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Clinical pharmacology news
Cancer cell 'degraders' target two proteins at once to defeat treatment resistance
Researchers from two Technion faculties have jointly developed a new compound and demonstrated its effectiveness against aggressive tumor cells.
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Experimental drug alleviates symptoms of Huntington's disease
The hereditary disorder Huntington's disease has so far been considered incurable. Its clinical manifestations include impaired motor control and psychiatric symptoms. A new study offers promising insights. It shows that ...
3 hours ago
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Three-in-one vaccine shows promise against 'tripledemic'
Flu season is no longer just flu season. Since 2022, the health care community has faced what's known as a "tripledemic" of seasonal influenza, COVID-19 and respiratory syncytial virus (RSV). That may mean the flu shot needs ...
4 hours ago
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Popular GLP-1 weight loss drugs are being misused by people struggling with eating disorders, research reveals
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as Ozempic or Wegovy, have revolutionized type 2 diabetes and weight-loss management, but they have also led to some unfortunate outcomes. A recent study in JAMA ...
Could one shot replace weekly GLP-1 drugs? DNA approach shows months-long effects in mice
Scientists at The Wistar Institute have shown that a single injection of a small, circular piece of genetic instruction can produce weight loss and blood glucose control in murine models that lasts up to 10 times as long ...
5 hours ago
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Fish-inspired sensor tracks how human heart tissue responds to disease and treatment
Engineers have developed a new way to monitor how tiny lab-grown human heart tissues beat—by effectively "listening" to the ripples they create. The team has created a wireless, noninvasive sensing platform that can biomechanically ...
5 hours ago
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Millions of New Yorkers consume cannabis; far fewer understand details, such as content and dosage
In 2023, about 2 million adults in New York state reported consuming some form of cannabis. However, only a small portion has a full understanding of cannabis product labeling, which includes ingredients, dosages and whether ...
2 hours ago
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Hospital discharge sedatives linked to more falls, readmissions and deaths in older adults
Older adults discharged from hospital with a new prescription for a sedative, especially a benzodiazepine or antipsychotic, are at increased risk of falls and other negative consequences, according to new research published ...
17 hours ago
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Scientists uncover how ovarian cancer resists chemotherapy—and how to reverse it
Michigan State University researchers have identified how ovarian cancer cells become resistant to chemotherapy and discovered a protein that, when blocked, can restore the drug's effectiveness.
Jun 28, 2026
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Melatonin can be a safe and effective sleep aid for all ages but improper dosing leads to real harms
Melatonin—a go-to sleep aid for kids and adults alike in many households in America—continues to create media buzz, with conflicting messages that leave people uncertain about its safety.
Jun 28, 2026
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Researchers discover a cause of neuron excitability in ALS, suggesting a new potential treatment
Digging deep into the molecular mechanisms behind ALS, researchers at the Les Turner ALS Center at Northwestern Medicine have discovered why nerve cells overfire in the disease. Not only that—they have also designed a new ...
Jun 28, 2026
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Existing drugs could be repurposed for longevity by tapping network of aging-related genes
The quest to prolong life has gone on for as long as human existence itself, from the mythical Fountain of Youth to quick-fix fads like intermittent fasting, supplements and injections. But if you take a look in your medicine ...
Jun 26, 2026
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Dual human antibodies stop lethal Nipah and Hendra even after infection begins
An international research team led by investigators in the Department of Microbiology at the Icahn School of Medicine at Mount Sinai has developed the first fully human monoclonal antibody cocktail shown to provide complete ...
Jun 26, 2026
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Serious statin muscle side effects are rare for most people, new calculator shows
Researchers at the Nuffield Department of Primary Care Health Sciences, University of Oxford, have developed a new calculator that estimates a person's risk of developing serious muscle disorders from statins. The tool could ...
Jun 26, 2026
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Cancer drug shortage renews calls for federal action
Cancer doctors across the United States are running short of essential generic chemotherapy drugs, and some fear the squeeze could force widespread rationing, The New York Times reported.
Jun 26, 2026
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Combination therapy can help global fight against antibiotic resistance
A Monash University-led study has found that an unusual pairing of two commonly used antibiotics can kill and stop the spread of resistance in a highly drug-resistant bacterium, Pseudomonas aeruginosa, which can cause life-threatening ...
Jun 25, 2026
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How 'peacemakers' of the immune system could unlock long-term disease remission
"Peacemaker" immune cells could help treat diseases ranging from type 1 diabetes to neurodegeneration by restoring immune tolerance, according to a new paper in Frontiers in Science.
Jun 25, 2026
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Unfolding stomach capsule could target ulcer-causing bacteria for 48 hours
Between 50% and 100% of people in countries with poor access to clean water are infected with a bacterium called Helicobacter pylori. This bacterium is a leading cause of stomach ulcers, and it can even cause gastric cancer.
Jun 25, 2026
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Small-molecule antiviral drug targets ACE2 receptor to block coronaviruses from entering cells
The ongoing evolution of SARS-CoV-2, particularly the rapid emergence of the omicron variant and its sublineages, has weakened the effectiveness of existing vaccines and antiviral drugs, underscoring the potential risk of ...
Jun 25, 2026
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Nanotech platform combining paclitaxel with siRNA boosts immune response against lung cancer
Researchers at the University of Arizona R. Ken Coit College of Pharmacy have developed a new strategy that helps the immune system recognize and attack lung cancer tumors more effectively. By packaging a chemotherapy drug ...
Jun 25, 2026
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New oral heart failure drug appears to be safe and well tolerated in 58-patient early clinical trial
An early clinical study shows that a new oral drug is safe and well tolerated in patients with chronic heart failure. The study, led by researchers at Karolinska Institutet, has been published in The Lancet.
Jun 25, 2026
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Eliminating cancer cells that survive KRAS inhibition: A potential way to prevent relapse
Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory systems are disrupted, cells can acquire the ability to grow uncontrollably and become cancerous. ...
Jun 25, 2026
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Why ibuprofen is better than paracetamol for period pain
For something that affects millions every month, period pain remains surprisingly poorly treated.
Jun 25, 2026
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New COPD injection targets proteins in body to reduce inflammation
For the first time, patients have received a new injection for chronic obstructive pulmonary disease (COPD), thanks to research by King's College London.
Jun 25, 2026
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GLP-1 weight-loss boom linked to surge in poison control calls
As the use of GLP-1 medications for weight loss surges, so do calls to U.S. poison control centers, according to a new study.
Jun 25, 2026
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Wireless biodegradable sensor could help injured knees heal without dangerous overloading
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Emerging mRNA vaccine strategies target cancer and pathogenic viruses in potent new ways
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