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Clinical pharmacology news
Drugging the undruggable: Cancer's slipperiest targets finally meet their match
Researchers at the University of British Columbia and BC Cancer have developed a new way to target proteins long considered "undruggable," opening the door to new treatments for prostate cancer and other serious diseases. ...
10 hours ago
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Apixaban linked to fewer blood clot complications in older adults than other blood thinners
Older adults recovering from serious blood clots often face long periods of hospitalization or rehabilitation due to a higher rate of recurrence. But a new study suggests that the choice of blood thinner may influence how ...
13 hours ago
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Sustained changes in postoperative pain management after parotidectomy linked to AAO-HNSF opioid prescribing guideline
A new retrospective study published in OTO Open, the open-access journal of the American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF), demonstrates that the Clinical Practice Guideline (CPG) Opioid ...
14 hours ago
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TBI survivors turn to psychedelics for symptom relief
A new study from the University of Victoria (UVic) has identified a segment of traumatic brain injury survivors who are using psychedelics to self-medicate for cognitive, mood and somatic symptoms such as headaches. In a ...
14 hours ago
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Tea tree oil may affect fertility, the EU says—a pharmacologist explains why that's so misleading
The heady scent of tea tree is one of the iconic smells of the Australian bush. And the essential oils derived from tea trees have been used as medicines, first by Indigenous people, then by colonists.
18 hours ago
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Semaglutide improves vascular responsiveness to insulin
Glucagon-like peptide-1 receptor agonists, known as GLP-1 drugs, are highly effective at helping people lose weight and substantially lower the risk of heart attacks, strokes, and death from heart disease. A new study conducted ...
22 hours ago
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Repurposed drugs may improve treatment for infant leukemia
Three clinically available drugs could pave the way for safer and more effective treatments for one of the most aggressive forms of childhood leukemia, a new study published in the journal HemaSphere suggests.
23 hours ago
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Combination treatment could be safer, more effective for drug overdoses involving severe agitation
A team of Marshall University researchers has published a new study suggesting a potential breakthrough in how doctors manage severe agitation caused by methamphetamine and/or cocaine use, particularly in cases in which opioids ...
Apr 26, 2026
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Weight-loss drugs could tackle Alzheimer's—study
A new study has found comprehensive evidence that "weight-loss" GLP-1 receptor agonists such as semaglutide are effective in tackling the biological drivers of Alzheimer's disease. The study, published in the journal Molecular ...
Apr 26, 2026
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Taking the guesswork out of drug development for Chagas disease
Researchers at Kent have established a computational protocol that could accelerate the development of more effective treatments for life-threatening parasitic infections such as Chagas disease, by enabling scientists to ...
Apr 26, 2026
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Depression treatment is shifting, and this mushroom-derived compound is driving one of psychiatry's biggest new tests
Depression is a debilitating mental health disorder that is estimated to affect approximately 5% of people worldwide. It is characterized by persistent feelings of sadness and hopelessness, a lack of interest in everyday ...
WHO approves first malaria treatment for infants
The World Health Organization announced Friday that it had given prequalification approval to a malaria treatment for newborns and infants for the first time.
Apr 25, 2026
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Exploiting a new vulnerability that targets 'zombie' cells as an anticancer therapy
A new set of drugs exploit a recently revealed weakness in "zombie-like"—or senescent—cells that could lead to new treatments for cancer and age-associated diseases. The study from the MRC Laboratory of Medical Sciences (LMS) ...
Apr 24, 2026
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US dentists still prescribe far more opioids for pain than peer nations
People getting their teeth pulled or drilled by dentists in the United States are still much more likely to get powerful opioid medications than dental patients in other developed countries or even the U.S. territory of Puerto ...
Apr 24, 2026
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US approves first gene therapy for rare form of hearing loss
US health officials on Thursday greenlit a first-of-its-kind gene therapy to treat a rare form of hereditary hearing loss, a breakthrough that could pave the way for other such hearing impairment treatments.
Apr 24, 2026
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Clopidogrel seems to outperform aspirin for secondary chronic maintenance therapy
New findings show that switching to clopidogrel, a blood thinner, alone after one year of dual antiplatelet therapy (DAPT) leads to better outcomes than aspirin, even in patients at high risk of bleeding and those who had ...
Apr 24, 2026
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About one-third of children and adolescents use dietary supplements in the US
About one-third of children and adolescents use dietary supplements in the United States, according to a study published online April 24 in Pediatrics Open Science.
Apr 24, 2026
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Freeze-dried platelet product slows swelling and bleeding in traumatic brain injuries
A freeze-dried blood product that could be stored for years on ambulances or in remote emergency departments is showing promise at treating traumatic brain injuries. The news comes from a mouse study done by researchers at ...
Apr 23, 2026
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Paxlovid looked like a COVID game-changer, but in vaccinated adults the real story is far more complicated
The results of two clinical trials—led by the Upstream Lab at St. Michael's Hospital in Toronto and Oxford University, published in the New England Journal of Medicine—provide new evidence to consider when funding, prescribing, ...
Apr 23, 2026
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New cellular target prevents hepatitis E infection
An international team of researchers has identified a promising new approach for treating infections with the Hepatitis E virus (HEV). At the center of the study is the drug Apilimod, which specifically blocks the entry of ...
Apr 23, 2026
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Finding the best dietary supplements for cycling performance—and recovery
Focusing on the rigors of elite cycling, Flinders University experts have put performance-enhancing and other dietary supplements under the microscope, rating some more highly than others. From carbs, beetroot juice and the ...
Apr 23, 2026
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Supplements for menopause: Here's what the evidence actually says
Social media is saturated with menopause solutions: powders for brain fog, gummies for sleep or capsules promising hormonal balance. Supplements such as magnesium, lion's mane, creatine and collagen are being marketed as ...
Apr 23, 2026
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US eases access to marijuana for medical use
The US government on Thursday made it easier for Americans to use cannabis for medical reasons by reclassifying the drug and enabling more research into its safety and efficacy.
Apr 23, 2026
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ADHD treatment despite a history of psychosis: Research finds no increased risk of relapse
People with a history of psychosis often also have attention-deficit/hyperactivity disorder (ADHD). However, treating this condition presents doctors with a clinical dilemma: Psychostimulants are considered effective for ...
Apr 22, 2026
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Kratom use is surging in the US, with life-changing consequences, study reveals
Kratom is a plant with psychoactive properties that, when taken at high doses, can produce effects similar to opioids. A new study published in Addiction has found that kratom use—measured as kratom exposures reported to ...
Apr 22, 2026
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