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Clinical pharmacology news
IV atorvastatin during myocardial infarction reduces myocardial damage compared to pre-infarction oral loading
Reducing the damage sustained by the heart during a myocardial infarction remains one of the major challenges in cardiology, even when the blocked coronary artery is reopened in a timely manner. Part of the myocardial injury ...
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'Molecular eraser' destroys cancerous mRNA before protein forms, reshaping cancer cells
Many of the deadliest forms of cancer are caused by a pathological mutation in the RAS protein. Yet, to date, no effective treatment for this cancer protein has been found. A new research approach aims to prevent the protein ...
8 hours ago
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Drug reduces the risk of developing rheumatoid arthritis, clinical trial finds
A clinical trial led by researchers from Hospital Clínic de Barcelona, the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) and the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC) compared the effectiveness ...
5 hours ago
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Why the liquid you take with your medication matters
Some alkaline mineral and medicinal waters may weaken the enteric coating of medications within just a few minutes, potentially reducing their effectiveness, according to a new study by Semmelweis University. The study, published ...
5 hours ago
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Once-weekly survodutide linked to drop in body weight in obesity
For adults with obesity without diabetes, once-weekly survodutide, an investigational glucagon receptor-glucagon-like peptide-1 receptor dual agonist, is associated with greater reductions in body weight than placebo, according ...
3 hours ago
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New protein targets reveal 13 drug repurposing leads for progressive multiple sclerosis
A new study identified protein targets and drug candidates, including opportunities to repurpose existing drugs. Six key proteins were highlighted as potentially providing new insights and supporting future treatment development ...
6 hours ago
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Girls are biggest consumers of anxiolytic and sedative drugs among adolescents in most EU countries
Xabi Martinez-Mendia, a researcher at the EHU-University of the Basque Country, has analyzed how adolescent psychotropic drug consumption is linked to gender inequality and economic factors in 32 European countries. Published ...
5 hours ago
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How modern rheumatoid arthritis treatments can protect bone health
A new review published in Calcified Tissue International highlights major advances in understanding and preventing bone loss in people with rheumatoid arthritis (RA), showing that modern antirheumatic therapies can significantly ...
6 hours ago
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Single high dose of psilocybin temporarily restores lost abilities in an 80-year-old Alzheimer's patient
Psilocybin is a naturally occurring psychoactive compound found in mushrooms of the Psilocybe genus. These mushrooms may have existed on Earth for nearly 65 million years, dating to the asteroid impact that caused the dinosaurs' ...
New GLP-3 drug significantly slashes both weight and blood sugar levels in Phase III trial
Over the past few years, GLP-1 drugs have transformed the treatment landscape for obesity and type 2 diabetes. By mimicking a hormone that helps regulate blood sugar, slows digestion and curbs appetite, these medications ...
A popular joint pain supplement may accelerate dementia
New research has found an association between taking glucosamine, a popular over-the-counter supplement used for joint pain, and a higher likelihood of progressing from mild cognitive impairment to Alzheimer's disease. The ...
Jun 9, 2026
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New Lassa fever vaccine shows promising results for first-in-human clinical trial
Researchers at the University of Maryland School of Medicine's Center for Vaccine Development and Global Health, or CVD, report encouraging results from an early clinical trial that tested a new dual vaccine against Lassa ...
Jun 9, 2026
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Drug apitegromab may stop muscle loss when taking weight loss drugs
A drug called apitegromab may help preserve lean body mass during weight loss with tirzepatide, a GLP-1 receptor agonist, according to a phase 2 clinical trial published in Nature Medicine. The findings suggest that blocking ...
Jun 9, 2026
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Key protein behind chemotherapy resistance in colorectal cancer identified
One of the most widely used chemotherapeutic agents for colorectal cancer is 5-fluorouracil (5-FU), a cornerstone treatment that has improved outcomes for countless patients. However, repeated treatment often leads to drug ...
Jun 9, 2026
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Physician–researcher's work yields landmark five-year data for Crohn's disease drug
A physician–scientist and national leader in inflammatory bowel disease at the University of Cincinnati has led the publication of landmark five-year efficacy and safety data for guselkumab, a biologic therapy for moderately ...
Jun 9, 2026
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Tiny molecular fix revived tuberculosis antibiotic candidate and led to two patents
How can we combat the growing global health crisis of antibiotic resistance? At Leiden University, researchers are tackling this issue from multiple angles. Ph.D. candidate Vladyslav Lysenko develops and redesigns new antibiotic ...
Jun 9, 2026
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Encouraging trial results for AstraZeneca's new weight-loss pill
A new pill developed by the British pharmaceutical firm AstraZeneca appears to help people lose a similar amount of weight as other oral GLP-1 drugs, trial results showed Monday.
Jun 9, 2026
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Medication burden and weight loss linked to fracture, fall risk in older adults
With an aging population now an irrefutable reality in Japan, concerns about the health and well-being of older adults have come to the forefront of public health dialogue. Older adults are especially at risk for fragility ...
Jun 9, 2026
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Ultrasound turns anticancer molecule into deep-lung bacteria killer
An anticancer medication called TLD1433, a ruthenium(II) complex that has entered Phase II trials for conditions such as non-muscle-invasive bladder cancer, is now being repurposed to address one of the biggest public health ...
New GLP-1 oral pill lowers blood sugar and reduces bodyweight, clinical trial finds
Oral GLP-1 medications have the potential to increase access to therapies that can help lower blood sugar and reduce bodyweight. At the American Diabetes Association's Scientific Session, Mass General Brigham physician investigator ...
Jun 8, 2026
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New drug could slow the development of Alzheimer's
"Compound 10" is how Ursula Quitterer refers to the chemical compound that her team has developed and that could slow the progression of Alzheimer's disease. Quitterer is a professor of molecular pharmacology at ETH Zurich ...
Jun 8, 2026
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Left-handed DNA tubes double cancer drug killing by boosting cell uptake
Researchers in the lab of Cancer Center at Illinois (CCIL) member Xing Wang have discovered the influential role of structural chirality, or "handedness," of a DNA nanostructure to dictate cancer cell response to targeted ...
Jun 8, 2026
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New map reveals how antidepressants reshape the brain's serotonin system
A new study has uncovered how antidepressants affect different groups of serotonin-producing brain cells in opposite ways, offering new insights into why selective serotonin reuptake inhibitors (SSRIs) can cause unpleasant ...
Jun 8, 2026
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Africa races for Ebola vaccine as outbreak outpaces response
Researchers racing to develop a vaccine to fight the growing Ebola outbreak centered in the Democratic Republic of the Congo (DRC) say doses could be ready for human testing within "two to three months," while the more promising ...
Jun 8, 2026
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Ozempic, GPL-1s may help curb substance use disorders, study finds
A new study led by researchers at the University of Texas at El Paso found that use of weight-loss drugs like Ozempic and other GLP-1s is associated with a lower risk of developing alcohol, opioid, nicotine and cocaine use ...
Jun 8, 2026
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