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Immunology news

Oncology & Cancer

Tracing dormant cancer cells: Chemotherapy spurs awakening, but senolytic drugs may prevent relapse

Breast cancer often relapses in distant organs even when complete regression of primary tumors is achieved after initial treatment. Dormant and persistent disseminated tumor cells (DTCs) have been observed in animals with ...

Diseases, Conditions, Syndromes

Alveolar macrophage cell surface receptor TREM2 promotes lung fibrosis, study shows

Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages—the white blood cells that defend the body by killing microbes, removing dead cells and stimulating immune responses—are ...

Diseases, Conditions, Syndromes

T cells take aim at Chikungunya virus

A new study, published recently in Nature Communications, offers the first-ever map of which parts of the Chikungunya virus trigger the strongest response from the body's T cells.

Neuroscience

How a multiple sclerosis drug reshapes the immune system

When ocrelizumab became the first FDA-approved treatment for early forms of multiple sclerosis (MS) in 2017, it offered patients immense hope. The long-awaited drug is a monoclonal antibody that depletes B cells—the immune ...

Oncology & Cancer

Presurgical radiation may curb pancreatic cancer recurrence

Adding targeted radiation to chemotherapy prior to surgery may offer better control of pancreatic tumors—potentially reducing the rate of recurrence after treatment, according to a new study from UT Southwestern Medical ...

Oncology & Cancer

New drug combination effective for T-cell lymphoma patients

Relapsed/refractory peripheral and cutaneous T-cell lymphomas (R/R PTCL and CTCL) are aggressive blood cancers that often resist standard therapy. Patients with these lymphomas may require stem cell transplants, but the disease ...

Medical research

How modified RNA tricks the innate immune system

The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component of this system are pattern recognition receptors, which recognize non-self RNA—such as that from ...

Immunology

How a common metabolite worsens inflammatory bowel disease

Northwestern Medicine investigators have identified a surprising culprit in the progression of inflammatory bowel disease: a naturally occurring metabolic compound in the gut, according to a study published in Nature Immunology.