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Oncology news
A powerful new cancer map tracks hundreds of mutations to one escape route and exposes a drug target
Diseases like cancer or neurodegeneration are known to arise from genetic misfires. But treating such complex conditions hasn't been simply a matter of identifying the malfunctioning genes involved. With hundreds of genetic ...
14 hours ago
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Off-label cancer drugs deliver durable benefit for some patients in large trial
The largest published prospective evaluation of off-label targeted cancer therapies has shown that more patients could benefit from existing drugs. After including over 1,600 patients in the Dutch multicenter DRUP trial, ...
14 hours ago
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Genome-wide analysis reveals host–virus genetic interactions in cancer risk
A study from Columbia University Mailman School of Public Health reports a major advance in understanding how interactions between human and viral genomes shape disease risk. The research found that variations in the Epstein–Barr ...
14 hours ago
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Mitochondria keep key immune cells battle-ready by sustaining electron flow, study reveals
Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) show that active mitochondria maintain dendritic cells, the immune system's sentinels, in a "ready-to-respond" state, linking cellular ...
14 hours ago
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A major cancer protein hijacks RNA editing, exposing a new weakness in prostate tumors
Northwestern Medicine scientists have uncovered an unexpected role for a well-known cancer-related protein, revealing a new layer of genetic regulation that could reshape how certain cancers are treated. In a new study published ...
7 hours ago
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Blood-based DNA signals may help track osteosarcoma in children
Detecting whether osteosarcoma, a rare but aggressive bone cancer that most often affects children and adolescents, has returned or spread remains a major challenge for patients and doctors. Blood-based biomarkers, which ...
15 hours ago
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Overloaded RNA 'editing room' reveals weakness in RAS-driven cancers
Researchers at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have identified an overworked cog in the cellular machinery of tumor cells that could be targeted by new treatment options for an aggressive ...
5 hours ago
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A molecular movie captures cancer's great escape from targeted therapy
Cancer drugs are designed to shut tumors down. But sometimes, in the very act of attacking a tumor, treatment can also help a small fraction of cancer cells become harder to kill. A new study from researchers at the Institute ...
20 hours ago
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BRCA's cancer map just grew: Gene mutations now implicated in thyroid, bladder, skin and head-neck cancers
An international group led by researchers from the RIKEN Center for Integrative Medical Sciences (IMS) in Japan has discovered associations between pathogenic variants of the BRCA 1 and 2 genes and four types of cancer. Published ...
13 hours ago
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AI-powered biochip detects genetic markers in 20 minutes
A team of scientists from NTU Singapore has developed a new biochip that, when paired with artificial intelligence, can quickly and accurately detect extremely small amounts of microRNAs, which are tiny genetic markers linked ...
6 hours ago
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From benign growth to pancreatic cancer: New study shows how the switch gets flipped
As we age, our cells accumulate genetic changes—mutations—some of which open the door to cancer. Scientists call these mutations "oncogenic," meaning "tumor-producing." By our senior years, we each may harbor as many as 100 ...
6 hours ago
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AI tool reveals rare cancer cells tied to faster disease progression
McGill University researchers have developed an artificial intelligence tool that can identify small groups of cells most responsible for driving aggressive cancers. The tool, called SIDISH, offers scientists a clearer path ...
7 hours ago
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3D brain tumor organoids provide new scientific opportunities for research community
Efforts to identify and evaluate next-generation therapeutics for pediatric brain tumors are easily stymied by the quality and availability of laboratory models for research. To address this issue, scientists at St. Jude ...
7 hours ago
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Hormone therapy remains underused in cervical cancer care as clinicians cite key barriers
Most oncologists say they would prescribe hormone therapy to cervical cancer patients who experience early menopause from radiation treatment, but barriers are keeping many from doing so in practice, according to a new University ...
9 hours ago
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How do cancer cells 'learn' to resist treatment?
Researchers at NYU Langone Health propose a model that could explain how cancer cells adapt to environmental stress, an approach that may lead to new therapies. Published online April 15 as the cover story of the journal ...
7 hours ago
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AI spots melanoma risk patterns in 6 million adults up to five years early
Health care registry data can show early risk patterns for melanoma skin cancer, according to a study from the University of Gothenburg. Using AI, it is possible to identify small groups within the population that have a ...
17 hours ago
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Combining new drug with chemotherapy extends survival of platinum-resistant ovarian cancer patients in clinical trial
Platinum-based chemotherapy is a standard treatment for ovarian cancer, but its effectiveness can be limited in some cases. In some patients, the disease returns or progresses within six months of the last platinum dose, ...
Multiple myeloma cells adapt after immunotherapy, helping explain why many patients relapse
Multiple myeloma is the second most common blood cancer in adults. It starts in the white blood cells that are responsible for creating antibodies that help the body fight infections. Once the myeloma cells begin to multiply, ...
Apr 14, 2026
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New drug doubles 1-year survival in pancreatic cancer trial
Pancreatic cancer is one of the deadliest cancers and among the hardest to treat, with most patients surviving less than a year after diagnosis. But a new drug developed at Northwestern University may soon help patients live ...
Apr 14, 2026
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A new way to determine which patients will respond best to bowel cancer treatment
Nearly 10,000 cases of advanced bowel cancer are diagnosed in England each year, with cases in young adults rising. There are limited options for treating advanced bowel cancer. Scientists have now developed an AI-powered ...
Apr 14, 2026
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High antibodies create disparities in donor search for blood and bone marrow transplants
People who have elevated levels of donor-specific anti-HLA antibodies (DSAs)—immune system proteins that can target and attack donor stem cells—wait an average of three additional months to receive blood or bone marrow transplants ...
Apr 14, 2026
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Hidden tumor protein may help forecast immunotherapy success in colon and rectal cancer
Determining the presence of a protein in non-tumor cells within the cancer microenvironment could be one of the keys to establishing prognosis in patients with colon and rectal cancer. It may also help identify which patients ...
Apr 14, 2026
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Norway's 'Oslo patient' reaches HIV remission after rare stem cell transplant donated by brother
A Norwegian man has been effectively cured of HIV after receiving a stem cell transplant from his brother, doctors announced on Monday.
Apr 13, 2026
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Radiation may spark tissue changes that help triple-negative breast cancer return
While radiation therapy is an effective tool to destroy cancer cells, a new study from Vanderbilt researchers suggests that in an aggressive form of breast cancer, it may also trigger a protective cellular response that may ...
Apr 13, 2026
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A newly identified RNA target could make EGFR drugs work better against glioblastoma
Scientists have discovered that increased expression of a novel long non-coding RNA drives glioblastoma cell growth alongside a genetic amplification found in more than half of glioblastoma tumors, according to a Northwestern ...
Apr 13, 2026
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