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Clinical pharmacology news
Weight loss drugs and surgery improve fat-to-muscle ratio in obesity
Both the new weight loss drugs and bariatric (weight loss) surgery improve body composition in patients with obesity by inducing a moderate loss of fat-free mass (including lean muscle) along with a substantial reduction ...
23 hours ago
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Control valve discovered in gut's plumbing system may hold answers to constipation and diarrhea
Although constipation and diarrhea may seem like opposite problems, they both hinge on the same underlying issue: how much fluid moves into the gut. These common issues affect millions of people in the U.S. each year, yet ...
Jan 9, 2026
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What does cannabis 'rescheduling' mean for science and society?
Tens of millions of Americans turn to cannabis products every week to try to ease their pain, calm their anxiety, get more sleep, help them cope with the side effects of chemotherapy, or just relax and unwind.
Jan 9, 2026
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Kids with fractures and sprains don't need oral opioids for their pain, researchers find
Kids with broken or sprained limbs don't need oral opioids to treat their pain, according to newly published findings from a cross-Canada study by pediatric emergency researchers. The study is published in JAMA.
Jan 8, 2026
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IV iron found to be most cost-effective treatment for women with iron deficiency anemia and heavy menstrual bleeding
A single dose of intravenous (IV) iron dextran is the most cost-effective treatment for women with heavy menstrual bleeding and iron deficiency anemia (IDA), according to new research published in Blood Advances.
Jan 8, 2026
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GLP-1 receptor agonists tied to reduced acute asthma exacerbations in teens with overweight, obesity
Glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with a lower risk for acute asthma exacerbations in adolescents with overweight or obesity, according to a research letter published online Dec. 29 in ...
Jan 8, 2026
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Longer treatment with medications for opioid use disorder associated with greater probability of survival
A new study of over 32,000 US veterans has found that the longer people stay on medications for opioid use disorder (buprenorphine, methadone, or extended-release naltrexone), the greater the probability of short- and medium-term ...
Jan 8, 2026
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Single-dose oral cholera vaccine completes phase 1 trial with promising results
A team of scientists and physicians at Mass General Brigham has developed a single-dose oral cholera vaccine and tested it in a phase 1 clinical trial, with results published in The Lancet Infectious Diseases.
Jan 7, 2026
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Light-triggered microneedle patch could make IVF hormone delivery painless and automated
A McGill University research team has developed a painless, automated way to deliver in vitro fertilization (IVF) hormones using a light-activated microneedle patch, an innovation that could ease one of the most stressful ...
Jan 7, 2026
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Gene therapy 'switch' may offer non-addictive pain relief
A preclinical study uncovered a new gene therapy that targets pain centers in the brain while eliminating the risk of addiction from narcotics treatments, a breakthrough which could provide hope for the more than 50 million ...
Jan 7, 2026
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Stopping weight loss drugs linked to weight regain and reversal of heart health markers
Stopping weight loss drugs is followed by weight regain and reversal of beneficial effects on heart and metabolic health markers such as high cholesterol and high blood pressure, finds a study published in The BMJ.
Jan 7, 2026
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Cholesterol-lowering drug can overcome chemotherapy resistance in triple-negative breast cancer, researchers discover
Triple-negative breast cancer (TNBC) is among the most aggressive types of breast cancer, lacking estrogen, progesterone, and HER2 receptors and thus relying primarily on cytotoxic chemotherapy. Despite initial responsiveness, ...
Jan 7, 2026
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In the UK, 1.6 million adults used weight loss drugs in the past year
An estimated 1.6 million adults in England, Wales and Scotland used drugs such as Wegovy and Mounjaro to help lose weight between early 2024 and early 2025, according to a new study by UCL (University College London) researchers.
Jan 7, 2026
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Uncovering why cancer immunotherapy leads to heart inflammation
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by using the patient's own T-cells to target tumors. However, they can cause rare, but potentially fatal cardiac inflammation known as ICI-myocarditis. ...
Jan 7, 2026
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Immune sabotage: How a Vitamin A byproduct compromises the body's normal anti-cancer response
Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A—all-trans retinoic acid—compromises both the body's ...
Jan 6, 2026
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Organ-on-a-chip simulates drug-triggered muscle and kidney injury
Rhabdomyolysis is a condition in which muscle damage—often caused by drug intake—can lead to impaired kidney function and acute kidney failure. However, there have been limitations in directly observing how muscle and ...
Jan 6, 2026
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Novo Nordisk launches daily weight-loss pill to expand GLP-1 access
A daily pill for weight loss has officially arrived in the U.S.
Jan 6, 2026
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FDA approves Myqorzo for symptomatic obstructive hypertrophic cardiomyopathy
The U.S. Food and Drug Administration has approved Myqorzo (aficamten) for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Approval of Myqorzo was granted to Cytokinetics.
Jan 6, 2026
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Schizophrenia-linked genetic variant renders brain receptor unresponsive to both natural and therapeutic compounds
A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely silence a brain receptor that pharmaceutical companies are racing to target with new drugs.
Jan 6, 2026
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Targeting aberrant learning may improve Parkinson's treatment
Northwestern Medicine scientists have discovered that targeting neuronal signaling controlling aberrant learning in the striatum may improve the efficacy of a first-line therapy for Parkinson's disease and has the potential ...
Jan 5, 2026
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Enzyme replacement therapy offers hope for ultra-rare Hunter syndrome
Ongoing clinical research at UNC could lead to a first-of-its-kind enzyme replacement therapy for Hunter syndrome, an ultra-rare disorder that causes progressive multisystem disease and neurologic decline.
Jan 5, 2026
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Medications may help the aging brain cope with surgery and memory impairment
Simple pharmaceutical interventions could help older brains cope with memory impairment and recovery after surgery, new studies in mice suggest.
Jan 5, 2026
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GLP-1 drugs might help quell sleep apnea, study suggests
A good night's sleep might be an additional benefit some gain from taking weight-loss drugs like Ozempic and Zepbound, a new study says.
Jan 5, 2026
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