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Allergy and immunology news
FDA approves gene therapy for severe leukocyte adhesion deficiency-I, a rare immune disorder
Dr. Donald Kohn has been developing gene therapies for rare pediatric immune disorders for over 30 years. This week, his role in a clinical trial has culminated in the first-ever U.S. Food and Drug Administration–approved ...
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Gut 'primes' pathogenic T cells responsible for neuroinflammation in multiple sclerosis, study finds
Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS). What makes the body turn against itself? ...
Mar 27, 2026
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Vitamin D supplements may shift immune responses to gut bacteria in IBD
Vitamin D supplementation may help shape how the immune system responds to gut bacteria in people with inflammatory bowel disease (IBD), according to a Mayo Clinic-led study published in Cell Reports Medicine.
Mar 26, 2026
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Single-cell study reveals how immune memory cells remember threats
Scientists at Cincinnati Children's have identified how certain immune cells are molecularly programmed to respond faster when the body encounters a familiar threat, shedding light on immune memory and its links to diseases ...
Mar 26, 2026
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Designing global flu vaccines? Studies suggest common IGHD deletions may block key antibodies
Inherited variations in antibody genes can affect how we respond to infections and vaccines, show two new studies from Karolinska Institutet published in the journal Immunity. The researchers have mapped immune gene variation ...
Mar 26, 2026
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How some autoantibodies contribute to clots: The C4BP link and a path to treatment
Northwestern Medicine investigators have uncovered a missing link behind the harmful effects of autoantibodies linked to blood clots, pregnancy complications and other inflammatory conditions, according to a new study published ...
Mar 26, 2026
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A new immunotherapy target? How SRC-3 in Tregs may reshape solid-tumor treatment
In 2023, researchers at Baylor College of Medicine led by the late Dr. Bert O'Malley discovered that the steroid receptor coactivator 3 (SRC-3) in immune cells called regulatory T cells (Tregs) plays a decisive role in shaping ...
Mar 26, 2026
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Why do some viruses linger for life? A 900,000-person study maps viral loads
Some viruses that make us sick are cleared by the immune system within days, while others lurk in our bodies for a lifetime and reemerge later to cause new problems. How and why viral levels in the body change over time—and ...
Mar 25, 2026
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Single-cell maps show chemokine signals collapse as aggressive lymphoma spreads
Lymph nodes are key control centers in the immune system and play an important role in defending the body against infections and tumors. For these processes to function properly, immune cells (B cells and T cells) must be ...
Mar 25, 2026
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Immune response to cancer may cause autoimmune disorders, including anti-NMDA receptor encephalitis
Consider two seemingly unrelated medical puzzles. First: Every day, our bodies produce hundreds of billions of new cells, many of which are mutated. If cancer arises from cellular mutation, why don't we all have the disease ...
Mar 25, 2026
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How STING gets moving: Study identifies transport protein key to immune response
UT Southwestern Medical Center researchers have identified how the quintessential immune protein known as stimulator of interferon genes (STING) migrates from one cellular organelle to another, a necessary step in its activation. ...
Mar 25, 2026
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Living with dogs: Examining asthma outcomes in children
Living with a dog does not seem to worsen long-term asthma severity in children with allergic asthma, but may increase the risk of asthma exacerbations slightly, according to a study from Karolinska Institutet in Sweden that ...
Mar 25, 2026
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A protein may help revive exhausted T cells in cancer immunotherapy
Immunotherapy has been one of the most transformative treatments for cancer patients in recent decades, shifting the emphasis from the broad-spectrum approach of chemotherapy to prompting the immune system's boldest warriors—its ...
Previously unrecognized immune response could enhance defense against cancer
In a paradigm-breaking study, researchers have discovered a novel way the immune system, specifically T cells, attack their target cells, reshaping long-held assumptions in immunology and demonstrating direct implications ...
Mar 24, 2026
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Autoantibodies implicated as drivers of long COVID in new study
A growing body of evidence suggests that long COVID (or post-COVID syndrome), a condition affecting more than 10% of people after a SARS-CoV-2 infection, may be driven by the immune system turning against the body. Now, new ...
Mar 24, 2026
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Short-lived fish offer new insights into the aging immune system
Our immune system protects the body from infections and harmful changes throughout our lives. However, it loses its effectiveness with age, resulting in an increased risk of disease. But what happens when the immune system ...
Mar 24, 2026
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Immune cell 'bloodhounds' track cancer cells' unique metabolic signatures and eliminate tumors in mice
A technique that transforms immune cells into cancer-seeking bloodhounds may overcome a roadblock that has hampered immunotherapy for solid tumors, according to a new study by Stanford Medicine researchers. The approach equips ...
Mar 24, 2026
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Local immune cell coordination in the lung reveals a new layer of defense
When a virus enters the lungs, the immune system has to react fast. The lung maintains its own community of immune cells capable of mounting a local defense on the spot. Researchers from the University of Basel now describe ...
Mar 24, 2026
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As antibiotics fail, a new treatment targets the host, not the bacteria
As antibiotic resistance continues to rise worldwide, scientists are searching for new strategies to combat infections. This latest research at Trinity Translational Medicine Institute at Trinity College Dublin combats this ...
Mar 24, 2026
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PP4 protein stops the body from overreacting to severe infection, scientists discover
When someone gets a bad infection, the body's immune system rushes in to fight the germs. But sometimes this defense system becomes too strong and starts hurting the person's own tissues and organs. This condition, known ...
Mar 24, 2026
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Existing medication can restore HIV-affected immune cells
HIV exhausts the body's immune system by overactivating it, despite effective antiviral treatment. Researchers from Linköping University in Sweden have conducted cell studies showing that an existing medication restores immune ...
Mar 23, 2026
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Dual immune response may keep HIV in check without medication
Imagine a game of chess where your opponent's king is in check. It cannot move, but the game is not over—the piece remains on the board. This is how the body might control HIV on its own: The virus would be contained and ...
Mar 23, 2026
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Scientists pinpoint a skin alarm system pathway that links local damage to systemic immune responses
Skin, our largest organ, acts as a protective barrier against pathogens that try to invade our bodies while constantly monitoring for potential threats. In the skin's outermost layer, the epidermis, reside keratinocytes, ...
Skin's immune response could be key to fighting dengue
Dengue, a mosquito-borne viral disease, infects an estimated 390 million people and causes around 20,000 deaths worldwide each year. New research suggests the skin is a major site of immune surveillance for dengue. The findings ...
Mar 23, 2026
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Welcome to allergy season. Here's how to protect yourself
Allergy season can be miserable for tens of millions of Americans when trees, grass, and other pollens cause runny noses, itchy eyes, coughing and sneezing.
Mar 23, 2026
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