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Clinical pharmacology news
HIV can develop resistance to blockbuster antiviral lenacapavir—but at a cost to the virus
Long-acting antiviral medications are transforming HIV prevention and care, requiring only minimalistic dosing. But as the use of lenacapavir expands, scientists are probing a critical question: If the virus evolves resistance, ...
20 hours ago
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Developing a human hepatocyte model with enhanced drug-metabolizing enzyme activity
A research team led by Associate Professor Shinpei Yamaguchi and the late Professor Masako Tada of the Faculty of Science, together with Professor Yojiro Anzai and Lecturer Yohei Iizaka of the Faculty of Pharmaceutical Sciences ...
14 hours ago
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A blood marker could predict how people respond to antidepressants
Major depressive disorder (MDD) is among the most common psychiatric disorders, affecting approximately 330 people worldwide. This disorder is characterized by persistent feelings of sadness, hopelessness, low motivation, ...
A new drug target for sleeping sickness and Chagas? Why the PEX38 protein stands out
Researchers working with Professor Ralf Erdmann at Ruhr University Bochum, Germany, have discovered a critical vulnerability shared by the pathogens that cause African sleeping sickness, Chagas disease, and leishmaniasis. ...
Feb 27, 2026
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Muscle repair may hinge on a timed metabolic 'switch,' study suggests
Scientists at the University of California, Irvine's School of Pharmacy & Pharmaceutical Sciences have discovered how muscle stem cells "flip a switch" to rebuild damaged muscle—a finding that could help address muscle ...
Feb 27, 2026
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Understanding GLP-1 signaling: A path to better therapies
About one in eight U.S. adults are currently taking a GLP-1 drug such as Ozempic, Wegovy, or Zepbound to treat diabetes, obesity, or other conditions, according to a KFF Health Tracking poll. But many suffer from significant ...
Feb 27, 2026
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Study compiles 30 years of adhesion GPCR modulators and their key concentrations
Adhesion GPCRs are a large class of surface proteins that recognize chemical and mechanical stimuli in the body. The rapidly expanding body of knowledge on the therapeutic targeting of these receptors is raising hopes for ...
Feb 27, 2026
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Monthly cabotegravir-rilpivirine injections superior to standard oral ART for HIV with adherence challenges
Monthly injections of long-acting cabotegravir-rilpivirine are superior to standard oral antiretroviral therapy (ART) in persons with human immunodeficiency virus (HIV) and medication adherence challenges, according to a ...
Feb 27, 2026
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Q&A: Prescription drug ads are everywhere. Is the 'ask your doctor' era over?
It's rare to make it through an episode of your favorite show without seeing a commercial for a prescription drug that includes a lengthy list of side effects and a prompt to speak with a doctor. And while these familiar ...
Feb 27, 2026
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Patients with atrial fibrillation face higher bleeding risks when treated with 2 common medications
Patients with atrial fibrillation who are prescribed diltiazem to control heart rate alongside anticoagulants (blood thinners) such as apixaban or rivaroxaban face a higher risk of serious bleeding compared with those taking ...
Feb 27, 2026
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Novel delivery method bypasses blood-brain barrier to treat ALS symptoms
A researcher at the University of Missouri has made a promising breakthrough in the quest to help people with amyotrophic lateral sclerosis (ALS), the neurodegenerative disorder commonly known as Lou Gehrig's disease. In ...
Feb 26, 2026
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Antibody developed to protect immune system cells in vitro from a dangerous hospital-acquired bacterium
A monoclonal antibody created by the Nanobiotechnology for Diagnostics group (Nb4D) at the Institute of Advanced Chemistry of Catalonia (IQAC), part of the Spanish National Research Council (CSIC), has demonstrated in cell ...
Feb 26, 2026
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New GLP-1 pill orforglipron outperforms oral semaglutide in yearlong diabetes trial
A novel GLP-1 receptor agonist (RA) pill called orforglipron leads to a larger reduction in blood sugar levels after a year than the current available oral GLP-1 RA (semaglutide), finds a phase 3 randomized controlled trial ...
Feb 26, 2026
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Oral semaglutide found to lower risk of heart failure events in people with type 2 diabetes
An international clinical trial has found that an oral form of semaglutide, a widely used diabetes drug, reduced the risk of serious heart failure events in people with type 2 diabetes who already had heart failure. The findings, ...
Feb 26, 2026
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Starving cancer: The effects of nutrient deprivation on synovial sarcoma
Synovial sarcoma is an aggressive malignant tumor that primarily affects the limbs of teenagers and young adults. While it can be cured if completely removed by surgery, recurrence or metastasis, the spread of cancer to organs ...
Feb 26, 2026
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Study identifies erythropoietin as a potential active ingredient in Primrose syndrome
A research team from Mannheim, Göttingen, Varna, and Princeton has discovered in animal studies with mice that the growth factor recombinant human erythropoietin (rhEPO) can significantly improve cognitive and social problems ...
Feb 26, 2026
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FDA approves Dupixent for allergic fungal rhinosinusitis
The U.S. Food and Drug Administration has approved Dupixent (dupilumab) for the treatment of adult and pediatric patients aged 6 years and older with allergic fungal rhinosinusitis (AFRS) and a history of sino-nasal surgery.
Feb 26, 2026
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Single daily pill shows promise as replacement for complex, multi-tablet HIV treatment regimens
A new, daily oral tablet that combines two current HIV treatment medications, bictegravir and lenacapavir (BIC/LEN), could effectively replace more complicated HIV treatment regimens used by people living with HIV who are ...
Feb 25, 2026
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Aspirin not a quick fix for preventing bowel cancer, review finds
Daily aspirin use does not offer a quick or reliable way to prevent bowel cancer in the general population and carries immediate risks of serious bleeding, a new Cochrane review finds.
Feb 25, 2026
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Many post-authorization studies fail to comply with public disclosure rules
Many post-authorization studies registered with the European Medicines Agency (EMA) fail to comply with legal requirements and recommendations to make their findings public, finds a study published by The BMJ. Post-authorization ...
Feb 25, 2026
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Opioids aren't effective for many acute pain conditions, researchers warn
A large review of opioid pain relievers prescribed for acute pain has found these medicines provide only small, short-term relief for some acute conditions and are ineffective for some others. The study set out to review ...
Feb 25, 2026
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Natural compound from pomegranate leaves disrupts disease-causing amyloid
A research team at Kumamoto University has discovered that a natural compound found in pomegranate leaves and branches can directly break down harmful protein aggregates linked to transthyretin (TTR) amyloidosis, a progressive ...
Feb 24, 2026
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New strategy grabs cancer's 'undruggable' proteins and throws them in the cellular trash
When cancer-driving proteins resist various treatments, Northwestern University scientists have uncovered a new solution. Don't fight them—throw them in the cellular trash. In a new study published in Nature Communications, ...
Feb 24, 2026
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How an anti-obesity drug improves metabolism beyond weight loss
Tirzepatide is one of the drugs that has revolutionized the treatment of obesity and other conditions such as diabetes in recent years. Despite its clinical success, its precise molecular and cellular mechanisms are still ...
Feb 24, 2026
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Lifespan-extending treatments increase variation in age at time of death
A key goal in aging research is not just to extend life, but to ensure more people live longer and healthier lives with less variation in age at death, a concept known as "squaring the survival curve." Using a recent meta-analysis, ...
Feb 24, 2026
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