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Inflammatory disorders news

Neuroscience

Raising eyebrows on neuroinflammation: Study finds novel role for 'skin plumping' molecule

This clear, gooey substance, which is naturally produced by the human body, has been popularized by cosmetic and skin care products that promote healthier, plumper and more supple skin. Also recognized for its abilities to ...

Immunology

How to equip the brake of immunity

The immune system is indispensable for defense against invading pathogens, but its aberrant activation may lead to autoimmune diseases. Regulatory T cells play a crucial role in preventing excess immune activation; mice without ...

Inflammatory disorders

Medication linked to increased risk of inflammatory bowel disease

Medications that target tumor necrosis factor alpha (TNFα), a protein involved in inflammation, have revolutionized the management of certain autoimmune diseases, but paradoxically, these agents might provoke the development ...

Medications

Using a common anticonvulsant to counteract inflammation

Serious conditions, including sepsis, stem from inflammation in the body, and there is a lack of effective medication for sepsis. A chromosomal protein called high-mobility group box 1 (HMGB1), secreted by immune and dying ...

Inflammatory disorders

Research highlights possible targets to help tackle Crohn's disease

Affecting around 115,000 people in the UK alone, Crohn's Disease is a lifelong condition which sees parts of the digestive system become inflamed. There is no precise cure and causes are believed to vary. But one indicator ...

Inflammatory disorders

Are we using biologic therapy properly?

The introduction of infliximab (Remicade), the first biologic therapy approved for the treatment of inflammatory bowel diseases (IBD), did not result in lower rates of hospitalizations or intestinal surgeries among patients ...

Diseases, Conditions, Syndromes

Study reveals a microbe's molecular role in Crohn's disease

Changes in the gut microbiome have long been linked with Crohn's disease and other forms of inflammatory bowel disease (IBD), but the biology behind those links has remained murky. Researchers at the Broad Institute, Massachusetts ...

Inflammatory disorders

Higher protein intake may curb age-related inflammation

We often hear that consuming protein may benefit people hoping to lose weight or build muscle mass. Now Tufts researchers have found that protein intake may also be associated with slower progression of age-related inflammation.

Inflammatory disorders

Half an hour of sun exposure daily may lower risk for pediatric IBD

(HealthDay)—Higher sun exposure in the previous summer or winter is associated with a lower risk for having pediatric inflammatory bowel disease (IBD), according to a study recently published in the Journal of Pediatric ...

Immunology

How chronic inflammation may drive down dopamine and motivation

Growing evidence shows that the brain's dopamine system, which drives motivation, is directly affected by chronic, low-grade inflammation. A new paper proposes that this connection between dopamine, effort and the inflammatory ...