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Medical research
Scientists find cell surface sugar that slows pancreatic cancer in mice—and it's detectable in patient blood samples
Pancreatic cancer has the highest mortality rate of all major cancers, and its incidence is climbing. Because it is typically asymptomatic at early stages, pancreatic cancer is especially difficult to catch and treat in time. ...
2 hours ago
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Medical research
Promising preclinical therapy exploits ALK protein to selectively destroy tumors while sparing healthy cells
Researchers at Children's Hospital of Philadelphia (CHOP) unveiled a novel antibody-drug conjugate (ADC) that shows striking efficacy against cancers that express the anaplastic lymphoma kinase (ALK) protein on the cancer ...
Sep 16, 2025
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Growth factor erythropoietin promotes protective myelin formation, showing therapeutic potential
In the brain, it is not only important that nerve cells send signals, but also how quickly they can do so. In order for information to flow smoothly, a kind of biological insulation is necessary. The brain forms specialized ...
Sep 16, 2025
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Old data can transform the future of health care
Patient preference studies (research into what patients value in their treatment) are increasingly used to inform drug development and regulatory approval decisions. But these studies are expensive and time-consuming to conduct. ...
Sep 15, 2025
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New trial aims to advance research into Strep A vaccine development
A new human challenge trial under way in Melbourne aims to advance research into Strep A, accelerating efforts toward the development of a vaccine.
Sep 15, 2025
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Association between trust of researchers and willingness to participate in Alzheimer's disease biomarker research
A new study has found that trust in researchers is the strongest factor influencing whether older adults are willing to participate in Alzheimer's disease and related dementia (ADRD) biomarker research. In a survey of 399 ...
Sep 15, 2025
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Microbial allies: Bacteria help fight against cancer
An international team of scientists led by researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and the University of Cologne have discovered that microbes associated with tumors produce a ...
Sep 12, 2025
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Identifying the interactions that drive cell migration in brain cancer
To move forward or migrate, the different cells in our body must exert forces or interact with their surrounding environment. Interestingly, however, a fault in these interactions can also be the reason for the spread of ...
Sep 12, 2025
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Scientists behind breakthrough cystic fibrosis treatment awarded top US prize
Cystic fibrosis was once a dire, likely deadly diagnosis, destroying a patient's ability to breathe and digest food—but a revolutionary new treatment offers reason for hope.
Sep 11, 2025
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Missing Y gene linked to male infertility
University of Hawaiʻi at Mānoa scientists have uncovered a direct link between a missing Y chromosome gene and male infertility. Their new research reveals that deleting this single gene in mice not only caused infertility ...
Sep 10, 2025
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Soft robot intubation device, designed specifically for non-expert users, could save lives
Maintaining an open airway is a critical priority in emergency medicine. Without the flow of oxygen, other emergency interventions can become ineffective at saving the patient's life. However, creating this airway through ...
Sep 10, 2025
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Inhibiting an astrocytic 'brake' that blocks spinal cord repair could pave path to neuronal regeneration
Spinal cord injuries caused by external trauma, such as traffic accidents or falls, often lead to the permanent loss of motor and sensory functions. This is because the spinal cord—the central pathway connecting the brain ...
Sep 10, 2025
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Brain asymmetry shapes direction of mental number line in early life
Lateralization of the brain—the tendency for the left and right hemispheres to specialize in different functions—underlies the development of a left-to-right mental number line, according to a study in newborn chicks.
Sep 9, 2025
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Using new blood biomarkers, researchers find Alzheimer's disease trial eligibility differs among various populations
Some of the populations with the highest risk for Alzheimer's disease remain greatly underrepresented in clinical trials—and a new study helps explain why.
Sep 8, 2025
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Bursting HIV's bubble: A new workflow to study HIV-1 genome-containing capsids
40 million people live with HIV globally, and that number continues to rise. While therapies exist to reduce the amount of HIV in a patient's body and, in turn, reduce HIV symptoms, there remains no cure. Engineering better ...
Sep 8, 2025
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Few women participate in studies for common cardiac conditions, according to study
Although cardiovascular disease is a leading cause of death for women, they remain underrepresented in clinical trials for common heart conditions. These findings, by investigators in the Smidt Heart Institute at Cedars-Sinai, ...
Sep 8, 2025
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New tool helps identify unreliable research trials
An international group of researchers has developed a new tool that can help identify problematic randomized controlled trials (RCTs), including fraudulent studies, where there are serious concerns about trustworthiness.
Sep 8, 2025
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No, organ transplants won't make you live forever, whatever Putin says
What do world leaders talk about when they think we're not listening? This week it was the idea of living forever.
Sep 6, 2025
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3D structure of human clusterin sheds light on Alzheimer's risk factor
Late-onset Alzheimer's disease (LOAD) is the most common form of dementia, with symptoms appearing after age 65. Since carriers of clusterin risk alleles have an increased likelihood of developing LOAD, the associated clusterin ...
Sep 5, 2025
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Changes at NIH give political appointees greater power to fund or block research
The Trump administration has given notice that political appointees, rather than scientists, will ultimately decide who gets grant money from the world's largest biomedical research funder—the federal government's National ...
Sep 5, 2025
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Stem cell scientists unlock blueprint for lab-grown kidney cells with preclinical value
In the lab, it's easier to grow simple balls of cells than complex asymmetrical structures with two distinct ends—like the one million filtering units—nephrons—that make up a human kidney. But new research unveils a ...
Sep 4, 2025
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Intestinal surface cells pull rather than push to remove weak neighbors, research reveals
Cells on the inner surface of the intestine are replaced every few days. But, how does this work? It was always assumed that cells leave the intestinal surface because excess cells are pushed out.
Sep 4, 2025
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Weight-loss drug semaglutide shown to reduce cocaine use in rats
Scientists have found that the diabetes/weight loss drug semaglutide, sold commercially under brand names like Ozempic and Wegovy, significantly reduces cocaine-seeking behavior in rats. This work needs to be confirmed in ...
Sep 4, 2025
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Peer review and editorial process yield improvements in randomized clinical trial abstracts
Peer review and the editorial process yield frequent improvements in research abstracts of randomized clinical trial (RCT) reports, according to a research letter published online Sept. 2 in the Annals of Internal Medicine.
Sep 3, 2025
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Bay Area doctor pursues cure for chronic hepatitis B as prevention falters
Liver specialist Maurizio Bonacini is in the race for a cure for hepatitis B, one of the world's most widespread diseases and a top cause of liver cancer around the globe.
Sep 3, 2025
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