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Clinical pharmacology news
Antibody drugs with strong immune cell binding linked to allergic reactions
Antibody therapeutics are laboratory-made proteins designed to work like the body's natural antibodies. They are widely used to treat diseases such as cancer by binding to specific targets, including cancer cells or inflammatory ...
15 hours ago
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Parkinson's add-on drugs may spur gut bacteria that break down levodopa, study finds
Levodopa—the gold-standard treatment for Parkinson's disease—increases dopamine in the brain. But as the disease progresses in severity, patients often need to take additional drugs to manage their symptoms. One class of ...
16 hours ago
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AAD: Subcutaneous amlitelimab aids atopic dermatitis outcomes through week 24
Amlitelimab, a fully human non-T cell depleting monoclonal antibody that selectively targets OX40-ligand (OX40L), is safe and effective, with potentially progressive efficacy over time, for patients with moderate-to-severe ...
9 hours ago
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Long-term opioid prescribing has fallen, but millions still receive extended opioid therapy
Long-term opioid prescribing has fallen in the United States over the last decade, but millions of patients still received opioids for 90 days or longer in 2023, according to a new research letter in JAMA led by University ...
16 hours ago
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Genetic predictors for GLP-1 weight loss efficacy and side effects identified
23andMe Research Institute, a nonprofit medical research organization, announced the publication of a study that identifies genetic predictors for GLP-1 weight loss efficacy and side effects. GLP-1 receptor agonists, including ...
16 hours ago
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Some common IBS treatments are linked to a higher risk of death, say study
A large, long-term study led by Cedars-Sinai Health Sciences University investigators suggests that some medications commonly prescribed to treat irritable bowel syndrome (IBS)—including antidepressants—may be associated ...
Apr 8, 2026
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CBD found to reverse brain damage in mouse model of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss, cognitive decline, and behavioral changes. The deficits linked to AD are known to result from the abnormal accumulation of ...
Treating tumors independently of oxygen: Photodynamic therapy uses hydrogen peroxide instead
Photodynamic treatment of cancer is based on administering an initially inactive substance that is only activated in the tumor via targeted light irradiation. It then generates reactive oxygen species that kill the cancer ...
Apr 7, 2026
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Molecular map could unlock new treatments for heart and lung diseases
Scientists have created a new "molecular map" uncovering how an important human receptor involved in blood clotting and inflammation works—an advance that could help us design better drugs for conditions such as pulmonary ...
Apr 7, 2026
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Massive eye drop recall reflects ongoing issues with manufacturing and FDA inspection
A California company has recalled more than 3.1 million bottles of lubricating eye drops because it had not properly tested—and thus could not prove—whether the products were sterile. These products are sold under several ...
Apr 7, 2026
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Can medicinal cannabis help kids' autism, ADHD or Tourette's? Here's what we know so far
In the past 10 years or so, there has been a lot of interest to see if medicinal cannabis can help children with emotional and behavioral problems—the ones associated with conditions such as autism, ADHD (attention-deficit ...
Apr 7, 2026
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GLP-1 agonist drugs show digestive side effects but may help fight infections
Originally developed to treat diabetes, a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are now stepping into the spotlight as weight loss drugs. A recent umbrella review draws attention to ...
First-in-class molecules dial down inflammation without compromising immunity
Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact—a long-sought goal in treating autoimmune diseases. The ...
Apr 6, 2026
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This is your brain on psychedelics: Neuroimaging study sheds light on cortical network effects
Psychedelic drugs are being investigated as scientific and clinical tools, but the brain mechanisms behind their effects remain unclear. Earlier brain imaging studies in small cohorts from single centers produced inconsistent ...
Apr 6, 2026
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Precision oncology success: Individualized multi-drug therapy outperforms standard care
A new article in the News and Perspectives section of the Journal of Medical Internet Research showcases the transformative potential of precision oncology. The article, "Further Promise and Potential for Precision Medicine ...
Apr 6, 2026
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Over 3 million eye drops recalled amid sterility concerns
More than 3 million bottles of over-the-counter eye drops are being recalled after officials raised concerns about the product's safety.
Apr 6, 2026
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This common antidepressant helps people cut back on methamphetamine: New study
Methamphetamine—more commonly known as meth, crystal or ice—is a highly addictive, stimulant drug.
Apr 5, 2026
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A potential universal flu shot? Intranasal EV vaccine protected mice from H5N1, H7N9
A novel vaccine platform has been developed to induce broad, protective immunity against numerous influenza virus infections, showing promise as an effective mucosal vaccine strategy, according to a study published by researchers ...
Apr 3, 2026
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Kratom poisonings surged 1,200% over the past decade, and regulators are struggling to keep up with the dangers
Proposals to ban or regulate kratom, a plant-based substance sold in gas stations, convenience stores and vape shops, are making headlines in local newspapers across the United States. But as lawmakers debate whether to regulate ...
Apr 3, 2026
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Mechanisms behind tumor suppressor BAP1 highlight new treatment strategies for aggressive cancers
A team of scientists led by the National Cancer Center Singapore (NCCS) and Duke-NUS Medical School (Duke-NUS) has found a new approach for treating some of the world's most aggressive cancers associated with BAP1 mutations. ...
Apr 2, 2026
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Small molecule drug candidate offers hope for rare kidney stone disease with no current treatment
Scientists at the Buck Institute for Research on Aging have shown that an orally administered small molecule, N-propargylglycine (N-PPG), can completely prevent the formation of calcium oxalate kidney stones, protect against ...
Apr 2, 2026
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Zebrafish reveal new insights into the biology of autism
In recent decades, the zebrafish has become one of the most valuable model organisms in scientific research. For a variety of reasons, including their genetic similarities to humans, these tiny tropical fish have helped researchers ...
Apr 2, 2026
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Innovative targeted therapy halts prostate cancer spread to the bone
New findings from VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM), published in Pharmacological Research, show that an innovative drug effectively prevents prostate tumors from spreading ...
Apr 2, 2026
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FDA approves new weight loss pill in record time
A new daily pill to help with weight loss has been approved by the U.S. Food and Drug Administration (FDA), and it moved through review faster than most drugs in recent years.
Apr 2, 2026
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New pill could change plaque psoriasis treatment
Folks with severe plaque psoriasis often have to choose between convenient pills that don't work very well or highly effective injections that come with the hassle of needles. That trade-off may soon change. New clinical ...
Apr 2, 2026
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