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Clinical pharmacology news
Scientists uncover how ovarian cancer resists chemotherapy—and how to reverse it
Michigan State University researchers have identified how ovarian cancer cells become resistant to chemotherapy and discovered a protein that, when blocked, can restore the drug's effectiveness.
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Researchers discover a cause of neuron excitability in ALS, suggesting a new potential treatment
Digging deep into the molecular mechanisms behind ALS, researchers at the Les Turner ALS Center at Northwestern Medicine have discovered why nerve cells overfire in the disease. Not only that—they have also designed a new ...
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Melatonin can be a safe and effective sleep aid for all ages but improper dosing leads to real harms
Melatonin—a go-to sleep aid for kids and adults alike in many households in America—continues to create media buzz, with conflicting messages that leave people uncertain about its safety.
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Existing drugs could be repurposed for longevity by tapping network of aging-related genes
The quest to prolong life has gone on for as long as human existence itself, from the mythical Fountain of Youth to quick-fix fads like intermittent fasting, supplements and injections. But if you take a look in your medicine ...
Jun 26, 2026
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Dual human antibodies stop lethal Nipah and Hendra even after infection begins
An international research team led by investigators in the Department of Microbiology at the Icahn School of Medicine at Mount Sinai has developed the first fully human monoclonal antibody cocktail shown to provide complete ...
Jun 26, 2026
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Serious statin muscle side effects are rare for most people, new calculator shows
Researchers at the Nuffield Department of Primary Care Health Sciences, University of Oxford, have developed a new calculator that estimates a person's risk of developing serious muscle disorders from statins. The tool could ...
Jun 26, 2026
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Cancer drug shortage renews calls for federal action
Cancer doctors across the United States are running short of essential generic chemotherapy drugs, and some fear the squeeze could force widespread rationing, The New York Times reported.
Jun 26, 2026
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Combination therapy can help global fight against antibiotic resistance
A Monash University-led study has found that an unusual pairing of two commonly used antibiotics can kill and stop the spread of resistance in a highly drug-resistant bacterium, Pseudomonas aeruginosa, which can cause life-threatening ...
Jun 25, 2026
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How 'peacemakers' of the immune system could unlock long-term disease remission
"Peacemaker" immune cells could help treat diseases ranging from type 1 diabetes to neurodegeneration by restoring immune tolerance, according to a new paper in Frontiers in Science.
Jun 25, 2026
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Unfolding stomach capsule could target ulcer-causing bacteria for 48 hours
Between 50% and 100% of people in countries with poor access to clean water are infected with a bacterium called Helicobacter pylori. This bacterium is a leading cause of stomach ulcers, and it can even cause gastric cancer.
Jun 25, 2026
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Small-molecule antiviral drug targets ACE2 receptor to block coronaviruses from entering cells
The ongoing evolution of SARS-CoV-2, particularly the rapid emergence of the omicron variant and its sublineages, has weakened the effectiveness of existing vaccines and antiviral drugs, underscoring the potential risk of ...
Jun 25, 2026
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Nanotech platform combining paclitaxel with siRNA boosts immune response against lung cancer
Researchers at the University of Arizona R. Ken Coit College of Pharmacy have developed a new strategy that helps the immune system recognize and attack lung cancer tumors more effectively. By packaging a chemotherapy drug ...
Jun 25, 2026
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New oral heart failure drug appears to be safe and well tolerated in 58-patient early clinical trial
An early clinical study shows that a new oral drug is safe and well tolerated in patients with chronic heart failure. The study, led by researchers at Karolinska Institutet, has been published in The Lancet.
Jun 25, 2026
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Eliminating cancer cells that survive KRAS inhibition: A potential way to prevent relapse
Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory systems are disrupted, cells can acquire the ability to grow uncontrollably and become cancerous. ...
Jun 25, 2026
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Why ibuprofen is better than paracetamol for period pain
For something that affects millions every month, period pain remains surprisingly poorly treated.
Jun 25, 2026
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GLP-1 weight-loss boom linked to surge in poison control calls
As the use of GLP-1 medications for weight loss surges, so do calls to U.S. poison control centers, according to a new study.
Jun 25, 2026
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New COPD injection targets proteins in body to reduce inflammation
For the first time, patients have received a new injection for chronic obstructive pulmonary disease (COPD), thanks to research by King's College London.
Jun 25, 2026
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Will GLP-1s lead to fewer prescriptions for older adults?
As people age, they often develop chronic conditions, many of which need to be managed with multiple prescription medications. While medications are important for disease management, polypharmacy poses an increased risk for ...
Jun 25, 2026
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Using AI to tackle global superbug crisis
The development of new antibiotics could be sped up thanks to a new tool that tests the reliability of AI. University of Queensland researchers designed a framework to address the global threat of antimicrobial resistance, ...
Jun 25, 2026
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Language models read doctors' notes to reveal why patients discontinue medication
Researchers at the University of Tartu showed that large language models can identify with high accuracy why patients stop using antidiabetic medications or statins based on doctors' electronic clinical notes. The study opens ...
Jun 25, 2026
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New oral GLP-1 drug delivers up to 12% weight loss in 36 weeks
A new strategy for delivering GLP-1 drugs to patients with obesity or who were overweight resulted in up to a 12% reduction in body weight after 36 weeks, according to a randomized phase II clinical trial published in Nature ...
Jun 24, 2026
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How high cholesterol dismantles the liver's defenses—and how a new drug could combat it
Cholesterol-related heart disease remains the leading cause of death worldwide, and while doctors have more tools than ever to treat it, many patients still can't achieve safe cholesterol levels or can't tolerate the side ...
Jun 24, 2026
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Hidden medication risks for older Australians in aged care transition revealed
New research has shown concerning patterns of medication use among older Australians transitioning into residential aged care that may increase the risk of medication-related harm, highlighting opportunities to improve medication ...
Jun 24, 2026
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Trials of two Ebola treatments to start in DRC next week: WHO
Trials of two separate potential treatments to fight the deadly Ebola outbreak in the Democratic Republic of Congo are expected to begin next week, the World Health Organization said Wednesday.
Jun 24, 2026
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Foundational research points to new therapeutic strategies for an emerging cancer drug
Pancreatic cancer is one of the deadliest cancers and the third-leading cause of cancer-related death in the United States. While scientists continue searching for new therapies, advances can also come from understanding ...
Jun 23, 2026
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