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Oncology news
Why some cancer therapies don't work for all patients: A tumor backup survival pathway
Drugs that block enzymes called tyrosine kinases are among the most effective targeted therapies for cancer. However, they typically work for only 40% to 80% of the patients who would be expected to respond to them. In a ...
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3D-printed ATLAS platform helps model cancer cell clusters behind metastasis
Metastasis, the spread of cancer from a primary tumor to other parts of the body, is difficult to study in the lab, in part because researchers lack reliable ways to recreate the conditions cancer cells encounter as they ...
2 hours ago
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Study of 11,000 tumors maps 134 DNA damage signatures across 16 cancers
A team of cancer genomics scientists from The University of Manchester and The Institute of Cancer Research, London, forensically examined the genetic make-up of tumors in 16 different cancers. Their findings, which have ...
6 hours ago
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A new immunotherapy target? How SRC-3 in Tregs may reshape solid-tumor treatment
In 2023, researchers at Baylor College of Medicine led by the late Dr. Bert O'Malley discovered that the steroid receptor coactivator 3 (SRC-3) in immune cells called regulatory T cells (Tregs) plays a decisive role in shaping ...
3 hours ago
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Early results from a trial of active surveillance for low-risk ductal carcinoma in situ are 'reassuring'
Researchers leading a trial of active surveillance for ductal carcinoma in situ (DCIS) have described early results as "reassuring" in a presentation at the 15th European Breast Cancer Conference (EBCC15) in Barcelona.
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Tumor DNA circulating in patients' blood after pre-surgery treatments predicts whether breast cancer will return
Fragments of tumor DNA circulating in the bloodstream of patients with breast cancer can predict whether they are likely to relapse, especially when samples are taken after the patients have received treatments prior to surgery. ...
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DOCK10 emerges as key trigger of dangerous insulin hypersecretion in rare pancreatic tumors
The dedicator of cytokinesis 10 (DOCK10) gene has been identified as a key driver of abnormal insulin secretion in insulinomas, as reported by researchers from Institute of Science Tokyo. Using surgical specimens and patient-derived ...
2 hours ago
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Practical recommendations to strengthen cancer microbiome research
An international team led by researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) and A*STAR Genome Institute of Singapore (A*STAR GIS), has published a paper in Nature Cancer ...
4 hours ago
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MetaRing quickly identifies breast cancer drug sensitivity
Recently, a research team led by Prof. Wang Hongzhi from the Hefei Institutes of Physical Science, Chinese Academy of Sciences, has developed a programmable plasmonic ring biosensor, MetaRing, capable of rapidly and accurately ...
5 hours ago
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Breast cancer hijacks the lung repair system to fuel tumor growth, study finds
Researchers at the CU Anschutz Cancer Center have discovered how breast cancer cells that spread to the lungs may take advantage of the body's natural healing response and how a commonly used drug might slow that process. ...
12 hours ago
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A machine learning model may enable liver cancer risk prediction with routine clinical information
A machine learning model that analyzes patient demographics, electronic health record data, and routine blood test results predicted a patient's risk of hepatocellular carcinoma (HCC), the most common type of liver cancer, ...
20 hours ago
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Common blood pressure drug can boost cancer treatment
In a new Dartmouth Cancer Center (DCC) study led by clinical researcher Tyler J. Curiel, MD, MPH, FACP, investigators found that the FDA-approved blood pressure drug telmisartan can significantly enhance the cancer-killing ...
Mar 25, 2026
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How inflammation may prime the gut for cancer
Chronic inflammation can raise a person's risk of cancer, and a new study reveals key details about how that might happen in the gut and points to better ways to identify and reduce risk. Scientists at the Broad Institute ...
Mar 25, 2026
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Single-cell maps show chemokine signals collapse as aggressive lymphoma spreads
Lymph nodes are key control centers in the immune system and play an important role in defending the body against infections and tumors. For these processes to function properly, immune cells (B cells and T cells) must be ...
Mar 25, 2026
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Simple blood tests may predict response to lymphoma treatment
Many people with an aggressive blood cancer called diffuse large B cell lymphoma are cured by the current gold standard of treatment: an antibody designed to wipe out cancerous B cells plus a combination of four chemotherapy ...
Mar 25, 2026
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Researchers uncover the driving force behind a lethal infant brain tumor
An international team led by researchers at Baylor College of Medicine, Texas Children's Hospital, McGill University and University of Pittsburgh School of Medicine has discovered what drives the growth of a lethal pediatric ...
Mar 25, 2026
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Immune response to cancer may cause autoimmune disorders, including anti-NMDA receptor encephalitis
Consider two seemingly unrelated medical puzzles. First: Every day, our bodies produce hundreds of billions of new cells, many of which are mutated. If cancer arises from cellular mutation, why don't we all have the disease ...
Mar 25, 2026
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ZR fusion protein sways normal brain cell development toward cancer growth, study reveals
A team of researchers at Baylor College of Medicine, St. Jude Children's Research Hospital, Texas Children's Hospital and collaborating institutions reveal in the journal Nature a novel mechanism that drives the development ...
Mar 25, 2026
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Clinical trial finds hormone patches to be effective for locally advanced prostate cancer
Hormone patches are as good at controlling locally advanced prostate cancer as the injections typically used to deliver hormone therapy, according to the results of a large clinical trial led by UCL (University College London) ...
Mar 25, 2026
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Brain metastasis study reveals how tumors hijack immune cells
A team from the Spanish National Cancer Research Centre (CNIO) has discovered a novel way in which tumor cells alter the brain to establish themselves and spread cancer. They also demonstrate that a drug that prevents this ...
Mar 25, 2026
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Cellular 'atlas' of prostate cancer opens new avenues for earlier detection
Prostate cancer affects one in five Australian men, making it the most common cancer in the country. Now, researchers at the Garvan Institute of Medical Research have produced the world's most detailed cellular "atlas" of ...
Mar 25, 2026
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Radiotherapy rather than surgery may help reduce risk of lymphedema in patients with breast cancer
Patients with breast cancer may be able to avoid lymphedema, which can occur after surgery to remove lymph nodes in the armpit (the axilla), by having radiotherapy instead. New findings, presented at the 15th European Breast ...
Mar 25, 2026
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Form of infant leukemia caused by NUTM1 gene rearrangements found to be highly treatable
Despite a host of checks and balances that usually prevent harmful genetic mutations, sometimes mistakes happen, with serious consequences. Now, researchers from Japan elucidate how a common mutation underlying a common childhood ...
Mar 25, 2026
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Elinzanetant reduces severity and frequency of hot flashes and night sweats in breast cancer patients: Clinical trial
Results from the OASIS 4 clinical trial show that a new drug, elinzanetant, relieved hot flashes and night sweats that can occur because of the menopause or because of hormone treatment for breast cancer. Now, a new analysis ...
Mar 25, 2026
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Experts propose 10-year trial testing GLP-1 drugs to prevent obesity-related cancers
In new research to be presented at the European Congress on Obesity (ECO2026) in Istanbul, Turkey (12–15 May), a global panel of 21 obesity and cancer experts suggest that to test the potential efficacy of the new generation ...
Mar 25, 2026
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