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Clinical pharmacology news
Study proposes reconsidering how histone deacetylase inhibitors work in cancer treatment
Researchers at Baylor College of Medicine and collaborating institutions are challenging the traditional understanding of how cancer drugs called histone deacetylase (HDAC) inhibitors function. For decades, scientists believed ...
9 hours ago
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Drug nearly doubles survival in advanced pancreatic cancer—how daraxonrasib overcame an 'undruggable' disease
For a long time, the likelihood of surviving pancreatic cancer has been extremely low. For patients who were diagnosed with metastatic pancreatic cancer between 2015 and 2021, about 97% died within five years of their diagnosis.
20 hours ago
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Antibody fragment prevents hemorrhages associated with new Alzheimer's treatments
In 2025, the European Medicines Agency approved two antibodies for Alzheimer's disease: lecanemab (LeqembiTM, from Biogen) and donanemab (Kisunla, from Eli Lilly and Co.), both based on immunotherapy (the use of molecules ...
Jun 6, 2026
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GLP-1-based meds are linked to fewer heart events in adults with obesity, autoimmune disease
Among adults with both obesity and an autoimmune disease, those taking a glucagon-like peptide-receptor 1 agonist (GLP-1RA) medication had lower rates of emergency department visits and were less likely to experience serious ...
Jun 6, 2026
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Vitamin A poisonings rose almost 40% as measles misinformation spread in 2025
There can be too much of a good thing, and that has been the case with Vitamin A in the U.S.. A recent study in JAMA Network Open has found that between January and March 2025, America's Poison Centers reported a 38.7% increase ...
Flu drugs show promise against cognitive decline
A class of flu drugs may reduce cognitive decline and premature aging in people living with chronic viral infection, reports a new study led by Northwestern University that began with blood samples from people with HIV and ...
Jun 5, 2026
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Three new Ebola vaccines are being developed: An infectious disease expert explains
When it comes to Ebola outbreaks, it's not often we have two pieces of good news in one week. First, we heard there's new funding of up to US$62 million to fast-track the development of vaccine candidates against the type ...
Jun 5, 2026
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Topical gel helps burn wounds heal faster using an existing FDA-approved drug
Researchers at the Terasaki Institute for Biomedical Innovation and the University of Arizona College of Medicine have developed a topical gel formulation with 4-aminopyridine (4-AP), to treat burn wounds, achieving near-complete ...
Jun 4, 2026
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New drug cuts relapse risk by half in rare immune disorder trial
Stanford Medicine researchers and their colleagues found that a new drug, obexelimab, significantly reduces the risk of relapse in patients with IgG4-related disease, a rare chronic immune condition often misdiagnosed as ...
Jun 4, 2026
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At least two weather patterns increase headaches, study suggests
Two specific weather patterns have been identified as capable of increasing the risk of headaches, thanks to physicians at the University of Cincinnati College of Medicine, along with researchers at the Icahn School of Medicine ...
Jun 4, 2026
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Injectable hydrogel relieves osteoarthritis pain and repairs cartilage in preclinical tests
For millions of people living with osteoarthritis, daily life can involve a frustrating cycle of pain and stiffness. While current treatments like over-the-counter medications or steroid injections can temporarily dull the ...
Jun 3, 2026
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New antibiotic kills drug-resistant bacteria by targeting previously unknown vulnerability
Researchers at McMaster University have discovered a new antibiotic that kills some of the world's most dangerous and drug-resistant bacteria—and does so by targeting a previously unknown vulnerability, opening the door to ...
Jun 3, 2026
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Potential gene therapy for late-stage Parkinson's side-effects uncovered
Northwestern Medicine scientists have discovered that suppressing excitatory synaptic transmission in a small group of neurons in the brain may reverse levodopa-induced dyskinesia in patients with late-stage Parkinson's disease ...
Jun 3, 2026
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AI misses cancer drug target, revealing why lab validation still matters
Researchers at the Icahn School of Medicine at Mount Sinai have identified a previously hidden druggable site in a cancer-related protein that could open the door toward the development of a new generation of more precise ...
Jun 3, 2026
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Aspirin may unmask silent bladder cancer by triggering bleeding
The presence of blood cells in urine is a sign of bladder cancer. Because aspirin blocks platelets from forming harmful blood clots, the medication can cause mild bleeding or worsen existing bleeding in the urinary tract. ...
Jun 3, 2026
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Novel vaccine adjuvant could make it easier to eradicate polio
In the United States, children routinely receive an injectable form of the polio vaccine. This vaccine is very effective at preventing illness, but it doesn't block transmission of the polio virus as well as the oral polio ...
Jun 3, 2026
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Life-changing benefits of hydroxyurea for sickle cell anemia affirmed by 10-year study
Fewer serious complications. Fewer hospitalizations and blood transfusions. Better growth and development. And a markedly lower risk of death from the complications of sickle cell anemia.
Jun 3, 2026
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Single-cell platform tracks antibody drug delivery inside stubborn solid tumors
A recent paper in Nature Biotechnology examines problems and solutions for antibody-based therapies for solid pancreatic cancers and tumors of the head and neck.
Jun 3, 2026
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Dengue vaccine shows favorable safety profile in travelers from non-endemic regions
Data from 1,028 people vaccinated with TAK-003 in Catalonia suggests the dengue vaccine has a good tolerability profile in routine clinical practice among travelers from regions where dengue is not endemic. The findings come ...
Jun 3, 2026
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Telehealth booms as demand for GLP-1s surges and questions mount about safety, oversight
Within 24 hours of injecting the first dose of a weight loss medication she received following a visit with a telehealth doctor, Karleigh McClain was admitted to the hospital, she said. The 31-year-old compliance consultant ...
Jun 3, 2026
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Semaglutide linked to better quality of life in diabetes and kidney disease, trial shows
New findings from the landmark FLOW trial, presented at the 63rd ERA Congress, show that once-weekly semaglutide significantly improved health-related quality of life in adults with type 2 diabetes and chronic kidney disease, ...
Jun 3, 2026
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To curb overprescribing for seniors, researchers urge annual prescription checkups
To address the growing problem of overprescribing for seniors, a new Canadian guideline is calling for routine medication reviews. In Canada, roughly two in three adults age 65 or older take five or more medications. While ...
Jun 3, 2026
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Mathematical modeling tackles the human psychedelic experience
Psychedelic drug experiences are among the most fascinating but mysterious journeys of the human mind. Long the domain of indigenous shamans and modern "psychonauts" who seek self-discovery, the sensory-rich experiences often ...
Jun 3, 2026
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Early paracetamol treatment may speed closure of preterm infants' ductus arteriosus
Patent ductus arteriosus (PDA) is a common condition in preterm infants in which the fetal blood vessel connection between the aorta and the pulmonary artery does not close normally after birth. The condition can increase ...
Jun 3, 2026
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Ranking high blood pressure drug combinations from most to least tolerated
The Global Hypertension Report by the World Health Organization (WHO) revealed that 1.4 billion people were living with hypertension in 2024. Yet, only a little over one in five of those diagnosed have it under control, whether ...
