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T-bet protein found essential for maintaining flu-fighting memory B cells

At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the immune system, and immune cells produce a potentially lifesaving antibody against the virus. Antigen ...

Medical research

Olorofim Phase IIb trial shows efficacy in invasive fungal disease for patients with limited treatment options

Researchers from KU Leuven, the University of California Davis Medical Center, the University of Cologne, and over 20 collaborating institutions report that the antifungal olorofim demonstrated efficacy and tolerability in ...

Medical research

New AI model could help scientists pinpoint signs of cancer cells

The Chan Zuckerberg Initiative (CZI) reports its latest AI model aimed at helping researchers better understand how cells behave by focusing on the key networks that control cell behavior, making complex biological problems, ...

Medical research

A new drug could soon help treat cancer and viral infections

An international team of researchers led by Konstanz biologists has identified a molecular mechanism that regulates the activity of N-myristoyltransferases. This enzyme plays a role in biological signaling pathways, where ...

Medical research

When stem cells feel the squeeze, they start building bone

In a discovery that could reshape approaches to regenerative medicine and bone repair, researchers have found that human stem cells can be prompted to begin turning into bone cells simply by squeezing through narrow spaces.

Medical research

Scientists create biological 'artificial intelligence' system

Australian scientists have successfully developed a research system that uses 'biological artificial intelligence' to design and evolve molecules with new or improved functions directly in mammal cells. The researchers said ...

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Preclinical study unlocks a mystery of rapid mouth healing

Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University of California, San Francisco (UCSF), has discovered ...

Medical research

NIH research funding drops $1B under Trump administration

Federal funding for medical research has dropped by roughly $1 billion this year, raising alarm among universities, medical centers and lawmakers who warn the shortfall could slow progress in cancer, diabetes and heart disease ...

Medical research

First transgenic primate model created for hepatitis B research

Researchers at Oregon Health & Science University have developed the first transgenic nonhuman primate model—genetically modified to carry a human gene—for studying hepatitis B virus. The breakthrough could lead to the ...

Medical research

Brain signals linked to sweet taste preference discovered

Researchers at Stony Brook University used genetic manipulation in a laboratory brain model to demonstrate that neurosteroids, signals involved in mood regulation and stress, can reduce the sensitivity and preference for ...

Medical research

Nasal COVID-19 vaccine to enter US clinical trials

A nasal vaccine for COVID-19—based on technology developed at Washington University in St. Louis—is poised to enter a phase 1 clinical trial in the U.S. after an investigational new drug application from Ocugen, Inc. ...