain cells involved in Parkinson's disease in the future. The results of the study, ...
14 hours ago
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ENDO: GLP-1 receptor agonists tied to higher hypotension risk in patients on BP meds
Among patients with preexisting hypertension taking antihypertensive medications, glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with an increase in hypotensive-related events, according to a study ...
10 hours ago
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Targeting delivery to the lungs: Inhaled vitamin D could be new strategy
People with chronic lung diseases like chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis tend to have low vitamin D levels, and these low levels are linked to worse respiratory health outcomes. This ...
13 hours ago
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Tirzepatide may change how the body uses energy, trial suggests
Tirzepatide doesn't just help people lose weight; it also activates brown adipose tissue, representing a major milestone in obesity research, according to a study presented at ENDO 2026, the Endocrine Society's annual meeting ...
13 hours ago
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As injectable peptides surge online, researchers warn regulation is falling behind
A new Viewpoint published in JAMA from researchers at the University of Queensland, the University of Toronto and the University of California, San Francisco, is raising concern about a fast-growing but poorly understood ...
13 hours ago
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Behavioral modifications like goal setting could lead to greater weight loss on tirzepatide
One of the largest real-world studies of people taking GLP-1 medications found women, those without pre-existing conditions such as type 2 diabetes and high blood pressure, and behavioral factors such as previously setting ...
13 hours ago
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Tirzepatide GLP-1 medication may be most effective for weight loss
GLP-1 medications are marketed to help you lose weight, but one may be better at it than the rest, according to a new meta-analysis from the University of Georgia.
17 hours ago
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Clinical trials suggest GLP-1s may improve fertility in men with obesity
GLP-1s do not harm male hormones or fertility after long-term use, according to a study being presented Monday at ENDO 2026, the Endocrine Society's annual meeting in Chicago. In fact, the research team found GLP-1s may improve ...
18 hours ago
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Study of 5.8 billion medicines dispensed in England exposes stark health inequalities
Scientists have revealed striking inequalities and changing trends in medicines dispensing for more than 52 million people living in England during and after the COVID-19 pandemic.
17 hours ago
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Laxative drug could ease depression-related brain fog, early trial suggests
People with depression who find that it affects their memory or attention span could benefit from an existing licensed drug currently used to treat chronic constipation.
Jun 14, 2026
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Creating mini-brains from stem cells reveals a new, promising treatment for a devastating childhood disease
Variants in the DHDDS gene cause a severe neurodegenerative condition, characterized by tremors, seizures, coordination and learning difficulties, usually manifesting in early childhood. This Parkinson's-like condition is ...
Jun 14, 2026
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Semaglutide linked to lower bone fracture risk
In people with type 2 diabetes, semaglutide was associated with a 15% reduction in bone fractures and greater weight loss compared with other anti-obesity medications, according to a study presented at ENDO 2026, the Endocrine ...
Jun 14, 2026
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Inflation Reduction Act's out-of-pocket cap lowered insulin costs, improved usage for some patients
The Inflation Reduction Act's attempt to improve insulin costs for Medicare beneficiaries—by capping out-of-pocket costs at $35—was associated with lower out-of-pocket costs and increased insulin use, but only for a small ...
Jun 14, 2026
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Glucosamine supplements may speed memory loss from Alzheimer's, new research shows
People with Alzheimer's disease who took the common supplement glucosamine were 25% more likely to die within five years than those who didn't. That's the key finding of a new study that my colleagues and I published in the ...
Jun 13, 2026
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Study finds exercise decreases among people taking GLP-1 medication
Adults with obesity who lost weight with glucagon-like peptide-1 (GLP-1) receptor agonist medications significantly decreased their physical activity, which is essential to protect muscle, according to a study presented at ...
Jun 13, 2026
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Adding genetic data to steroid prescribing can help predict side effects, data suggest
Oral corticosteroids (OCSs) are widely used and effective in the treatment of chronic inflammatory conditions such as arthritis, asthma and autoimmune diseases. They work by reducing inflammation, relieving pain and calming ...
Jun 13, 2026
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Key mechanism regulating the anti-inflammatory function of extracellular vesicles identified
A study led by the Innovation in Vesicles and Cells for Application in Therapy (IVECAT) group at the Germans Trias i Pujol Research Institute (IGTP) has identified a key mechanism regulating the anti-inflammatory function ...
Jun 13, 2026
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Engineers find a way to deliver drugs directly to the esophagus
There are few treatment options available for people with disorders of the esophagus. Delivering drugs directly to this part of the body is difficult, so patients are usually treated with systemic drugs, which can have unwanted ...
Jun 12, 2026
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Scientists track single-dose vaccines for Andes hantavirus strain
In a study published in The Lancet, researchers at The University of Texas Medical Branch (UTMB) report the development of new vaccines that, in animal testing, provided full protection against the deadly Andes hantavirus ...
Jun 12, 2026
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Metal-free carbon monoxide prodrugs may help prevent cancer's deadly spread
A carefully designed metal-free carbon monoxide prodrug—an inactive compound that is converted into its active form in the body—may help prevent some of the deadliest forms of cancer from spreading, according to researchers ...
Jun 12, 2026
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A fentanyl countermeasure that adapts to combat future black-market drugs
Fentanyl and related variants of the synthetic opioid kill more Americans each year than car accidents and gun violence combined. In too-high doses, the drugs hijack brain chemistry and shut down the signals that control ...
Jun 12, 2026
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