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Oncology news
Investigational vaccine generates immune response to KRAS mutations in pancreatic cancer study
An investigational vaccine helped the immune system recognize and respond to mutations that drive most pancreatic cancers, according to results from a randomized phase 2 clinical trial led by Mayo Clinic researchers. The ...
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How cancers evade chemotherapy by entering a 'zombie-like state'
Scientists at Trinity College Dublin have made a breakthrough in understanding how cancer cells can evade the cell-killing effects of chemotherapy and enter a "zombie-like state," called premature senescence, that can attract ...
15 hours ago
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A precision T-cell therapy stalls treatment-resistant cancers in clinical trial
Early results of the first clinical trial to evaluate the drug invikafusp alfa (invika) in humans indicate that the treatment may be capable of managing cancers that have rebuffed most other interventions, including standard ...
14 hours ago
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Diagnostic test could help doctors refine prostate cancer treatment
Prostate cancer is the most common cancer in men—in 2013, it affected more than 1 million men across the world. The cancer does not behave the same way in every patient, and doctors have long faced a difficult balancing act ...
9 hours ago
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Cancer cells' own carbon monoxide fuels anticancer drug production in lab tests
What if we could use a cancer's own byproduct to make drugs that destroy tumor cells from the inside? That is what Katsunori Tanaka and his team have done at the RIKEN Pioneering Research Institute (PRI) in Japan.
16 hours ago
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Six-gene scoring system could help predict leukemia survival
The activity of six different genes can help determine survival in patients with acute myeloid leukemia (AML), according to a study published in Science Advances. The findings by researchers at the Center for Genomic Regulation ...
15 hours ago
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Reprogramming tumor microenvironment could improve prospects for treatment of pancreatic cancer
Pancreatic cancer is one of the most aggressive and difficult-to-treat cancers. One reason for its resistance to therapy is the dense tissue surrounding the tumor that acts as a protective barrier and suppresses the immune ...
10 hours ago
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Melanoma vaccine reduces death or cancer recurrence by 42%
In a world-first international trial, adding intismeran, a type of personalized therapeutic cancer vaccine made from each patient's own tumor, to pembrolizumab immunotherapy after surgery for high-risk melanoma reduced the ...
11 hours ago
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Online resources and coaching helped people seek genetic testing for cancer
About 10% of cancers are linked to an inherited genetic variant, but as few as one in 15 cancer patients eligible for genetic testing complete it.
13 hours ago
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Study identifies potential new treatment targets for the most common type of bowel cancer
Research published today identifies potential new ways to treat the most common type of colorectal cancer in Ireland. The study, conducted by an international research team led by RCSI University of Medicine and Health Sciences ...
14 hours ago
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Overlooked 'off switch' in lung tumors may explain why immunotherapy doesn't work for everyone
An overlooked mechanism in lung cancer tumors may help explain why most patients don't respond to immunotherapy, according to new research led by Olga Anczuków, professor at The Jackson Laboratory for Genomic Medicine in ...
17 hours ago
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Standard kidney function tests underestimate chronic kidney disease in people with cancer
New research indicates that commonly used measures of kidney function underestimate the prevalence of chronic kidney disease (CKD) in patients with cancer. The findings will be presented at ASN Kidney Week 2026, Oct. 22–25.
11 hours ago
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ESMO: New analysis reinforces survival benefits of targeted therapy for advanced pancreatic cancer
A new analysis of a phase 3 clinical trial found that the targeted drug daraxonrasib improved survival compared with standard chemotherapy across multiple groups of patients with advanced pancreatic cancer, including those ...
15 hours ago
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Real-world results confirm benefit of antigen therapy for prostate cancer
Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy is safe and effective for patients with metastatic castration-resistant prostate cancer (mCRPC) in routine clinical practice, consistent with ...
16 hours ago
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AI breast cancer survival model could improve accuracy and personalize care
New University of Cincinnati Cancer Center research published in the Journal of Statistical Theory and Practice describes the potential for a more robust and accurate breast cancer survival model that combines statistical ...
19 hours ago
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AI tool may support dermatologists in assessing skin lesions for cancer risk
Mayo Clinic researchers have found that an artificial intelligence (AI) tool may provide dermatologists with additional information to help assess whether skin lesions are cancerous and inform their clinical decisions about ...
19 hours ago
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Updated cancer treatment framework offers new guidance on actionability and resistance biomarkers
ESMO has published version 2 of the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT), a major update to the internationally recognized precision oncology framework that helps oncologists assess the clinical ...
21 hours ago
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Study identifies key drivers of microbiome-linked cancer immunotherapy side effect
Scientists at the University of Pittsburgh uncovered the unstable immune cells that can cause up to 40% of immunotherapy patients to experience serious side effects and showed that diet and microbiome composition influence ...
Oct 22, 2026
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Study reveals how melanoma outmaneuvers both drugs and immune defenses
Melanoma is one of the most difficult cancers to treat due to its resistance to targeted drug therapies. But a new study from the University of Kentucky Markey Cancer Center shows that the cancer is playing offense as well ...
Oct 22, 2026
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Liver tumors form without detectable driver mutations in mice, revealing epigenetic route
Cancers can develop through epigenetic pathways even without driver gene mutations (DGMs), according to a study from Science Tokyo. Researchers uncovered the YAP1–TEAD–TET1 axis, which triggers DNA demethylation and activates ...
Oct 22, 2026
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'Molecular glue' stabilizes protein that inhibits development of non–small cell lung cancer and uterine cancer
Protein phosphatase 2A plays a central role in controlling many cell signaling pathways, which are frequently disrupted during tumor development and growth.
Oct 22, 2026
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New AI platform helps uncover promising cancer drug combinations
UCLA investigators have developed a new artificial intelligence-based platform that could help scientists identify promising drug combinations to overcome treatment resistance in cancer.
Oct 22, 2026
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No disease recurrences after short course of neoadjuvant immunotherapy, according to follow-up
A short course of neoadjuvant immunotherapy continues to show long-term outcomes in patients with locally advanced mismatch repair–deficient (dMMR) colon cancer. In the NICHE-2 study, none of the 111 patients in the primary ...
Oct 22, 2026
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Comprehensive DNA sequencing reveals hidden drivers of cancer
Michigan's Oncology Sequencing Program, or MiOncoSeq, was the first of its kind in the nation to sequence patient tumors. Launched in 2010, the program analyzes DNA and RNA from normal tissue and tumors to identify alterations ...
Oct 22, 2026
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Earlier survivorship care linked to lower risk of head and neck cancer recurrence and death
Beginning survivorship care for head and neck cancer patients earlier is linked to better survival and lower recurrence, according to a new University of Pittsburgh study published in JAMA Otolaryngology–Head & Neck Surgery.
Oct 22, 2026
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