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Clinical pharmacology news
Why caffeine can sabotage deep sleep even when you still get eight hours
Evening coffee has sparked controversy for years. Some people fall asleep without difficulty, while others toss and turn for half the night. However, a growing body of research suggests the question of whether coffee makes ...
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Tirzepatide superior to intensified conventional care for early type 2 diabetes
Tirzepatide is superior to intensified conventional care (ICC) for adults with early type 2 diabetes (T2D) uncontrolled with metformin, according to a study published online May 26 in the Annals of Internal Medicine.
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KRAS degradation induces rapid lung cancer regression in preclinical mouse models
KRAS is one of the oncogenes most frequently altered in cancer, mutating in approximately one-third of lung adenocarcinomas. For decades, it was considered undruggable, until the recent approval of the first inhibitors against ...
9 hours ago
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Direct-to-consumer pharmacies could save commercially insured patients 85% on high-cost generic drugs, report suggests
A report comparing the Mark Cuban Cost Plus Drug Company (MCCPDC) to copayments or coinsurance under employer-sponsored insurance found that patients with high-cost generic prescriptions could lower their out-of-pocket costs ...
May 26, 2026
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Experimental mRNA vaccine shows promise against multiple Ebola strains
Scientists from China have developed a new broad-spectrum mRNA vaccine that could provide long-term protection against the most lethal family of Ebola viruses, including the Bundibugyo strain behind the current outbreak in ...
AI-guided drug search flags folic acid for diabetic wound healing
Researchers from the National University of Singapore (NUS) have developed an AI-guided workflow that combines artificial intelligence (AI) with molecular simulations to identify potential drug candidates for diabetic wound ...
May 25, 2026
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Macrophage cell therapy boosts four-year transplant-free survival in advanced cirrhosis
A new type of cell therapy shows promise as the first treatment for advanced liver disease, following results from a clinical trial. Patients with the condition who were treated with the cell therapy had a significantly lower ...
May 25, 2026
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FDA approves Enhertu as neoadjuvant, adjuvant treatment for breast cancer
The U.S. Food and Drug Administration has approved AstraZeneca's Enhertu (fam-trastuzumab deruxtecan-nxki) for both the neoadjuvant and adjuvant treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive ...
May 25, 2026
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The enhanced games, or 'steroid Olympics', are on—they pose risks for athletes and viewers
The inaugural Enhanced Games are underway in Las Vegas and are set to be a unique spectacle that promotes drug-induced "enhancement." The International Olympic Committee has condemned the event as a way to "destroy any concept ...
May 25, 2026
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Cholesterol-craving cancers need lipid enzymes to use metabolites for growth, study shows
While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite. Some tumor cells use as much cholesterol as they can access to accelerate their growth ...
May 22, 2026
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A once-daily pill takes aim at measles, croup and other dangerous viruses
A new oral antiviral drug candidate has been developed for the treatment of diseases caused by orthoparamyxoviruses, such as measles and croup syndrome, according to a study published by researchers in the Center for Translational ...
May 22, 2026
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Psilocybin cuts nerve pain for weeks and boosts gabapentin in mice
A single dose of psilocybin, the active compound in magic mushrooms, reduces nerve pain for up to a month and makes a widely used painkiller work more effectively, University of Reading research has found.
May 22, 2026
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Nitric oxide rewires gene expression in the brain, offering new insight into Alzheimer's disease
Genes undergo extensive editing through a process called alternative splicing, which greatly increases the size of the functional genome—the working portion of our DNA that helps make each person unique. Put simply, a single ...
May 22, 2026
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Researchers identify avenue for enhanced GLP-1-induced weight loss
A team of researchers at the National Institutes of Health (NIH) have unveiled new details about the events GLP-1 receptor agonists trigger within neurons, which have been largely unexplored until now. A study in mice identified ...
May 22, 2026
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Common epilepsy drug disrupts early brain growth in human organoids after 30-day exposure
It is known that the antiepileptic drug valproate increases the risk of developmental disorders in unborn children. A study conducted by the Karlsruhe Institute of Technology (KIT), the Heidelberg Academy of Sciences and ...
May 22, 2026
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A single dose of psilocybin eased depression symptoms for months, our study found
A single dose of psilocybin eased symptoms of depression within days, with benefits lasting for more than three months compared to placebo, our new study has found.
May 22, 2026
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Weight loss drug semaglutide helps patients who do not respond to bariatric surgery, research finds
Metabolic/bariatric surgery is a highly effective treatment for people living with severe obesity and/or metabolic health conditions, which works through changing the anatomy of the digestive system and thereby changing the ...
May 22, 2026
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Ozempic and other GLP-1 RAs could slow progression of some cancers, data suggest
Real-world data show that GLP-1 receptor agonists (GLP-1s) may reduce metastatic progression of certain obesity-related cancers, namely lung, breast, colorectal, and liver cancers. In addition, GLP-1 receptor (GLP-1R) expression ...
May 22, 2026
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EU regulator approves pill form of Novo Nordisk's Wegovy weight loss drug
Novo Nordisk has obtained approval for the pill form of its popular Wegovy anti-obesity drug in the European Union, the bloc's medicines regulator said on Friday.
May 22, 2026
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New indicator for response to therapy in pediatric cancers identified
A study by researchers at the University of Birmingham has identified a new biomarker for response to a specific cancer therapy, treating children with Ewing Sarcoma and other tumor types. The study, which is a Phase I/II ...
May 22, 2026
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Novel combination therapy could reduce leukemia relapse rate, extending window for bone marrow transplants
A research team from the Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has developed a novel combination therapy that significantly improves treatment ...
May 21, 2026
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Dementia drug may help treat alcohol withdrawal
A new study from researchers at the University of Kentucky's Sanders-Brown Center on Aging is exploring whether a drug originally developed to combat neuroinflammation in dementia could also help reduce the harmful brain ...
May 21, 2026
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Researcher develops 'smart, tiny bubbles' to treat cancer and heart disease
A cell 500 times thinner than a human hair could heal hearts and kill cancer cells, thanks to a patent-pending technology created by a University of Central Florida researcher and now licensed to a university donor in hopes ...
May 21, 2026
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Oral drug proves highly effective against chemotherapy-related low platelets in GI cancer trial
An oral medication already approved for thrombocytopenia in patients with liver disease significantly improved platelet recovery and helped patients with gastrointestinal cancers maintain platelet counts needed to continue ...
May 21, 2026
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Scientists make surprising discovery and find a possible new ally in the opioid crisis
Scientists at Bowling Green State University recently made a series of discoveries that could have wide-ranging implications for the future of the national opioid crisis. Through a partnership with the Toledo Lucas County ...
May 20, 2026
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