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Allergy and immunology news
Children with a common genetic variant may have more inflammation in response to an asthma drug
Children with a variant in the SERPINE1 gene—which is found in 60% of the population—may be less responsive to mepolizumab, a drug used to treat asthma flares, according to a study published in the Journal of Allergy and ...
3 hours ago
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Atlas of immune cells explains how genetic variants cause disease
Scientists have identified thousands of genetic differences that change a person's risk of disease, but working out how they actually affect biology—an important step toward creating new treatments—has been much more challenging. ...
16 hours ago
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Fast-acting immune cells blur traditional divide between innate and adaptive immunity
Researchers at the Francis Crick Institute, King's College London and Complutense University of Madrid have shown that γδ T cells use adaptive immune receptors to drive rapid, innate-like responses to tissue stress, inflammation ...
21 hours ago
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Precisely timed signals recreate key antibody factory features in human blood cells
Researchers at the University of Osaka have developed a simple culture method that converts B cells isolated from human blood into cells resembling germinal center B cells, which refine antibodies after infection or vaccination.
14 hours ago
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An omega-3 paradox: When 'healthy fats' shut down defenses against cancer
Omega fatty acids have long been recognized for their benefits: supporting cardiovascular health, reducing systemic inflammation, and promoting brain development and cognitive function. But scientists now warn of a long-unrecognized ...
Investigators identify a metabolic weak point in exhausted immune cells in head and neck cancer
Immune cells can reach head and neck tumors, but once there, many stop functioning. This helps explain why immunotherapy with immune checkpoint inhibitors—which have transformed treatment for some cancers—benefits only 17%–23% ...
16 hours ago
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Microplastics clog liver immune cells, driving fat buildup in mice
Microplastics appear capable of significantly impairing the function of phagocytes in the liver, at least in mice. In turn, this disrupts the metabolism of this vital organ and increases the build-up of fat inside it. These ...
Sep 29, 2026
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A blood-based approach could enable personalized immunotherapy without the need for a tumor biopsy
In a study published in Cancer Discovery, cancer neoantigens and neoantigen-specific T cells were identified from patient blood samples by analyzing circulating tumor DNA (ctDNA) and immune cells.
Sep 29, 2026
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A new era of discovery for immunology: Expert Q& A
When two people become ill at the same time, they often experience different symptoms. For instance, during the COVID-19 pandemic, some people had symptoms akin to a mild flu, while others were critically ill. Similarly, ...
Sep 29, 2026
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Metabolic activity of gut bacteria can either promote or inhibit function of CAR T cells in cancer therapy
Immunotherapies, especially CAR T-cell therapy, have fundamentally changed cancer treatment in recent years, particularly for certain forms of leukemia and lymphoma. Yet not all tumors respond equally well, and the reasons ...
Sep 28, 2026
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Blocking immune cells' path into the brain limits neurodegeneration
There is no treatment available today to stop the death of brain cells in neurodegenerative diseases known as tauopathies, including Alzheimer's disease, in which twisted clumps of a protein called tau accumulate in the brain.
Sep 28, 2026
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A missing piece in the cell death and inflammation signaling pathway puzzle has been revealed
An international research team has discovered a previously unknown mechanism that plays a key role in the signaling pathways involved in programmed cell death. The team identified the protein HERC4 as an essential component ...
Sep 28, 2026
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Lower dietary diversity in the first year linked to atopic dermatitis
Lower dietary diversity during the first year of life is associated with an increased risk of atopic dermatitis (AD) later in life, according to a study published online Sept. 20 in Pediatric Allergy and Immunology.
Sep 28, 2026
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Study identifies two factors that may help patients benefit from off-the-shelf CAR T-cell therapies
Researchers at The University of Texas MD Anderson Cancer Center have traced how off-the-shelf chimeric antigen receptor (CAR) T cells behave in patients, revealing how immune rejection and differences among CAR T cells influence ...
Sep 25, 2026
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Wiskott-Aldrich syndrome: Long-term results of gene therapy developed
A single infusion of genetically corrected autologous hematopoietic stem cells can provide lasting clinical benefits for patients with Wiskott-Aldrich syndrome, a rare genetic disorder that impairs immune and platelet function, ...
Sep 24, 2026
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Immune cells reveal widespread SMN protein loss in spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neurodegenerative disorder that leads to muscle loss and can severely impair the mobility of those affected. It is usually caused by a defect in the SMN1 gene, which is expressed in all ...
Sep 24, 2026
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Scientists find the gene that drives T-cell exhaustion, revealing new strategy to improve immune responses
Immunotherapy, which uses a patient's immune system to treat disease, has increased survival for some adults and children with cancer. However, it has had limited success against many pediatric solid tumors, in part because ...
Sep 23, 2026
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Computer-designed T-cell receptors boost attacks on cancer and viral targets in early tests
A joint team of researchers at Bar-Ilan University and the Weizmann Institute has used advanced computational design methods to enhance the ability of genetically engineered immune cells to recognize and attack cancer and ...
Sep 23, 2026
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Newly discovered inflammatory cell signaling could open the door to autoimmune disease treatments
Our understanding of how cells interact with each other has been driven for decades by the central concept of receptor-mediated signal transduction. Now, researchers from Boston Children's Hospital are reporting the discovery ...
Sep 23, 2026
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High-fat diets suppress enzyme in immune cells, promoting fat tissue inflammation in mice
A group of innate immune cells, known as group 2 lymphoid cells (ILC2), are essential for maintaining a stable metabolism in adipose tissue. Obesity significantly impairs the number and function of ILC2 cells, leading to ...
Sep 23, 2026
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Study identifies potential RAS inhibitor-immunotherapy strategy for pancreatic cancer
Pancreatic cancer does not respond to most immunotherapies, but RAS inhibitors could alter tumors to make them more sensitive to a novel immunotherapeutic approach. In pancreatic tumors with RAS mutations, RAS inhibitors ...
Sep 23, 2026
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Engineered 'triple-threat' immune cells could fight plaque buildup that causes heart attacks and strokes
A UCLA research team has engineered a new type of immune cell that attacks atherosclerotic plaques—the fatty buildup inside artery walls that drives most heart attacks and strokes. These engineered cells work by recognizing ...
Sep 22, 2026
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'Plug-and-play' CAR T technology adapts as cancer changes
Researchers from City of Hope have developed a new "plug-and-play" technology that adds engineered molecules to chimeric antigen receptor (CAR) T cells after treatment, allowing scientists to better control the cells and ...
Sep 22, 2026
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Immune cells that may help sustain type 1 diabetes attack identified
Type 1 diabetes isn't an overnight attack against the body's ability to make insulin. It can be a sustained campaign over years that relentlessly targets insulin-producing cells in the pancreas. Scientists have not fully ...
Sep 22, 2026
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Why repeated exposures may make allergies worse
A new preclinical study led by investigators from Mass General Brigham offers a potential explanation for two longstanding questions in allergy: Why do allergies often emerge only after repeated exposure, and why do people ...
Sep 22, 2026
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