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Immunology news
Immunology
Innovative surfaces to rapidly load bone implants with antibiotics
Infectious complications are not uncommon after implant placement. The risk is higher in heavily contaminated wounds, which are particularly common in war zones such as Ukraine, where many bone injuries require treatment. ...
49 minutes ago
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VEXAS syndrome research reveals overactive bone marrow stem cells may drive inflammation
Researchers at Memorial Sloan Kettering Cancer Center (MSK) have developed some of the first robust laboratory models of a confounding adult-onset inflammatory disease called VEXAS syndrome—shedding new light on its mechanisms ...
7 hours ago
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Antibody therapy foils pancreatic cancer's sugar-based disguise to reawaken immune system
Pancreatic cancer is notoriously hard to treat and often resists the most advanced immunotherapies. Northwestern Medicine scientists have uncovered a novel explanation for that resistance: Pancreatic tumors use a sugar-based ...
13 hours ago
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How a tiny RNA molecule in the kidney triggers a deadly autoimmune disease
Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering a chain reaction.
13 hours ago
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Mitochondrial protein represents promising target for autoimmune disease treatment
A new study led by Swansea University has revealed a new way to potentially treat certain autoimmune diseases by targeting a protein that helps regulate energy production in immune cells.
9 hours ago
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Mapping the heart: How cells coordinate repair after heart attack
Over the course of evolution, the human heart has largely lost its ability to regenerate. Our distant ancestors were not afflicted by heart attacks—a condition that emerged primarily with modern lifestyles marked by poor ...
5 hours ago
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Immunotherapy resistance in kidney cancer driven by myeloid cell signaling
Immunotherapy with immune checkpoint inhibitors is standard first-line treatment for advanced renal cell carcinoma (RCC), but not every patient responds.
15 hours ago
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Restoring youthful microvascular function to aging skin
The New York University School of Medicine and collaborators found that capillary-associated macrophages in skin decline with age, weakening microvascular repair and reducing perfusion in mice, with skin restoration possible ...
Could a cancer vaccine developed long ago hold the key to long-term survival in breast cancer?
A small group of women with advanced breast cancer received a vaccine via a clinical trial more than 20 years ago. Today, they're all still alive. Scientists say that kind of long-term survival is almost unheard of for patients ...
Oct 31, 2025
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DNA copy-number changes help melanoma develop resistance to immunotherapy, study finds
A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators reveals how melanoma, the deadliest form of skin cancer, evolves to resist immunotherapy and identifies a potential strategy to prevent or reverse ...
Oct 31, 2025
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Researchers unravel mystery behind rare pregnancy disorder
Leiden researchers have found clues to why a rare pregnancy disorder is mild in some babies but life-threatening in others. Their discovery opens the door to a test that could identify severe cases during pregnancy. Fortunately, ...
Oct 31, 2025
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How Staph aureus reshapes immune system in children with rare genetic skin disorder
Scientists have demonstrated for the first time how Staphylococcus aureus—a leading cause of skin infections—reshapes the immune system's inflammatory responses in children with a rare skin condition.
The thymus hosts more 'cellular teachers' than we thought, study finds
A Czech scientist has contributed to understanding the function of the thymus—the training center of the immune system. T lymphocytes, key defensive cells, learn in the thymus not to mistake the body's own tissues for foreign ...
Oct 30, 2025
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Early clinical trial tests immune-boosting therapy before prostate cancer surgery
A small, early clinical trial led by the Icahn School of Medicine at Mount Sinai and collaborators has shown that directly injecting an immune-activating compound into prostate tumors before surgery appears safe and may help ...
Oct 30, 2025
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Dual studies uncover complementary strategies to overcome resistance to KRAS G12C inhibitors in lung cancer
Two companion studies published in Cancer Research by scientists at Moffitt Cancer Center identify distinct but complementary approaches to overcoming drug resistance in KRAS G12C-mutant non-small cell lung cancer.
Oct 30, 2025
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Immune cell subset reveals biological age beyond chronological years
Ben-Gurion University of the Negev's Prof. Alon Monsonego had discovered that T helper lymphocytes, a subset of immune cells which regulate immunity, undergo functional changes with age. These changes can indicate the biological ...
Oct 29, 2025
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Chemotherapy nerve damage linked to immune cell stress pathway activation
Scientists at Wake Forest University School of Medicine, in collaboration with researchers at Weill Cornell Medicine, have made a breakthrough in understanding why many cancer patients develop nerve damage after chemotherapy. ...
Oct 29, 2025
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Injectable drug helps asthma patients clear mucus-clogged airways
An anti-inflammation injectable drug can reduce mucus buildup and improve breathing among asthma patients, a new clinical trial says.
Oct 29, 2025
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Enhancing the body's 'first responder' cells may boost immune therapy for cancer
Mayo Clinic researchers have identified a specific immune cell that can be targeted to give a boost to standard immunotherapies for cancer. Two research teams, working collaboratively but using distinct approaches, found ...
Oct 29, 2025
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Clinical trial presents promising DNA-encoded therapy for long-lasting protection against COVID-19
A new way to deliver protective antibodies against COVID-19 was tested in a Phase I clinical trial. Instead of injecting pre-made antibodies into patients, this approach encouraged the body to produce its own antibodies to ...
Oxygen deprivation heightens risk of illness by changing genes, researchers discover
Low oxygen levels in the blood can alter the genetic makeup of key immune cells, weakening the body's ability to fight infection, new research shows.
Oct 28, 2025
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Custom-designed protein receptors help T cells target solid tumors more effectively
Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), have revolutionized cancer ...
Oct 28, 2025
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AI models help pinpoint key neoantigens for personalized skin cancer vaccines
In a new study, University of Arizona researchers created a model for cutaneous squamous cell carcinoma, a type of skin cancer, and identified two mutated tumor proteins, or neoantigens, that contain features of good candidates ...
Oct 28, 2025
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In-surgery radiation cuts pancreatic cancer return
Using targeted radiation during surgery—referred to as intraoperative radiation—to eliminate pancreatic cancer cells that have spread to areas around the pancreas, investigators at Johns Hopkins have been able to reduce ...
Oct 28, 2025
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