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Clinical pharmacology news
GLP-1 medication changes may support long-term weight management
Patients without diabetes who switched GLP-1 receptor agonist (GLP-1RA) drugs for overweight or obesity were more likely to stick with their treatment longer than those who didn't switch, according to a new study by UT Southwestern ...
2 hours ago
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Nanohydrogels steer cancer drugs to tumors, aiming to spare healthy tissue
Exhaustion creeps in. Appetite vanishes. Hair thins. The person in the mirror looks gaunt. It's the paradox of cancer treatment: The same drugs meant to save a life can also wear the body down. Nick Housley, assistant professor ...
8 hours ago
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Wegovy may have highest 'eye stroke' and sight loss risk among semaglutide GLP-1 agonists
Wegovy, a GLP-1 agonist for weight loss, may carry the highest risk of "eye stroke" (ischemic optic neuropathy) and sudden sight loss of the semaglutide drugs, finds an analysis of unintended side effect reports published ...
2 hours ago
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Does ginkgo help memory? New review finds limited gains, mainly in dementia
An updated systematic review of dozens of studies finds that Ginkgo biloba may offer modest short-term improvements for people with dementia, but shows little to no benefit for individuals with subjective memory complaints, ...
7 hours ago
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Experimental vaccine could help turn the tide on America's opioid epidemic
Virginia Tech researchers are advancing a new generation of vaccines designed to block opioids from reaching the brain and triggering their addictive effects, work that could help prevent overdose deaths that now exceed 100,000 ...
8 hours ago
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2018 to 2025 saw rise in GLP-1 receptor agonist Rx for bariatric surgery-eligible patients
Among patients eligible for metabolic and bariatric surgery (MBS), glucagon-like peptide-1 receptor agonist (GLP-1 RA) prescriptions increased from 2018 to 2025, while MBS use decreased beginning in 2023, according to a research ...
4 hours ago
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Approved IV drug reduces lupus symptoms, clinical trial finds
An already-approved IV drug significantly reduces the symptoms of lupus, a new clinical trial showed. More than three-quarters of lupus patients taking obinutuzumab (Gazvya) had a significant improvement in their symptoms ...
4 hours ago
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Most blood thinners not tied to higher risks after free flap surgery
Blood thinners are a common medication for much of the older adult population, prescribed to prevent blood clots that can cause adverse events like heart attack or stroke. They are often stopped prior to most surgeries because ...
2 hours ago
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New mRNA platform remains effective even in aging and obesity
Since the COVID-19 pandemic, mRNA vaccines have gained attention as a next-generation pharmaceutical technology. mRNA therapeutics work by delivering genetic instructions that enable cells to produce specific proteins for ...
8 hours ago
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Rapid opioid dose reduction increases risk of mental health emergency department presentations
New Monash University research has found that rapidly reducing or abruptly stopping prescription opioids significantly increases the risk of mental health or substance use-related emergency presentations. For the study, researchers ...
4 hours ago
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Spike in deaths from novel benzos a major public health concern
Poisoning deaths from "novel" benzodiazepines (NBZDs)—designed to mimic brand-name drugs like Valium and Xanax but with greater potency—have spiked in the last six years. Out of nearly 260 fatal NBZD-related toxicity ...
2 hours ago
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Boron agents reach previously untreatable tumors
Boron agents termed GluBs, developed by Science Tokyo researchers, have overcome a key limitation in cancer therapy by entering tumor cells through a pathway that standard drugs cannot use. The GluBs target ASCT2, a transporter ...
10 hours ago
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Study demonstrates potential broad-spectrum anti-alphavirus therapeutics
A recent collaborative study has identified two promising single-domain antibodies (sdAbs) that may offer a therapeutic option against multiple subtypes of Venezuelan equine encephalitis virus (VEEV). The researchers, from ...
3 hours ago
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FDA finds little evidence that a generic drug can help people with autism
The Food and Drug Administration on Tuesday approved a generic medication for a rare brain disorder, while walking back statements by President Donald Trump and other administration officials that the drug showed great promise ...
9 hours ago
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Mouse brain study reveals why blockbuster weight-loss drugs may work differently in females and males
The drugs have names that sound like small planets: semaglutide, liraglutide, lixisenatide. Collectively, they belong to a class of glucagon-like peptide 1 (GLP-1) analogs that has reshaped the treatment of obesity and diabetes ...
20 hours ago
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Cancer drug reduces early Alzheimer's-like brain hyperconnectivity in lab tests
Neuroscientists at King's College London have pinpointed a mechanism behind the increased neural connectivity observed in the very early stages of Alzheimer's disease. Published in Translational Psychiatry, the study also ...
Mar 9, 2026
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Hidden blood mutations drive severe inflammatory bowel disease, but a new treatment target is in sight
Indiana University School of Medicine scientists have uncovered new evidence that an age-related blood condition may contribute to inflammatory bowel disease (IBD). Their findings suggest that a new drug strategy targeting ...
Mar 9, 2026
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Human intestinal cell model enables precise detection of drug-induced barrier damage
Researchers have developed a human intestinal cell model that closely mimics the structure and function of the human gut, enabling more precise prediction of drug-induced gastrointestinal toxicity during the preclinical stage ...
Mar 9, 2026
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Team approach, low-cost interventions lead to major reduction in opioid prescriptions after surgery
A novel team approach founded on a culture change among clinicians and doctor-patient communication successfully reduced post-surgical opioid use, a new study led by University of Rochester Medical Center (URMC) researchers ...
Mar 9, 2026
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Study reveals how antibiotic use during leukemia treatment reshapes the gut microbiome
Patients undergoing intensive chemotherapy for acute myeloid leukemia are routinely treated with multiple antibiotics to prevent infection, a practice that new research from Texas A&M University shows can significantly reshape ...
Mar 9, 2026
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Study highlights stroke risk linked to recreational drugs, including among young users
The recreational drugs cannabis, cocaine and amphetamines significantly increase the risk of stroke—including among younger users—Cambridge researchers have concluded after analyzing data from more than 100 million people.
Mar 8, 2026
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A potential broad coronavirus drug target: Blocking tRNA-modifying enzymes slows viral proteins
Coronaviruses not only use the machinery of the human cells they infect: they modify them to achieve optimal conditions to produce viral proteins and thus spread more quickly. This is the main conclusion of a study by Pompeu ...
Mar 7, 2026
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How do GLP-1 agonists affect gene expression?
GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve cardiovascular health. ...
Mar 6, 2026
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PET imaging study reveals how ketamine relieves treatment-resistant depression
Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and approximately 30% of patients develop treatment-resistant depression (TRD), a condition that does not respond adequately to conventional ...
Mar 6, 2026
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Creating less trippy, more therapeutic 'magic mushrooms'
Psilocybin—the psychoactive compound in "magic mushrooms"—is gaining scientific attention for its potential in treating neuropsychiatric conditions including depression, anxiety, substance use disorders and certain neurodegenerative ...
Mar 6, 2026
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