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Preventing overhydration: Study uncovers a neural circuit that prompts mice to stop drinking

Identifying the neural mechanisms that support the regulation of vital physiological processes, such as drinking, eating and sleeping, is a long-standing goal within the neuroscience research community. As the disruption ...

Medical research

Discovery of 'primed' state in neuromuscular receptors may guide future drug design

An international research team led by a University of Ottawa Faculty of Medicine investigator has revealed ultra-detailed intricacies in how nerve signals activate at the neuromuscular junction, a specialized synapse that ...

Medical research

Cardamom seeds revealed as potential source of antiviral treatment

Plant-based materials have traditionally been used to treat a variety of viral infections. Now, researchers have found that cardamom seed extract, as well as its main bioactive ingredient, 1,8-cineole, can have potent antiviral ...

Medical research

mRNA therapy restores sperm production and fertility in mice

For many couples facing infertility, medicine offers a range of solutions. But for men with non-obstructive azoospermia (NOA)—a genetic condition where sperm production stalls—options remain limited.

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Ketogenic diet may protect against stress experienced in the womb

Researchers have shown that young rats fed a ketogenic diet—a diet with high fat and low carbohydrates—are protected from the lasting experience of pre‑natal stress. This work, which has not yet been confirmed in humans, ...

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A global standard to measure outcomes in dengue treatment trials

The first global standard that harmonizes what outcomes to measure in dengue treatment trials has been published Oct. 7 in The Lancet Infectious Diseases. Co-led by researchers at King's and the University of Oxford, this ...

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Adjusting drug timing can boost fertility, study suggests

Researchers at Osaka Metropolitan University have found that changing the timing of fertility drugs to match the follicle maturity period significantly increases the number of ovulated oocytes—the cells that develop into ...

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How a gift card could help speed up Alzheimer's clinical research

Offering a modest gift card significantly increased enrollment of low-income individuals in a patient registry designed to accelerate Alzheimer's disease clinical trials, a new USC study published in JAMA Health Forum finds.

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CaMKIIα redox mechanism revealed as key to learning and memory

A research team led by Prof. Chen Chang from the Institute of Biophysics of the Chinese Academy of Sciences, in collaboration with Prof. Huang Zhangjian of China Pharmaceutical University, has uncovered a previously unknown ...

Medical research

How the body's cells change shape to deal with wounds

The body's cells change their shape to close gaps such as wounds—with part of the cell flexing depending on the curve of the gap and the organization of cell-internal structures, a new study reveals.

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Geroscience: Rethinking how medicine can approach aging

A review published in the journal JAMA highlights innovative strategies to slow the biological aging process, an emerging approach with significant potential to prevent or delay multiple chronic diseases at once, one of the ...

Medical research

Flatworms could replace rats for in vivo brain studies

Tiny pond worms could help find new ways to treat schizophrenia, develop an understanding of drug addiction and test new medicines for mental illnesses—all while reducing the number of mice and rats used in early medical ...