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Clinical pharmacology news
Weight-loss drug semaglutide does not slow Alzheimer's disease, two clinical trials find
Oral semaglutide (a GLP-1 pill) is not effective at slowing progression in patients with mild Alzheimer's disease, finds the first large Phase III randomized controlled trials on the topic published in The Lancet.
14 hours ago
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Promising active substance against hepatitis E identified
Around 70,000 people die each year from infections with the hepatitis E virus. There is currently neither a vaccine nor a specific drug against this virus. This could change with the identification of bemnifosbuvir as a compound ...
19 hours ago
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India to tackle global obesity with cheap fat-loss jabs
A deluge of weight-loss drugs is set to transform the global fight against obesity as India prepares to unleash low-cost generic versions of injections like Ozempic after a key patent expired Friday.
23 hours ago
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Psilocybin combined with psychotherapy shows significant efficacy in treatment-resistant depression
There is an urgent need for new and more effective treatments for depression. The results of a recent study show that psilocybin, an active compound found in certain mushrooms, can have a significant antidepressant effect. ...
Mar 19, 2026
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Pythons' feast-and-famine life hints at new weight loss pathway
Pythons don't nibble. They chomp, squeeze, and swallow their prey whole in a meal that can approach 100% of their body weight. But even as they slither stealthily around the forest, months or even a year may pass between ...
Mar 19, 2026
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Early clinical results deliver encouraging milestone for malaria drug candidate
Findings from two early clinical studies suggest a new dual-action antimalarial drug candidate is well tolerated in humans. The first-in-class clinical candidate, MK7602, is being developed by WEHI and global biopharmaceutical ...
Mar 19, 2026
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Clot buster may stop promising stroke medicine from working properly
A clotbusting drug commonly used to treat ischemic stroke interacts negatively with a promising anti-inflammatory treatment (anakinra), underscoring the need to test new stroke therapies alongside existing standard care. ...
Mar 19, 2026
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Stopping GLP-1 drugs can quickly erase cardiovascular benefits
Following a rapid increase in popularity of GLP-1 drugs for diabetes and weight loss, such as semaglutide and tirzepatide, approximately one in eight U.S. adults now take these medications, which also provide cardiovascular ...
Mar 18, 2026
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Are psychedelics better than antidepressants? New study says no
Psychedelic-assisted therapy may be no more effective than traditional antidepressants when patients know what drugs they are actually taking, according to a first-of-its kind analysis that compared how well each type of ...
Mar 18, 2026
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GLP-1 medications used to treat diabetes and obesity may also help alleviate symptoms of anxiety and depression
GLP-1 medications used to treat diabetes and obesity were associated with a reduced need for hospital care and sickness absence due to psychiatric reasons, a new study shows. The large register-based study was carried out ...
Mar 18, 2026
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Experimental hookworm vaccine shows promising protection in phase 2 human trial
Researchers at the George Washington University School of Medicine and Health Sciences in partnership with Baylor College of Medicine report encouraging results from a phase 2 clinical trial evaluating a candidate vaccine ...
Mar 18, 2026
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FDA-approved compound promotes neuroprotective effects in Parkinson's disease
Northwestern Medicine scientists have discovered that an FDA-approved compound promotes neuroprotective effects in experimental models of Parkinson's disease. The compound, N-acetyl-L-leucine (NALL), simultaneously targets ...
Mar 18, 2026
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What is 'eye stroke' and why has it been linked to weight loss injections?
The phrase "eye stroke" has recently appeared in news reports about a very rare side effect of weight-loss injections. It's not a formal medical diagnosis, but a shorthand used to describe a condition in which reduced blood ...
Mar 18, 2026
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Study of coroners' reports highlights safety concerns linked to fentanyl patch deaths
Fentanyl is a highly potent and fast-acting synthetic opioid used to treat severe pain and is available in several forms, including injections, nasal sprays and skin patches. The study, which is published in the British Journal ...
Mar 18, 2026
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Could an anti-aging therapy worsen myelin loss? Findings raise caution and MS clues
A two-drug combination frequently used in anti-aging research causes brain damage in mice, report University of Connecticut researchers in the Proceedings of the National Academy of Sciences. The findings, titled "Senolytic ...
Mar 17, 2026
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Hidden drug reservoirs in cancer cells could explain treatment resistance
One of oncology's biggest challenges is that the same treatment can work well for some patients but fail completely in others. A study published in Nature Communications, by a multidisciplinary team led by Dr. Louise Fets ...
Mar 17, 2026
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Engineered bacteria deliver cancer drug directly inside tumors in mice
Every year, millions of people are diagnosed with cancer globally; however, current treatments are limited by disease complexity. A study published in the open-access journal in PLOS Biology by Tianyu Jiang at Shandong University, ...
Mar 17, 2026
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Osteoporosis drugs may cut dementia risk by 16%, study of 120,000 finds
A research team from the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine of the University of Hong Kong (HKUMed), has found that nitrogen-containing bisphosphonates (NBPs), a medication widely used in the ...
Mar 17, 2026
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Scientists find promising drug target for tuberculosis
Researchers from Imperial and the London School of Hygiene & Tropical Medicine (LSHTM) have discovered a drug target that could potentially help tackle drug-resistant tuberculosis, one of the biggest causes of death worldwide.
Mar 17, 2026
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Metformin use linked to lower odds of new-onset neovascular age-related macular degeneration
Metformin use is associated with reduced odds of new-onset International Classification of Diseases (ICD) coding of neovascular age-related macular degeneration (nAMD), according to a study published online Jan. 30 in Ophthalmology ...
Mar 17, 2026
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Magic mushroom‑infused products appear in Colorado gas stations: What public health officials want consumers to know
A Denver food and cannabis investigator became suspicious of PolkaDot-branded chocolate bars sitting next to convenience store energy shots and nicotine pouches in January 2026.
Mar 17, 2026
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Repurposing obsolete radioactive devices as radioisotope sources
To produce actinium-227, the isotope used for an FDA-approved cancer treatment, the first step is to bombard targets of the radioisotope radium-226 in ORNL's High Flux Isotope Reactor (HFIR). The problem? Radium, produced ...
Mar 17, 2026
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Can 'mini brains' replace lab animals? Organoids are changing how scientists study disease
As a researcher, I still remember the discomfort I felt every time I had to sacrifice laboratory animals for an experiment. For decades, animals like mice, rats and pigs have been essential tools in biomedical research. Yet ...
Mar 17, 2026
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New video series boosts safe psychotropic use in aged care
Researchers at Monash University and Flinders University have launched a series of microlearning education videos designed to support safer, more appropriate use of psychotropic medications for people living with dementia ...
Mar 17, 2026
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Q&A: Exploring the rise of telehealth-prescribed stimulants
In just one click, almost anything can be delivered to one's front door. Today's digital landscape offers countless conveniences through instant items and services, including prescription drugs.
Mar 17, 2026
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