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Clinical pharmacology news
Targeting the untargetable cancer—rezatapopt, an oral p53 reactivator
Memorial Sloan Kettering Cancer Center investigators and collaborators have tested rezatapopt, an oral p53 reactivator designed for tumors with TP53 Y220C, and observed antitumor activity across multiple solid tumor types ...
11 hours ago
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Growth hormone receptor could serve as possible target for improving lung cancer treatment
Researchers at Ohio University have discovered what may be a new way to fight lung cancer that is resistant to other treatments. The study, published in the International Journal of Molecular Science and led by Goll-Ohio ...
4 hours ago
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Statins, diuretics, and other common heart drugs do not worsen survival in multiple myeloma, scientists report
Commonly prescribed cardiovascular medications—such as statins, diuretics, and blood pressure drugs—appear to have little or no negative impact on survival among people living with multiple myeloma, according to new international ...
9 hours ago
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New drug could boost efforts to wipe out sleeping sickness
A new treatment for sleeping sickness could make it much easier to treat and possibly eliminate the deadly disease.
4 hours ago
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FDA to offer cash bonuses for faster drug reviews
The U.S. Food and Drug Administration's (FDA) chief says the agency will begin offering bonuses to drug reviewers who complete their work ahead of schedule.
5 hours ago
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International mpox trial finds no clinical benefit from tecovirimat
An international, randomized, double-blind, placebo-controlled Phase III study—the largest of its kind for mpox—found that tecovirimat did not improve clinical outcomes for adults with clade II mpox compared with placebo, ...
10 hours ago
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Chocolate male supplement recalled over hidden erectile dysfunction drug
A chocolate male enhancement product is being pulled from store shelves after federal health officials found it contains a hidden prescription drug. The company—USALESS.COM, based in Brooklyn, New York—is recalling its ...
2 hours ago
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Single dose of non-prescribed Adderall raises blood pressure and heart rate in healthy young adults, finds study
A Mayo Clinic study found that a single 25 mg dose of a combination of amphetamine-dextroamphetamine salts (Adderall) can have measurable cardiovascular effects in healthy young adults. The study aimed to better understand ...
3 hours ago
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Ivermectin was touted as a cure for COVID, now it's being tested for cancer. But what can it actually treat?
Ivermectin was originally celebrated as a revolutionary treatment for parasitic disease in humans and animals. It has since evolved into a focal point of misinformation and heated debate.
Mar 1, 2026
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HIV can develop resistance to blockbuster antiviral lenacapavir—but at a cost to the virus
Long-acting antiviral medications are transforming HIV prevention and care, requiring only minimalistic dosing. But as the use of lenacapavir expands, scientists are probing a critical question: If the virus evolves resistance, ...
Developing a human hepatocyte model with enhanced drug-metabolizing enzyme activity
A research team led by Associate Professor Shinpei Yamaguchi and the late Professor Masako Tada of the Faculty of Science, together with Professor Yojiro Anzai and Lecturer Yohei Iizaka of the Faculty of Pharmaceutical Sciences ...
Feb 28, 2026
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A blood marker could predict how people respond to antidepressants
Major depressive disorder (MDD) is among the most common psychiatric disorders, affecting approximately 330 million people worldwide. This disorder is characterized by persistent feelings of sadness, hopelessness, low motivation, ...
A new drug target for sleeping sickness and Chagas? Why the PEX38 protein stands out
Researchers working with Professor Ralf Erdmann at Ruhr University Bochum, Germany, have discovered a critical vulnerability shared by the pathogens that cause African sleeping sickness, Chagas disease, and leishmaniasis. ...
Feb 27, 2026
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Muscle repair may hinge on a timed metabolic 'switch,' study suggests
Scientists at the University of California, Irvine's School of Pharmacy & Pharmaceutical Sciences have discovered how muscle stem cells "flip a switch" to rebuild damaged muscle—a finding that could help address muscle ...
Feb 27, 2026
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Understanding GLP-1 signaling: A path to better therapies
About one in eight U.S. adults are currently taking a GLP-1 drug such as Ozempic, Wegovy, or Zepbound to treat diabetes, obesity, or other conditions, according to a KFF Health Tracking poll. But many suffer from significant ...
Feb 27, 2026
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Monthly cabotegravir-rilpivirine injections superior to standard oral ART for HIV with adherence challenges
Monthly injections of long-acting cabotegravir-rilpivirine are superior to standard oral antiretroviral therapy (ART) in persons with human immunodeficiency virus (HIV) and medication adherence challenges, according to a ...
Feb 27, 2026
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Study compiles 30 years of adhesion GPCR modulators and their key concentrations
Adhesion GPCRs are a large class of surface proteins that recognize chemical and mechanical stimuli in the body. The rapidly expanding body of knowledge on the therapeutic targeting of these receptors is raising hopes for ...
Feb 27, 2026
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Patients with atrial fibrillation face higher bleeding risks when treated with 2 common medications
Patients with atrial fibrillation who are prescribed diltiazem to control heart rate alongside anticoagulants (blood thinners) such as apixaban or rivaroxaban face a higher risk of serious bleeding compared with those taking ...
Feb 27, 2026
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Q&A: Prescription drug ads are everywhere. Is the 'ask your doctor' era over?
It's rare to make it through an episode of your favorite show without seeing a commercial for a prescription drug that includes a lengthy list of side effects and a prompt to speak with a doctor. And while these familiar ...
Feb 27, 2026
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Novel delivery method bypasses blood-brain barrier to treat ALS symptoms
A researcher at the University of Missouri has made a promising breakthrough in the quest to help people with amyotrophic lateral sclerosis (ALS), the neurodegenerative disorder commonly known as Lou Gehrig's disease. In ...
Feb 26, 2026
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Antibody developed to protect immune system cells in vitro from a dangerous hospital-acquired bacterium
A monoclonal antibody created by the Nanobiotechnology for Diagnostics group (Nb4D) at the Institute of Advanced Chemistry of Catalonia (IQAC), part of the Spanish National Research Council (CSIC), has demonstrated in cell ...
Feb 26, 2026
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New GLP-1 pill orforglipron outperforms oral semaglutide in yearlong diabetes trial
A novel GLP-1 receptor agonist (RA) pill called orforglipron leads to a larger reduction in blood sugar levels after a year than the current available oral GLP-1 RA (semaglutide), finds a phase 3 randomized controlled trial ...
Feb 26, 2026
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Oral semaglutide found to lower risk of heart failure events in people with type 2 diabetes
An international clinical trial has found that an oral form of semaglutide, a widely used diabetes drug, reduced the risk of serious heart failure events in people with type 2 diabetes who already had heart failure. The findings, ...
Feb 26, 2026
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Starving cancer: The effects of nutrient deprivation on synovial sarcoma
Synovial sarcoma is an aggressive malignant tumor that primarily affects the limbs of teenagers and young adults. While it can be cured if completely removed by surgery, recurrence or metastasis, the spread of cancer to organs ...
Feb 26, 2026
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Study identifies erythropoietin as a potential active ingredient in Primrose syndrome
A research team from Mannheim, Göttingen, Varna, and Princeton has discovered in animal studies with mice that the growth factor recombinant human erythropoietin (rhEPO) can significantly improve cognitive and social problems ...
Feb 26, 2026
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