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Allergy and immunology news
Autoantibodies could shape cancer risk, growth and response to immunotherapy
Scientists have long sought to understand why some people with no known risk factors develop cancer while others with significant risk never do. The answer may lie in immune proteins known as autoantibodies (auto-Abs), suggests ...
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Experimental plague vaccine strategy protects mice with missing key immune defenses
The plague has killed more people than World War II. The bacterium Yersinia pestis (Yp), which causes plague, has triggered three major pandemics throughout history, leaving behind a casualty toll of more than 200 million ...
Jul 24, 2026
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Inherited gene variants may shape CAR-T therapy benefits and toxic side effects
Chimeric antigen receptor (CAR)-T cell therapy, which reprograms an individual's immune cells to seek out and destroy certain cancer cells, has revolutionized treatment for blood cancers such as lymphoma. But in some patients, ...
Jul 24, 2026
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Brain immunity may undergo a major midlife overhaul linked to neuroinflammation
A new study indicates that the immune cell landscape of the hippocampus, a brain region critical for learning and memory, rapidly undergoes substantial remodeling beginning in midlife. This previously unrecognized shift suggests ...
Jul 23, 2026
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Ancient molecule made inside tumors drives immune response, study finds
An ancient molecule that existed long before the circulatory system evolved has been found to support cancer immunotherapy. Researchers at Nagoya University in Japan found that complement C3 protein acts inside tumors to ...
Jul 23, 2026
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Dormant pigment cells found in vitiligo patches may offer treatment target
Vitiligo is an autoimmune disease in which the body's immune system attacks and destroys melanocytes, the cells that produce the skin pigment melanin. Once the melanocytes are gone, the skin turns white, leading to the characteristic ...
Jul 23, 2026
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New immune mechanism helps explain why ovarian cancer stops responding to chemotherapy
Scientists at The Wistar Institute have identified a new mechanism behind the chemotherapy resistance that makes ovarian cancer so lethal. In a new study published in The Journal for ImmunoTherapy of Cancer, the researchers ...
Jul 23, 2026
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New strategy could prevent T cell exhaustion and boost immunotherapy
A major pillar of cancer immunotherapy involves stimulating T cells, the specialized killers of the immune system, to attack tumors. But this strategy has been undermined by the tendency of T cells to tire out before finishing ...
Jul 23, 2026
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How systemic immune regulation is 'hijacked' during tumor progression
The immune system plays a critical role in protecting the body from cancer by recognizing and eliminating abnormal cells before they can develop into tumors. This process relies on T cells that can recognize tumor-derived ...
Jul 23, 2026
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Mass-producible immune cells kill patient-derived colorectal tumors in mice
Off-the-shelf and mass-producible immune cells fight solid human tumors engrafted in mice. The Kobe University development is a significant contribution toward faster, cheaper cancer immunotherapy.
Jul 23, 2026
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Gut immune cells may help explain how B-cell depletion controls MS
B-cell depletion therapies, in which B cells of the immune system that may drive disease activity in multiple sclerosis (MS) are temporarily removed, have contributed significantly to improved treatment for patients in recent ...
Jul 22, 2026
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Immune changes emerge up to 10 years before inflammatory bowel disease diagnosis
Researchers at the Icahn School of Medicine at Mount Sinai have identified immune system changes that can be detected up to 10 years before inflammatory bowel disease (IBD) develops, offering new insight into how the disease ...
Jul 22, 2026
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Skin-bone marrow axis discovery opens new doors for psoriasis treatment
Psoriasis is a chronic inflammatory skin disease affecting more than 60 million people worldwide, characterized by painful red patches, scaling and skin thickening. While existing biologic treatments largely focus on calming ...
Jul 22, 2026
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Tick-borne meat allergy: Many carry alpha-gal antibodies without symptoms
Many more Americans than previously estimated carry antibodies related to a meat allergy caused by tick bites, a new study says. Nearly 1 in 4 adults in states with the highest rates of alpha-gal syndrome carry antibodies ...
Jul 22, 2026
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Thymus-derived hormone may suppress age-related inflammation and boost cancer therapy
Chronic, low-grade inflammation in the body—a phenomenon known as "inflammaging" because it increases with age—has been linked to many of today's leading causes of illness and death, including cancer, heart disease, metabolic ...
Jul 21, 2026
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'Cellular behavioromics' reveals how immune cells swarm during sepsis
Despite the best efforts of intensive care unit (ICU) staff and physicians and the most advanced life support, Dr. Bryan Yipp, witnesses many deaths in the ICU attributed to sepsis. "Sepsis is the body's overwhelming immune ...
Jul 21, 2026
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Synthetic peptide blocks key asthma inflammation switch in cells and mice
A team from the University of Bonn and the Research Center Borstel, Leibniz Lung Center (FZB) has discovered a previously unknown mechanism of action for a synthetic peptide that mitigates excessive inflammatory responses ...
Jul 21, 2026
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Researchers find new strategy to help immune system fight pancreatic cancer
Researchers from the University of Minnesota Medical School have identified why pancreatic cancer is difficult for the immune system to recognize and attack, paving the way for a new approach to improve immunotherapy. The ...
Jul 21, 2026
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Timing of JAK initiation, shingles vaccine administration can affect outcomes in rheumatoid arthritis
For patients with rheumatoid arthritis (RA), the timing of Janus kinase (JAK) inhibitor initiation relative to administration of recombinant zoster vaccine (RZV) can affect early response and arthritis control, according ...
Jul 21, 2026
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Researchers uncover 'hidden key' to immunotherapy for intractable brain tumors
Researchers have uncovered a clue to why immune checkpoint inhibitors—cancer therapies that release the immune "brakes" exploited by tumors to evade attack—show limited efficacy in some brain tumors. A KAIST research team ...
Jul 20, 2026
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Building a blueprint to manipulate the immune system
Why do some vaccines protect for a lifetime, while threats like tumors and viruses present such an ongoing challenge? The answer lies in the immune system's memory and how invading pathogens hack the system.
Jul 20, 2026
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Crystal-clear images reveal how pregnancy antibodies cause harm in babies
Using advanced electron microscopy, researchers in Leiden have captured detailed images showing how, in the rare pregnancy disorder FNAIT, antibodies produced by the mother can cause bleeding in fetuses. The findings, published ...
Jul 20, 2026
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Interferon alpha may drive Sjögren's disease in 60% of patients
Interferon alpha is an inflammatory mediator that can cause Sjögren's syndrome, an autoimmune disease. This was revealed in a study carried out by University Hospital Bonn together with the University of Bonn, the University ...
Jul 20, 2026
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Study reveals why key antiviral defenses failed in some severe COVID-19 patients
Although the COVID-19 pandemic has largely subsided, scientists continue to investigate why the virus proved so deadly, causing at least 3 million deaths worldwide, according to the latest estimates by the World Health Organization ...
Jul 20, 2026
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Long non-coding RNA emerges as a 'kill switch' for macrophages
Macrophages are considered the "scavenger cells" of the immune system, but some pathogens exploit these very cells as hiding places. Researchers from the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg ...
Jul 20, 2026
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