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T-bet protein found essential for maintaining flu-fighting memory B cells

At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the immune system, and immune cells produce a potentially lifesaving antibody against the virus. Antigen ...

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Olorofim Phase IIb trial shows efficacy in invasive fungal disease for patients with limited treatment options

Researchers from KU Leuven, the University of California Davis Medical Center, the University of Cologne, and over 20 collaborating institutions report that the antifungal olorofim demonstrated efficacy and tolerability in ...

Medical research

New AI model could help scientists pinpoint signs of cancer cells

The Chan Zuckerberg Initiative (CZI) reports its latest AI model aimed at helping researchers better understand how cells behave by focusing on the key networks that control cell behavior, making complex biological problems, ...

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A new drug could soon help treat cancer and viral infections

An international team of researchers led by Konstanz biologists has identified a molecular mechanism that regulates the activity of N-myristoyltransferases. This enzyme plays a role in biological signaling pathways, where ...

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When stem cells feel the squeeze, they start building bone

In a discovery that could reshape approaches to regenerative medicine and bone repair, researchers have found that human stem cells can be prompted to begin turning into bone cells simply by squeezing through narrow spaces.

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Scientists create biological 'artificial intelligence' system

Australian scientists have successfully developed a research system that uses 'biological artificial intelligence' to design and evolve molecules with new or improved functions directly in mammal cells. The researchers said ...

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Preclinical study unlocks a mystery of rapid mouth healing

Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University of California, San Francisco (UCSF), has discovered ...

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Protein structure at the heart of heart disease discovered

Low-density lipoproteins (LDL)—commonly known as bad cholesterol—have long been on scientists' radar as a major contributor to heart disease. But these microscopic troublemakers have hidden their inner workings behind ...

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Key takeaways from the latest research into gut bacteria

Weighing in at nearly 2 kilos, our gut bacteria seem to play an even bigger role than was previously thought. These bacteria can influence our mood and act as a communication center. Gut microbiota researchers Åsa Håkansson ...

Medical research

β-glucans show promise as adjuvants for allergy treatment

A recent study carried out by a research team from the Paul-Ehrlich-Institut investigated the immunomodulating properties of β-glucans. These are natural sugar compounds found in bacteria, fungi and grains. The results indicate ...

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Cannabinoids offer new hope for safe and effective pain relief

Chronic pain is a global health challenge, with current treatment options often limited by side effects, addiction risk, and diminished effectiveness over time. In a new study, Yale researchers identify alternative compounds ...

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Research ties mouth cancer to oral microbiome shifts

Oral squamous cell cancer, or OSCC, arises in the cells that line the mouth. The disease is often diagnosed at a late stage, which comes with a poor prognosis, and 450,000 people die from it every year, according to the International ...

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Cancer-fighting compound shows immense potential to eradicate HIV

A compound with the unpresuming designation of EBC-46 has made a splash in recent years for its cancer-fighting prowess. Now a new study led by Stanford researchers has revealed that EBC-46 also shows immense potential for ...

Medical research

Researchers pinpoint keys to cell therapy response for leukemia

Dana-Farber Cancer Institute researchers have identified factors that determine whether donor lymphocyte infusion (DLI), a standard therapy for patients with acute myeloid leukemia (AML) who have relapsed after allogenic ...

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Mapping the brain's self-healing abilities after stroke

A new study by researchers at the Department of Molecular Medicine at SDU sheds light on one of the most severe consequences of stroke: damage to the brain's "cables"—the so-called nerve fibers—which leads to permanent ...