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Allergy and immunology news
Study identifies two factors that may help patients benefit from off-the-shelf CAR T-cell therapies
Researchers at The University of Texas MD Anderson Cancer Center have traced how off-the-shelf chimeric antigen receptor (CAR) T cells behave in patients, revealing how immune rejection and differences among CAR T cells influence ...
Sep 25, 2026
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Wiskott-Aldrich syndrome: Long-term results of gene therapy developed
A single infusion of genetically corrected autologous hematopoietic stem cells can provide lasting clinical benefits for patients with Wiskott-Aldrich syndrome, a rare genetic disorder that impairs immune and platelet function, ...
Sep 24, 2026
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Immune cells reveal widespread SMN protein loss in spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neurodegenerative disorder that leads to muscle loss and can severely impair the mobility of those affected. It is usually caused by a defect in the SMN1 gene, which is expressed in all ...
Sep 24, 2026
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Scientists find the gene that drives T-cell exhaustion, revealing new strategy to improve immune responses
Immunotherapy, which uses a patient's immune system to treat disease, has increased survival for some adults and children with cancer. However, it has had limited success against many pediatric solid tumors, in part because ...
Sep 23, 2026
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Computer-designed T-cell receptors boost attacks on cancer and viral targets in early tests
A joint team of researchers at Bar-Ilan University and the Weizmann Institute has used advanced computational design methods to enhance the ability of genetically engineered immune cells to recognize and attack cancer and ...
Sep 23, 2026
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Newly discovered inflammatory cell signaling could open the door to autoimmune disease treatments
Our understanding of how cells interact with each other has been driven for decades by the central concept of receptor-mediated signal transduction. Now, researchers from Boston Children's Hospital are reporting the discovery ...
Sep 23, 2026
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High-fat diets suppress enzyme in immune cells, promoting fat tissue inflammation in mice
A group of innate immune cells, known as group 2 lymphoid cells (ILC2), are essential for maintaining a stable metabolism in adipose tissue. Obesity significantly impairs the number and function of ILC2 cells, leading to ...
Sep 23, 2026
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Study identifies potential RAS inhibitor-immunotherapy strategy for pancreatic cancer
Pancreatic cancer does not respond to most immunotherapies, but RAS inhibitors could alter tumors to make them more sensitive to a novel immunotherapeutic approach. In pancreatic tumors with RAS mutations, RAS inhibitors ...
Sep 23, 2026
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Engineered 'triple-threat' immune cells could fight plaque buildup that causes heart attacks and strokes
A UCLA research team has engineered a new type of immune cell that attacks atherosclerotic plaques—the fatty buildup inside artery walls that drives most heart attacks and strokes. These engineered cells work by recognizing ...
Sep 22, 2026
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'Plug-and-play' CAR T technology adapts as cancer changes
Researchers from City of Hope have developed a new "plug-and-play" technology that adds engineered molecules to chimeric antigen receptor (CAR) T cells after treatment, allowing scientists to better control the cells and ...
Sep 22, 2026
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Immune cells that may help sustain type 1 diabetes attack identified
Type 1 diabetes isn't an overnight attack against the body's ability to make insulin. It can be a sustained campaign over years that relentlessly targets insulin-producing cells in the pancreas. Scientists have not fully ...
Sep 22, 2026
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Why repeated exposures may make allergies worse
A new preclinical study led by investigators from Mass General Brigham offers a potential explanation for two longstanding questions in allergy: Why do allergies often emerge only after repeated exposure, and why do people ...
Sep 22, 2026
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Restoring brain immune balance opens new avenue for Alzheimer's treatment
Professor Minah Suh of the Department of Biomedical Engineering at Sungkyunkwan University, in collaboration with the biotechnology company IMNEWRUN and Professor Ho-Keun Kwon's team at Yonsei University College of Medicine, ...
Sep 21, 2026
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Activated donor immune cells may prevent severe complication after allogeneic stem cell transplantation
Researchers have successfully conducted the first clinical trial using activated regulatory T cells (ATregs, Actileucel)—derived from white blood cells of healthy blood donors. This novel cell therapy aims to prevent graft-versus-host ...
Sep 20, 2026
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Eating more eggs and peanuts while pregnant does not prevent infant allergies, clinical trial finds
Millions of people around the globe might never know the taste of a PB&J sandwich or crème brûlée because of severe peanut and egg allergies. For a long time, avoiding exposure to allergy-causing foods early in life was considered ...
How a single viral protein hijacks immune cells to supercharge COVID-19 infection
In the sickest COVID-19 patients, SARS-CoV-2 doesn't just cause severe damage by directly infecting airway cells. The virus can also trigger hyperinflammation—a cycle in which immune cells themselves become infected, stop ...
Sep 18, 2026
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B cells may help predict risk of colitis from immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown role for B cells, adaptive immune cells, in triggering and sustaining colitis as a side effect of immune checkpoint inhibitors, ...
Sep 18, 2026
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Teaching the immune system to control HIV
There is no cure for HIV. While scientists have made considerable progress in controlling the infection, patients still must take daily antiretroviral medication for the rest of their lives. Results from a clinical trial ...
Sep 17, 2026
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Cancer biologists bring in the B-cell reinforcements for immunotherapy
Cancer is the second-leading cause of death in the United States, according to a 2026 Cancer Research Institute report. Cancer biologists are keenly aware of this statistic, as it drives innovations that revolutionize cancer ...
Sep 17, 2026
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Making invisible cancers visible: A new route to turn 'cold' tumors 'hot'
One of the biggest challenges in cancer immunotherapy may not be that immune cells are too weak, but that some tumors give them too little to see. New research from Dana-Farber Cancer Institute scientists reveals how cancers ...
Sep 17, 2026
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Vaccination: Why don't we all experience the same side effects?
Redness and pain at the injection site, fever, fatigue or headaches: Vaccines can cause side effects, but their frequency and severity vary considerably from person to person. Why?
Sep 17, 2026
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Big data analysis sheds light on psoriasis's genetic code
A research team from South Korea has revealed the specific mechanisms behind the onset of psoriasis by combining large-scale genomic data from more than 1.1 million people with advanced single-cell analysis technology. The ...
Sep 17, 2026
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Dietitians release first nutrition-focused guide for alpha-gal syndrome
A tick-borne food allergy that was almost unheard of years ago is now so common in Kentucky that many residents know someone living with it. To help patients, families, clinicians and the community make sense of it, registered ...
Sep 17, 2026
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For people with a rare skin disorder, high allergy risk adds another burden
For as long as Laura Hogan, 69, can remember, living with the rare skin condition lamellar ichthyosis has meant more than managing painful blisters and scaly skin. Throughout her life, she also has dealt with food allergies, ...
Sep 17, 2026
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Boosted Bacille Calmette-Guérin vaccine strategy significantly reduces tuberculosis relapse, scientists find
Tuberculosis (TB) remains one of the world's leading causes of death, and preventing post-treatment relapse continues to be a major global health challenge. But a new study led by scientists at the Hackensack Meridian Center ...
Sep 17, 2026
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