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Clinical pharmacology news
Adding opioids or benzodiazepines to gabapentinoids boosts drug poisoning risk, analysis shows
People who take gabapentinoids, a medication prescribed increasingly frequently worldwide, particularly for chronic pain, face a much greater risk of drug poisoning if they are also taking another medication, finds a new ...
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A major pregnancy scare collapses: Tylenol shows no autism risk in more than 1.5 million children
Acetaminophen, which also goes by names like paracetamol or Tylenol, is a common over-the-counter pain reliever and fever reducer. It is often prescribed during pregnancy to help with mild to moderate pain. Recently, there ...
3 hours ago
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First-of-its-kind drug aims to protect the heart while increasing effectiveness of cancer treatments
A team of University of Alberta researchers has developed a cardio-oncology drug that protects the heart from chemotherapy damage while enhancing the effectiveness of cancer treatments against tumor growth and spread. In ...
2 hours ago
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A black licorice compound slashes gut inflammation and cell death in IBD models and animals
A new study published in Stem Cell Reports demonstrates how a human stem cell-derived model of the intestine can be used to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a ...
4 hours ago
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Much-hyped Alzheimer's drugs removed amyloid yet brought no meaningful gains over 18 months
Drugs once hailed as a breakthrough in the fight against Alzheimer's disease do not meaningfully help patients, a major review found Thursday, however some experts criticized the research.
10 hours ago
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New anti-clotting medication lowers risk of stroke without added bleeding
A large international study has found that asundexian, an investigational anti-clotting medication, reduces the risk of a stroke in people who recently experienced a stroke or transient ischemic attack (TIA) caused by a clot ...
22 hours ago
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For women with primary progressive MS, could bestselling drug be doing more harm than good?
The US Food and Drug Administration (FDA) is reviewing a petition to revoke the approval of Roche's top-selling drug ocrelizumab (Ocrevus) for treating primary progressive multiple sclerosis (PPMS)—a form of MS thought to ...
21 hours ago
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Why psychedelic mental health trials may be less reliable than they appear
Drug trials generally involve comparing a treatment with a nonactive, placebo version, an approach called "blinding" because patients must be "blind" as to which they've received for the trial to work. Canadian researchers ...
23 hours ago
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Anti-amyloid Alzheimer's drugs show no clinically meaningful effect
Drugs that target amyloid beta proteins in the brain likely have no clinically meaningful positive effects, while increasing the risk of bleeding and swelling in the brain, a new review in the Cochrane Database of Systematic ...
19 hours ago
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New weight loss pill gets approval, but FDA seeks more safety data
The U.S. Food and Drug Administration (FDA) has told Eli Lilly to study possible heart, liver and other risks tied to its new obesity drug Foundayo, according to an approval letter released Tuesday.
18 hours ago
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Australia's 60-day prescriptions are saving millions; why aren't more patients getting them?
A landmark government policy designed to slash the cost of medicines for millions of Australians is falling well short of its potential because GPs and pharmacists have been slow to adopt it, new research has found. The study, ...
21 hours ago
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Off-label cancer drugs deliver durable benefit for some patients in large trial
The largest published prospective evaluation of off-label targeted cancer therapies has shown that more patients could benefit from existing drugs. After including over 1,600 patients in the Dutch multicenter DRUP trial, ...
Apr 15, 2026
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New research shows a free online tool could improve opioid safety for millions of Australians
New Monash University research has found that a free, interactive online tool can help people taking prescription opioids for pain to better understand their risks and adopt safer behaviors, more than doubling requests for ...
Apr 15, 2026
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Ads for GLP‑1 drugs are flooding the internet. Here's how to know if it's safe to buy them online
If you watched the Super Bowl in 2026, you likely saw Serena Williams share her weight loss journey on GLP-1 medications in a commercial.
Apr 15, 2026
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New drug doubles 1-year survival in pancreatic cancer trial
Pancreatic cancer is one of the deadliest cancers and among the hardest to treat, with most patients surviving less than a year after diagnosis. But a new drug developed at Northwestern University may soon help patients live ...
Apr 14, 2026
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GLP-1 medicine improves liver health independent of weight loss, study finds
Researchers at Toronto's Sinai Health have found that semaglutide—the active ingredient in popular weight loss drugs that mimic the gut hormone GLP-1—acts directly on a subset of liver cells to improve organ function and ...
Apr 14, 2026
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'Not your parents' cannabis:' Legalization lights up innovation—but not clinical research
State-level cannabis legalization in the U.S. is producing a lot of innovative ways to get high, but little in the way of evidence-based medical research to improve public health, according to new research from economists ...
Apr 14, 2026
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This laser breakthrough supercharges osteoporosis treatment by exposing bone's hidden growth switch
A research team has discovered a new mechanism and drug combination strategy that can effectively treat osteoporosis, a representative disease of super-aging societies. The research findings were published on April 2 in Bone ...
Apr 14, 2026
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Antibiotics can trigger bacteria to release bubbles of inflammation tinder, making it harder to treat infection
Antibiotics are designed to kill harmful bacteria and help the body recover from infection. But some antibiotics may also push bacteria to release tiny particles that can make inflammation worse.
Apr 14, 2026
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Scientists make Parkinson's drug from plastic in world first
It's easy to see discarded plastic as nothing more than waste. Much of it ends up in landfill, breaking down into microplastics that seep into water supplies and threaten the environment, and potentially human health. But ...
Apr 14, 2026
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Students publish paper validating optimal caffeine dosage for newborns with heart disease
Montana State University students published a paper alongside Duke University researchers in the Journal of Pediatric Pharmacology and Therapeutics this spring, validating a study on the optimal caffeine dosage for newborn ...
Apr 14, 2026
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New primary care campaign seeks to cut benzodiazepine overuse with reviews and patient support
The widespread use of benzodiazepines—better known as sleeping pills or anxiety medication—among the population has become a serious public health issue. These psychotropic drugs, central nervous system depressants prescribed ...
Apr 14, 2026
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Researchers demonstrate drug's effectiveness in drawing out dormant HIV from immune cells
Human immunodeficiency virus-1 (HIV) is one of the most challenging viruses for doctors to treat. Even with effective antiretroviral therapy, immune cells infected with HIV can hide and lie inactive in certain areas of the ...
Apr 13, 2026
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Pain-sensing neurons mapped in unprecedented detail, pointing to new chronic pain drug targets
One in five people worldwide suffers from chronic inflammatory pain. Meanwhile, about two thirds of those affected find little relief from existing pain medications; new therapeutic approaches are urgently needed. "We first ...
Apr 13, 2026
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Environmental enrichment lowered stress hormones tied to fentanyl relapse in rats
Combating the opioid crisis relies on identifying new prevention strategies for problematic fentanyl use. In a collaboration between Washington State University and Washington University in St. Louis, researchers led by Jose ...
Apr 13, 2026
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