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Immunology news
Oncology & Cancer
Study shows IL-36 gamma 'armored' CAR T cells can eradicate solid tumors
A laboratory study out of Roswell Park Comprehensive Cancer Center outlines a new way to boost the effectiveness of chimeric antigen receptor (CAR) T-cell therapy in solid-tumor cancers, resulting in their eradication. Led ...
18 hours ago
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Oncology & Cancer
Mini-tumors combine synthetic and real cells to simulate immune responses
Normally, the immune system recognizes and eliminates abnormal cells. However, cancer cells can develop strategies to evade this control: they block defense mechanisms or send inhibitory signals. In this way, tumors can grow ...
17 hours ago
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Switching immune cells to 'night mode' could limit damage after a heart attack
Researchers at Yale University School of Medicine have identified a way to suppress the daily fluctuations in the activity of key immune cells known as neutrophils.
19 hours ago
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New immunotherapy targets for glioblastoma identified by mapping cell interactions
Glioblastoma is the most common form of brain cancer in adults, and its consequences are usually quick and fatal. After receiving standard-of-care treatment (surgery followed by radiation and chemotherapy), fewer than half ...
18 hours ago
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Exploring how misguided antibodies cause attacks on the nervous system
A review on autoimmune neurological diseases reveals what occurs in our body when the immune system, by mistake, produces antibodies that target a protein essential for the normal functioning of nerves. The result is hyperexcitability, ...
16 hours ago
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CAR T-cell therapy accelerates intestinal healing in aging mice
Ever notice that as you get older, some foods no longer sit with you the same? This could be due to a breakdown of the intestinal epithelium, a single layer of cells that forms the organ's lining. The intestine plays a crucial ...
Dec 11, 2025
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Antibody formulation could enable simple injections instead of lengthy hospital infusions
Antibody treatments for cancer and other diseases are typically delivered intravenously, because of the large volumes that are needed per dose. This means the patient has to go to a hospital for every treatment, where they ...
Dec 11, 2025
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How CAR T-cell therapies target myeloma at the molecular level
In multiple myeloma, plasma cells proliferate uncontrollably in the bone marrow, disrupting the growth of healthy blood-forming cells. If the disease recurs after treatment or fails to respond, CAR T-cell therapy may be considered. ...
Dec 11, 2025
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Tricking tumors into marking themselves for destruction with focused ultrasound
USC biomedical engineers have found a way to make a solid tumor paint a target on its own back in order to train the body's immune system to find and destroy it.
Dec 11, 2025
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New vulnerability of asthma immune cells discovered
Why do certain immune cells remain permanently active in allergic asthma—even in an environment that should actually damage them? A team from the University Hospital Bonn (UKB) and the University of Bonn has discovered ...
Dec 11, 2025
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Farm-living families develop earlier immune maturation against food allergies, study finds
Children who grow up in farming communities have long been known to develop far fewer allergies than their urban peers. A new study from the University of Rochester Medical Center (URMC), offers one possible reason why: their ...
Dec 11, 2025
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Short-term stress primes immune cells for action in animal models
Stress affects many systems in our body and biologists Marcel Schaaf and Erin Faught at Radboud University are figuring out how that works. Their recent study showed how stress changes behavior by using two different receptors. ...
Dec 11, 2025
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CAR-T therapy yields long-term survival for patients with lymphoma
A study published in the Journal of Clinical Oncology confirms that one of the first Food and Drug Administration-approved CAR-T cell therapies offers long-term survival and potential cures for adult patients with relapsed ...
Dec 11, 2025
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Allergy risk varies by region: IgE profiles highlight environmental influence and hypoallergenic region
Allergic sensitization follows distinct regional patterns, and molecular IgE profiling can reveal these profiles in detail. An international research team has now demonstrated both phenomena in a population-based study of ...
Dec 11, 2025
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Gut cells aid intestinal healing, hope for IBD patients
A team led by scientists at King's College London, in collaboration with national and international partners, has discovered how a specific group of immune cells in the gut—Group 3 Innate Lymphoid Cells (ILC3s)—promote ...
Dec 11, 2025
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Preoperative radiation may improve antitumor immune response in most common form of breast cancer
Preoperative radiation improved T-cell infiltration (TCI) in patients with hormone receptor (HR)-positive, HER2-negative breast cancer when administered in combination with pembrolizumab (Keytruda) and chemotherapy and led ...
Dec 11, 2025
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Immune system's 'on-off' switch may hold answers for cancer and autoimmunity
A single signaling pathway controls whether immune cells attack or befriend cells they encounter while patrolling our bodies, researchers at Stanford Medicine have found. Manipulating this pathway could allow researchers ...
Dec 10, 2025
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Next-generation CAR T cells show stronger, safer response in animal models
Researchers from the Keck School of Medicine of USC have developed a new type of chimeric antigen receptor (CAR) T cell that elicits a more controlled immune response to cancer in mice—effectively killing cancer cells, ...
Dec 10, 2025
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How the immune system stalls weight loss
Researchers at the University of California San Diego School of Medicine have uncovered a surprising new function for immune cells: preventing excess weight loss.
Dec 10, 2025
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AI identifies key mpox protein for new vaccine and antibody therapies
With the help of artificial intelligence, an international team of researchers has made the first major inroad to date toward a new and more effective way to fight the monkeypox virus (MPXV), which causes a painful and sometimes ...
Dec 10, 2025
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Pulmonary fibrosis traced to key signaling pathway
Idiopathic pulmonary fibrosis (IPF) is a chronic disease in which healthy lung tissue is gradually replaced by scar tissue. While the early events that initiate this change are poorly understood, recent research suggests ...
Dec 10, 2025
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In pneumonia's tug-of-war, lung microbiome could tip the balance
Northwestern University scientists have potentially uncovered a previously unknown, hidden player in pneumonia. In a new study, scientists found the lungs' own microbial community, or microbiome, appears to influence how ...
Dec 10, 2025
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Real-time imaging captures what happens to cancer cells arriving in the brain
Metastasis occurs when cancer cells break away from the original tumor and travel through the bloodstream to form new tumors in other parts of the body. It is the leading cause of cancer-related death. Brain metastasis is ...
Dec 10, 2025
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Anxiety and insomnia may lower natural killer cell count, potentially repressing immune function
Natural killer (NK) cells are the bodyguards of our immune system. As a first line of defense, they destroy invading pathogens, foreign bodies, and infected cells in early stages, thereby preventing them from spreading. NK ...
Dec 10, 2025
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Study unveils improved mRNA cancer vaccine targeting
No matter where cancer cells grow in the human body, they are a threat to our health and our lives. But instead of treating them with chemotherapy or radiation—which have undesirable side effects—what if we could train ...
Dec 10, 2025
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