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Clinical pharmacology news
Q&A: What does science say about plants as medicine?
Plants have always played an integral role in traditional medicine and healing practices, according to Kent Vrana, Elliot S. Vesell Professor of Pharmacology at Penn State College of Medicine, and they continue to shape health ...
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Pakistani genomes reveal 34,000 knockouts that could explain why mouse-based drugs fail in humans
A comprehensive analysis of 173,303 genomes from Pakistan, published today in Nature, is upending how scientists understand human genetics and drug development. By identifying 34,000 people who are "human knockouts," with ...
5 hours ago
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Legalizing cannabis increases use and addiction, unless it is tightly controlled, says research
Removing criminal penalties for possessing cannabis for personal use, or introducing tightly controlled legalization of cannabis, does not appear to increase levels of cannabis use. However, the commercial sale of cannabis ...
2 hours ago
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Inhibiting high levels of leukemia ABCD1 protein with jojoba could lead to new treatment option
University of Guelph research published in the journal publication Blood has uncovered a surprising weakness in acute myeloid leukemia (AML) that a compound in a common skin care ingredient may be able to target.
3 hours ago
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An experimental molecule 'reprograms' the brain's defenses against Alzheimer's disease
A team has identified an experimental molecule capable of "reprogramming" the brain's immune cells to restore part of their protective function against Alzheimer's disease. The study, published in the journal Cell Death and ...
15 hours ago
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Why weight‑loss drugs don't work for some people
Weight-loss jabs are the latest craze for shedding a few pounds. Their effect has been dramatic, with drugs such as Ozempic and Wegovy (semaglutide) causing users to lose up to 15% of their body fat on average.
5 hours ago
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FAP-targeted radiopharmaceutical therapy shows broad effectiveness across multiple cancers
A novel radiopharmaceutical therapy approach that targets fibroblast activation protein (FAP)—which is highly expressed in many types of cancer—is safe and effective for patients, according to a new study published in the ...
3 hours ago
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Researchers discover a new therapeutic target to prevent thrombi with a lower bleeding risk
Antiplatelet drugs are one of the main tools used to prevent thrombus formation in people who have had a heart attack or stroke or who have cardiovascular diseases with a high thrombotic risk. These treatments work by reducing ...
8 hours ago
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How do beta blocker heart drugs actually work for anxiety?
A reality TV star's claim that a beta blocker dulled their emotions and made them appear calm on camera has sparked a wave of social media commentary.
10 hours ago
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Can use of popular weight loss medications reduce behaviors linked to violent crime?
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for diabetes and obesity, but studies have found evidence that the medications may also influence behavior, such as supporting impulse control and ...
18 hours ago
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Beyond GLP-1s: The next chapter of obesity care
The rapid rise of GLP-1 medications such as semaglutide and tirzepatide has transformed obesity treatment. Still, experts say medications alone are not enough to address one of the nation's most pressing chronic diseases.
16 hours ago
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Kidney healing improves after protein blockade, with less scarring and faster recovery
A drug previously developed at UCLA to help heart tissue repair itself after a heart attack might also help kidney tissue repair and regenerate, researchers have found.
Jun 16, 2026
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Hidden PIM1 pathway helps prostate cancer survive treatment, pointing to new drug strategy
Cancer cells are remarkably good at adapting to stress. When treatments damage them, they often find new ways to survive, fueling drug resistance and disease progression.
Jun 16, 2026
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Tirzepatide outperformed semaglutide weight-loss drug results in real world patients, study shows
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become popular for weight loss, but results vary from person to person and from drug to drug. Venky Soundararajan and colleagues explored the full range of responses ...
Jun 16, 2026
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Repurposed drugs move through late-stage trials at up to 90% lower cost
Universities and hospitals are repurposing existing drugs through late-stage trials with funded costs up to 90% lower than those in the pharmaceutical industry. This "hidden" research system, which operates outside the patent ...
Jun 16, 2026
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ADA: Orforglipron beneficial for reducing HbA1c in type 2 diabetes
Orforglipron is beneficial for blood glucose control in individuals with type 2 diabetes using metformin or taking insulin glargine, according to two studies published online June 8 in The Lancet and the JAMA to coincide ...
Jun 16, 2026
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Three men's health drugs that were originally designed for a different purpose
Many medicines begin life with one purpose and end up proving useful for a completely different reason.
Jun 16, 2026
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Copper drug restores memory and clears toxic Alzheimer's proteins, preclinical study finds
Monash University researchers have found in laboratory experiments that a drug that delivers copper to the brain significantly reduces toxic Alzheimer's proteins and improves long-term spatial memory.
Jun 15, 2026
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Why some cancers return: Robotic mini tumor tests point to new ways to target persister cells
Cancer drugs can shrink fast-growing tumors. But sometimes a few tumor cells survive. These "persister" cells seed new tumors, forcing cancer patients into arduous cycles of testing and treatment.
Jun 15, 2026
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Combo treatment delays multiple myeloma progression and may improve survival, study finds
Patients with multiple myeloma who received a new immunotherapy combination lived significantly longer without their cancer worsening and showed early signs of improved survival in a large international clinical trial.
Jun 15, 2026
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Anti-inflammatory molecule shows potential against Parkinson's in murine study
Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have discovered a new strategy that may protect neurons and other brain cells involved in Parkinson's disease in the future. The results of the study, ...
Jun 15, 2026
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Targeting delivery to the lungs: Inhaled vitamin D could be new strategy
People with chronic lung diseases like chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis tend to have low vitamin D levels, and these low levels are linked to worse respiratory health outcomes. This ...
Jun 15, 2026
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ENDO: GLP-1 receptor agonists tied to higher hypotension risk in patients on BP meds
Among patients with preexisting hypertension taking antihypertensive medications, glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with an increase in hypotensive-related events, according to a study ...
Jun 15, 2026
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Tirzepatide GLP-1 medication may be most effective for weight loss
GLP-1 medications are marketed to help you lose weight, but one may be better at it than the rest, according to a new meta-analysis from the University of Georgia.
Jun 15, 2026
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Tirzepatide may change how the body uses energy, trial suggests
Tirzepatide doesn't just help people lose weight; it also activates brown adipose tissue, representing a major milestone in obesity research, according to a study presented at ENDO 2026, the Endocrine Society's annual meeting ...
Jun 15, 2026
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