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Clinical pharmacology news
New drug combination doubles down on Alzheimer's treatments
A new study has found that combining the current medications for Alzheimer's disease with small molecules derived from micronutrients found in grapes, berries, peanuts and turmeric is a safer and more effective way to treat ...
20 hours ago
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Experimental drug cuts Parkinson's-linked protein up to 60% in early trial
An experimental drug designed to silence a gene strongly linked to Parkinson's disease has shown encouraging effects in a first-in-human clinical trial, according to a study published in Nature Medicine. The drug, known as ...
22 hours ago
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Coffee's sweet spot may help mental health in the long run
Your morning cup of coffee may be more than just a pick-me-up. It may also be a simple boost for your mental well-being. In a recent study, researchers from Fudan University, China, wanted to find out whether the amount of ...
Injectable peptides are the new anti‑aging trend. But what evidence do we have they're safe for humans?
Injectable peptides are the new anti-aging trend sweeping the beauty industry. These compounds are promoted on social media as tools for skin repair, collagen production and "cellular rejuvenation." They are widely available ...
Apr 11, 2026
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AI scans 400,000 Reddit posts to flag overlooked GLP-1 side effects
By using AI to analyze more than 400,000 Reddit posts, Penn researchers have identified patient-reported symptoms associated with GLP-1s, the popular weight-loss and diabetes drugs semaglutide and tirzepatide, that may not ...
Apr 10, 2026
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How the blood-brain barrier opens: Two proteins may guide future drug delivery
The cells that line the blood vessels in our brains are highly selective. By deciding which molecules are allowed in and out of our most important organ, the barrier these cells form is critical for keeping us alive. But ...
Apr 9, 2026
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Without the right tests, the best medicines make no difference
A new analysis from UC San Francisco argues that diagnostics—medical tests that match patients to the appropriate treatment—are being overlooked both in the United States and around the world. This is slowing progress against ...
Apr 9, 2026
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Why autism affects more men than women—MDGA1 gene mutation may help explain
Researchers have discovered that a mutation of the MDGA1 gene, a key factor modulating the connections and characteristics between nerve cells, serves as a new cause of autism spectrum disorder (ASD), and suggested the possibility ...
Apr 9, 2026
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Flu treatment shields lungs, cuts pneumonia risk
A new flu treatment could drastically reduce one of flu's deadliest complications—bacterial pneumonia—by helping the lungs defend themselves, rather than targeting the virus directly. Influenza specialist Associate Professor ...
Apr 9, 2026
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Psilocybin mushrooms are going mainstream, but scientific research and regulation lag behind
Amid a renaissance in the science of psychedelics, public interest in psilocybin—or magic mushrooms, as they've long been known—is surging.
Apr 9, 2026
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Some common IBS treatments are linked to a higher risk of death, say study
A large, long-term study led by Cedars-Sinai Health Sciences University investigators suggests that some medications commonly prescribed to treat irritable bowel syndrome (IBS)—including antidepressants—may be associated ...
Apr 8, 2026
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Parkinson's add-on drugs may spur gut bacteria that break down levodopa, study finds
Levodopa—the gold-standard treatment for Parkinson's disease—increases dopamine in the brain. But as the disease progresses in severity, patients often need to take additional drugs to manage their symptoms. One class of ...
Apr 8, 2026
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Antibody drugs with strong immune cell binding linked to allergic reactions
Antibody therapeutics are laboratory-made proteins designed to work like the body's natural antibodies. They are widely used to treat diseases such as cancer by binding to specific targets, including cancer cells or inflammatory ...
Apr 8, 2026
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Long-term opioid prescribing has fallen, but millions still receive extended opioid therapy
Long-term opioid prescribing has fallen in the United States over the last decade, but millions of patients still received opioids for 90 days or longer in 2023, according to a new research letter in JAMA led by University ...
Apr 8, 2026
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AAD: Subcutaneous amlitelimab aids atopic dermatitis outcomes through week 24
Amlitelimab, a fully human non-T cell depleting monoclonal antibody that selectively targets OX40-ligand (OX40L), is safe and effective, with potentially progressive efficacy over time, for patients with moderate-to-severe ...
Apr 8, 2026
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Genetic predictors for GLP-1 weight loss efficacy and side effects identified
23andMe Research Institute, a nonprofit medical research organization, announced the publication of a study that identifies genetic predictors for GLP-1 weight loss efficacy and side effects. GLP-1 receptor agonists, including ...
Apr 8, 2026
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CBD found to reverse brain damage in mouse model of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss, cognitive decline, and behavioral changes. The deficits linked to AD are known to result from the abnormal accumulation of ...
Treating tumors independently of oxygen: Photodynamic therapy uses hydrogen peroxide instead
Photodynamic treatment of cancer is based on administering an initially inactive substance that is only activated in the tumor via targeted light irradiation. It then generates reactive oxygen species that kill the cancer ...
Apr 7, 2026
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Molecular map could unlock new treatments for heart and lung diseases
Scientists have created a new "molecular map" uncovering how an important human receptor involved in blood clotting and inflammation works—an advance that could help us design better drugs for conditions such as pulmonary ...
Apr 7, 2026
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Massive eye drop recall reflects ongoing issues with manufacturing and FDA inspection
A California company has recalled more than 3.1 million bottles of lubricating eye drops because it had not properly tested—and thus could not prove—whether the products were sterile. These products are sold under several ...
Apr 7, 2026
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Can medicinal cannabis help kids' autism, ADHD or Tourette's? Here's what we know so far
In the past 10 years or so, there has been a lot of interest to see if medicinal cannabis can help children with emotional and behavioral problems—the ones associated with conditions such as autism, ADHD (attention-deficit ...
Apr 7, 2026
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GLP-1 agonist drugs show digestive side effects but may help fight infections
Originally developed to treat diabetes, a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are now stepping into the spotlight as weight loss drugs. A recent umbrella review draws attention to ...
First-in-class molecules dial down inflammation without compromising immunity
Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact—a long-sought goal in treating autoimmune diseases. The ...
Apr 6, 2026
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This is your brain on psychedelics: Neuroimaging study sheds light on cortical network effects
Psychedelic drugs are being investigated as scientific and clinical tools, but the brain mechanisms behind their effects remain unclear. Earlier brain imaging studies in small cohorts from single centers produced inconsistent ...
Apr 6, 2026
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Precision oncology success: Individualized multi-drug therapy outperforms standard care
A new article in the News and Perspectives section of the Journal of Medical Internet Research showcases the transformative potential of precision oncology. The article, "Further Promise and Potential for Precision Medicine ...
Apr 6, 2026
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