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Gastroenterology news

Stomach bacterium hijacks healing signals to drive precancerous changes, study finds

Stomach cancer is one of the deadliest forms of cancer. Unlike many other types of cancer, however, one of its main causes is well known: chronic infection with the bacterium Helicobacter pylori. A team headed by Charité—Universitätsmedizin ...

Experimental mRNA therapy dramatically extends treatment window for acetaminophen overdose in preclinical models

When a patient arrives at the hospital with an acetaminophen overdose, it's often a race against the clock. The only FDA-approved antidote for overdose-related liver injury, N‑acetylcysteine, must be administered within hours ...

Gut microbiome can reveal risk of type 2 diabetes

Changes in the composition of gut bacteria could provide an early warning of type 2 diabetes (T2D), according to new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) ...

Probiotics linked to fewer deaths in premature babies

Probiotic supplementation in very preterm babies was linked to a lower risk of both severe intestinal disease and death. This is shown by a new study from the Karolinska Institutet, published in JAMA Network Open. The findings ...

B cells may help predict risk of colitis from immunotherapy

Researchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown role for B cells, adaptive immune cells, in triggering and sustaining colitis as a side effect of immune checkpoint inhibitors, ...

Beyond GLP-1s: The next chapter of obesity care

The rapid rise of GLP-1 medications such as semaglutide and tirzepatide has transformed obesity treatment. Still, experts say medications alone are not enough to address one of the nation's most pressing chronic diseases.

Genetic marker may flag severe IBD earlier in some patients

In the largest genetic study of inflammatory bowel disease (IBD) traits to date, researchers have identified a genetic marker associated with more severe ulcerative colitis and Crohn's disease—the major forms of IBD.

Megacolon: When constipation becomes something more serious

The colon is about one and a half meters long and plays a vital role in moving waste through the body. In rare cases, it can become so stretched that it begins to lose its ability to work properly, like an elastic band that ...

Engineers find a way to deliver drugs directly to the esophagus

There are few treatment options available for people with disorders of the esophagus. Delivering drugs directly to this part of the body is difficult, so patients are usually treated with systemic drugs, which can have unwanted ...