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Clinical pharmacology news
FDA-approved compound promotes neuroprotective effects in Parkinson's disease
Northwestern Medicine scientists have discovered that an FDA-approved compound promotes neuroprotective effects in experimental models of Parkinson's disease. The compound, N-acetyl-L-leucine (NALL), simultaneously targets ...
13 minutes ago
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Could an anti-aging therapy worsen myelin loss? Findings raise caution and MS clues
A two-drug combination frequently used in anti-aging research causes brain damage in mice, report University of Connecticut researchers in the Proceedings of the National Academy of Sciences. The findings, titled "Senolytic ...
16 hours ago
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Hidden drug reservoirs in cancer cells could explain treatment resistance
One of oncology's biggest challenges is that the same treatment can work well for some patients but fail completely in others. A study published in Nature Communications, by a multidisciplinary team led by Dr. Louise Fets ...
17 hours ago
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Engineered bacteria deliver cancer drug directly inside tumors in mice
Every year, millions of people are diagnosed with cancer globally; however, current treatments are limited by disease complexity. A study published in the open-access journal in PLOS Biology by Tianyu Jiang at Shandong University, ...
19 hours ago
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Osteoporosis drugs may cut dementia risk by 16%, study of 120,000 finds
A research team from the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine of the University of Hong Kong (HKUMed), has found that nitrogen-containing bisphosphonates (NBPs), a medication widely used in the ...
14 hours ago
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Scientists find promising drug target for tuberculosis
Researchers from Imperial and the London School of Hygiene & Tropical Medicine (LSHTM) have discovered a drug target that could potentially help tackle drug-resistant tuberculosis, one of the biggest causes of death worldwide.
17 hours ago
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Metformin use linked to lower odds of new-onset neovascular age-related macular degeneration
Metformin use is associated with reduced odds of new-onset International Classification of Diseases (ICD) coding of neovascular age-related macular degeneration (nAMD), according to a study published online Jan. 30 in Ophthalmology ...
12 hours ago
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Magic mushroom‑infused products appear in Colorado gas stations: What public health officials want consumers to know
A Denver food and cannabis investigator became suspicious of PolkaDot-branded chocolate bars sitting next to convenience store energy shots and nicotine pouches in January 2026.
21 hours ago
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Repurposing obsolete radioactive devices as radioisotope sources
To produce actinium-227, the isotope used for an FDA-approved cancer treatment, the first step is to bombard targets of the radioisotope radium-226 in ORNL's High Flux Isotope Reactor (HFIR). The problem? Radium, produced ...
20 hours ago
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Q&A: Exploring the rise of telehealth-prescribed stimulants
In just one click, almost anything can be delivered to one's front door. Today's digital landscape offers countless conveniences through instant items and services, including prescription drugs.
20 hours ago
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Can 'mini brains' replace lab animals? Organoids are changing how scientists study disease
As a researcher, I still remember the discomfort I felt every time I had to sacrifice laboratory animals for an experiment. For decades, animals like mice, rats and pigs have been essential tools in biomedical research. Yet ...
22 hours ago
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New video series boosts safe psychotropic use in aged care
Researchers at Monash University and Flinders University have launched a series of microlearning education videos designed to support safer, more appropriate use of psychotropic medications for people living with dementia ...
Mar 17, 2026
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Stem cell therapy shows promise for reversing aging-related frailty in new clinical trial
Stem cells are gaining attention for their potential to treat leukemia, certain solid tumor cancers, and inherited metabolic disorders. Now, a clinical trial reports that a single dose can significantly improve physical strength ...
No evidence to suggest medicinal cannabis is effective for depression, anxiety or PTSD, says systematic review
A landmark paper published in Lancet Psychiatry—the largest-ever review of the safety and efficacy of cannabinoids across a range of mental health conditions—found no evidence that medicinal cannabis is effective in treating ...
Mar 16, 2026
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Twice‑yearly injectable HIV regimen treatment demonstrates strong efficacy and safety in Phase 2 trial
A new study published in The Lancet Microbe reports the first twice-yearly injectable HIV treatment regimen—combining lenacapavir, teropavimab, and zinlirvimab—has achieved high rates of viral suppression and demonstrated ...
Mar 16, 2026
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Experimental oral therapy PrimeC shows safety and signals of clinical benefit in ALS
In a phase 2b clinical trial, an investigational oral therapy called PrimeC was found to be safe and well tolerated in people living with amyotrophic lateral sclerosis (ALS), with exploratory findings suggesting target engagement ...
Mar 16, 2026
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Inappropriate antibiotic use for COVID-19 is linked to resistance
Taking azithromycin for as little as one day triggers antibiotic resistance in the respiratory tract, according to a first-of-its kind look by scientists at UC San Francisco of the changes that occur in the microbiome of ...
Mar 16, 2026
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Novel cancer drug delivery system improves Paclitaxel absorption
Recent advances in drug discovery research have led to the development of numerous drug candidate compounds with high therapeutic efficacy. However, many of these compounds possess properties that make them difficult to handle, ...
Mar 16, 2026
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Results support use of weekly extended-release buprenorphine for opioid use disorder during pregnancy
In a clinical trial, a research team found that administering weekly injectable extended-release buprenorphine for treatment of opioid use disorder (OUD) during pregnancy led to higher rates of abstinence from illicit opioids ...
Mar 16, 2026
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Could paraxanthine replace caffeine? What we know about the new stimulant appearing in coffee and energy drinks
Paraxanthine, a compound the body naturally produces when it breaks down caffeine, is starting to appear in energy drinks and even some coffee products as a potential caffeine alternative.
Mar 16, 2026
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Links between brain regions could predict the efficacy of antidepressants
Major depressive disorder (MDD) is a severe form of depression characterized by a persistent low mood, hopelessness, disruptions in sleep and/or eating habits, as well as a loss of motivation and interest in daily activities. ...
Higher buprenorphine doses help patients stay in opioid use disorder treatment, new study finds
Patients who are prescribed higher daily doses of the medication buprenorphine for opioid use disorder are significantly more likely to stay in treatment. Those on 17 to 24 milligrams averaged 190 days in care compared to ...
Mar 15, 2026
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How psychedelics push your brain to dream while awake: New study
A new study in mice suggests psychedelics make the brain more likely to "see" images from memory rather than what's actually in front of it.
Mar 14, 2026
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FDA warns Novo Nordisk broke safety reporting rules
Federal regulators have warned the maker of Ozempic and Wegovy that it failed to report possible drug side effects to the government.
Mar 14, 2026
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Kids can take tablets, so why are we still giving liquid medicines?
When six-year-old Seren was prescribed antibiotics, taking them four times a day quickly became a battle. The orange liquid tasted revolting, and much of it ended up on kitchen surfaces rather than in her mouth. Her mother ...
Mar 14, 2026
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