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Allergy and immunology news

New tracking tool reveals how T cells adapt in different organs

Our immune system relies on T cells to fight infections. But T cells don't just show up and react—first, they train, get a game plan, and coordinate their defenses in lymphoid organs. Researchers have struggled to understand ...

Overcoming ovarian cancer's resistance to immunotherapy

Cells in our immune system are best known for providing security against external invaders such as bacteria and viruses. These immune cells also guard against internal threats, including cancerous tumors. Different forms ...

Molecular target drives immunogenicity in cancer immunotherapy

Researchers at the National University of Singapore (NUS) have identified a protein called tyrosine phosphatase 1B (PTP1B) as a potential "switch" that can modulate a type of cancer cell death known as immunogenic cell death ...

How the fats we eat shape our ability to fight disease

The types of fats we consume directly impacts the survival and strength of the body's immune cells and ability to fight disease, researchers have found. A University of Queensland team led an international collaboration that ...

Painless skin patch offers new way to monitor immune health

Researchers at The Jackson Laboratory (JAX), in collaboration with the Massachusetts Institute of Technology (MIT), have developed the first bandage-like microneedle patch that can sample the body's immune responses painlessly ...

Smart patch detects allergies before symptoms strike

A wearable device that alerts people with food allergies before a reaction begins has the potential to reduce life-threatening anaphylaxis and transform allergy management from reactive to preventive care. The AllergE patch ...

How a tick could help prevent diseases like MS and cancer

A team from the Monash University Biomedicine Discovery Institute has identified a tick-derived evasin that can bind to two major classes of chemokines, a discovery that is important for the development of therapeutics targeting ...

Newly found immune cells link strep throat to psoriasis

A common strep throat infection can trigger guttate psoriasis by altering the behavior of key immune cells, according to a new study from Karolinska Institutet published in eBioMedicine. The findings suggest how an infection ...

Engineered CAR-NK cells appear more 'attack-ready'

Researchers at the Ribeirao Preto Blood Center and the Center for Cell-Based Therapy (CTC) conducted a study using the NK-92 cell line to test new models of chimeric antigen receptors (CARs) with specific costimulatory domains, ...

Gene variants help explain why food allergies run in families

People often remark that allergies run in their family, but the genetic causes have remained unclear. Previous food allergy genetic research has relied upon broad but surface-level methods called genome-wide association studies.

Discovery could improve immune checkpoint inhibitor safety

For many people diagnosed with cancer, treatment with immune checkpoint inhibitors (ICIs) has dramatically extended lives. Some of these treatments, such as Keytruda and Opdivo, have become familiar brand names. However, ...

How age, sex and genetics shape our antibodies

Age, biological sex, and human genetic factors influence the production of antibodies during the immune response. A team of scientists from the Institut Pasteur, the CNRS and the Collège de France have shown that these factors ...

How vaccines give our immune systems a home advantage

We are now approaching six years since COVID-19 was declared a pandemic by the World Health Organization, yet talk of vaccines and our immune systems persists in our cultural conversations—from political arenas to the dinner ...

Optimizing CAR T-cell therapy to tackle solid tumors

In 2024, Professor Sebastian Kobold's research group at LMU University Hospital had already shown that the metabolite prostaglandin E2 can block T cells—the killer cells of the immune system—in the vicinity of a tumor, ...