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Clinical pharmacology news
Experimental Alzheimer's drug reverses memory loss in mice by reprogramming gene activity
A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease. Unlike current drugs, which mainly ...
12 hours ago
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Roflumilast cream has long-term safety, efficacy in young children
For children aged 2 to 5 years with atopic dermatitis (AD), roflumilast cream 0.05% has a favorable long-term safety profile and efficacy for up to 56 weeks, according to a study published online March 8 in Pediatric Dermatology.
4 hours ago
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Novel compounds open new research avenues for Alzheimer's disease therapeutics
Alzheimer's disease is the most common cause of dementia, and it affects over 7 million people in the United States alone. Although there are treatments that can slow its progression, most of them treat its symptoms only ...
14 hours ago
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Aligning genomic data and clinical health records identifies potential medications for treating alcohol use disorder
A novel approach has identified drugs in current use that could be repurposed for treating alcohol use disorder (AUD). In 2023, 28 million US adults had experienced AUD in the past year. But only three medications are approved ...
9 hours ago
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Berberine as a natural Ozempic? An analysis of a popular myth
In recent years, berberine has increasingly appeared in the public sphere as a "natural way" to improve metabolism. In social media, it is sometimes compared to incretin drugs and even referred to as "plant-based Ozempic." ...
17 hours ago
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What happens when patients stop taking GLP-1 drugs? New study reveals real world insights
As the use of injectable GLP-1 drugs continues to rise, questions persist about what happens after patients stop taking them in real-world settings. A new Cleveland Clinic analysis of nearly 8,000 patients suggests that discontinuing ...
10 hours ago
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Study finds CDK4/6 plus EGFR blockade kills pancreatic cancer cells without KRAS drugs
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 inhibition offers an indirect ...
12 hours ago
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Scientists find a new therapeutic target present on up to half of all tumors
For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden ...
Mar 12, 2026
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Federal drug price reforms are improving medication adherence, new study finds
More than 1 in 4 U.S. adults struggle to afford their prescription medications. Those who can't are left with grim choices—such as skipping doses, cutting pills in half, or abandoning prescriptions entirely—that can come ...
Mar 12, 2026
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Romiplostim prevents serious side effect of chemotherapy in phase 3 trial
Results from a global phase 3 clinical trial led by investigators at Mass General Brigham show that the medication romiplostim can effectively prevent chemotherapy from destroying platelet-producing bone marrow cells, a common ...
Mar 12, 2026
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FDA provides fast track designation to nipocalimab for systemic lupus erythematosus
Johnson & Johnson's nipocalimab has been granted U.S. Food and Drug Administration Fast Track designation as a potential treatment for adults with systemic lupus erythematosus (SLE).
Mar 12, 2026
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Evaluating the effects of hypnotics for insomnia in obstructive sleep apnea
Obstructive sleep apnea (OSA) is a common sleep disorder characterized by oxygen desaturation due to repeated airway collapse during sleep. This leads to oxygen desaturation or awakening from sleep. It is often linked to ...
Mar 12, 2026
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Trial finds vitamin D supplements don't reduce COVID severity but could reduce long COVID risk
In a large, randomized trial, researchers at Mass General Brigham found that high-dose vitamin D3 did not reduce COVID-19 infection severity, but may impact long COVID outcomes. Results of the study are published in The Journal ...
Mar 12, 2026
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Large-scale study challenges link between acetaminophen use during pregnancy and autism risk in children
A team of Taiwanese researchers have used a nationwide, population-based cohort to examine whether taking acetaminophen during pregnancy might be linked to a higher likelihood of attention-deficit/hyperactivity disorder ...
Active ingredient of Viagra can help treat rare genetic disease
Sildenafil—an active ingredient also marketed under the name of Viagra—improves symptoms in patients with Leigh syndrome. This has now been reported in the journal Cell by researchers at Charité—Universitätsmedizin ...
Mar 11, 2026
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New malaria vaccine shows promise in preclinical trials
Malaria is caused by a parasite that is spread to humans by infected mosquitoes. In 2024, almost 282 million people worldwide were infected and 610,000 died, according to the World Health Organization. Malaria is a leading ...
Mar 11, 2026
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Claims data study ties epilepsy drugs in pregnancy to developmental risks
Findings published by The BMJ reinforce previous research linking use of the antiseizure drug valproate during pregnancy to neurodevelopmental disorders such as ADHD and autism in children, and indicate no substantial risk ...
Mar 11, 2026
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Safer blood clot treatment: Apixaban beats rivaroxaban in head-to-head comparison
The first clinical trial to compare two commonly used drugs head-to-head for venous thrombosis treatment has found a clear winner: while both drugs work well to prevent recurrent blood clots, apixaban is safer than rivaroxaban, ...
Mar 11, 2026
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Dengue vaccine remains 80.5% effective against severe cases after five years
In a phase 3 clinical trial, the tetravalent dengue vaccine, developed by the Butantan Institute in São Paulo, Brazil, was 80.5% effective against severe dengue cases with warning signs over a five-year period. The results ...
Mar 11, 2026
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Study finds ALS drug hope via AI and veteran records
A Lawrence Livermore National Laboratory (LLNL)-led team of scientists and computational engineers using one of the largest electronic health record datasets ever assembled for ALS has identified several existing medications ...
Mar 11, 2026
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Study uncovers a new mechanism explaining how chemicals affect sex hormones
Researchers at the University of Oulu have identified a previously unknown mechanism in humans that may explain why certain medicines and environmental chemicals disrupt the balance of sex hormones. The finding deepens scientific ...
Mar 11, 2026
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Many older adults develop cardiovascular conditions that affect anti-amyloid treatment
A new study finds that a significant portion of older adults with mild cognitive impairment or dementia develop new cardiovascular diagnoses each year that may require treatment with anticoagulants or thrombolytics—medications ...
Mar 11, 2026
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Medicinal cannabis eases endometriosis, pelvic pain
Medicinal cannabis could provide a new treatment option for those with endometriosis, with a study led by the University of Otago, Wellington showing it reduced pain, improved sleep and lowered anxiety. The study, led by ...
Mar 11, 2026
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FDA approves Sotyktu for adults with active psoriatic arthritis
The U.S. Food and Drug Administration has approved Sotyktu (deucravacitinib) for the treatment of adults with active psoriatic arthritis.
Mar 11, 2026
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