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Clinical pharmacology news
Synthetic compound targets malaria at multiple stages to prevent its transmission
Brazilian researchers have developed a synthetic compound that has the potential to treat malaria and block its transmission. The new molecule acts during three phases of the disease cycle, eliminating the asexual form of ...
6 minutes ago
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Nasal bird flu vaccine shows strong protection against infection in rodents
Since it was first detected in the U.S. in 2014, H5N1 avian influenza, commonly known as bird flu, has jumped from wild birds to farm animals and then to people, causing more than 70 human cases in the U.S. since 2022, including ...
Jan 30, 2026
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Metformin shown to prevent long COVID across risk groups in multiple randomized trials
Multiple randomized clinical trials and electronic health record studies now show that metformin, a widely used and well-established medication, significantly reduces the risk of developing long COVID when taken during or ...
Jan 29, 2026
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Faster to trials? Low-dose THC plus celecoxib improved cognition in Alzheimer's model mice
In recent years, research into cannabis and its main psychoactive ingredient, Δ⁹-tetrahydrocannabinol (THC), has unearthed medical benefits including anti-inflammatory and neuroprotective properties. However, THC is also ...
Jan 29, 2026
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Vaping zebrafish suggest e-cigarette exposure disrupts gut microbial networks and neurobehavior
Electronic cigarettes (e-cigarettes), widely marketed as a safer alternative to traditional cigarettes, are now hooking younger generations. World Health Organization data from 2025 show that at least 15 million adolescents ...
Jan 29, 2026
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Sex determines the connection between diseases: Study exposes historical biases in public health
Biological differences between women and men lead to variations in the appearance and progression of many diseases, which influence diagnosis and response to treatments. These differences also affect the relationship between ...
Jan 29, 2026
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Study confirms rare CYP2C19 and CYP2D6 variants reduce drug-metabolizing activity
A new in vivo pharmacokinetic recall study involving 114 participants in the Estonian Biobank has provided the first clinical confirmation that previously uncharacterized genetic variants in the drug-metabolizing enzymes ...
Jan 29, 2026
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When should dentists prescribe antibiotics? Some countries don't even have guidelines to answer this question
We're all familiar with the idea that we have to use antibiotics wisely. You've probably seen a poster at your local health center warning about their loss of effectiveness, and with good reason—bacterial resistance to ...
Jan 29, 2026
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Medicare to negotiate lower prices for Botox and 14 other major drugs
Fifteen prescription medications, including Botox and the diabetes drug Trulicity, will be the focus of federal price negotiations that could lower prices for Medicare patients.
Jan 29, 2026
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UK drug policy shows limited impact on novel psychoactive substances
Novel psychoactive substances (NPS) are chemically engineered substances designed to mimic the effects of traditional controlled drugs such as opioids, stimulants, and cannabinoids. These compounds pose significant health ...
Jan 29, 2026
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What medications are safe to take during pregnancy?
What's safe, what's not, and when to get your OB involved.
Jan 29, 2026
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Berberine shows no advantage over placebo for reducing liver and belly fat
A multicenter research effort in China conducted clinical trial testing of oral berberine for six months in diabetes-free adults with obesity and metabolic dysfunction-associated steatotic liver disease. Visceral adipose ...
Statins emerge as potential cancer immunotherapy boosters
Cancer immunotherapy has transformed modern oncology by harnessing the body's own immune system to combat malignant disease. Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have produced durable responses in ...
Jan 28, 2026
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No more jet lag? Scientists discover oral compound that helps 'reset' the body clock forward
A Japanese research team has discovered a new compound that can advance the body's internal clock—offering hope for faster recovery from jet lag and better adaptation to night-shift work. The compound, called Mic-628, specifically ...
Jan 28, 2026
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Tiny peptide shows promise in slowing epilepsy progression
Epilepsy is one of the most common neurological disorders in the world. According to the World Health Organization, around 50 million people live with epilepsy, a condition marked by recurring seizures that can also affect ...
Jan 28, 2026
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Antidepressants not linked to worse early outcomes after traumatic brain injury
Taking certain antidepressants at the time of a traumatic brain injury (TBI) is not associated with an increased risk of death, brain surgery, or longer hospital stays, according to a new study. For the study, researchers ...
Jan 28, 2026
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New research shows cannabis is effective for acute migraine treatment
In a study, published in Headache: The Journal of Head and Face Pain, researchers at University of California San Diego School of Medicine demonstrate for the first time in a placebo-controlled clinical trial that cannabis ...
Jan 28, 2026
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Enzyme PARG identified as a new target to enhance chemotherapy in colorectal cancer
Colorectal cancer is one of the most prevalent tumors and a leading cause of cancer-related mortality. Despite advances achieved in recent years, resistance to available treatments remains one of the main clinical challenges, ...
Jan 28, 2026
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Subcutaneous delivery of hyaluronidase may boost effectiveness of cancer immunotherapy
Monash University researchers, alongside key partner Halozyme Therapeutics, report findings in support of shifting the way anti-cancer immunotherapy is administered from intravenous administration to subcutaneous administration ...
Jan 28, 2026
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Clinical trial of early morning shift workers shows promise of new drug for reducing excessive sleepiness
Many more people work very early morning shifts than overnight ones, and a large proportion struggle with excessive sleepiness from shift work disorder, leading to problems with focus, performance, and safety. A recent clinical ...
Jan 28, 2026
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Team unveils simpler, faster way to make vaccines
UVA Health scientists have developed a promising new way to create vaccines that could be faster, cheaper, and easier to distribute than current options. The University of Virginia School of Medicine's Dr. Steven L. Zeichner ...
Jan 28, 2026
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Study identifies drug combinations that protect stem cell heart grafts from rejection
While current clinical trials for cardiac regeneration using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) employ immunosuppressive regimens used in heart transplants, the precise immunosuppressive regimen ...
Jan 28, 2026
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Acetaminophen and ibuprofen safe in first year of life, study finds
A new study supports the safety of the common painkillers acetaminophen and ibuprofen in the first year of life, and finds no link to eczema or bronchiolitis, a common respiratory illness.
Jan 27, 2026
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Study compares ways to support opioid deprescribing in primary care
A study published in The Annals of Family Medicine examined how different types of support for 32 primary care clinics affected opioid prescribing and overall costs using a 2 x 2 design. Clinics were divided into four groups: ...
Jan 27, 2026
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