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Oncology news
Combination therapy does not meet primary endpoints in first-line PD-L1-high metastatic non-small cell lung cancer
Sacituzumab govitecan (SG) plus pembrolizumab did not demonstrate a statistically significant improvement in progression-free survival compared with pembrolizumab alone as first-line treatment for patients with metastatic ...
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Ivonescimab significantly improves overall survival versus pembrolizumab in advanced lung cancer
Ivonescimab significantly prolonged overall survival compared with pembrolizumab as first-line treatment for patients with PD-L1-positive advanced non-small cell lung cancer (NSCLC), according to a prespecified interim analysis ...
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Trial shows risvutatug rezetecan significantly improves overall survival in relapsed small-cell lung cancer
Results from the randomized Phase III ARTEMIS-008 trial show that risvutatug rezetecan (Ris-Rez), a B7-H3-directed antibody-drug conjugate, significantly improved overall survival compared with topotecan in patients with ...
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Tam-Peli extends survival by nearly four months in relapsed small-cell lung cancer
The phase 3 TAISHAN-302 trial found that tambotatug pelitecan (Tam-Peli, YL201), a novel anti-B7-H3 antibody-drug conjugate, significantly improved overall survival, progression-free survival and objective response rate compared ...
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Trial supports MRI surveillance over preventive brain radiation in small-cell lung cancer
Results from the international phase 3 SWOG S1827 MAVERICK trial show that brain MRI surveillance alone improved cognitive failure-free survival compared with MRI surveillance plus prophylactic cranial irradiation (PCI) in ...
49 minutes ago
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AI virtual cell uses protein dynamics to predict personalized breast cancer treatments
Not all cancer cells are the same, and neither are their responses to drugs. Finding the right drug for the right cancer cell is a long battle in drug development and in designing effective treatments. A new AI tool called ...
Subcutaneous tarlatamab shows favorable safety profile and antitumor activity in extensive-stage small cell lung cancer
Subcutaneous administration of tarlatamab was well tolerated and demonstrated preliminary antitumor activity in patients with previously treated extensive-stage small cell lung cancer (ES-SCLC), according to findings from ...
18 hours ago
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Extended-interval tarlatamab dosing shows consistent activity and safety in previously treated small cell lung cancer
Extended-interval dosing regimens of tarlatamab demonstrated efficacy, safety and pharmacokinetic profiles generally consistent with the established every-two-week regimen in patients with previously treated small cell lung ...
17 hours ago
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Pumitamig plus elfetabart drozuntecan shows encouraging early activity in small cell lung cancer
The investigational combination of pumitamig and elfetabart drozuntecan (elfe-D) demonstrated a manageable safety profile and encouraging early antitumor activity in patients with small cell lung cancer (SCLC), according ...
17 hours ago
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Investigational EGFR x HER3 therapy supports Phase III dose after lung cancer trial
An investigational EGFR x HER3 antibody-drug conjugate demonstrated promising efficacy with a tolerable safety profile in patients with previously treated EGFR-mutated non-small cell lung cancer (NSCLC), supporting selection ...
17 hours ago
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Perioperative atezolizumab + chemotherapy more than doubles event-free survival in resectable stage II–IIIB NSCLC
Patients with resectable stage II–IIIB non-small cell lung cancer (NSCLC) treated with perioperative atezolizumab plus platinum-based chemotherapy experienced a median event-free survival of 62.8 months compared with 34.9 ...
17 hours ago
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Local consolidative therapy does not improve survival after dual immunotherapy in metastatic NSCLC
Adding local consolidative therapy (LCT) after induction treatment with nivolumab plus ipilimumab did not improve overall survival or progression-free survival in patients with metastatic non-small cell lung cancer (NSCLC), ...
17 hours ago
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Drinking very hot tea and coffee is linked to a greater risk of esophageal cancer
That morning brew may be doing you more harm than good. A study of almost 1 million tea and coffee drinkers has linked very hot drinks to a threefold greater risk of developing one type of esophageal cancer.
New findings link obesity to loss of natural breast cancer protection
A research team at Huntsman Cancer Institute at the University of Utah (the U) has found that obesity prevents a biological process that kills cancerous cells, revealing a possible reason obesity is a risk factor for breast ...
Sep 11, 2026
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New 'smart' nanoparticles help the immune system better attack tumors
Adelaide University researchers have developed a new way to use mRNA technology to reprogram tumor-supporting immune cells and strengthen the body's anticancer immune response.
Sep 11, 2026
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First-in-human study attacks inoperable pancreatic tumors with laser light
UCI Health, the clinical enterprise of the University of California, Irvine, is conducting a first-in-human, Phase I clinical trial using laser light to target localized but inoperable pancreatic tumors to help patients become ...
Sep 11, 2026
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Giant-nucleus cells are key markers for early-stage cancer, study suggests
Iron is an essential micronutrient, but excess iron can damage cells and increase cancer risk. While many cells die from iron-induced oxidative stress, a subset survives and may become cancerous. Previously, the identity ...
Sep 11, 2026
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Chemotherapy alters 'Darwinian battleground' in our bodies
Cancer treatments, including chemotherapy and radiation therapy, give a growth advantage to cells with particular genetic changes in healthy tissue, new research finds.
Sep 11, 2026
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AI-enabled analysis of pathology slides may help assess risk of pancreatic cancer recurrence
Mayo Clinic researchers have found that artificial intelligence (AI)-enabled spatial analysis can identify patterns in routine pathology slides that may help clinicians identify which patients with pancreatic cancer are at ...
Sep 11, 2026
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Cancer is now the leading health threat for 9/11 survivors 25 years on
Twenty-five years after the World Trade Center attacks, cancer has become the defining health problem among survivors who breathed the toxic dust.
Sep 11, 2026
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Breast, cervical and colorectal cancer screening rates significantly lower for millions of U.S. adults with disabilities
Missing routine cancer screening tests can lead to critical delays in diagnosis and treatment. A new study by researchers at the American Cancer Society (ACS) shows that millions of U.S. adults with disabilities who are eligible ...
Sep 11, 2026
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COVID-19 pandemic accelerated adoption of shorter, lower-burden (lower cost) breast radiation therapy
The COVID-19 pandemic accelerated the adoption of shorter-course radiation therapy for women with early-stage breast cancer, leading to reduced treatment burden and lower health care spending, according to a new study published ...
Sep 11, 2026
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Novel immunotherapy leads to complete regression of chemotherapy-resistant liver cancer in 3-year-old
A new report in the New England Journal of Medicine by researchers at Baylor College of Medicine, Texas Children's Hospital and Seattle Children's describes a complete regression of hepatoblastoma, the most common pediatric ...
Sep 10, 2026
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AI-designed proteins outperform existing CAR T designs against BCMA tumors in mice
CAR T cell therapy, which involves genetically modifying a patient's own immune cells to fight cancer, is a technique that has shown great promise, especially against blood cancers. But currently, only about 4% of patients ...
Sep 10, 2026
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Platinum chemotherapy may cause decades' worth of DNA changes in children's healthy cells
The amount of DNA damage caused by certain chemotherapies used to effectively treat childhood cancer has been revealed, along with a hidden impact on the liver, paving the way for future research into new ways to mitigate ...
Sep 10, 2026
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