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Immunology news
Oncology & Cancer
GD2 CAR T treatment induces durable remissions in high-risk neuroblastoma
From Bambino Gesù Children's Hospital in Rome comes a report that a third-generation CAR T cell therapy targeting GD2, designated GD2–CART01, induced durable remissions and long-term survival in children with high-risk ...
6 hours ago
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Newly identified immune response controls Oropouche infection and prevents neurological damage
Research conducted on mice has identified that the rapid response of a specific type of defense cell is essential for controlling Oropouche virus infections and preventing serious neurological damage.
7 hours ago
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Review calls for age-specific immunotherapy in childhood brain tumors
Pediatric brain tumors are the deadliest form of childhood cancer, yet most treatments are adapted from adult care and often miss the mark. A new study led by a second-year medical student at Dell Medical School at The University ...
5 hours ago
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Finding patterns in genetic uncertainty: Clues for inborn errors of immunity
Behind every unexplained medical condition is a patient hoping for clarity and understanding. For people with suspected inborn errors of immunity (IEIs), genetic testing can facilitate individually tailored and effective ...
9 hours ago
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Researchers identify new method to protect against sepsis
A team of University of Saskatchewan (USask) researchers have identified a pathway to help the human body defend itself against sepsis—a life-threatening condition caused by the body's inappropriate response to an infection.
11 hours ago
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Researchers work to make blood cancer a manageable illness with mutation identification
As blood cancers are constantly evolving and developing mutations that grow resistance to current treatments, researchers in the University of Cincinnati Cancer Center's Leukemia and Drug Development Lab (LDDL) are constantly ...
6 hours ago
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Pollen season is lasting longer, worsening allergies and altering pollinators
Fall is in the air. Chicago evenings have a crisp breeze. But something has been bugging Annie Andrews.
10 hours ago
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Engineered antibodies can direct T-cells to kill cytomegalovirus-infected cells
A UCLA research team has found a new way to prompt the immune system to kill cells infected with cytomegalovirus (CMV), a life-threatening infection that is particularly deadly in immunocompromised people.
Sep 12, 2025
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Antigen amplification strategy shows promise for more precise next-generation immunotherapies
Tumor immunotherapies, especially those leveraging T-cells to identify and eliminate cancer cells, represent a major breakthrough in cancer treatment. However, many tumor-associated antigens are not expressed at a high enough ...
Sep 12, 2025
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New antibody cocktail shows promise for treating multiple strains of flu
While vaccines can be very effective for preventing viruses, like the influenza A virus (IAV), they are often strain-specific and prone to viral escape mutations. IAV alone is responsible for around 500,000 deaths worldwide ...
Pre-wired ability in 'resting' T cells remembers past viral foes, holding promise for targeted cancer therapies
A team of immunologists at the University of Massachusetts Amherst has turned what we know about T-cells, one of the most important parts of the body's immune system, on its head, opening the door to next-generation cancer ...
Sep 11, 2025
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How a cell receptor dampens the immune response against fungal infection
People are exposed to millions of fungal spores every day, even potentially harmful ones like those from Aspergillus fumigatus. For most individuals, this constant exposure is harmless, as the immune system efficiently clears ...
Sep 11, 2025
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How to help your back-to-school kid with their allergies
Back-to-school is an exciting time for kids and parents, but it also marks the beginning of fall allergies as well as the cold and flu season.
Sep 11, 2025
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Antioxidant shield for T cell telomeres shows promise against tumor-induced exhaustion
Tumors are stressful places for cancer-fighting immune cells. Low oxygen, high acid levels, and other stressors put strain on mitochondria, the cell's energy factories, leading to T cell exhaustion and poor cancer outcomes.
Sep 10, 2025
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A 'universal' therapy against the seasonal flu? Antibody cocktail targets virus weak spot
An unusual therapy developed at The Jackson Laboratory (JAX) could change the way the world fights influenza, one of the deadliest infectious diseases. In a new study in Science Advances, researchers report that a cocktail ...
Sep 10, 2025
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Repurposing a diabetes medication to prime CAR T cancer targets
Urothelial carcinoma (UC) is the second most common genitourinary cancer, leading to over 16,000 deaths a year in the United States. Despite recent advances, the 5-year survival rate for metastatic UC remains about 5% to ...
Sep 10, 2025
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AI model helps identify therapeutic antibodies to boost pandemic preparedness
Scientists at Scripps Research have developed a novel method that uses artificial intelligence (AI) and advanced imaging techniques to more accurately and efficiently identify therapeutic antibodies to treat infectious diseases.
Sep 10, 2025
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Hydrogel-based approach sustains human lymph nodes for longer, enabling more accurate studies of immune responses
A new method to keep human lymph node tissue alive and functioning outside the body for several days could give researchers a much clearer view of how our immune system responds to infections, vaccines and cancer, without ...
Sep 10, 2025
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Immune cell growth factor can promote lung tissue repair after viral inflammation
When the lungs are attacked by a virus, the damage doesn't stop there. The body's natural defenses cause inflammation while fighting the virus, often leaving lasting problems. The cells that make up the lungs' mucosal lining ...
Sep 10, 2025
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Lung cancer rewires immune cells in bone marrow to weaken body's defenses
Lung tumors don't just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature that tumors rewire ...
Sep 10, 2025
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Researchers uncover how COVID-19 may linger in cancer patients and affect treatment outcomes
New research from the University of Minnesota Medical School is providing important insights into how COVID-19 persists in cancer patients even long after testing positive. The findings were recently published in iScience.
Sep 10, 2025
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Specialized macrophages on adipose nerves curb age-related inflammation in mice
Yale School of Medicine-led research reports that nerve-associated macrophages help maintain healthy fat over a lifespan and curb age-related inflammation.
Immune defense punches holes in the heart, research reveals
In a study published in Science, researchers found that the defense protein "Resistin like molecule gamma" (Relmy), produced by neutrophils, punches holes into heart cells after a heart attack. This promotes dangerous, fast, ...
Sep 9, 2025
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How fat disables the brain's immune shield in Alzheimer's disease
It was long thought that fat in the brain played no role in neurodegenerative diseases, but Purdue University researchers are challenging that assumption.
Sep 9, 2025
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