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Allergy and immunology news
Study in Drosophila reveals how the immune system adjusts development in response to excess sugar
Diets rich in sugars and fats are associated with metabolic disorders such as insulin resistance, chronic inflammation and diabetes. During development, these imbalances can have a particularly significant impact, as the ...
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Butyrate alters dendritic cell development and surface markers through epigenetic control, study finds
The benefits of dietary fiber extend beyond digestive health, as dietary fiber-derived metabolites produced by gut microbiota can influence immune function. Short-chain fatty acids (SCFAs) are secondary metabolites produced ...
36 minutes ago
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Targeted IL-15 drug in patient testing revives exhausted T cells without triggering severe inflammation
For some people, cancer immunotherapies are life-changing. These treatments can turn the body's own immune system against a tumor, either eliminating it or shrinking it enough to make surgery possible. But these therapies ...
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Two patients with severe autoimmune disease remain relapse-free for over 15 years after stem cell transplant
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune condition in which the body's own defenses turn against the optic nerves and spinal cord. This confusion leads to inflammation that can rob people of their ...
How RSV manipulates the immune response in respiratory cells
Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infections, particularly in newborns and older adults. How the virus manages to evade the immune system and what changes it triggers in infected cells ...
9 hours ago
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Can we cure asthma? Yes, and we have a plan
Asthma is conventionally viewed as "treatable but incurable." In other words, we can manage its symptoms but not reverse the underlying condition. But advances in science are challenging this view, and we think a cure may ...
5 hours ago
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How neutrophils help triple-negative breast cancer cells spread
Researchers at Baylor College of Medicine and collaborating institutions have discovered how immune cells called neutrophils can help triple-negative breast cancer (TNBC) cells metastasize to other organs. The study, published ...
10 hours ago
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Neuroimmune abnormalities may play a key role in fibromyalgia
Fibromyalgia is a complex disorder characterized primarily by chronic widespread pain, fatigue and other physical and cognitive symptoms. Although it affects millions of people worldwide, the underlying biological mechanisms ...
Jun 21, 2026
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A renewable cell source for cancer immunotherapy could make off-the-shelf treatments possible
In a paper published in Cell, a USC Stem Cell-led team reports a new way of generating a renewable and expandable supply of the progenitor cells that give rise to macrophages. These immune cells help drive the body's response ...
Jun 19, 2026
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New tool maps how T cells move within tumors
Researchers at UT Southwestern Medical Center led a study to develop a computational method that reveals how immune cells navigate the complex environment inside tumors, offering insights that could inform future cancer therapies. ...
Jun 19, 2026
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Lab-on-a-chip platform shows how immune cells attack cancer cells
Immunotherapies are a promising approach in the fight against cancer. Researchers at the Technical University of Munich (TUM) have developed a lab-on-a-chip system called CellTrap. It makes it possible to observe the interactions ...
Jun 18, 2026
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A diet-derived nutrient in breast milk may shape immune development
Trans-vaccenic acid (TVA), the most abundant trans fatty acid found in human breast milk, helps boost immune system development and has long-lasting effects on immune system health in mice, according to a new study by researchers ...
Jun 18, 2026
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SARS and MERS trigger immune brake that shuts down antiviral defenses, study finds
Researchers from Trinity have discovered how two deadly coronaviruses (SARS1 and MERS) outsmart one of our most important antiviral defenses by shutting down parts of the immune system. The findings help explain why certain ...
Jun 18, 2026
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Rewired metabolism helps revive exhausted immune cells and boost cancer immunity
Researchers from National Taiwan University (NTU) and National Taiwan University Hospital (NTUH) have identified a promising way to reinvigorate the body's cancer-fighting immune cells by rewiring their metabolism, revealing ...
Jun 17, 2026
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Diabetes and obesity drugs may help with inflammation and repair of skin
GLP-1 receptor agonists are currently among the most widely discussed classes of drugs worldwide. They have gained popularity for their effectiveness in treating type 2 diabetes and obesity, but increasing evidence suggests ...
Jun 17, 2026
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An intranasal flu vaccine approved two decades ago may have underappreciated immune benefits
For decades, influenza vaccines have been judged largely by the antibodies they generate in the bloodstream, a measure that has remained the gold standard since the first flu immunizations were administered in the 1940s.
Immune cell circuit restores barrier function in inflammatory bowel disease
Scientists have discovered a new protective communication circuit between specialized immune cells in the intestines, a circuit that may be therapeutically targeted to improve inflammatory bowel disease outcomes, according ...
Jun 16, 2026
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Mapping immune cell interactions in gut tissue reveals changes in ulcerative colitis
In a new study published in Science Immunology, researchers at King's College London looked at a type of tissue important for the immune response called gut-associated lymphoid tissue (GALT), which is located within the lining ...
Jun 16, 2026
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Crohn's atlas maps gene shifts across more than 50 gut cell types
A detailed cellular study of Crohn's disease has mapped how gene activity changes across more than 50 cell types in the gut. The study provides an open resource of the genes that characterize each cell type and those whose ...
Jun 15, 2026
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In vivo CRISPR therapy successfully reduces hereditary angioedema attacks in first Phase III trial
Researchers from Amsterdam UMC, in collaboration with other hospitals, have successfully completed the first Phase III study of an in vivo CRISPR therapy. In this large-scale, double-blind trial, 80 patients with hereditary ...
Jun 15, 2026
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Genetic cause for rare skin condition points to new therapeutic option
An international team of researchers report in the journal Nature Immunology that a mutation in the gene OTULIN causes pediatric-onset pyoderma gangrenosum, characterized by recurrent ulcerating skin sores. They classify ...
Jun 15, 2026
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Why some immunotherapy fails: Tumor-triggered neutrophils can shut down cancer-killing T cells
Certain white blood cells in the immune system, known as neutrophils, can make cancer immunotherapy less effective, according to a new study from Karolinska Institutet published in the journal Immunity. The results show that ...
Jun 15, 2026
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Asthma attacks reshape airway tissue through mechanical stress, lung-on-a-chip reveals
About 25 million people in the U.S.—roughly eight out of 100—are diagnosed with asthma. Allergens, air pollution, extreme weather conditions and other irritants can cause chronic lung inflammation, leading to coughing, wheezing ...
Jun 15, 2026
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Immune activation may determine success of dual-target CAR T therapy in glioblastoma
Dual-target CAR T-cell therapy for recurrent glioblastoma (GBM), delivered directly into the cerebrospinal fluid (CSF), triggers a broad immune response, with natural killer (NK) cell activation linked to better patient outcomes ...
Jun 15, 2026
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Target with potential to improve CAR T-cell therapy response in patients with blood cancers identified
Researchers at the University of Maryland School of Medicine (UMSOM) have identified a target that may improve the response to CAR T-cell therapy, a treatment for patients with recurrent or difficult-to-treat blood cancers.
Jun 15, 2026
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