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Clinical pharmacology news
Clues to psilocybin's epigenetic effects on people with alcohol use disorder
Some psychedelics, psychoactive substances that alter people's mood, perceptions and mental processes, were recently found to be promising alternative treatments for some mental health disorders. The substance that has attracted ...
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Mass spectrometry platform could shrink cancer drug discovery cycle to four hours
Researchers at the Purdue Institute for Cancer Research (PICR) have developed a next-generation technology platform designed to accelerate one of the slowest and most challenging stages of cancer drug discovery: identifying ...
Jun 20, 2026
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The over‑50s are most likely to overdose. Here's how older people use drugs
When many of us think about drug overdose, we picture young people at a music festival or people dependent on street heroin. But the latest figures from the Penington Institute show older Australians are increasingly dying ...
Jun 20, 2026
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Hibernation-like cooling after stroke may reduce brain damage
Our body loves the state of homeostasis, where everything is in perfect equilibrium, from temperature to pH levels to fluid balance. As soon as the body's core temperature drops below 95°F (35°C) and stays there for a long ...
Gene therapy shows promise in ARC syndrome, a deadly childhood liver disease
A new gene therapy has been used to successfully treat a deadly childhood liver disease in mice that model the disease, according to researchers at UCL and Great Ormond Street Hospital. Arthrogryposis, renal dysfunction and ...
Jun 19, 2026
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FDA approves another over-the-counter naloxone nasal spray
The U.S. Food and Drug Administration has approved another over-the-counter intranasal naloxone product, Rextovy (naloxone hydrochloride), for the emergency treatment of opioid overdose. The nonprescription approval was granted ...
Jun 19, 2026
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Engineered probiotic heads to human trials
A probiotic bioengineered by UBC Okanagan researchers to thrive in the inflamed gut is set to enter human clinical trials in Australia this summer, capping a decade-long effort to turn a beneficial bacterium into a treatment ...
Jun 19, 2026
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Examining the cardioprotective effects of heart failure treatments in patients with cancer
Patients receiving cancer treatment often face the added complication of side effects affecting the heart, which can lead to the need to discontinue anticancer therapy, reducing its effectiveness. Researchers from the Erasmus ...
Jun 19, 2026
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Epigenetic drugs could protect blood vessels in obesity and diabetes
People with obesity and type 2 diabetes are at high risk of blood vessel damage. This risk depends not only on the genes a person carries, but also on how they are "read." By changing the epigenetic reading signals in the ...
Jun 18, 2026
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Global clinical trial reveals safest, most effective antibiotics for golden staph bloodstream infections
An international clinical trial has identified the optimal antibiotics for golden staph bloodstream infections, a breakthrough set to reshape treatment for the life-threatening condition. The SNAP Trial found that the standard ...
Jun 18, 2026
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AI screens 6 million compounds to uncover two leads against drug-resistant gonorrhea
With tens of millions of annual cases, gonorrhea is the second most frequently reported sexually transmitted infection (STI). In the U.S. alone, more than 600,000 cases are reported each year. If left untreated, gonorrhea ...
Jun 18, 2026
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FDA panel backs first-of-its-kind flu vaccine using mRNA technology
A new kind of flu vaccine moved a step closer to the U.S. market Thursday as federal health advisers recommended approval of the first made with the same mRNA technology that was key to ending the COVID-19 pandemic.
Jun 18, 2026
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Rhythmic drug dosing may boost safety and efficacy in chronic liver disease
Metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are progressive chronic liver diseases linked to abnormal bile acid metabolism. Although ...
Jun 18, 2026
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The vaccines and treatments being developed for Ebola outbreak
There are no vaccines or treatments for the strain of Ebola that has killed more than 200 people in DR Congo and Uganda, but several are being urgently developed in the hope of reining in the outbreak.
Jun 18, 2026
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Cannabis caution as study finds increased psychosis risk for young people
Young people who use cannabis daily are up to four times more likely to develop psychosis than those who don't, according to an international study led by University of Queensland researchers. The review analyzed evidence ...
Jun 18, 2026
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Time for better opioid detoxification strategies, researchers say
Addiction services must urgently consider the way they offer support for those wanting to come off opioid substitutes through detoxification, according to researchers at Imperial College London.
Jun 18, 2026
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Legalizing cannabis increases use and addiction, unless it is tightly controlled, says research
Removing criminal penalties for possessing cannabis for personal use, or introducing tightly controlled legalization of cannabis, does not appear to increase levels of cannabis use. However, the commercial sale of cannabis ...
Jun 17, 2026
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Pakistani genomes reveal 34,000 knockouts that could explain why mouse-based drugs fail in humans
A comprehensive analysis of 173,303 genomes from Pakistan, published today in Nature, is upending how scientists understand human genetics and drug development. By identifying 34,000 people who are "human knockouts," with ...
Jun 17, 2026
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Inhibiting high levels of leukemia ABCD1 protein with jojoba could lead to new treatment option
University of Guelph research published in the journal publication Blood has uncovered a surprising weakness in acute myeloid leukemia (AML) that a compound in a common skin care ingredient may be able to target.
Jun 17, 2026
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An experimental molecule 'reprograms' the brain's defenses against Alzheimer's disease
A team has identified an experimental molecule capable of "reprogramming" the brain's immune cells to restore part of their protective function against Alzheimer's disease. The study, published in the journal Cell Death and ...
Jun 17, 2026
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Why weight‑loss drugs don't work for some people
Weight-loss jabs are the latest craze for shedding a few pounds. Their effect has been dramatic, with drugs such as Ozempic and Wegovy (semaglutide) causing users to lose up to 15% of their body fat on average.
Jun 17, 2026
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Q&A: What does science say about plants as medicine?
Plants have always played an integral role in traditional medicine and healing practices, according to Kent Vrana, Elliot S. Vesell Professor of Pharmacology at Penn State College of Medicine, and they continue to shape health ...
Jun 17, 2026
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FAP-targeted radiopharmaceutical therapy shows broad effectiveness across multiple cancers
A novel radiopharmaceutical therapy approach that targets fibroblast activation protein (FAP)—which is highly expressed in many types of cancer—is safe and effective for patients, according to a new study published in the ...
Jun 17, 2026
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Can use of popular weight loss medications reduce behaviors linked to violent crime?
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for diabetes and obesity, but studies have found evidence that the medications may also influence behavior, such as supporting impulse control and ...
Jun 17, 2026
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How do beta blocker heart drugs actually work for anxiety?
A reality TV star's claim that a beta blocker dulled their emotions and made them appear calm on camera has sparked a wave of social media commentary.
Jun 17, 2026
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