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Clinical pharmacology news
UK's growing synthetic opioid problem: Nitazene deaths could be underestimated by a third
The presence of nitazenes on the unregulated drug market has risen steeply in the last seven years—prompting UK and international bodies to issue public health warnings about their use. King's College London research, published ...
2 hours ago
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Simple patch can make medications safer and more effective
Vancomycin is the antibiotic doctors reach for when almost nothing else will work. It's used in hospitals for serious drug-resistant infections, or for when an infection is spreading through the patient's bloodstream, but ...
Feb 7, 2026
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You've reached your weight loss goal on GLP-1 medications. What now?
GLP-1 drugs have ushered in a new era in weight loss.
Feb 7, 2026
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Diabetes drug may slow kidney aging, study in fast-aging fish finds
A group of medications often used to treat diabetes may also help protect aging kidneys, according to a new study.
Feb 7, 2026
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Stroke drug loberamisal may boost recovery when started within 48 hours
Stroke patients treated intravenously with loberamisal, a novel neuroprotective medication, daily for 10 days and starting within 48 hours of stroke symptoms, had better recovery than patients who received a placebo, according ...
Feb 7, 2026
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Two key enzymes drive fat loss while preserving muscle: New pathway may lead to safer obesity treatments
A team of scientists has uncovered a critical mechanism that could pave the way for safer and more effective obesity treatments. The findings, published in Nature Communications, shed light on how leptin, a hormone that regulates ...
Feb 6, 2026
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RNA therapeutics shrink metastasized lung tumors in mouse study
A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or ...
Feb 6, 2026
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Dual-action molecule design concentrates cancer treatment in tumor cells to allow higher doses
Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more effectively. The new approach could be a way to deliver treatment directly to tumors at higher doses, while ...
Feb 6, 2026
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Tiny 'mini-me' organs grown from children's cells are transforming cystic fibrosis care
When UNSW Associate Professor Shafagh Waters explains cystic fibrosis (CF) to the children she works with, she asks them to imagine what is happening inside their own bodies. "I tell them to picture an airport," she says. ...
Feb 6, 2026
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Synergizing global clinical trials data: GLP-1 receptor agonist safety and novel clinical applications
A research team led by the Department of Medicine, under the School of Clinical Medicine, LKS Faculty of Medicine of the University of Hong Kong (HKUMed), has synergized the impacts of worldwide clinical trial data through ...
Feb 6, 2026
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Nasal spray for flu prevention shows promising trial results
Researchers have developed a nasal spray for flu prevention that has shown promising results in preliminary human trials. Seasonal influenza (the flu) is an acute respiratory infection that affects up to one billion people ...
Experimental pill dramatically reduces 'bad' cholesterol
An experimental pill called enlicitide slashed levels of low-density lipoprotein (LDL) cholesterol, commonly known as "bad" cholesterol, by up to 60%, according to a new phase three clinical trial published in the New England ...
Feb 5, 2026
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Statins do not cause the majority of side effects listed in package leaflets, large-scale analysis finds
Statins do not cause the majority of the conditions that have been listed in their package leaflets, including memory loss, depression, sleep disturbance, and erectile and sexual dysfunction, according to the most comprehensive ...
Feb 5, 2026
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Blocking PTP1B protein may slow memory loss in Alzheimer's
Alzheimer's disease is often measured in statistics: millions affected worldwide, cases rising sharply, costs climbing into the trillions. For families, the disease is experienced far more intimately. "It's a slow bereavement," ...
Feb 5, 2026
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Trojan horse delivery system uses gold nanoparticles to drive mRNA into tumors
University of Oklahoma researchers have created a new drug delivery system that helps cancer cells take in much more of a treatment, improving its ability to kill tumors. The findings are published in Science Advances.
Feb 5, 2026
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Fentanyl is changing how doctors treat opioid use disorder
For years, buprenorphine—one of the primary medications used to treat opioid use disorder—has been a critical bridge to recovery, helping to reduce illicit drug use and overdose deaths. But with the changing landscape ...
Feb 5, 2026
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Clopidogrel shown to be superior to aspirin for long-term antiplatelet therapy after coronary stenting
A research team has demonstrated that clopidogrel is more effective than aspirin as a long-term antiplatelet therapy in patients at high risk of recurrent cardiovascular events after coronary stent implantation. The team ...
Feb 5, 2026
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New paper urges caution as FDA plans to phase out animal testing in drug development
Replacing animal testing with alternate methodologies in preclinical drug trials holds potential for the development of cheaper, safer pharmaceuticals as well as alleviating animal suffering. But according to a new paper ...
Feb 5, 2026
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New medication may reduce chances of a second clot-caused stroke without bleeding risk
An investigational anti-clotting medication, asundexian, has demonstrated a reduction in the risk of a second ischemic (clot-caused) stroke without raising bleeding concerns, according to a preliminary late-breaking science ...
Feb 5, 2026
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Study identifies key predictors for chronic opioid use following surgery
For many Americans, a routine surgical procedure serves as their first introduction to opioid pain medication. While most stop using these drugs as they heal, a considerable number of "opioid-naïve" patients transition into ...
Feb 5, 2026
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FDA approves quadruplet regimen for adults with newly diagnosed multiple myeloma
The U.S. Food and Drug Administration has approved Darzalex Faspro (daratumumab and hyaluronidase-fihj) in combination with bortezomib, lenalidomide, and dexamethasone (D-VRd) for the treatment of adult patients with newly ...
Feb 5, 2026
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A common immunosuppressant may alter brain immune cells during early development
Researchers at University of Tsukuba have discovered that an immunosuppressive drug affects microglia, the resident immune cells of the brain. In mouse models, the drug reduced levels of guanosine nucleotides, which are essential ...
Feb 5, 2026
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Novo Nordisk vows legal action to protect Wegovy pill
Novo Nordisk said Thursday it would take legal action against a US chain offering a copycat of the new pill version of its Wegovy weight-loss drug.
Feb 5, 2026
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Self-regulating living implant could end daily insulin injections
A pioneering study marks a major step toward eliminating the need for daily insulin injections for people with diabetes. The study was led by Assistant Professor Shady Farah of the Faculty of Chemical Engineering at the Technion—Israel ...
Feb 4, 2026
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Semaglutide improves cardiovascular health but price reductions are needed to make it cost-effective, study finds
Semaglutide, the active ingredient in the weight-loss medications Ozempic and Wegovy, offers substantial cardiovascular benefits for selected patients without diabetes who have established heart disease, but further price ...
Feb 4, 2026
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