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Clinical pharmacology news
Magic mushroom‑infused products appear in Colorado gas stations: What public health officials want consumers to know
A Denver food and cannabis investigator became suspicious of PolkaDot-branded chocolate bars sitting next to convenience store energy shots and nicotine pouches in January 2026.
47 minutes ago
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Repurposing obsolete radioactive devices as radioisotope sources
To produce actinium-227, the isotope used for an FDA-approved cancer treatment, the first step is to bombard targets of the radioisotope radium-226 in ORNL's High Flux Isotope Reactor (HFIR). The problem? Radium, produced ...
27 minutes ago
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Q&A: Exploring the rise of telehealth-prescribed stimulants
In just one click, almost anything can be delivered to one's front door. Today's digital landscape offers countless conveniences through instant items and services, including prescription drugs.
6 minutes ago
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Can 'mini brains' replace lab animals? Organoids are changing how scientists study disease
As a researcher, I still remember the discomfort I felt every time I had to sacrifice laboratory animals for an experiment. For decades, animals like mice, rats and pigs have been essential tools in biomedical research. Yet ...
2 hours ago
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New video series boosts safe psychotropic use in aged care
Researchers at Monash University and Flinders University have launched a series of microlearning education videos designed to support safer, more appropriate use of psychotropic medications for people living with dementia ...
4 hours ago
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No evidence to suggest medicinal cannabis is effective for depression, anxiety or PTSD, says systematic review
A landmark paper published in Lancet Psychiatry—the largest-ever review of the safety and efficacy of cannabinoids across a range of mental health conditions—found no evidence that medicinal cannabis is effective in treating ...
17 hours ago
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Novel cancer drug delivery system improves Paclitaxel absorption
Recent advances in drug discovery research have led to the development of numerous drug candidate compounds with high therapeutic efficacy. However, many of these compounds possess properties that make them difficult to handle, ...
21 hours ago
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Inappropriate antibiotic use for COVID-19 is linked to resistance
Taking azithromycin for as little as one day triggers antibiotic resistance in the respiratory tract, according to a first-of-its kind look by scientists at UC San Francisco of the changes that occur in the microbiome of ...
22 hours ago
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Stem cell therapy shows promise for reversing aging-related frailty in new clinical trial
Stem cells are gaining attention for their potential to treat leukemia, certain solid tumor cancers, and inherited metabolic disorders. Now, a clinical trial reports that a single dose can significantly improve physical strength ...
Experimental oral therapy PrimeC shows safety and signals of clinical benefit in ALS
In a phase 2b clinical trial, an investigational oral therapy called PrimeC was found to be safe and well tolerated in people living with amyotrophic lateral sclerosis (ALS), with exploratory findings suggesting target engagement ...
Mar 16, 2026
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Twice‑yearly injectable HIV regimen treatment demonstrates strong efficacy and safety in Phase 2 trial
A new study published in The Lancet Microbe reports the first twice-yearly injectable HIV treatment regimen—combining lenacapavir, teropavimab, and zinlirvimab—has achieved high rates of viral suppression and demonstrated ...
Mar 16, 2026
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Results support use of weekly extended-release buprenorphine for opioid use disorder during pregnancy
In a clinical trial, a research team found that administering weekly injectable extended-release buprenorphine for treatment of opioid use disorder (OUD) during pregnancy led to higher rates of abstinence from illicit opioids ...
Mar 16, 2026
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Could paraxanthine replace caffeine? What we know about the new stimulant appearing in coffee and energy drinks
Paraxanthine, a compound the body naturally produces when it breaks down caffeine, is starting to appear in energy drinks and even some coffee products as a potential caffeine alternative.
Mar 16, 2026
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Links between brain regions could predict the efficacy of antidepressants
Major depressive disorder (MDD) is a severe form of depression characterized by a persistent low mood, hopelessness, disruptions in sleep and/or eating habits, as well as a loss of motivation and interest in daily activities. ...
Higher buprenorphine doses help patients stay in opioid use disorder treatment, new study finds
Patients who are prescribed higher daily doses of the medication buprenorphine for opioid use disorder are significantly more likely to stay in treatment. Those on 17 to 24 milligrams averaged 190 days in care compared to ...
Mar 15, 2026
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How psychedelics push your brain to dream while awake: New study
A new study in mice suggests psychedelics make the brain more likely to "see" images from memory rather than what's actually in front of it.
Mar 14, 2026
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FDA warns Novo Nordisk broke safety reporting rules
Federal regulators have warned the maker of Ozempic and Wegovy that it failed to report possible drug side effects to the government.
Mar 14, 2026
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Kids can take tablets, so why are we still giving liquid medicines?
When six-year-old Seren was prescribed antibiotics, taking them four times a day quickly became a battle. The orange liquid tasted revolting, and much of it ended up on kitchen surfaces rather than in her mouth. Her mother ...
Mar 14, 2026
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Experimental Alzheimer's drug reverses memory loss in mice by reprogramming gene activity
A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease. Unlike current drugs, which mainly ...
Mar 13, 2026
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How vitamin B2 could pave the way to new cancer therapies
The human body cannot produce vitamin B2—also known as riboflavin—itself; it must absorb the important substance through diet. The vitamin can be found in dairy products, eggs, meat and green vegetables. The metabolism ...
Mar 13, 2026
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Novel compounds open new research avenues for Alzheimer's disease therapeutics
Alzheimer's disease is the most common cause of dementia, and it affects over 7 million people in the United States alone. Although there are treatments that can slow its progression, most of them treat its symptoms only ...
Mar 13, 2026
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Berberine as a natural Ozempic? An analysis of a popular myth
In recent years, berberine has increasingly appeared in the public sphere as a "natural way" to improve metabolism. In social media, it is sometimes compared to incretin drugs and even referred to as "plant-based Ozempic." ...
Mar 13, 2026
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Roflumilast cream has long-term safety, efficacy in young children
For children aged 2 to 5 years with atopic dermatitis (AD), roflumilast cream 0.05% has a favorable long-term safety profile and efficacy for up to 56 weeks, according to a study published online March 8 in Pediatric Dermatology.
Mar 13, 2026
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What happens when patients stop taking GLP-1 drugs? New study reveals real world insights
As the use of injectable GLP-1 drugs continues to rise, questions persist about what happens after patients stop taking them in real-world settings. A new Cleveland Clinic analysis of nearly 8,000 patients suggests that discontinuing ...
Mar 13, 2026
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Study finds CDK4/6 plus EGFR blockade kills pancreatic cancer cells without KRAS drugs
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 inhibition offers an indirect ...
Mar 13, 2026
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