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Clinical pharmacology news
New GLP-1 pill orforglipron outperforms oral semaglutide in yearlong diabetes trial
A novel GLP-1 receptor agonist (RA) pill called orforglipron leads to a larger reduction in blood sugar levels after a year than the current available oral GLP-1 RA (semaglutide), finds a phase 3 randomized controlled trial ...
4 hours ago
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Single daily pill shows promise as replacement for complex, multi-tablet HIV treatment regimens
A new, daily oral tablet that combines two current HIV treatment medications, bictegravir and lenacapavir (BIC/LEN), could effectively replace more complicated HIV treatment regimens used by people living with HIV who are ...
21 hours ago
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Aspirin not a quick fix for preventing bowel cancer, review finds
Daily aspirin use does not offer a quick or reliable way to prevent bowel cancer in the general population and carries immediate risks of serious bleeding, a new Cochrane review finds.
14 hours ago
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Many post-authorization studies fail to comply with public disclosure rules
Many post-authorization studies registered with the European Medicines Agency (EMA) fail to comply with legal requirements and recommendations to make their findings public, finds a study published by The BMJ. Post-authorization ...
16 hours ago
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Opioids aren't effective for many acute pain conditions, researchers warn
A large review of opioid pain relievers prescribed for acute pain has found these medicines provide only small, short-term relief for some acute conditions and are ineffective for some others. The study set out to review ...
Feb 25, 2026
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Natural compound from pomegranate leaves disrupts disease-causing amyloid
A research team at Kumamoto University has discovered that a natural compound found in pomegranate leaves and branches can directly break down harmful protein aggregates linked to transthyretin (TTR) amyloidosis, a progressive ...
Feb 24, 2026
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New strategy grabs cancer's 'undruggable' proteins and throws them in the cellular trash
When cancer-driving proteins resist various treatments, Northwestern University scientists have uncovered a new solution. Don't fight them—throw them in the cellular trash. In a new study published in Nature Communications, ...
Feb 24, 2026
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How an anti-obesity drug improves metabolism beyond weight loss
Tirzepatide is one of the drugs that has revolutionized the treatment of obesity and other conditions such as diabetes in recent years. Despite its clinical success, its precise molecular and cellular mechanisms are still ...
Feb 24, 2026
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Lifespan-extending treatments increase variation in age at time of death
A key goal in aging research is not just to extend life, but to ensure more people live longer and healthier lives with less variation in age at death, a concept known as "squaring the survival curve." Using a recent meta-analysis, ...
Feb 24, 2026
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FDA cracks down on weight-loss drug alternatives as thousands sickened in Maryland
Popular weight-loss drugs, including Ozempic, Wegovy, Trulicity and Mounjaro, produced by independent pharmacy labs, sickened some 8,000 or more Marylanders a year by 2024. The Food and Drug Administration has announced that ...
Feb 24, 2026
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Can you take antidepressants while pregnant?
Many women who become pregnant while taking antidepressants face a difficult decision: Should they continue their medication to protect themselves against severe depression, or stop to avoid possible risks to the baby? New ...
Feb 24, 2026
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New drug candidate prevents preterm birth in preclinical studies
New research shows that Rytvela, an anti-inflammatory drug candidate, decreased premature birth and infant mortality when administered after the onset of preterm labor in a preclinical mouse model. The current standard treatment ...
Feb 24, 2026
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New 'liver-on-a-chip' device could make drug safety testing more reliable
Creating a drug that might help treat or cure a health condition in humans is a long, complex process. After developing a candidate drug that shows potential—a process that, in and of itself, can take decades—scientists ...
Feb 23, 2026
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Osteoporosis drug shows potential against diseases caused by excess iron
Researchers at the University of São Paulo (USP) in Brazil have discovered that two osteoporosis drugs (etidronate and tiludronate) may combat diseases caused by iron accumulation in the body. In tests conducted on human ...
Feb 23, 2026
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Semaglutide may increase risk for nonarteritic anterior ischemic optic neuropathy
People with type 2 diabetes starting semaglutide have more than a doubled risk for nonarteritic anterior ischemic optic neuropathy (NAION) versus those starting sodium-glucose cotransporter-2 inhibitors (SGLT2is), according ...
Feb 23, 2026
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Off-label antipsychotic use widespread among older adults, study finds
A large registry study in Finland by the University of Oulu and the University of Eastern Finland shows that many older adults receive antipsychotic medications for purposes other than those officially approved. Known as ...
Feb 23, 2026
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FDA proposes new system for approving customized drugs and therapies for rare diseases
Federal health officials on Monday laid out a proposal to spur development of customized treatments for patients with hard-to-treat diseases, including for rare genetic conditions that the pharmaceutical industry has long ...
Feb 23, 2026
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New 'navigator' model aims to speed cell and gene therapies to patients
Despite innovative new research, many cell and gene therapies do not make it all the way to the patients. Researchers and clinicians in Lund have now presented a new model for cooperation that will shorten lead times and ...
Feb 22, 2026
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Scientists develop first-of-its-kind antibody to block Epstein Barr virus
Fred Hutch Cancer Center scientists reached a crucial milestone in blocking Epstein Barr virus (EBV), a pathogen estimated to infect 95% of the global population that is linked to multiple types of cancer, neurodegenerative ...
Feb 21, 2026
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Study finds tirzepatide cuts alcohol intake by more than half in rodents
For the first time, researchers show that tirzepatide—the active ingredient in the diabetes and weight-loss drug Mounjaro—reduces alcohol intake as well as relapse-like behaviors in rats and mice. The findings are considered ...
Feb 20, 2026
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Immune cells from pediatricians help uncover an antibody cocktail against RSV and hMPV
Researchers in China recently published a study in Science Translational Medicine describing a new antibody cocktail for protection against two common viruses. The proposed preventative treatment consists of antibodies identified ...
'The munchies' are real and could benefit those with no appetite
The urgent onset of "the munchies" after cannabis use isn't imaginary—it's a cognitive response that occurs regardless of sex, age, weight or recent food consumption and could offer clues to help people struggling with ...
Feb 19, 2026
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Can the mental health benefits of exercise be bottled?
We all know the feeling: the mental clarity that comes after a good run or a heavy workout. Science backs this up, even showing that for non-severe depression, exercise can be just as effective as antidepressants or therapy. ...
Feb 19, 2026
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What's next for GLP-1s?
Now that GLP-1 drugs have revolutionized how millions of Americans treat obesity and Type 2 diabetes, scientists are exploring the benefits of using the drugs for a host of other chronic diseases—many with few treatment ...
Feb 19, 2026
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FDA will drop two-study requirement for new drug approvals, aiming to speed access
The Food and Drug Administration plans to drop its longtime standard of requiring two rigorous studies to win approval for new drugs, the latest change from Trump administration officials vowing to speed up the availability ...
Feb 19, 2026
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