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Allergy and immunology news
Same-day chemotherapy boosts cancer vaccine responses in preclinical models
Both the clinical effects and the unpleasant side effects of chemotherapies, from hair loss to mouth sores to gastrointestinal discomfort, stem from their indiscriminate destruction of cells prone to rapid proliferation. ...
Oct 2, 2026
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Discovery explains how immune cells target DNA mutations to improve antibodies
Scientists at the Montreal Clinical Research Institute (IRCM), led by Université de Montréal medical professor Javier Di Noia, have shed light on a fundamental mystery in immunology: How do immune cells manage to concentrate ...
Oct 1, 2026
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Immune aging accelerates around 40 and 60, with key differences between men and women
It's one of the biggest mysteries of age-related research: Despite living longer, women are more likely than men to develop age- and immune-related conditions, yet the biological reasons behind these differences remain poorly ...
Oct 1, 2026
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Gut bacterial compound worsens brain injury after stroke, study suggests
Researchers at LMU have discovered how a metabolite produced by gut bacteria can influence brain damage after stroke. Their paper is published in the journal Cell.
Oct 1, 2026
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Before the first bite: A missing gut protein may set the stage for peanut allergy
For most people, a peanut butter sandwich poses no threat. But for the roughly 1.6 million children in the United States with peanut allergy, exposure can trigger a life-threatening reaction. Why some individuals are susceptible ...
Oct 1, 2026
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Children with a common genetic variant may have more inflammation in response to an asthma drug
Children with a variant in the SERPINE1 gene—which is found in 60% of the population—may be less responsive to mepolizumab, a drug used to treat asthma flares, according to a study published in the Journal of Allergy and ...
Oct 1, 2026
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An omega-3 paradox: When 'healthy fats' shut down defenses against cancer
Omega fatty acids have long been recognized for their benefits: supporting cardiovascular health, reducing systemic inflammation, and promoting brain development and cognitive function. But scientists now warn of a long-unrecognized ...
Fast-acting immune cells blur traditional divide between innate and adaptive immunity
Researchers at the Francis Crick Institute, King's College London and Complutense University of Madrid have shown that γδ T cells use adaptive immune receptors to drive rapid, innate-like responses to tissue stress, inflammation ...
Sep 30, 2026
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Atlas of immune cells explains how genetic variants cause disease
Scientists have identified thousands of genetic differences that change a person's risk of disease, but working out how they actually affect biology—an important step toward creating new treatments—has been much more challenging. ...
Sep 30, 2026
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Precisely timed signals recreate key antibody factory features in human blood cells
Researchers at the University of Osaka have developed a simple culture method that converts B cells isolated from human blood into cells resembling germinal center B cells, which refine antibodies after infection or vaccination.
Sep 30, 2026
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Investigators identify a metabolic weak point in exhausted immune cells in head and neck cancer
Immune cells can reach head and neck tumors, but once there, many stop functioning. This helps explain why immunotherapy with immune checkpoint inhibitors—which have transformed treatment for some cancers—benefits only 17%–23% ...
Sep 30, 2026
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Microplastics clog liver immune cells, driving fat buildup in mice
Microplastics appear capable of significantly impairing the function of phagocytes in the liver, at least in mice. In turn, this disrupts the metabolism of this vital organ and increases the build-up of fat inside it. These ...
Sep 29, 2026
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A blood-based approach could enable personalized immunotherapy without the need for a tumor biopsy
In a study published in Cancer Discovery, cancer neoantigens and neoantigen-specific T cells were identified from patient blood samples by analyzing circulating tumor DNA (ctDNA) and immune cells.
Sep 29, 2026
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A new era of discovery for immunology: Expert Q& A
When two people become ill at the same time, they often experience different symptoms. For instance, during the COVID-19 pandemic, some people had symptoms akin to a mild flu, while others were critically ill. Similarly, ...
Sep 29, 2026
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Metabolic activity of gut bacteria can either promote or inhibit function of CAR T cells in cancer therapy
Immunotherapies, especially CAR T-cell therapy, have fundamentally changed cancer treatment in recent years, particularly for certain forms of leukemia and lymphoma. Yet not all tumors respond equally well, and the reasons ...
Sep 28, 2026
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Blocking immune cells' path into the brain limits neurodegeneration
There is no treatment available today to stop the death of brain cells in neurodegenerative diseases known as tauopathies, including Alzheimer's disease, in which twisted clumps of a protein called tau accumulate in the brain.
Sep 28, 2026
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A missing piece in the cell death and inflammation signaling pathway puzzle has been revealed
An international research team has discovered a previously unknown mechanism that plays a key role in the signaling pathways involved in programmed cell death. The team identified the protein HERC4 as an essential component ...
Sep 28, 2026
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Lower dietary diversity in the first year linked to atopic dermatitis
Lower dietary diversity during the first year of life is associated with an increased risk of atopic dermatitis (AD) later in life, according to a study published online Sept. 20 in Pediatric Allergy and Immunology.
Sep 28, 2026
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Study identifies two factors that may help patients benefit from off-the-shelf CAR T-cell therapies
Researchers at The University of Texas MD Anderson Cancer Center have traced how off-the-shelf chimeric antigen receptor (CAR) T cells behave in patients, revealing how immune rejection and differences among CAR T cells influence ...
Sep 25, 2026
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Wiskott-Aldrich syndrome: Long-term results of gene therapy developed
A single infusion of genetically corrected autologous hematopoietic stem cells can provide lasting clinical benefits for patients with Wiskott-Aldrich syndrome, a rare genetic disorder that impairs immune and platelet function, ...
Sep 24, 2026
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Immune cells reveal widespread SMN protein loss in spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neurodegenerative disorder that leads to muscle loss and can severely impair the mobility of those affected. It is usually caused by a defect in the SMN1 gene, which is expressed in all ...
Sep 24, 2026
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Scientists find the gene that drives T-cell exhaustion, revealing new strategy to improve immune responses
Immunotherapy, which uses a patient's immune system to treat disease, has increased survival for some adults and children with cancer. However, it has had limited success against many pediatric solid tumors, in part because ...
Sep 23, 2026
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Computer-designed T-cell receptors boost attacks on cancer and viral targets in early tests
A joint team of researchers at Bar-Ilan University and the Weizmann Institute has used advanced computational design methods to enhance the ability of genetically engineered immune cells to recognize and attack cancer and ...
Sep 23, 2026
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Newly discovered inflammatory cell signaling could open the door to autoimmune disease treatments
Our understanding of how cells interact with each other has been driven for decades by the central concept of receptor-mediated signal transduction. Now, researchers from Boston Children's Hospital are reporting the discovery ...
Sep 23, 2026
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High-fat diets suppress enzyme in immune cells, promoting fat tissue inflammation in mice
A group of innate immune cells, known as group 2 lymphoid cells (ILC2), are essential for maintaining a stable metabolism in adipose tissue. Obesity significantly impairs the number and function of ILC2 cells, leading to ...
Sep 23, 2026
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