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Clinical pharmacology news
ADA: Once-weekly cagrilintide + semaglutide promising in type 2 diabetes
Once-weekly cagrilintide, an amylin receptor agonist, plus semaglutide is efficacious for adults with type 2 diabetes inadequately controlled with diet and exercise, receiving metformin with or without a sodium glucose cotransporter ...
1 hour ago
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Scientists track single-dose vaccines for Andes hantavirus strain
In a study published in The Lancet, researchers at The University of Texas Medical Branch (UTMB) report the development of new vaccines that, in animal testing, provided full protection against the deadly Andes hantavirus ...
8 hours ago
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Metal-free carbon monoxide prodrugs may help prevent cancer's deadly spread
A carefully designed metal-free carbon monoxide prodrug—an inactive compound that is converted into its active form in the body—may help prevent some of the deadliest forms of cancer from spreading, according to researchers ...
2 hours ago
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Engineers find a way to deliver drugs directly to the esophagus
There are few treatment options available for people with disorders of the esophagus. Delivering drugs directly to this part of the body is difficult, so patients are usually treated with systemic drugs, which can have unwanted ...
10 hours ago
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A fentanyl countermeasure that adapts to combat future black-market drugs
Fentanyl and related variants of the synthetic opioid kill more Americans each year than car accidents and gun violence combined. In too-high doses, the drugs hijack brain chemistry and shut down the signals that control ...
8 hours ago
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Shorter clinical trials of medication for alcohol use disorder can be as useful or more useful than longer trials
Randomized control trials that are shorter than 12 weeks show similar results to longer trials when assessing a new medication's effectiveness in helping someone with alcohol use disorder reduce or stop drinking. And in trials ...
3 hours ago
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Popular joint pain supplement might increase Alzheimer's risk, study says
A popular over-the-counter supplement taken for joint pain might increase people's risk for Alzheimer's disease, a new study says.
16 hours ago
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Cancer drug combo activates inflammatory signal that could boost immune response
What if a new combination of cancer drugs could sound an alarm, alerting the body's immune system to invoke a targeted response to cancer cells? Findings from a new study appear in a paper published in Nucleic Acids Research.
Jun 11, 2026
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New study shows metformin given during acute COVID-19 infection reduced risk of clinician-diagnosed long COVID by 50%
New findings from the ACTIV-6 randomized clinical trial provide important confirmation of prior clinical trial results that metformin, a widely available and inexpensive medication with an established safety record, reduced ...
Jun 11, 2026
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Drug reduces the risk of developing rheumatoid arthritis, clinical trial finds
A clinical trial led by researchers from Hospital Clínic de Barcelona, the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) and the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC) compared the effectiveness ...
Jun 10, 2026
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'Molecular eraser' destroys cancerous mRNA before protein forms, reshaping cancer cells
Many of the deadliest forms of cancer are caused by a pathological mutation in the RAS protein. Yet, to date, no effective treatment for this cancer protein has been found. A new research approach aims to prevent the protein ...
Jun 10, 2026
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Why the liquid you take with your medication matters
Some alkaline mineral and medicinal waters may weaken the enteric coating of medications within just a few minutes, potentially reducing their effectiveness, according to a new study by Semmelweis University. The study, published ...
Jun 10, 2026
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IV atorvastatin during myocardial infarction reduces myocardial damage compared to pre-infarction oral loading
Reducing the damage sustained by the heart during a myocardial infarction remains one of the major challenges in cardiology, even when the blocked coronary artery is reopened in a timely manner. Part of the myocardial injury ...
Jun 10, 2026
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New protein targets reveal 13 drug repurposing leads for progressive multiple sclerosis
A new study identified protein targets and drug candidates, including opportunities to repurpose existing drugs. Six key proteins were highlighted as potentially providing new insights and supporting future treatment development ...
Jun 10, 2026
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Once-weekly survodutide linked to drop in body weight in obesity
For adults with obesity without diabetes, once-weekly survodutide, an investigational glucagon receptor-glucagon-like peptide-1 receptor dual agonist, is associated with greater reductions in body weight than placebo, according ...
Jun 10, 2026
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Girls are biggest consumers of anxiolytic and sedative drugs among adolescents in most EU countries
Xabi Martinez-Mendia, a researcher at the EHU-University of the Basque Country, has analyzed how adolescent psychotropic drug consumption is linked to gender inequality and economic factors in 32 European countries. Published ...
Jun 10, 2026
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How modern rheumatoid arthritis treatments can protect bone health
A new review published in Calcified Tissue International highlights major advances in understanding and preventing bone loss in people with rheumatoid arthritis (RA), showing that modern antirheumatic therapies can significantly ...
Jun 10, 2026
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Single high dose of psilocybin temporarily restores lost abilities in an 80-year-old Alzheimer's patient
Psilocybin is a naturally occurring psychoactive compound found in mushrooms of the Psilocybe genus. These mushrooms may have existed on Earth for nearly 65 million years, dating to the asteroid impact that caused the dinosaurs' ...
New GLP-3 drug significantly slashes both weight and blood sugar levels in Phase III trial
Over the past few years, GLP-1 drugs have transformed the treatment landscape for obesity and type 2 diabetes. By mimicking a hormone that helps regulate blood sugar, slows digestion and curbs appetite, these medications ...
A popular joint pain supplement may accelerate dementia
New research has found an association between taking glucosamine, a popular over-the-counter supplement used for joint pain, and a higher likelihood of progressing from mild cognitive impairment to Alzheimer's disease. The ...
Jun 9, 2026
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New Lassa fever vaccine shows promising results for first-in-human clinical trial
Researchers at the University of Maryland School of Medicine's Center for Vaccine Development and Global Health, or CVD, report encouraging results from an early clinical trial that tested a new dual vaccine against Lassa ...
Jun 9, 2026
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Drug apitegromab may stop muscle loss when taking weight loss drugs
A drug called apitegromab may help preserve lean body mass during weight loss with tirzepatide, a GLP-1 receptor agonist, according to a phase 2 clinical trial published in Nature Medicine. The findings suggest that blocking ...
Jun 9, 2026
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Physician–researcher's work yields landmark five-year data for Crohn's disease drug
A physician–scientist and national leader in inflammatory bowel disease at the University of Cincinnati has led the publication of landmark five-year efficacy and safety data for guselkumab, a biologic therapy for moderately ...
Jun 9, 2026
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Key protein behind chemotherapy resistance in colorectal cancer identified
One of the most widely used chemotherapeutic agents for colorectal cancer is 5-fluorouracil (5-FU), a cornerstone treatment that has improved outcomes for countless patients. However, repeated treatment often leads to drug ...
Jun 9, 2026
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Encouraging trial results for AstraZeneca's new weight-loss pill
A new pill developed by the British pharmaceutical firm AstraZeneca appears to help people lose a similar amount of weight as other oral GLP-1 drugs, trial results showed Monday.
Jun 9, 2026
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