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Bone marrow model built entirely from human cells can reduce animal testing

Our body's "blood factory" consists of specialized tissue made up of bone cells, blood vessels, nerves and other cell types. Now, researchers have succeeded for the first time in recreating this cellular complexity in the ...

Medical research

How cancer cells 'break through' tight tissue gaps

Aggressive cancer cells are masters of movement. When they spread through the body, they cause metastasis, which significantly reduces a person's chance of survival. For this spreading to take place, they can switch between ...

Medical research

Non-opioid pain relief: Brain's 'cleanup crew' reveals a new target

Chronic pain is a daily reality for millions of Americans, interfering with their everyday activities and quality of life. An estimated 24.3% of adults in the United States experienced chronic pain in 2023, and current treatment ...

Medical research

New study identifies part of brain animals use to make inferences

Animals survive in changing and unpredictable environments by not merely responding to new circumstances, but also, like humans, by forming inferences about their surroundings—for instance, squirrels understand that certain ...

Medical research

Researcher out to solve mystery of migraine

Often dismissed as a minor ailment, migraine is a debilitating neurological disease affecting hundreds of thousands of New Zealanders. At the University of Otago's School of Biomedical Sciences, world-leading research by ...

Medical research

Surprising blood stem cell diversification revealed in humans

Every second, millions of blood cells are produced in the human body, and about 90% of the cells replaced daily are blood cells. These include red blood cells essential for oxygen transport, platelets for blood clotting, ...

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Opt-out organ donation policies may reduce organ supply

Every day, 17 Americans die while waiting for an organ transplant. Opt-out organ donation policies, which enroll everyone into post-mortem donation programs by default unless people choose to opt out, have been touted as ...

Medical research

A 'bird's eye view' of how human brains operate

A new study provides the best evidence to date that the connection patterns between various parts of the human brain can tell scientists the specialized functions of each region.

Medical research

AI helps scientists correct mistakes in medical studies

Randomized, controlled clinical trials are crucial for telling whether a new treatment is safe and effective. But often scientists don't fully report the details of their trials in a way that allows other researchers to gauge ...

Medical research

Scientists find cells that know when, where and how to grow teeth

Tooth development is a dynamic process that involves the stages of the bud, the cap, and the bell, followed by root development and subsequent tooth formation. Processes such as the bud-to-cap transition are mediated by epithelial-mesenchymal ...

Medical research

Blood analyses in dogs could provide insights into human aging

Lab-based studies have provided lots of information on the biology of aging, but it's unclear how lab discoveries apply to aging in the real world. Research in Aging Cell provides insights into aging based on studies in dogs.

Medical research

Pulse oximeter index offers non-invasive guides for fluid therapy

A prospective study conducted at Avicenna University Hospital (Cadi Ayyad University) suggests that the plethysmographic perfusion index (PPI), a noninvasive parameter derived from pulse oximetry, can help identify fluid ...