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Immunology news
Diseases, Conditions, Syndromes
AI identifies key mpox protein for new vaccine and antibody therapies
With the help of artificial intelligence, an international team of researchers has made the first major inroad to date toward a new and more effective way to fight the monkeypox virus (MPXV), which causes a painful and sometimes ...
6 hours ago
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Oncology & Cancer
Next-generation CAR T cells show stronger, safer response in animal models
Researchers from the Keck School of Medicine of USC have developed a new type of chimeric antigen receptor (CAR) T cell that elicits a more controlled immune response to cancer in mice—effectively killing cancer cells, ...
6 hours ago
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Off-the-shelf immunotherapy offers new hope for toughest myeloma
A new Mayo Clinic study published in the New England Journal of Medicine has uncovered that an off-the-shelf, dual-antibody therapy can generate deep and durable responses in extramedullary multiple myeloma—one of the most ...
3 hours ago
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Cell-free DNA could detect adverse events from immunotherapy
A noninvasive blood test to detect genetic material shed by tumors may help clinicians identify adverse events related to treatment with immune checkpoint inhibitor drugs, investigators at the Johns Hopkins Kimmel Cancer ...
3 hours ago
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Study unveils improved mRNA cancer vaccine targeting
No matter where cancer cells grow in the human body, they are a threat to our health and our lives. But instead of treating them with chemotherapy or radiation—which have undesirable side effects—what if we could train ...
4 hours ago
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Immune system's 'on-off' switch may hold answers for cancer and autoimmunity
A single signaling pathway controls whether immune cells attack or befriend cells they encounter while patrolling our bodies, researchers at Stanford Medicine have found. Manipulating this pathway could allow researchers ...
9 hours ago
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How the immune system stalls weight loss
Researchers at the University of California San Diego School of Medicine have uncovered a surprising new function for immune cells: preventing excess weight loss.
9 hours ago
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Pulmonary fibrosis traced to key signaling pathway
Idiopathic pulmonary fibrosis (IPF) is a chronic disease in which healthy lung tissue is gradually replaced by scar tissue. While the early events that initiate this change are poorly understood, recent research suggests ...
9 hours ago
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In pneumonia's tug-of-war, lung microbiome could tip the balance
Northwestern University scientists have potentially uncovered a previously unknown, hidden player in pneumonia. In a new study, scientists found the lungs' own microbial community, or microbiome, appears to influence how ...
9 hours ago
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How can we better protect a transplanted kidney? AI-based antibody analytics point the way
When we think of kidney transplantation, we usually focus on surgery, immunosuppressive drugs, and early post-operative tests. Much less attention is paid to what happens months or years later, when a silent damaging process ...
5 hours ago
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Real-time imaging captures what happens to cancer cells arriving in the brain
Metastasis occurs when cancer cells break away from the original tumor and travel through the bloodstream to form new tumors in other parts of the body. It is the leading cause of cancer-related death. Brain metastasis is ...
10 hours ago
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Specialized gut cells linked to celiac disease reveal new immune role
The human small intestine absorbs nutrients while protecting us from potentially harmful microbes. One of the cell types that plays a key role in this protection is the microfold cell (M cell). These cells detect bacteria ...
6 hours ago
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New cancer therapy brings remission for patients with deadly T-cell leukemia
A small group of patients with an otherwise incurable form of T‑cell leukemia have seen their cancer driven into remission by an innovative form of immune therapy.
4 hours ago
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Immune 'switch' identified as a potential target to curb chronic inflammation in cirrhosis
Chronic liver inflammation is one of the most serious complications associated with liver cirrhosis. Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified a molecular mechanism that acts as ...
4 hours ago
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Anxiety and insomnia may lower natural killer cell count, potentially repressing immune function
Natural killer (NK) cells are the bodyguards of our immune system. As a first line of defense, they destroy invading pathogens, foreign bodies, and infected cells in early stages, thereby preventing them from spreading. NK ...
20 hours ago
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FDA approves expanded indication for Jaypirca
The U.S. Food and Drug Administration has approved an expanded indication for Eli Lilly's Jaypirca (pirtobrutinib), the first and only noncovalent Bruton tyrosine kinase (BTK) inhibitor for adults with relapsed or refractory ...
11 hours ago
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Adding tucatinib to first-line maintenance therapy delays disease progression in HER2-positive metastatic breast cancer
Adding tucatinib (Tukysa) to first-line maintenance therapy with trastuzumab (Herceptin) and pertuzumab (Perjeta) delayed disease progression in patients with HER2-positive metastatic breast cancer, potentially extending ...
12 hours ago
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Sacituzumab govitecan-hziy led to similar progression-free survival as standard of care for some breast cancers: Trial
Patients with hormone receptor (HR)-positive, HER2-negative advanced breast cancers had similar progression-free survival (PFS) whether they were treated with sacituzumab govitecan-hziy (Trodelvy) or standard-of-care chemotherapy ...
12 hours ago
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Dietary restriction fuels T cells with ketones, boosting their cancer-fighting stamina
Reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively, reports a study by Van Andel Institute scientists and collaborators. The findings lay the groundwork for developing dietary strategies ...
Dec 9, 2025
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Disarming cancer stem cells' shield makes immunotherapy more effective
Immunotherapy has revolutionized cancer care by training the immune system to detect and destroy tumors. For many patients, it works very well in shrinking tumors and sending cancer into remission, an undetectable state of ...
Dec 9, 2025
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Experimental antibody enables lasting platelet stability in autoimmune bleeding condition
More than half of patients in a Phase III clinical trial who received a limited course of the experimental monoclonal antibody ianalumab for primary immune thrombocytopenia (ITP), an autoimmune disorder that can cause life-threatening ...
Dec 9, 2025
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Combination treatment shows large improvement in survival for people with relapsed myeloma
At the American Society of Hematology Conference in Orlando, new results from the MajesTEC-3 study show that combining teclistamab with daratumumab could help people with myeloma whose cancer has come back or hasn't responded ...
Dec 9, 2025
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Team discovers how to target 'undruggable' protein that fuels aggressive leukemia
Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs—a discovery that could open the ...
Dec 9, 2025
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Researchers find vital clue in the progression of Type 1 diabetes
Type 1 diabetes is a disease in which the body mistakenly attacks itself as the immune system destroys the pancreas's insulin-producing cells. Why the immune system turns against these cells remains one of the enduring questions ...
Dec 9, 2025
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Tec-Dara combination offers improvement over standard second-line therapies for relapsed, refractory multiple myeloma
Patients with relapsed or refractory (R/R) multiple myeloma who received a combination of teclistamab, a bispecific monoclonal antibody, and daratumumab, a CD38-directed monoclonal antibody, were 83% more likely to be alive ...
Dec 9, 2025
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