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Rescued by fat bubbles: Scientists treat rare genetic disease with designer molecule

Tiny fat bubbles carrying gene therapy have successfully repaired DNA in the lungs and liver of animals with alpha-1 antitrypsin deficiency—a promising leap toward treating humans with this rare inherited disease.

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Inhaled farm dust alters gut bacteria and weakens intestinal barrier in mice

Inhaling agricultural dust may pose significant risks to gut health for workers in animal agriculture, a University of California, Riverside, study has found.

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Researchers link CAR-T cell aging to cancer relapse

Mayo Clinic researchers have discovered a key reason some cancer patients relapse after receiving chimeric antigen receptor T-cell therapy, or CAR-T cell therapy. Over time, the engineered immune cells age and lose their ...

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New AI model could help scientists pinpoint signs of cancer cells

The Chan Zuckerberg Initiative (CZI) reports its latest AI model aimed at helping researchers better understand how cells behave by focusing on the key networks that control cell behavior, making complex biological problems, ...

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A new drug could soon help treat cancer and viral infections

An international team of researchers led by Konstanz biologists has identified a molecular mechanism that regulates the activity of N-myristoyltransferases. This enzyme plays a role in biological signaling pathways, where ...

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Study sheds light on bacteria associated with pre-term birth

Researchers from North Carolina State University have found that multiple species of Gardnerella, bacteria sometimes associated with bacterial vaginosis (BV) and pre-term birth, can coexist in the same vaginal microbiome. ...

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Fruit fly wing research offers window into birth defects

If fruit fly wings do not develop into the right shape, the flies will die. UC Riverside researchers have learned how fly embryo cells develop as they need to, opening a window into human development and possible treatments ...

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New data outline positive effects of endurance exercise training

Treadmill training, a form of endurance exercise, was found to be highly effective "with robust improvements in skeletal muscle citrate synthase activity in as little as [one to two] weeks, and improvements in maximum run ...

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The brain might also have a microbiome—what you need to know

The microbes that live in your gut are having their moment in the sun. Even if you haven't been following the research, you can't have missed the hundreds of adverts for probiotics and prebiotics, aimed at selling you products ...

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Study paves the way for an active agent against hepatitis E

At present, there is no specific active substance against hepatitis E. As the disease kills 70,000 people every year, researchers are actively searching for one. The team from the Department of Molecular and Medical Virology ...

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Fighting fat and inflammation: Scientists develop new compounds

Modified derivatives of natural products have led to significant therapeutic advances and commercial success in recent times. Menthol is a naturally occurring cyclic monoterpene alcohol found in various plants, particularly ...

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Axons in female mammal brains may be more prone to concussions

Important brain structures that are key for signaling in the brain are narrower and less dense in females, and more likely to be damaged by brain injuries, such as concussion. Long-term cognitive deficits occur when the signals ...