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Clinical pharmacology news
New oral GLP-1 drug delivers up to 12% weight loss in 36 weeks
A new strategy for delivering GLP-1 drugs to patients with obesity or who were overweight resulted in up to a 12% reduction in body weight after 36 weeks, according to a randomized phase II clinical trial published in Nature ...
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How high cholesterol dismantles the liver's defenses—and how a new drug could combat it
Cholesterol-related heart disease remains the leading cause of death worldwide, and while doctors have more tools than ever to treat it, many patients still can't achieve safe cholesterol levels or can't tolerate the side ...
10 hours ago
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Trials of two Ebola treatments to start in DRC next week: WHO
Trials of two separate potential treatments to fight the deadly Ebola outbreak in the Democratic Republic of Congo are expected to begin next week, the World Health Organization said Wednesday.
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Hidden medication risks for older Australians in aged care transition revealed
New research has shown concerning patterns of medication use among older Australians transitioning into residential aged care that may increase the risk of medication-related harm, highlighting opportunities to improve medication ...
10 hours ago
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Foundational research points to new therapeutic strategies for an emerging cancer drug
Pancreatic cancer is one of the deadliest cancers and the third-leading cause of cancer-related death in the United States. While scientists continue searching for new therapies, advances can also come from understanding ...
Jun 23, 2026
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FDA approves oral Utebzi antibiotic for complicated urinary tract infections
The U.S. Food and Drug Administration has approved GSK's Utebzi (tebipenem pivoxil), an oral antibiotic, for the treatment of complicated urinary tract infections (cUTIs).
Jun 23, 2026
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Lab-engineered proteins: A promising treatment for liver disease
The research group led by CIC biomaGUNE's Ikerbasque Research Professor Aitziber L. Cortajarena has developed an innovative anti-fibrotic and anti-tumor treatment by binding a synthetic protein to gold nanoclusters (small ...
Jun 23, 2026
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Testosterone therapy labels and limits may change under FDA proposal
The U.S. Food and Drug Administration (FDA) is asking drugmakers to update the prescribing information on testosterone replacement therapy products to reflect newer clinical evidence.
Jun 23, 2026
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Promising single-dose malaria treatment advances toward pan-African clinical trial
Researchers at the German Center for Infection Research (DZIF) have developed a promising single-dose malaria treatment that could help address growing drug resistance and simplify treatment for patients. The four-drug combination ...
Jun 23, 2026
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Expert explains how two pieces of federal action may impact marijuana research, sales, transport, and consumption
As the U.S. Drug Enforcement Administration (DEA) gears up for its administrative hearing on the fate of federal marijuana legalization, UNLV Cannabis Policy Institute (CPI) director Riana Durrett offers a rundown on decades ...
Jun 23, 2026
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Erucamide molecule strengthens the eye's response to damage in retinal disease
Many conditions that cause vision loss share a common feature: the gradual breakdown of the retina, the light-sensing tissue at the back of the eye. Although scientists know some of the structural changes that ensue as this ...
Jun 22, 2026
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Weight‑loss drugs like Ozempic could work for addiction too—and we finally know how
For many people, the thought of a tasty burger or a cold pint of beer conjures a vivid mental image and drives behavior. This link between thinking and doing serves a clear function—it motivates us to get the necessities ...
Jun 22, 2026
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Protective human antibodies target West Nile and related viruses
West Nile virus (WNV) is transmitted by mosquitoes and is increasingly relevant for Europe and worldwide. It can cause severe brain infection and death, yet there is no specific antiviral treatment or approved human vaccine. ...
Jun 22, 2026
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Can supplements keep your brain sharp? Why the evidence is more complicated than it seems
Many of us would like to keep our brains sharp as we get older. That has helped create a growing market for "brain-health" supplements. These include fish oil capsules and postbiotics, the beneficial, nonliving compounds ...
Jun 22, 2026
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Engineers test, validate novel method to improve pharmaceutical research and development
A patent-pending innovation created and validated in Purdue University's College of Engineering could strengthen pharmaceutical research and development in the areas of batch verification, encapsulation efficiency screening ...
Jun 22, 2026
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Study links real-time prescription monitoring to drop in high risk medication prescribing
Research shows that patients who see multiple doctors for high-risk medicines face increased risks of dependence, overdose and death, as well as reduced continuity of care.
Jun 22, 2026
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Clues to psilocybin's epigenetic effects on people with alcohol use disorder
Some psychedelics, psychoactive substances that alter people's mood, perceptions and mental processes, were recently found to be promising alternative treatments for some mental health disorders. The substance that has attracted ...
Common dizziness drug class shows promise for treating vestibular migraine
A new study finds that a class of oral and intranasal medications known as gepants may be an effective and well-tolerated treatment for vestibular migraine (VM). The findings are published in the journal Otolaryngology–Head ...
Jun 21, 2026
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Mass spectrometry platform could shrink cancer drug discovery cycle to four hours
Researchers at the Purdue Institute for Cancer Research (PICR) have developed a next-generation technology platform designed to accelerate one of the slowest and most challenging stages of cancer drug discovery: identifying ...
Jun 20, 2026
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The over‑50s are most likely to overdose. Here's how older people use drugs
When many of us think about drug overdose, we picture young people at a music festival or people dependent on street heroin. But the latest figures from the Penington Institute show older Australians are increasingly dying ...
Jun 20, 2026
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Hibernation-like cooling after stroke may reduce brain damage
Our body loves the state of homeostasis, where everything is in perfect equilibrium, from temperature to pH levels to fluid balance. As soon as the body's core temperature drops below 95°F (35°C) and stays there for a long ...
Gene therapy shows promise in ARC syndrome, a deadly childhood liver disease
A new gene therapy has been used to successfully treat a deadly childhood liver disease in mice that model the disease, according to researchers at UCL and Great Ormond Street Hospital. Arthrogryposis, renal dysfunction and ...
Jun 19, 2026
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FDA approves another over-the-counter naloxone nasal spray
The U.S. Food and Drug Administration has approved another over-the-counter intranasal naloxone product, Rextovy (naloxone hydrochloride), for the emergency treatment of opioid overdose. The nonprescription approval was granted ...
Jun 19, 2026
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Engineered probiotic heads to human trials
A probiotic bioengineered by UBC Okanagan researchers to thrive in the inflamed gut is set to enter human clinical trials in Australia this summer, capping a decade-long effort to turn a beneficial bacterium into a treatment ...
Jun 19, 2026
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Examining the cardioprotective effects of heart failure treatments in patients with cancer
Patients receiving cancer treatment often face the added complication of side effects affecting the heart, which can lead to the need to discontinue anticancer therapy, reducing its effectiveness. Researchers from the Erasmus ...
Jun 19, 2026
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