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Clinical pharmacology news
Epigenetic drugs could protect blood vessels in obesity and diabetes
People with obesity and type 2 diabetes are at high risk of blood vessel damage. This risk depends not only on the genes a person carries, but also on how they are "read." By changing the epigenetic reading signals in the ...
8 hours ago
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Global clinical trial reveals safest, most effective antibiotics for golden staph bloodstream infections
An international clinical trial has identified the optimal antibiotics for golden staph bloodstream infections, a breakthrough set to reshape treatment for the life-threatening condition. The SNAP Trial found that the standard ...
13 hours ago
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AI screens 6 million compounds to uncover two leads against drug-resistant gonorrhea
With tens of millions of annual cases, gonorrhea is the second most frequently reported sexually transmitted infection (STI). In the U.S. alone, more than 600,000 cases are reported each year. If left untreated, gonorrhea ...
15 hours ago
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FDA panel considers a first-of-its-kind flu vaccine using mRNA technology
U.S. health advisers are debating a new kind of flu vaccine Thursday, the first made with the same mRNA technology that was key to ending the COVID-19 pandemic.
9 hours ago
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Rhythmic drug dosing may boost safety and efficacy in chronic liver disease
Metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are progressive chronic liver diseases linked to abnormal bile acid metabolism. Although ...
12 hours ago
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The vaccines and treatments being developed for Ebola outbreak
There are no vaccines or treatments for the strain of Ebola that has killed more than 200 people in DR Congo and Uganda, but several are being urgently developed in the hope of reining in the outbreak.
7 hours ago
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Time for better opioid detoxification strategies, researchers say
Addiction services must urgently consider the way they offer support for those wanting to come off opioid substitutes through detoxification, according to researchers at Imperial College London.
11 hours ago
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Cannabis caution as study finds increased psychosis risk for young people
Young people who use cannabis daily are up to four times more likely to develop psychosis than those who don't, according to an international study led by University of Queensland researchers. The review analyzed evidence ...
14 hours ago
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Legalizing cannabis increases use and addiction, unless it is tightly controlled, says research
Removing criminal penalties for possessing cannabis for personal use, or introducing tightly controlled legalization of cannabis, does not appear to increase levels of cannabis use. However, the commercial sale of cannabis ...
Jun 17, 2026
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Pakistani genomes reveal 34,000 knockouts that could explain why mouse-based drugs fail in humans
A comprehensive analysis of 173,303 genomes from Pakistan, published today in Nature, is upending how scientists understand human genetics and drug development. By identifying 34,000 people who are "human knockouts," with ...
Jun 17, 2026
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Inhibiting high levels of leukemia ABCD1 protein with jojoba could lead to new treatment option
University of Guelph research published in the journal publication Blood has uncovered a surprising weakness in acute myeloid leukemia (AML) that a compound in a common skin care ingredient may be able to target.
Jun 17, 2026
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An experimental molecule 'reprograms' the brain's defenses against Alzheimer's disease
A team has identified an experimental molecule capable of "reprogramming" the brain's immune cells to restore part of their protective function against Alzheimer's disease. The study, published in the journal Cell Death and ...
Jun 17, 2026
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Q&A: What does science say about plants as medicine?
Plants have always played an integral role in traditional medicine and healing practices, according to Kent Vrana, Elliot S. Vesell Professor of Pharmacology at Penn State College of Medicine, and they continue to shape health ...
Jun 17, 2026
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Why weight‑loss drugs don't work for some people
Weight-loss jabs are the latest craze for shedding a few pounds. Their effect has been dramatic, with drugs such as Ozempic and Wegovy (semaglutide) causing users to lose up to 15% of their body fat on average.
Jun 17, 2026
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FAP-targeted radiopharmaceutical therapy shows broad effectiveness across multiple cancers
A novel radiopharmaceutical therapy approach that targets fibroblast activation protein (FAP)—which is highly expressed in many types of cancer—is safe and effective for patients, according to a new study published in the ...
Jun 17, 2026
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How do beta blocker heart drugs actually work for anxiety?
A reality TV star's claim that a beta blocker dulled their emotions and made them appear calm on camera has sparked a wave of social media commentary.
Jun 17, 2026
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Researchers discover a new therapeutic target to prevent thrombi with a lower bleeding risk
Antiplatelet drugs are one of the main tools used to prevent thrombus formation in people who have had a heart attack or stroke or who have cardiovascular diseases with a high thrombotic risk. These treatments work by reducing ...
Jun 17, 2026
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Can use of popular weight loss medications reduce behaviors linked to violent crime?
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for diabetes and obesity, but studies have found evidence that the medications may also influence behavior, such as supporting impulse control and ...
Jun 17, 2026
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Beyond GLP-1s: The next chapter of obesity care
The rapid rise of GLP-1 medications such as semaglutide and tirzepatide has transformed obesity treatment. Still, experts say medications alone are not enough to address one of the nation's most pressing chronic diseases.
Jun 17, 2026
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Kidney healing improves after protein blockade, with less scarring and faster recovery
A drug previously developed at UCLA to help heart tissue repair itself after a heart attack might also help kidney tissue repair and regenerate, researchers have found.
Jun 16, 2026
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Hidden PIM1 pathway helps prostate cancer survive treatment, pointing to new drug strategy
Cancer cells are remarkably good at adapting to stress. When treatments damage them, they often find new ways to survive, fueling drug resistance and disease progression.
Jun 16, 2026
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Tirzepatide outperformed semaglutide weight-loss drug results in real world patients, study shows
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become popular for weight loss, but results vary from person to person and from drug to drug. Venky Soundararajan and colleagues explored the full range of responses ...
Jun 16, 2026
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Repurposed drugs move through late-stage trials at up to 90% lower cost
Universities and hospitals are repurposing existing drugs through late-stage trials with funded costs up to 90% lower than those in the pharmaceutical industry. This "hidden" research system, which operates outside the patent ...
Jun 16, 2026
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ADA: Orforglipron beneficial for reducing HbA1c in type 2 diabetes
Orforglipron is beneficial for blood glucose control in individuals with type 2 diabetes using metformin or taking insulin glargine, according to two studies published online June 8 in The Lancet and the JAMA to coincide ...
Jun 16, 2026
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Three men's health drugs that were originally designed for a different purpose
Many medicines begin life with one purpose and end up proving useful for a completely different reason.
Jun 16, 2026
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