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Immunology news

Immunology

Isolated gut microbe drives stronger responses to cancer therapy

The National Cancer Center Research Institute in Tokyo reports that a newly isolated gut bacterium, designated Hominenteromicrobium strain YB328, mobilizes specialized dendritic cells to strengthen the impact of PD-1 blockade ...

Oncology & Cancer

A new framework for understanding and tackling CAR T toxicities

Immunotherapy using CAR T cells is finding ever more applications. In addition to their use in the treatment of blood and lymphatic cancers, CAR T cells are now also being investigated for solid tumors and various autoimmune ...

Oncology & Cancer

Plant compound slows cervical cancer growth in preclinical model

Cervical cancer is one of the most common gynecologic cancers worldwide and continues to be a leading cause of cancer-related death in women. While early detection through screening has improved outcomes, treatment options ...

Immunology

Penicillin allergy testing needed to fight antibiotic resistance

Penicillins are first-choice antibiotics for many common infections, but more than one in 15 UK adults have a penicillin allergy label on their medical records. In the event of an infection, they will be prescribed alternative ...

Immunology

Cancer drug shows promise as treatment for blindness

Singapore researchers have discovered that a new cancer drug, originally developed at A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB), shows potential as a new treatment approach for two leading causes of blindness ...

Oncology & Cancer

Controlled physical barrier created to boost cancer immunotherapy

A study led by Prof. Liang Xingjie's team from the National Center for Nanoscience and Technology of the Chinese Academy of Sciences (CAS) reported a biomimetic physical barrier (BPB) that temporarily blocks T cell-tumor ...

Immunology

New route into cells could make gene therapies safer

Scientists from the Centenary Institute and the University of Sydney have made a landmark discovery that could lead to safer and more effective gene therapies for a range of serious genetic disorders including Duchenne muscular ...

Immunology

Immunotherapy resistance linked to cytoplasmic WEE1 protein

Immune checkpoints are regulatory proteins that prevent the immune system from attacking healthy tissues. Some cancer cells exploit these checkpoints to avoid immune detection. Immune checkpoint blockade (ICB)—a therapy ...

Oncology & Cancer

Fighting leukemia by breaking a hidden cell loop

Researchers at MUSC Hollings Cancer Center have identified a signaling loop involved in the growth and persistence of leukemia cells—and developed a novel immunotherapy that can disrupt that loop to boost immune function ...

Diseases, Conditions, Syndromes

What a disease in cats may teach us about long COVID

Feline infectious peritonitis, or FIP, is a serious and historically fatal disease in cats caused by a coronavirus. It behaves in many ways like severe coronavirus infections in humans, causing widespread inflammation, T ...

Diseases, Conditions, Syndromes

How Zika virus knocks out our immune defenses

Zika virus and dengue virus are very close relatives. Both are mosquito-borne flaviviruses, and both specialize in infecting a host's dendritic cells.

Medical research

How stem cells calm the body's immune response

Our blood consists of many cell types that develop through different stages from a precursor type—the blood stem cell. An international research team led by Universitätsmedizin Frankfurt and Goethe University has now investigated ...

Immunology

Ultrafine bubble showers may help suppress atopic dermatitis

Bubble baths might be soothing soaks, but bubble showers could be the next thing in keeping the skin clean. An Osaka Metropolitan University-led medical research team found that ultrafine bubble showers might help prevent ...

Immunology

High-fat diet linked to weakened infection response in mice

A new study published in The Journal of Immunology reveals how a high-fat diet may impair the immune system's ability to respond to infection by impacting the function of neutrophils, one of the first immune cells to respond ...

Genetics

Illuminating the immune response to aberrant DNA

Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as well as transformation during cancer. Researchers led by Ikerbasque Research Professor Sergio P. Acebrón ...