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Discovery of 'primed' state in neuromuscular receptors may guide future drug design

An international research team led by a University of Ottawa Faculty of Medicine investigator has revealed ultra-detailed intricacies in how nerve signals activate at the neuromuscular junction, a specialized synapse that ...

Medical research

Preventing overhydration: Study uncovers a neural circuit that prompts mice to stop drinking

Identifying the neural mechanisms that support the regulation of vital physiological processes, such as drinking, eating and sleeping, is a long-standing goal within the neuroscience research community. As the disruption ...

Medical research

Cardamom seeds revealed as potential source of antiviral treatment

Plant-based materials have traditionally been used to treat a variety of viral infections. Now, researchers have found that cardamom seed extract, as well as its main bioactive ingredient, 1,8-cineole, can have potent antiviral ...

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mRNA therapy restores sperm production and fertility in mice

For many couples facing infertility, medicine offers a range of solutions. But for men with non-obstructive azoospermia (NOA)—a genetic condition where sperm production stalls—options remain limited.

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Ketogenic diet may protect against stress experienced in the womb

Researchers have shown that young rats fed a ketogenic diet—a diet with high fat and low carbohydrates—are protected from the lasting experience of pre‑natal stress. This work, which has not yet been confirmed in humans, ...

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A global standard to measure outcomes in dengue treatment trials

The first global standard that harmonizes what outcomes to measure in dengue treatment trials has been published Oct. 7 in The Lancet Infectious Diseases. Co-led by researchers at King's and the University of Oxford, this ...

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New tool helps identify unreliable research trials

An international group of researchers has developed a new tool that can help identify problematic randomized controlled trials (RCTs), including fraudulent studies, where there are serious concerns about trustworthiness.

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Weight-loss drug semaglutide shown to reduce cocaine use in rats

Scientists have found that the diabetes/weight loss drug semaglutide, sold commercially under brand names like Ozempic and Wegovy, significantly reduces cocaine-seeking behavior in rats. This work needs to be confirmed in ...

Medical research

Pioneering strategy may keep breast cancer from coming back

A first-of-its-kind clinical trial has shown it's possible to identify breast cancer survivors who are at higher risk of their cancer coming back due to the presence of dormant cancer cells and to effectively treat these ...

Medical research

Could octopuses hold the key to curing cancer?

Scientific breakthroughs often emerge from unexpected and unlikely places. The development of penicillin was an accident, Velcro was inspired by plant burrs and multiple cancer treatments have been developed from sea sponges.