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Immunology news

Oncology & Cancer

Tumor bacteria linked to immunotherapy resistance in head and neck cancer

Cleveland Clinic researchers have discovered that bacteria inside cancerous tumors may be key to understanding why immunotherapy works for some patients but not others.

Immunology

Loss of vitamin C synthesis protects animals from deadly schistosome infection

Scientists at Children's Medical Center Research Institute at UT Southwestern (CRI) have discovered a benefit of vitamin C deficiency: protection from a major parasitic disease. Their research suggests an explanation for ...

Immunology

Key lung immune cells can intensify allergic reactions

Alveolar macrophages are immune cells that live in the tiny air sacs of the lungs. Under normal conditions, these cells act as guardians, keeping the lungs healthy, supporting breathing, and preventing unnecessary immune ...

Oncology & Cancer

Engineered dendritic cells boost cancer immunotherapy

EPFL researchers have successfully engineered cells of the immune system to more effectively recognize cancer cells. The work, covered in two papers, turns the previously lab-based method into a full-blown immunotherapy strategy.

Diseases, Conditions, Syndromes

Pulmonary fibrosis traced to key signaling pathway

Idiopathic pulmonary fibrosis (IPF) is a chronic disease in which healthy lung tissue is gradually replaced by scar tissue. While the early events that initiate this change are poorly understood, recent research suggests ...

Immunology

Study unveils improved mRNA cancer vaccine targeting

No matter where cancer cells grow in the human body, they are a threat to our health and our lives. But instead of treating them with chemotherapy or radiation—which have undesirable side effects—what if we could train ...

Oncology & Cancer

Cell-free DNA could detect adverse events from immunotherapy

A noninvasive blood test to detect genetic material shed by tumors may help clinicians identify adverse events related to treatment with immune checkpoint inhibitor drugs, investigators at the Johns Hopkins Kimmel Cancer ...

Oncology & Cancer

Off-the-shelf immunotherapy offers new hope for toughest myeloma

A new Mayo Clinic study published in the New England Journal of Medicine has uncovered that an off-the-shelf, dual-antibody therapy can generate deep and durable responses in extramedullary multiple myeloma—one of the most ...

Oncology & Cancer

FDA approves expanded indication for Jaypirca

The U.S. Food and Drug Administration has approved an expanded indication for Eli Lilly's Jaypirca (pirtobrutinib), the first and only noncovalent Bruton tyrosine kinase (BTK) inhibitor for adults with relapsed or refractory ...

Diabetes

Researchers find vital clue in the progression of Type 1 diabetes

Type 1 diabetes is a disease in which the body mistakenly attacks itself as the immune system destroys the pancreas's insulin-producing cells. Why the immune system turns against these cells remains one of the enduring questions ...