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Immunology news
Oncology & Cancer
CAR-T cells engineered to attack two leukemia proteins show promise in preclinical tests
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive form of blood cancer that can occur in both children and adults. It is characterized by failures in the maturation of T-lymphocytes, key immune cells involved ...
21 minutes ago
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Health
A Māori worldview describes the immune system as a guardian—this could improve public health in Aotearoa NZ
In biomedical science, the immune system is described as a cellular defense network that identifies and neutralizes threats. In te ao Māori (the Māori worldview), it can be seen as a dynamic system of guardianship, known ...
14 minutes ago
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Common medication for lung cancer symptoms found to limit immunotherapy effectiveness
Corticosteroids, a commonly prescribed medication to alleviate cancer-related symptoms for non-small cell lung cancer patients treated with immunotherapy, are the main reason certain immunotherapies may fail in treating the ...
2 hours ago
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Tracing dormant cancer cells: Chemotherapy spurs awakening, but senolytic drugs may prevent relapse
Breast cancer often relapses in distant organs even when complete regression of primary tumors is achieved after initial treatment. Dormant and persistent disseminated tumor cells (DTCs) have been observed in animals with ...
Jul 4, 2025
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Alveolar macrophage cell surface receptor TREM2 promotes lung fibrosis, study shows
Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages—the white blood cells that defend the body by killing microbes, removing dead cells and stimulating immune responses—are ...
Jul 3, 2025
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T cells take aim at Chikungunya virus
A new study, published recently in Nature Communications, offers the first-ever map of which parts of the Chikungunya virus trigger the strongest response from the body's T cells.
Jul 3, 2025
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Antibody sIgM emerges as a key guardian of gut health and metabolism
A pioneering new study published in Nature Microbiology, led by J. Oriol Sunyer, professor of immunology and pathobiology at the School of Veterinary Medicine, and a team of researchers at Penn Vet and the University of New ...
Jul 3, 2025
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Researchers reveal key differences in STING inhibition between humans and mice
Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's natural defenses against cancer. This pathway, which plays a key role in helping the body defend ...
Jul 3, 2025
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Rare kidney cancer resists immune therapies due to lack of active T-cells
Cancer-fighting T-cells, the immune system's primary enforcers, are scarce in the rare kidney cancer called chromophobe renal cell carcinoma (ChRCC) and those that are present are indifferent to the tumor threat and traditional ...
Jul 3, 2025
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Combined therapy integrates Chinese herb Astragalus and methotrexate to address drug resistance in autoimmune diseases
Researchers at the School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), have found that combining the active ingredient extracted from the traditional Chinese medicine Astragalus membranaceus ...
Jul 3, 2025
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New evidence shows that timely introduction of peanuts and eggs reduces allergy risks
Families who introduce peanut butter and eggs to their baby's diet at about six months of age can significantly reduce the chances of them developing a life-threatening allergy, according to a study published in the Journal ...
Jul 3, 2025
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Engineered cell cross-talk unlocks CAR-T potential against glioblastoma
A team of researchers from the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan), led by Nadia Coltella and Luigi Naldini, has unveiled a powerful strategy to rejuvenate the effectiveness of chimeric antigen ...
Jul 2, 2025
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New genetic marker linked to improved survival with immunotherapy in ovarian and other cancers
Patients with ovarian clear cell carcinoma (OCCC) whose tumors have specific mutations in the PPP2R1A gene were found to have improved survival following immunotherapy compared to patients without these mutations, according ...
Jul 2, 2025
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Researchers find immune pathway in joint tissue involved in early rheumatoid arthritis
A new study by scientists at the University of Colorado Anschutz Medical Campus reveals that joint tissue from patients with early-stage rheumatoid arthritis often have high levels of a protein called granzyme used by the ...
Jul 2, 2025
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Unexpected immune response can limit effectiveness of phage therapy against bacterial infections
As antibiotic-resistant "superbugs" make infections trickier to treat, some in the medical community are turning to bacteriophages for backup. Also known as phages, these viruses exclusively target bacteria, allowing them ...
Jul 2, 2025
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Scientists uncover immune cells that help prostate cancer resist treatment—and reveal a way to stop them
Scientists have revealed how certain immune cells may be quietly helping prostate cancer grow—and how blocking them could help the body fight back.
Jul 2, 2025
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How a multiple sclerosis drug reshapes the immune system
When ocrelizumab became the first FDA-approved treatment for early forms of multiple sclerosis (MS) in 2017, it offered patients immense hope. The long-awaited drug is a monoclonal antibody that depletes B cells—the immune ...
Jul 2, 2025
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Gut microbes and tryptophan enhance immunotherapy for difficult-to-treat brain tumors
Advanced treatments, known as immunotherapies that activate T cells—our body's immune cells—to eliminate cancer cells, have shown limited efficacy as standalone therapies for glioblastoma, the most lethal form of brain ...
Jul 2, 2025
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Presurgical radiation may curb pancreatic cancer recurrence
Adding targeted radiation to chemotherapy prior to surgery may offer better control of pancreatic tumors—potentially reducing the rate of recurrence after treatment, according to a new study from UT Southwestern Medical ...
Jul 2, 2025
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Engineers create first immunocompetent leukemia device for CAR T immunotherapy screening
A team of researchers led by NYU Tandon School of Engineering's Weiqiang Chen has developed a miniature device that could transform how blood cancer treatments are tested and tailored for patients.
Jul 1, 2025
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New drug combination effective for T-cell lymphoma patients
Relapsed/refractory peripheral and cutaneous T-cell lymphomas (R/R PTCL and CTCL) are aggressive blood cancers that often resist standard therapy. Patients with these lymphomas may require stem cell transplants, but the disease ...
Jul 1, 2025
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How modified RNA tricks the innate immune system
The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component of this system are pattern recognition receptors, which recognize non-self RNA—such as that from ...
Jul 1, 2025
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FDA approves Benlysta autoinjector for pediatric patients with active lupus nephritis
The U.S. Food and Drug Administration has approved GSK's autoinjector of Benlysta (belimumab) for subcutaneous injection in patients ≥5 years of age with active lupus nephritis who are receiving standard therapy.
Jul 1, 2025
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Engineered protein can turn off tissue-damaging immune cells in autoimmune diseases
An engineered protein turns off the kind of immune cells most likely to damage tissue as part of type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice.
Jun 30, 2025
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How a common metabolite worsens inflammatory bowel disease
Northwestern Medicine investigators have identified a surprising culprit in the progression of inflammatory bowel disease: a naturally occurring metabolic compound in the gut, according to a study published in Nature Immunology.
Jun 30, 2025
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