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Clinical pharmacology news
Small molecule drug candidate offers hope for rare kidney stone disease with no current treatment
Scientists at the Buck Institute for Research on Aging have shown that an orally administered small molecule, N-propargylglycine (N-PPG), can completely prevent the formation of calcium oxalate kidney stones, protect against ...
5 minutes ago
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Zebrafish reveal new insights into the biology of autism
In recent decades, the zebrafish has become one of the most valuable model organisms in scientific research. For a variety of reasons, including their genetic similarities to humans, these tiny tropical fish have helped researchers ...
2 hours ago
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Poison centers see jump in kava calls
Calls to poison centers about kava—a drug found in drinks marketed as a healthy alternative to alcoholic beverages—rose 383% between 2011 and 2025, according to a new UVA Health study. The findings have been published in ...
4 hours ago
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First-in-class dual HIF inhibitors eliminate tumors in mice when combined with immunotherapy
Researchers at Johns Hopkins University and the University of Maryland School of Pharmacy have developed a set of novel, first-in-class drugs that inhibit hypoxia-inducible factors 1 and 2, a pair of transcription factors ...
7 hours ago
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Dangers of 'anti-aging' supplements in cancer protection revealed
Millions of Americans take daily supplements—nicotinamide mononucleotide (NMN), nicotinamide riboside (NR) and nicotinamide (NAM)—to boost energy, slow aging and protect the heart and brain. Many cancer patients also take ...
23 hours ago
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Will medicinal cannabis help my mental health? Here are the evidence and the risks
Anxiety, depression and post-traumatic stress disorder (PTSD) are among the most common mental health conditions for which Australians are prescribed medicinal cannabis.
22 hours ago
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Small molecule could slow or stop progress of Parkinson's disease and related brain disorders, not just treat symptoms
A team of researchers from NYU Abu Dhabi and the University of Denver has identified a promising small molecule that could help slow or halt the progression of serious brain diseases such as Parkinson's disease, offering ...
Apr 1, 2026
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Gene editing therapy shows success against severe sickle cell disease
New results from a clinical trial show promising outcomes for a gene-edited treatment for severe sickle cell disease, a genetic blood disorder with few curative options. After research conducted as part of the multicenter ...
Apr 1, 2026
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Common antidepressant offers fresh hope for people looking to reduce methamphetamine use
For the first time, people who want to stop using crystal methamphetamine may be able to treat their addiction with a cheap and readily available medication, say researchers at the National Drug and Alcohol Research Center ...
Apr 1, 2026
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A safer opioid? DFNZ discovery suggests pain relief with minimal addictive properties
Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential as a therapy for both pain and opioid use disorder. In a study published in Nature, the team observed ...
Apr 1, 2026
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Natural compound nigericin reduces endotrophin tied to obesity, study shows
Obesity is known to be a major risk factor that exacerbates metabolic disorders, such as type 2 diabetes. A key molecule involved in this process is endotrophin, a signaling protein that links excess fat accumulation to metabolic ...
Apr 1, 2026
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AAD: Significant benefits seen for brepocitinib 30 mg in dermatomyositis
For adults with dermatomyositis, brepocitinib, an oral tyrosine kinase 2/Janus kinase 1 inhibitor, demonstrates significant benefits at a 30-mg dose compared with placebo, according to a study published online March 28 in ...
Apr 1, 2026
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Probing a paradoxical drug response for irregular heartbeat
Irregular heartbeat, or arrhythmia, can be treated with various procedures or medication, but not all medications work for all patients. In fact, one arrhythmia medication can actually cause arrhythmia in people with a common ...
Apr 1, 2026
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More patients receive recommended heart failure treatment, Swedish registry study finds
An increasing proportion of patients with heart failure receive a combination of four medications shown to improve prognosis and recommended in guidelines. However, there is still room for improving adherence and persistence ...
Apr 1, 2026
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Mirror fragments intercept Alzheimer's-causing protein
Understanding how proteins interact with their own mirror images enabled a Kobe University research team to design a small mirror protein that disables a causal factor of Alzheimer's disease, amyloid-beta.
Mar 31, 2026
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Nursing home flu outbreaks—statistical approach reveals keys to preventing hospitalizations
In nursing homes, influenza spreads quickly. Even in facilities with separate wings, staff move throughout the home, caring for medically complex older adults who often share rooms. In this way, a single case of influenza ...
Mar 31, 2026
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New discovery could slow Parkinson's disease and reduce life-threatening lung injury
Scientists at Florida International University have developed a promising new compound that could slow the progression of Parkinson's disease and protect against life-threatening lung injury by targeting a key process inside ...
Mar 31, 2026
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Common antidepressant may ease long COVID fatigue
A randomized clinical trial found that the antidepressant fluvoxamine significantly reduces long COVID-related fatigue, one of the condition's most persistent and debilitating symptoms, while the diabetes drug metformin showed ...
Mar 31, 2026
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Common antidepressant eases fatigue associated with long COVID, study finds
A global research team co‑led by McMaster University has identified one of the first medications shown to meaningfully reduce fatigue in people living with long COVID—a breakthrough for millions still struggling with persistent ...
Mar 31, 2026
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Sotatercept shows promise for a type of pulmonary hypertension linked to heart failure with preserved EF
Patients who have heart failure with preserved ejection fraction (HFpEF) and high blood pressure in the lungs (pulmonary hypertension) experienced significant improvements in blood pressure and vascular health after taking ...
Mar 31, 2026
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Investigational drug delivers mixed results for uncontrolled blood pressure
The investigational drug tonlamarsen—which is designed to lower blood pressure by reducing the production of angiotensinogen, a protein that turns into the hormone that regulates blood pressure—caused a significant and sustained ...
Mar 31, 2026
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Organ-on-a-chip technology replicates decades of human aging in just four days
Over one billion people worldwide are over 60, and the population is projected to more than double by 2050. But as more people live into their 60s, 70s, and 80s, health care systems across the globe may face new challenges ...
Mar 30, 2026
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Placing battery tech directly on tissue to deliver lithium ions for targeted pain relief
A new study from the University of Chicago taps an ingredient most often used in the lithium-ion batteries that power our devices to open new avenues in biomedical technology. Lithium plays vital roles in the body, but taking ...
Mar 30, 2026
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New compound MF-8 may treat anxiety and memory loss with fewer side effects
Scientists at City University of Hong Kong (CityUHK) have made progress in recent months with the discovery of a novel compound, named MF-8. The compound and its associated pharmaceuticals demonstrate significant potential ...
Mar 30, 2026
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Brain wiring model could shorten path to new medicines
A new, more life-like physical model of microscopic nerve fibers called axons could speed up the discovery of medicines for multiple sclerosis and other degenerative brain diseases, suggests a new study led by UCL researchers. ...
Mar 30, 2026
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