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Clinical pharmacology news

Q&A: What does science say about plants as medicine?

Plants have always played an integral role in traditional medicine and healing practices, according to Kent Vrana, Elliot S. Vesell Professor of Pharmacology at Penn State College of Medicine, and they continue to shape health ...

Pakistani genomes reveal 34,000 knockouts that could explain why mouse-based drugs fail in humans

A comprehensive analysis of 173,303 genomes from Pakistan, published today in Nature, is upending how scientists understand human genetics and drug development. By identifying 34,000 people who are "human knockouts," with ...

Why weight‑loss drugs don't work for some people

Weight-loss jabs are the latest craze for shedding a few pounds. Their effect has been dramatic, with drugs such as Ozempic and Wegovy (semaglutide) causing users to lose up to 15% of their body fat on average.

Beyond GLP-1s: The next chapter of obesity care

The rapid rise of GLP-1 medications such as semaglutide and tirzepatide has transformed obesity treatment. Still, experts say medications alone are not enough to address one of the nation's most pressing chronic diseases.