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Clinical pharmacology news
First-in-class molecules dial down inflammation without compromising immunity
Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact—a long-sought goal in treating autoimmune diseases. The ...
4 hours ago
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GLP-1 agonist drugs show digestive side effects but may help fight infections
Originally developed to treat diabetes, a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are now stepping into the spotlight as weight loss drugs. A recent umbrella review draws attention to ...
10 hours ago
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This is your brain on psychedelics: Neuroimaging study sheds light on cortical network effects
Psychedelic drugs are being investigated as scientific and clinical tools, but the brain mechanisms behind their effects remain unclear. Earlier brain imaging studies in small cohorts from single centers produced inconsistent ...
5 hours ago
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Precision oncology success: Individualized multi-drug therapy outperforms standard care
A new article in the News and Perspectives section of the Journal of Medical Internet Research showcases the transformative potential of precision oncology. The article, "Further Promise and Potential for Precision Medicine ...
10 hours ago
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Over 3 million eye drops recalled amid sterility concerns
More than 3 million bottles of over-the-counter eye drops are being recalled after officials raised concerns about the product's safety.
9 hours ago
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This common antidepressant helps people cut back on methamphetamine: New study
Methamphetamine—more commonly known as meth, crystal or ice—is a highly addictive, stimulant drug.
Apr 5, 2026
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A potential universal flu shot? Intranasal EV vaccine protected mice from H5N1, H7N9
A novel vaccine platform has been developed to induce broad, protective immunity against numerous influenza virus infections, showing promise as an effective mucosal vaccine strategy, according to a study published by researchers ...
Apr 3, 2026
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Kratom poisonings surged 1,200% over the past decade, and regulators are struggling to keep up with the dangers
Proposals to ban or regulate kratom, a plant-based substance sold in gas stations, convenience stores and vape shops, are making headlines in local newspapers across the United States. But as lawmakers debate whether to regulate ...
Apr 3, 2026
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Mechanisms behind tumor suppressor BAP1 highlight new treatment strategies for aggressive cancers
A team of scientists led by the National Cancer Center Singapore (NCCS) and Duke-NUS Medical School (Duke-NUS) has found a new approach for treating some of the world's most aggressive cancers associated with BAP1 mutations. ...
Apr 2, 2026
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Small molecule drug candidate offers hope for rare kidney stone disease with no current treatment
Scientists at the Buck Institute for Research on Aging have shown that an orally administered small molecule, N-propargylglycine (N-PPG), can completely prevent the formation of calcium oxalate kidney stones, protect against ...
Apr 2, 2026
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Zebrafish reveal new insights into the biology of autism
In recent decades, the zebrafish has become one of the most valuable model organisms in scientific research. For a variety of reasons, including their genetic similarities to humans, these tiny tropical fish have helped researchers ...
Apr 2, 2026
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Innovative targeted therapy halts prostate cancer spread to the bone
New findings from VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM), published in Pharmacological Research, show that an innovative drug effectively prevents prostate tumors from spreading ...
Apr 2, 2026
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FDA approves new weight loss pill in record time
A new daily pill to help with weight loss has been approved by the U.S. Food and Drug Administration (FDA), and it moved through review faster than most drugs in recent years.
Apr 2, 2026
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New pill could change plaque psoriasis treatment
Folks with severe plaque psoriasis often have to choose between convenient pills that don't work very well or highly effective injections that come with the hassle of needles. That trade-off may soon change. New clinical ...
Apr 2, 2026
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First-in-class dual HIF inhibitors eliminate tumors in mice when combined with immunotherapy
Researchers at Johns Hopkins University and the University of Maryland School of Pharmacy have developed a set of novel, first-in-class drugs that inhibit hypoxia-inducible factors 1 and 2, a pair of transcription factors ...
Apr 2, 2026
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Poison centers see jump in kava calls
Calls to poison centers about kava—a drug found in drinks marketed as a healthy alternative to alcoholic beverages—rose 383% between 2011 and 2025, according to a new UVA Health study. The findings have been published in ...
Apr 2, 2026
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Small molecule could slow or stop progress of Parkinson's disease and related brain disorders, not just treat symptoms
A team of researchers from NYU Abu Dhabi and the University of Denver has identified a promising small molecule that could help slow or halt the progression of serious brain diseases such as Parkinson's disease, offering ...
Apr 1, 2026
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Common antidepressant offers fresh hope for people looking to reduce methamphetamine use
For the first time, people who want to stop using crystal methamphetamine may be able to treat their addiction with a cheap and readily available medication, say researchers at the National Drug and Alcohol Research Center ...
Apr 1, 2026
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A safer opioid? DFNZ discovery suggests pain relief with minimal addictive properties
Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential as a therapy for both pain and opioid use disorder. In a study published in Nature, the team observed ...
Apr 1, 2026
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Natural compound nigericin reduces endotrophin tied to obesity, study shows
Obesity is known to be a major risk factor that exacerbates metabolic disorders, such as type 2 diabetes. A key molecule involved in this process is endotrophin, a signaling protein that links excess fat accumulation to metabolic ...
Apr 1, 2026
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Gene editing therapy shows success against severe sickle cell disease
New results from a clinical trial show promising outcomes for a gene-edited treatment for severe sickle cell disease, a genetic blood disorder with few curative options. After research conducted as part of the multicenter ...
Apr 1, 2026
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Dangers of 'anti-aging' supplements in cancer protection revealed
Millions of Americans take daily supplements—nicotinamide mononucleotide (NMN), nicotinamide riboside (NR) and nicotinamide (NAM)—to boost energy, slow aging and protect the heart and brain. Many cancer patients also take ...
Apr 1, 2026
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Probing a paradoxical drug response for irregular heartbeat
Irregular heartbeat, or arrhythmia, can be treated with various procedures or medication, but not all medications work for all patients. In fact, one arrhythmia medication can actually cause arrhythmia in people with a common ...
Apr 1, 2026
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Will medicinal cannabis help my mental health? Here are the evidence and the risks
Anxiety, depression and post-traumatic stress disorder (PTSD) are among the most common mental health conditions for which Australians are prescribed medicinal cannabis.
Apr 1, 2026
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AAD: Significant benefits seen for brepocitinib 30 mg in dermatomyositis
For adults with dermatomyositis, brepocitinib, an oral tyrosine kinase 2/Janus kinase 1 inhibitor, demonstrates significant benefits at a 30-mg dose compared with placebo, according to a study published online March 28 in ...
Apr 1, 2026
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